EC Number   |
Natural Substrates |
|---|
    6.3.5.2 | ATP + xanthosine 5'-phosphate + L-glutamine + H2O |
- |
| 6.3.5.2 | ATP + XMP + L-glutamine + H2O |
- |
| 6.3.5.2 | ATP + XMP + L-glutamine + H2O |
the N-terminal glutaminase domain of the enzyme generates ammonia from glutamine and the C-terminal synthetase domain aminates xanthine monophosphate to form GMP |
| 6.3.5.2 | more |
final step of de novo guanine nucleotide biosynthesis |
| 6.3.5.2 | more |
enzyme activity is linked with cellular proliferation in differentiating, regenerating and neoplastic tissues |
| 6.3.5.2 | more |
enzyme of the purine salvage pathway |
| 6.3.5.2 | more |
key enzyme in the de novo synthesis of guanine nucleotides |
| 6.3.5.2 | more |
GMP is necessary for DNA and RNA synthesis. Expression of the gene encoding GMP synthase coincides with the points in the life cycle with increased DNA and RNA synthesis |
| 6.3.5.2 | more |
the enzyme is essential for de novo purine synthesis. Translocations of the MLL gene at chromosome band 11q23 are prevalent in patients with leukemia after treatment with epipodiphyllotoxins and other DNA topoisomerase II inhibitors. The MLL gene fuses with one of many different partner genes. GMPS is the first partner gene of MLL on chromosome 3Q and the first gene of this type in leukemia-associated translocations |
| 6.3.5.2 | more |
GMP synthetase stimulates histone H2B deubiquitylation by the epigenetic silencer USP7, GMP synthetase can regulate chromatin silencing via modulation of H2B deubiquitylation by USP7 |
