Ligand diphosphoric acid

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Basic Ligand Information

Molecular Structure
Picture of diphosphoric acid (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
H4O7P2
diphosphoric acid
XPPKVPWEQAFLFU-UHFFFAOYSA-N
Synonyms:
diphosphate, P2O74-, Pyrophosphate, pyrophosphoric acid

Show all pahtways known for Show all pathways known for diphosphoric acid

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (75 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
orotidine 5-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate
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5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = L-glutamine + 5-phospho-alpha-D-ribose 1-diphosphate + H2O
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1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = ATP + 5-phospho-alpha-D-ribose 1-diphosphate
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beta-nicotinate D-ribonucleotide + diphosphate + CO2 = pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate
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diphosphate + L-serine = phosphate + O-phospho-L-serine
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diphosphate + D-fructose 6-phosphate = phosphate + D-fructose 1,6-bisphosphate
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diphosphate + acetate = phosphate + acetyl phosphate
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diphosphate + GDP-mannose = GTP + alpha-D-mannose 1-phosphate
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diphosphate + UDP-N-acetyl-D-glucosamine = UTP + N-acetyl-alpha-D-glucosamine 1-phosphate
show the reaction diagram
dTDP-glucose + diphosphate = dTTP + alpha-D-glucose 1-phosphate
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diphosphate + ADP-D-ribose = ATP + D-ribose 5-phosphate
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AMP + phosphoenolpyruvate + diphosphate = ATP + pyruvate + phosphate
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diphosphate + microsomal polypeptides = phosphate + phosphorylated microsomal polypeptides
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diphosphate + H2O = 2 phosphate
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diphosphate + H2O = 2 phosphate
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diphosphate + H2O = 2 phosphate
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CMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine = CTP + (R)-4'-phosphopantothenate + L-cysteine
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (1403 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
L-tyrosine + NADPH + H+ + ATP = L-tyrosinal + NADP+ + AMP + diphosphate
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fatty acid + ATP + NADPH + H+ = fatty aldehyde + AMP + diphosphate + NADP+
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L-2-aminoadipate + NADPH + H+ + ATP = (S)-2-amino-6-oxohexanoate + NADP+ + AMP + diphosphate
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presqualene diphosphate + NADPH + H+ = squalene + diphosphate + NADP+
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trans,octacis-decaprenyl phosphate + 5-phospho-alpha-D-ribose 1-diphosphate = trans,octacis-decaprenylphospho-beta-D-ribofuranose 5-phosphate + diphosphate
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neamine + 5-phospho-alpha-D-ribose 1-diphosphate = 5''-phosphoribostamycin + diphosphate
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fumigaclavine A + dimethylallyl diphosphate = fumigaclavine C + diphosphate
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geranyl diphosphate + 2,4-dihydroxy-6-pentylbenzoate = diphosphate + cannabigerolate
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(7,8-dihydropterin-6-yl)methyl diphosphate + 4-(beta-D-ribofuranosyl)aniline 5'-phosphate = N-[(7,8-dihydropterin-6-yl)methyl]-4-(beta-D-ribofuranosyl)aniline 5'-phosphate + diphosphate
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dimethylallyl diphosphate + brevianamide F = diphosphate + tryprostatin B
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dimethylallyl diphosphate + 12alpha,13alpha-dihydroxyfumitremorgin C = diphosphate + fumitremorgin B
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dimethylallyl diphosphate + 4-hydroxyphenylpyruvate = diphosphate + 3-dimethylallyl-4-hydroxyphenylpyruvate
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geranylgeranyl diphosphate + homogentisate = diphosphate + 6-geranylgeranyl-2-methylbenzene-1,4-diol + CO2
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all-trans-nonaprenyl diphosphate + homogentisate = diphosphate + 2-methyl-6-all-trans-nonaprenylbenzene-1,4-diol + CO2
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dimethylallyl diphosphate + 5,10-dihydrophenazine 1-carboxylate = diphosphate + 5,10-dihydro-9-dimethylallylphenazine 1-carboxylate
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dimethylallyl diphosphate + L-tyrosine = diphosphate + 4-O-dimethylallyl-L-tyrosine
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geranyl diphosphate + flaviolin = 3-linalylflaviolin + diphosphate
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geranyl diphosphate + 2-O-methyl-3-methylflaviolin = diphosphate + 6-(3,7-dimethylocta-1,6-dien-3-yl)-5,7-dihydroxy-2-methoxy-3-methylnaphthalene-1,4-dione 6-prenyl-2-methoxy-3-methylflaviolin
