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Literature summary for 6.3.5.2 extracted from

  • Matsui, H.; Sato, K.; Enei, H.; Hirose, Y.
    Production of guanosine by psicofuranine and decoyinine resistant mutants of Bacillus subtilis (1979), Agric. Biol. Chem., 43, 1739-1744.
No PubMed abstract available

Protein Variants

Protein Variants Comment Organism
GP-1 psicofuranine, decoyinine and adenosine strongly inhibit wild type enzyme. Mutant enzyme GP-1 shows decreased inhibition with adenosine and psicofuranine, but inhibition by decoyinine does not vary, complete loss of inhibition in mutant MG-1 Bacillus subtilis

Inhibitors

Inhibitors Comment Organism Structure
6-Amino-9-D-psicofuranosylpurine strong inhibition of wild type enzyme, mutant enzyme GP-1 with decreased inhibition, complete loss of inhibition of mutant enzyme MG-1 Bacillus subtilis
adenosine strong inhibition of wild type enzyme, mutant GP-1 with decreased inhibition, complete loss of inhibition in mutant MG-1 Bacillus subtilis
Decoyinine strong inhibition of wild type enzyme, and mutant enzyme GP-1, complete loss of inhibition in mutant MG-1 Bacillus subtilis

Organism

Organism UniProt Comment Textmining
Bacillus subtilis
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wild type strain AG169, psicofuranine-resistant mutant GP-1, and decoyinine-resistant mutants MG-1 and MG-4
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + XMP + Gln
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Bacillus subtilis AMP + diphosphate + GMP + Glu
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