Ligand diphosphoric acid

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Basic Ligand Information

Molecular Structure
Picture of diphosphoric acid (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
H4O7P2
diphosphoric acid
XPPKVPWEQAFLFU-UHFFFAOYSA-N
Synonyms:
(phosphate)2, diphosphate, P2O74-, Pyrophosphate, pyrophosphoric acid
Pathway Source
Pathways
BRENDA
(5R)-carbapenem carboxylate biosynthesis, 3-phenylpropionate degradation, 6-hydroxymethyl-dihydropterin diphosphate biosynthesis, acetate fermentation, adipate degradation more
MetaCyc
(+)-camphor biosynthesis, (+)-camphor degradation, (-)-camphor biosynthesis, (-)-camphor degradation, (-)-microperfuranone biosynthesis more


Show all pahtways known for Show all BRENDA pathways known for diphosphoric acid

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (102 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = L-glutamine + 5-phospho-alpha-D-ribose 1-diphosphate + H2O
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beta-nicotinate D-ribonucleotide + diphosphate + CO2 = pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate
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UMP + diphosphate = uracil + 5-phospho-alpha-D-ribose 1-diphosphate
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diphosphate + L-serine = phosphate + O-phospho-L-serine
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diphosphate + GDP-mannose = GTP + alpha-D-mannose 1-phosphate
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dTDP-glucose + diphosphate = dTTP + alpha-D-glucose 1-phosphate
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diphosphate + CDP-diacylglycerol = CTP + phosphatidate
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a tRNA with a 3' CCA end + 3 diphosphate = a tRNA precursor + 2 CTP + ATP
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UDP-D-glucose + diphosphate = UTP + alpha-D-glucose 1-phosphate
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diphosphate + ADP-D-ribose = ATP + D-ribose 5-phosphate
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AMP + phosphoenolpyruvate + diphosphate = ATP + pyruvate + phosphate
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diphosphate + microsomal polypeptides = phosphate + phosphorylated microsomal polypeptides
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diphosphate + H2O = 2 phosphate
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diphosphate + H2O = 2 phosphate
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diphosphate + H2O = 2 phosphate
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AMP + diphosphate + [E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine = ATP + [NEDD8 protein] + [E1 NEDD8-activating enzyme]-L-cysteine
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CMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine = CTP + (R)-4'-phosphopantothenate + L-cysteine
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In Vivo Product in Enzyme-catalyzed Reactions (1863 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
luciferin + O2 + ATP = oxyluciferin + AMP + diphosphate + CO2 + light
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luciferin + O2 + ATP = oxyluciferin + AMP + diphosphate + CO2 + light
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L-tyrosine + NADPH + H+ + ATP = L-tyrosinal + NADP+ + AMP + diphosphate
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L-2-aminoadipate + NADPH + H+ + ATP = (S)-2-amino-6-oxohexanoate + NADP+ + AMP + diphosphate
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presqualene diphosphate + NADPH + H+ = squalene + diphosphate + NADP+
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trans,octacis-decaprenyl phosphate + 5-phospho-alpha-D-ribose 1-diphosphate = trans,octacis-decaprenylphospho-beta-D-ribofuranose 5-phosphate + diphosphate
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neamine + 5-phospho-alpha-D-ribose 1-diphosphate = 5''-phosphoribostamycin + diphosphate
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fumigaclavine A + dimethylallyl diphosphate = fumigaclavine C + diphosphate
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(7,8-dihydropterin-6-yl)methyl diphosphate + 4-(beta-D-ribofuranosyl)aniline 5'-phosphate = N-[(7,8-dihydropterin-6-yl)methyl]-4-(beta-D-ribofuranosyl)aniline 5'-phosphate + diphosphate
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dimethylallyl diphosphate + 12alpha,13alpha-dihydroxyfumitremorgin C = diphosphate + fumitremorgin B
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dimethylallyl diphosphate + 4-hydroxyphenylpyruvate = diphosphate + 3-dimethylallyl-4-hydroxyphenylpyruvate
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geranylgeranyl diphosphate + homogentisate = diphosphate + 6-geranylgeranyl-2-methylbenzene-1,4-diol + CO2
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dimethylallyl diphosphate + 5,10-dihydrophenazine 1-carboxylate = diphosphate + 5,10-dihydro-9-dimethylallylphenazine 1-carboxylate
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dimethylallyl diphosphate + L-tyrosine = diphosphate + 4-O-dimethylallyl-L-tyrosine
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geranyl diphosphate + flaviolin = 3-linalylflaviolin + diphosphate
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geranyl diphosphate + 2-O-methyl-3-methylflaviolin = diphosphate + (E)-7-((3,7-dimethylocta-2,6-dien-1-yl)oxy)-5-hydroxy-2-methoxy-3-methylnaphthalene-1,4-dione + 6-prenyl-2-methoxy-3-methylflaviolin