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geranyl diphosphate + 2-O-methyl-3-methylflaviolin = diphosphate + 7-[[(2E)-3,7-dimethylocta-2,6-dien-1-yl]oxy]-5-hydroxy-2-methoxy-3-methylnaphthalene-1,4-dione
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dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + nerylneryl diphosphate
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2 (2E,6E)-farnesyl diphosphate + NADPH + H+ = squalene + 2 diphosphate + NADP+
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dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + neryl diphosphate
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(2E,6E)-farnesyl diphosphate + 4 isopentenyl diphosphate = 4 diphosphate + all-trans-heptaprenyl diphosphate
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2 dimethylallyl diphosphate + 2 (6aS,11aS)-3,6a,9-trihydroxypterocarpan = 2 diphosphate + (6aS,11aS)-2-dimethylallyl-3,6a,9-trihydroxypterocarpan + (6aS,11aS)-4-dimethylallyl-3,6a,9-trihydroxypterocarpan
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geranylgeranyl diphosphate + sn-glycerol 1-phosphate = diphosphate + 3-(O-geranylgeranyl)-sn-glycerol 1-phosphate
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geranylgeranyl diphosphate + 3-(O-geranylgeranyl)-sn-glycerol 1-phosphate = diphosphate + 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate
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dimethylallyl diphosphate + leachianone G = diphosphate + sophoraflavanone G
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octaprenyl diphosphate + 1,4-dihydroxy-2-naphthoate = a demethylmenaquinol + diphosphate + CO2
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dimethylallyl diphosphate + L-tryptophan = diphosphate + 7-(3-methylbut-2-enyl)-L-tryptophan
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geranylgeranyl diphosphate + 2 isopentenyl diphosphate = 2 diphosphate + all-trans-hexaprenyl diphosphate
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(2E,6E)-farnesyl diphosphate + 3 isopentenyl diphosphate = 3 diphosphate + all-trans-hexaprenyl diphosphate
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geranylgeranyl diphosphate + 5 isopentenyl diphosphate = 5 diphosphate + all-trans-nonaprenyl diphosphate
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all-trans-geranylfarnesyl diphosphate + 6 isopentenyl diphosphate = 6 diphosphate + hexatrans,tetracis-undecaprenyl diphosphate
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(2E,6E)-farnesyl diphosphate + 5 isopentenyl diphosphate = 5 diphosphate + all-trans-octaprenyl diphosphate
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(2E,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate = 7 diphosphate + all-trans-decaprenyl diphosphate
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geranyl diphosphate + 4-hydroxybenzoate = 3-geranyl-4-hydroxybenzoate + diphosphate
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(2E,6E)-farnesyl diphosphate = 15-cis-4,4'-diapophytoene + 2 diphosphate
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dimethylallyl diphosphate + L-tryptophan = diphosphate + 5-(3-methylbut-2-enyl)-L-tryptophan
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geranylfarnesyl diphosphate + 6 isopentenyl diphosphate = 6 diphosphate + tetratrans,hexacis-undecaprenyl diphosphate
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bacteriochlorophyllide a + phytyl diphosphate = bacteriochlorophyll a + diphosphate
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adenosylcobinamide phosphate + GTP = adenosylcobinamide-GDP + diphosphate
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ATP + (R)-4-phosphopantoate + beta-alanine = AMP + diphosphate + (R)-4'-phosphopantothenate
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phosphate + acetyl phosphate = diphosphate + acetate
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[pyruvate, phosphate dikinase] phosphate + phosphate = [pyruvate, phosphate dikinase] + diphosphate
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UTP + alpha-D-xylose 1-phosphate = diphosphate + UDP-xylose
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UTP + alpha-D-galactose 1-phosphate = diphosphate + UDP-alpha-D-galactose
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CTP + ethanolamine phosphate = diphosphate + CDP-ethanolamine
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ATP + RNA = diphosphate + RNA(A)n
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CTP + alpha-D-glucose 1-phosphate = diphosphate + CDP-glucose
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GTP + alpha-D-mannose 1-phosphate = diphosphate + GDP-mannose
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CTP + 3-deoxy-D-manno-octulosonate = diphosphate + CMP-3-deoxy-D-manno-octulosonate
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GTP + GTP = diphosphate + P1,P4-bis(5'-guanosyl)tetraphosphate
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ATP + gentamicin A = diphosphate + 2''-adenylylgentamicin A
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ATP + streptomycin = diphosphate + 3''-adenylylstreptomycin
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UTP + RNAn = diphosphate + RNAn+1
