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Literature summary for 6.3.5.2 extracted from

  • Oliver, J.C.; Linger, R.S.; Chittur, S.V.; Davisson, V.J.
    Substrate activation and conformational dynamics of guanosine 5'-monophosphate synthetase (2013), Biochemistry, 52, 5225-5235.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli DH5alpha cells Escherichia coli

Protein Variants

Protein Variants Comment Organism
37W the mutant shows severely reduced specific activity compared to the wild type enzyme Escherichia coli
W37A the mutant shows slightly reduced specific activity compared to the wild type enzyme Escherichia coli

Inhibitors

Inhibitors Comment Organism Structure
XMP substrate inhibition above 0.2 mM Escherichia coli

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + XMP + L-glutamine + H2O Escherichia coli
-
AMP + diphosphate + GMP + L-glutamate
-
?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + XMP + L-glutamine + H2O
-
Escherichia coli AMP + diphosphate + GMP + L-glutamate
-
?

Synonyms

Synonyms Comment Organism
GMP synthetase
-
Escherichia coli
GMPS
-
Escherichia coli
GuaA
-
Escherichia coli
Guanosine 5'-monophosphate synthetase
-
Escherichia coli

Cofactor

Cofactor Comment Organism Structure
ATP
-
Escherichia coli