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geranyl diphosphate + 2-O-methyl-3-methylflaviolin = diphosphate + 7-[[(2E)-3,7-dimethylocta-2,6-dien-1-yl]oxy]-5-hydroxy-2-methoxy-3-methylnaphthalene-1,4-dione
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tuberculosinyl diphosphate + adenosine = 1-tuberculosinyladenosine + diphosphate
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dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + neryl diphosphate
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2 dimethylallyl diphosphate + 2 (6aS,11aS)-3,6a,9-trihydroxypterocarpan = 2 diphosphate + (6aS,11aS)-2-dimethylallyl-3,6a,9-trihydroxypterocarpan + (6aS,11aS)-4-dimethylallyl-3,6a,9-trihydroxypterocarpan
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geranylgeranyl diphosphate + sn-glycerol 1-phosphate = diphosphate + 3-(O-geranylgeranyl)-sn-glycerol 1-phosphate
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geranylgeranyl diphosphate + 3-(O-geranylgeranyl)-sn-glycerol 1-phosphate = diphosphate + 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate
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2 dimethylallyl diphosphate = diphosphate + lavandulyl diphosphate
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dimethylallyl diphosphate + leachianone G = diphosphate + sophoraflavanone G
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octaprenyl diphosphate + 1,4-dihydroxy-2-naphthoate = a demethylmenaquinol + diphosphate + CO2
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dimethylallyl diphosphate + L-tryptophan = diphosphate + 7-(3-methylbut-2-enyl)-L-tryptophan
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geranylgeranyl diphosphate + 2 isopentenyl diphosphate = 2 diphosphate + all-trans-hexaprenyl diphosphate
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all-trans-geranylfarnesyl diphosphate + 6 isopentenyl diphosphate = 6 diphosphate + hexatrans,tetracis-undecaprenyl diphosphate
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(2E,6E)-farnesyl diphosphate + 5 isopentenyl diphosphate = 5 diphosphate + all-trans-octaprenyl diphosphate
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(2E,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate = 7 diphosphate + all-trans-decaprenyl diphosphate
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geranyl diphosphate + 4-hydroxybenzoate = 3-geranyl-4-hydroxybenzoate + diphosphate
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dimethylallyl diphosphate + L-tryptophan = diphosphate + 5-(3-methylbut-2-enyl)-L-tryptophan
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geranylfarnesyl diphosphate + 6 isopentenyl diphosphate = 6 diphosphate + tetratrans,hexacis-undecaprenyl diphosphate
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bacteriochlorophyllide a + phytyl diphosphate = bacteriochlorophyll a + diphosphate
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dimethylallyl diphosphate + L-tryptophan = diphosphate + 1-(2-methylbut-3-en-2-yl)-L-tryptophan
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adenosylcobinamide phosphate + GTP = adenosylcobinamide-GDP + diphosphate
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ATP + (R)-4-phosphopantoate + beta-alanine = AMP + diphosphate + (R)-4'-phosphopantothenate
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[pyruvate, phosphate dikinase] phosphate + phosphate = [pyruvate, phosphate dikinase] + diphosphate
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NTP + 7 dNTP = N(pdN)7 + 7 diphosphate
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CTP + N5-phospho-L-glutamine = diphosphate + N5-(cytidine 5'-diphosphoramidyl)-L-glutamine
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2-hydroxyethylphosphonate + CTP = cytidine 5'-[[hydroxy(2-hydroxyethyl)phosphonoyl]phosphate] + diphosphate
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phosphoenolpyruvate + GTP = enolpyruvoyl-2-diphospho-5'-guanosine + diphosphate
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3-phospho-D-glycerate + GTP = 3-(D-glyceryl)-diphospho-5'-guanosine + diphosphate
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UTP + alpha-D-xylose 1-phosphate = diphosphate + UDP-xylose
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UTP + alpha-D-galactose 1-phosphate = diphosphate + UDP-alpha-D-galactose
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CTP + ethanolamine phosphate = diphosphate + CDP-ethanolamine
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CTP + alpha-D-glucose 1-phosphate = diphosphate + CDP-glucose
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GTP + alpha-D-mannose 1-phosphate = diphosphate + GDP-mannose
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CTP + 3-deoxy-D-manno-octulosonate = diphosphate + CMP-3-deoxy-D-manno-octulosonate
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UTP + 1-phospho-alpha-D-glucuronate = diphosphate + UDP-alpha-D-glucuronate
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GTP + GTP = diphosphate + P1,P4-bis(5'-guanosyl)tetraphosphate
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2'-(5''-triphosphoribosyl)-3'-dephospho-CoA + apo-citrate lyase = holo-citrate lyase + diphosphate
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GTP + adenosylcobinamide phosphate = diphosphate + adenosylcobinamide-GDP
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CTP + 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate = diphosphate + CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol
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(2S)-2-phospholactate + GTP = lactyl-2-diphospho-5'-guanosine + diphosphate
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