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ATP + 2,3-dihydroxybenzoate = diphosphate + (2,3-dihydroxybenzoyl)adenylate
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2'-(5''-triphosphoribosyl)-3'-dephospho-CoA + apo-citrate lyase = holo-citrate lyase + diphosphate
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GTP + adenosylcobinamide phosphate = diphosphate + adenosylcobinamide-GDP
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CTP + 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate = diphosphate + CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol
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(2S)-2-phospholactate + GTP = lactyl-2-diphospho-5'-guanosine + diphosphate
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D-glycero-beta-D-manno-heptose 1-phosphate + ATP = ADP-D-glycero-beta-D-manno-heptose + diphosphate
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D-glycero-D-alpha-manno-heptose 1-phosphate + GTP = GDP-D-glycero-D-alpha-manno-heptose + diphosphate
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ATP + [sulfur-carrier protein ThiS] = diphosphate + adenylyl-[sulfur-carrier protein ThiS]
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ATP + molybdopterin = diphosphate + adenylyl-molybdopterin
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CTP + molybdenum cofactor = diphosphate + cytidylyl molybdenum cofactor
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GTP + MoO2(OH)Dtpp-mP = diphosphate + MoO2(OH)Dtpp-mGDP
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ATP + [molybdopterin-synthase sulfur-carrier protein]-Gly-Gly = diphosphate + [molybdopterin-synthase sulfur-carrier protein]-Gly-Gly-AMP
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CTP + 5,7-bis(acetylamino)-3,5,7,9-tetradeoxy-L-glycero-alpha-L-manno-2-nonulopyranosonic acid = diphosphate + CMP-5,7-bis(acetylamino)-3,5,7,9-tetradeoxy-L-glycero-alpha-L-manno-2-nonulopyranosonic acid
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UTP + N-acetyl-alpha-D-galactosamine 1-phosphate = diphosphate + UDP-N-acetyl-alpha-D-galactosamine
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3 ATP = pppA2'p5'A2'p5'A + 2 diphosphate
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2 ATP = 2 diphosphate + cyclic di-3',5'-adenylate
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5'-triphospho-mRNA + GDP = diphosphate + guanosine 5'-triphospho-mRNA
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CTP + 8-amino-3,8-dideoxy-alpha-D-manno-octulosonate = diphosphate + CMP-8-amino-3,8-dideoxy-alpha-D-manno-octulosonate
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GTP + valienol 1-phosphate = diphosphate + GDP-valienol
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CTP + phosphonoformate = CMP-5'-phosphonoformate + diphosphate
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ATP + D-ribose 5-phosphate = diphosphate + ADP-D-ribose
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ATP + 3-hydroxy-4-methylanthranilate = diphosphate + 3-hydroxy-4-methylanthranilyl-adenylate
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NTP + 7 dNTP = N(pdN)7 + 7 diphosphate
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thiamine diphosphate + ATP = adenosine thiamine triphosphate + diphosphate
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ATP + Urm1p-terminal-Gly = diphosphate + Urm1p-terminal-Gly-AMP
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ATP + pyruvate + phosphate = AMP + phosphoenolpyruvate + diphosphate
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triphosphate + [microsomal membrane protein] = diphosphate + phosphorylated [microsomal membrane protein]
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2 ATP = diadenosine 5',5'''-P1,P4-tetraphosphate + diphosphate
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a [protein]-S-sulfanyl-L-cysteine + uridine34 in tRNA + ATP + reduced acceptor = a [protein]-L-cysteine + 2-thiouridine34 in tRNA + AMP + diphosphate + acceptor
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a [protein]-S-sulfanyl-L-cysteine + 5-taurinomethyluridine34 in tRNA + ATP + reduced acceptor = a [protein]-L-cysteine + 5-taurinomethyl-2-thiouridine34 in tRNA + AMP + diphosphate + acceptor
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ATP + H2O = AMP + diphosphate
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prenyl diphosphate + H2O = prenol + diphosphate
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geranyl diphosphate + H2O = geraniol + diphosphate
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(+)-kolavenyl diphosphate + H2O = (+)-kolavelool + diphosphate
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geranylgeranyl diphosphate + H2O = geranylgeraniol + diphosphate
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(2E,6E)-farnesyl diphosphate + H2O = (2E,6E)-farnesol + diphosphate
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dCTP + H2O = dUMP + diphosphate + NH3
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GTP + H2O = 7,8-dihydroneopterin 2',3'-cyclic phosphate + formate + diphosphate
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dCTP + H2O = dCMP + diphosphate
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triphosphate + H2O = diphosphate + phosphate
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ATP + H2O = AMP + diphosphate
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phosphate + phosphoenolpyruvate + CO2 = diphosphate + oxaloacetate
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geranyl diphosphate = (-)-endo-fenchol + diphosphate
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(2E,6E)-farnesyl diphosphate = bicyclogermacrene + diphosphate
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(2E,6E)-farnesyl diphosphate = alpha-humulene + diphosphate
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geranyl diphosphate = tricyclene + diphosphate
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geranyl diphosphate = (E)-beta-ocimene + diphosphate
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geranyl diphosphate = (+)-car-3-ene + diphosphate
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geranyl diphosphate + H2O = 1,8-cineole + diphosphate
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geranyl diphosphate + H2O = cis-sabinene hydrate + diphosphate
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geranyl diphosphate = (+)-sabinene + diphosphate
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geranyl diphosphate + H2O = alpha-terpineol + diphosphate
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geranyl diphosphate = terpinolene + diphosphate
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geranyl diphosphate = gamma-terpinene + diphosphate
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geranyl diphosphate = alpha-terpinene + diphosphate
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geranyl diphosphate = camphene + diphosphate
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(E)-2-methylgeranyl diphosphate + H2O = 2-methylisoborneol + diphosphate
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geranyl diphosphate = beta-pinene + diphosphate
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geranyl diphosphate = alpha-pinene + diphosphate
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geranyl diphosphate = beta-pinene + diphosphate
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(2E,6E)-farnesyl diphosphate = beta-sesquiphellandrene + diphosphate
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(2E,6E)-farnesyl diphosphate = alpha-muurolene + diphosphate
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(2E,6E)-farnesyl diphosphate = gamma-muurolene + diphosphate
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(2E,6E)-farnesyl diphosphate = beta-copaene + diphosphate
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(2E,6E)-farnesyl diphosphate = beta-cubebene + diphosphate
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(2E,6E)-farnesyl diphosphate = (+)-sativene + diphosphate
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all-trans-heptaprenyl diphosphate = tetraprenyl-beta-curcumene + diphosphate
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(+)-copalyl diphosphate = miltiradiene + diphosphate
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(2E,6E)-farnesyl diphosphate = DELTA6-protoilludene + diphosphate
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(13E)-8alpha-hydroxylabd-13-en-15-yl diphosphate = cis-abienol + diphosphate
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(2E,6E)-farnesyl diphosphate + H2O = kunzeaol + diphosphate
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(2E,6E,10E,14E)-geranylfarnesyl diphosphate + H2O = ophiobolin F + diphosphate
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geranylgeranyl diphosphate + H2O = cyclooctat-9-en-7-ol + diphosphate
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(+)-copalyl diphosphate = pimara-8(14),15-diene + diphosphate
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geranylgeranyl diphosphate = cembrene C + diphosphate
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geranylgeranyl diphosphate = (R)-nephthenol + diphosphate
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geranylgeranyl diphosphate = (1S,4E,8E,12E)-2,2,5,9,13-pentamethylcyclopentadeca-4,8,12-trien-1-ol + diphosphate
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presqualene diphosphate + H2O = hydroxysqualene + diphosphate
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(2E,6E)-farnesyl diphosphate + H2O = (+)-isoafricanol + diphosphate
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geranylgeranyl diphosphate = (-)-spiroviolene + diphosphate
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geranylgeranyl diphosphate = tsukubadiene + diphosphate
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(2E,6E)-farnesyl diphosphate = (2S,3R,6S,9S)-(-)-protoillud-7-ene + diphosphate
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(2E,6E)-farnesyl diphosphate = (3S)-(+)-asterisca-2(9),6-diene + diphosphate
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(2E,6E)-farnesyl diphosphate = (-)-alpha-amorphene + diphosphate
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(2E,6E)-farnesyl diphosphate + H2O = (+)-corvol ether B + diphosphate
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(2E,6E)-farnesyl diphosphate = (+)-eremophilene + diphosphate
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(2E,6E)-farnesyl diphosphate = (1R,4R,5S)-(-)-guaia-6,10(14)-diene + diphosphate
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(2E,6E)-farnesyl diphosphate + H2O = (+)-(1(10)E,4E,6S,7R)-germacradien-6-ol + diphosphate
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geranylgeranyl diphosphate + H2O = (3E,7E)-dolabella-3,7-dien-18-ol + diphosphate
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geranylgeranyl diphosphate + H2O = (3E,7E)-dolathalia-3,7,11-triene + diphosphate
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(2E,6E)-farnesyl diphosphate + H2O = 7-epi-alpha-eudesmol + diphosphate
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(2E,6E)-farnesyl diphosphate + H2O = 4-epi-cubebol + diphosphate
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(2E,6E)-farnesyl diphosphate + H2O = (+)-corvol ether A + diphosphate
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(2E,6E,10E,14E)-geranylfarnesyl diphosphate + H2O = sesterfisherol + diphosphate
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geranyl diphosphate = beta-thujene + diphosphate
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(2E,6E,10E,14E)-geranylfarnesyl diphosphate = stellata-2,6,19-triene + diphosphate
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(2E,6E)-farnesyl diphosphate = guaia-4,6-diene + diphosphate
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geranylgeranyl diphosphate = pseudolaratriene + diphosphate
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(2E,6E)-farnesyl diphosphate = selina-4(15),7(11)-diene + diphosphate
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(2E,6E)-farnesyl diphosphate + H2O = (+)-(2S,3R,9R)-pristinol + diphosphate
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(+)-copalyl diphosphate + H2O = nezukol + diphosphate
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(2E,6E)-farnesyl diphosphate + H2O = 5-hydroxy-alpha-gurjunene + diphosphate
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ent-copalyl diphosphate = ent-atiserene + diphosphate
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(2E,6E)-farnesyl diphosphate + H2O = (2Z,6E)-hedycaryol + diphosphate
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peregrinol diphosphate = (13epsilon)-9,13-epoxylabda-14-ene + diphosphate
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(13E)-8alpha-hydroxylabd-13-en-15-yl diphosphate = manoyl oxide + diphosphate
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geranylgeranyl diphosphate = cycloaraneosene + diphosphate
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geranylgeranyl diphosphate = rhizathalene A + diphosphate
show the reaction diagram
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trans,trans-farnesyl diphosphate = vetispiradiene + diphosphate
show the reaction diagram
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geranyl diphosphate + H2O = (3R)-linalool + diphosphate
show the reaction diagram
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dimethylallyl diphosphate = isoprene + diphosphate
show the reaction diagram
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ent-copalyl diphosphate = ent-cassa-12,15-diene + diphosphate
show the reaction diagram
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ent-copalyl diphosphate = ent-pimara-8(14),15-diene + diphosphate
show the reaction diagram
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(+)-copalyl diphosphate = abieta-8(14),12-diene + diphosphate
show the reaction diagram
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9alpha-copalyl diphosphate = stemod-13(17)-ene + diphosphate
show the reaction diagram
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terpentedienyl diphosphate = terpentetriene + diphosphate
show the reaction diagram
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(2E,6E)-farnesyl diphosphate = (Z)-gamma-bisabolene + diphosphate
show the reaction diagram
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geranylgeranyl diphosphate = elisabethatriene + diphosphate
show the reaction diagram
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9alpha-copalyl diphosphate + H2O = aphidicolan-16beta-ol + diphosphate
show the reaction diagram
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geranylgeranyl diphosphate = fusicocca-2,10(14)-diene + diphosphate
show the reaction diagram
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(+)-copalyl diphosphate = isopimara-7,15-diene + diphosphate
show the reaction diagram
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(2E,6E)-farnesyl diphosphate = (E)-beta-farnesene + diphosphate
show the reaction diagram
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(2E,6E)-farnesyl diphosphate + H2O = (3R,6E)-nerolidol + diphosphate
show the reaction diagram
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(2Z,6Z)-farnesyl diphosphate = (+)-alpha-santalene + diphosphate
show the reaction diagram
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(2Z,6Z)-farnesyl diphosphate = (+)-endo-beta-bergamotene + diphosphate
show the reaction diagram
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(2Z,6Z)-farnesyl diphosphate = (-)-endo-alpha-bergamotene + diphosphate
show the reaction diagram
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(2E,6E)-farnesyl diphosphate = (S)-beta-bisabolene + diphosphate
show the reaction diagram
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(2E,6E)-farnesyl diphosphate = longifolene + diphosphate
show the reaction diagram
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