Reference on EC 3.4.24.B15 - PHEX peptidase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Boeckmann, B.; Bairoch, A.; Apweiler, R.; Blatter, M.C.; Estreicher, A.; Gasteiger, E.; Martin M.J.; Michoud, K.; O'Donovan, C.; Phan, I.; Pilbout, S.; Schneider, M.
The SWISS-PROT protein knowledgebase and its supplement TrEMBL
Nucleic Acids Res.
31
365-370
2003
Mus musculus (P70669), Homo sapiens (P78562)
Guo, R.; Liu, S.; Spurney, R.F.; Quarles, L.D.
Analysis of recombinant Phex: an endopeptidase in search of a substrate
Am. J. Physiol.
281
E837-847
2001
Homo sapiens, Mus musculus
Bowe, A.E.; Finnegan, R.; Jan de Beur, S.M.; Cho, J.; Levine, M.A.; Kumar, R.; Schiavi, S.C.
FGF-23 inhibits renal tubular phosphate transport and is a PHEX substrate
Biochem. Biophys. Res. Commun.
284
977-981
2001
Homo sapiens
Guo, R.; Rowe, P.S.; Liu, S.; Simpson, L.G.; Xiao, Z.S.; Darryl Quarles, L.D.
Inhibition of MEPE cleavage by Phex
Biochem. Biophys. Res. Commun.
297
38-45
2002
Mus musculus
Boileau, G.; Tenenhouse, H.S.; Desgroseillers, L.; Crine, P.
Characterization of PHEX endopeptidase catalytic activity: identification of parathyroid-hormone-related peptide107-139 as a substrate and osteocalcin, PPi and phosphate as inhibitors
Biochem. J.
355
707-713
2001
Homo sapiens
Campos, M.; Couture, C.; Hirata, I.Y.; Juliano, M.A.; Loisel, T.P.; Crine, P.; Juliano, L.; Boileau, G.; Carmona, A.K.
Human recombinant endopeptidase PHEX has a strict S1' specificity for acidic residues and cleaves peptides derived from fibroblast growth factor-23 and matrix extracellular phosphoglycoprotein
Biochem. J.
373
271-279
2003
Homo sapiens
Brooks, P.C.; Silletti, S.; von Schalscha, T.L.; Friedlander, M.; Cheresh, D.A.
Disruption of angiogenesis by PEX, a noncatalytic metalloproteinase fragment with integrin binding activity
Cell
92
391-400
1998
Gallus gallus
Turner, A.J.; Tanzawa, K.
Mammalian membrane metallopeptidases: NEP, ECE, KELL, and PEX
FASEB J.
11
355-364
1997
Homo sapiens
Qin, C.; Brunn, J.C.; Cook, R.G.; Orkiszewski, R.S.; Malone, J.P.; Veis, A.; Butler, W.T.
Evidence for the proteolytic processing of dentin matrix protein 1: Identification and characterization of processed fragments and cleavage sites
J. Biol. Chem.
278
34700-34708
2003
Rattus norvegicus
Liu, S.; Guo, R.; Simpson, L.G.; Xiao, Z.S.; Burnham, C.E.; Quarles, L.D.
Regulation of fibroblastic growth factor 23 expression but not degradation by PHEX
J. Biol. Chem.
278
37419-37426
2003
Homo sapiens
Alos, N.; Ecarot, B.
Downregulation of osteoblast Phex expression by PTH
Bone
37
589-598
2005
Mus musculus, Mus musculus C57/BL6J
Ito, M.; Akai, E.; Izuka, M.; Segawa, H.; Kuwahata, M.; Miyamoto, K.
Cloning and characterization of three PHEX homologues in Drosophila
J. Bone Miner. Metab.
22
3-11
2004
Drosophila melanogaster
Erben, R.G.; Mayer, D.; Weber, K.; Jonsson, K.; Jueppner, H.; Lanske, B.
Overexpression of human PHEX under the human beta-actin promoter does not fully rescue the Hyp mouse phenotype
J. Bone Miner. Res.
20
1149-1160
2005
Homo sapiens, Mus musculus
Yuan, B.; Takaiwa, M.; Clemens, T.L.; Feng, J.Q.; Kumar, R.; Rowe, P.S.; Xie, Y.; Drezner, M.K.
Aberrant Phex function in osteoblasts and osteocytes alone underlies murine X-linked hypophosphatemia
J. Clin. Invest.
118
722-734
2008
Mus musculus
Lo, F.S.; Kuo, M.T.; Wang, C.J.; Chang, C.H.; Lee, Z.L.; Van, Y.H.
Two novel PHEX mutations in Taiwanese patients with X-linked hypophosphatemic rickets
Nephron. Physiol.
103
p157-p163
2006
Homo sapiens
Roetzer, K.M.; Varga, F.; Zwettler, E.; Nawrot-Wawrzyniak, K.; Haller, J.; Forster, E.; Klaushofer, K.
Novel PHEX mutation associated with hypophosphatemic rickets
Nephron. Physiol.
106
8-12
2007
Homo sapiens (P78562)
Boskey, A.; Frank, A.; Fujimoto, Y.; Spevak, L.; Verdelis, K.; Ellis, B.; Troiano, N.; Philbrick, W.; Carpenter, T.
The PHEX transgene corrects mineralization defects in 9-month-old hypophosphatemic mice
Calcif. Tissue Int.
84
126-137
2009
Mus musculus (P70669)
Clausmeyer, S.; Hesse, V.; Clemens, P.C.; Engelbach, M.; Kreuzer, M.; Becker-Rose, P.; Spital, H.; Schulze, E.; Raue, F.
Mutational analysis of the PHEX gene: novel point mutations and detection of large deletions by MLPA in patients with X-linked hypophosphatemic rickets
Calcif. Tissue Int.
85
211-220
2009
Homo sapiens (P78562)
Gaucher, C.; Walrant-Debray, O.; Nguyen, T.M.; Esterle, L.; Garabedian, M.; Jehan, F.
PHEX analysis in 118 pedigrees reveals new genetic clues in hypophosphatemic rickets
Hum. Genet.
125
401-411
2009
Homo sapiens (P78562)
Sabbagh, Y.; Jones, A.O.; Tenenhouse, H.S.
PHEXdb, a locus-specific database for mutations causing X-linked hypophosphatemia
Hum. Mutat.
16
1-6
2000
Homo sapiens (P78562)
Barros, N.M.; Nascimento, F.D.; Oliveira, V.; Juliano, M.A.; Juliano, L.; Loisel, T.; Nader, H.B.; Boileau, G.; Tersariol, I.L.; Carmona, A.K.
The critical interaction of the metallopeptidase PHEX with heparan sulfate proteoglycans
Int. J. Biochem. Cell Biol.
40
2781-2792
2008
Homo sapiens
Guo, R.; Quarles, L.D.
Cloning and sequencing of human PEX from a bone cDNA library: evidence for its developmental stage-specific regulation in osteoblasts
J. Bone Miner. Res.
12
1009-1017
1997
Mus musculus (P70669), Homo sapiens (P78562)
Addison, W.N.; Masica, D.L.; Gray, J.J.; McKee, M.D.
Phosphorylation-dependent inhibition of mineralization by osteopontin ASARM peptides is regulated by PHEX cleavage
J. Bone Miner. Res.
25
695-705
2010
Homo sapiens
Chandran, M.; Chng, C.L.; Zhao, Y.; Bee, Y.M.; Phua, L.Y.; Clarke, B.L.
Novel PHEX Gene Mutation Associated with X Linked Hypophosphatemic Rickets
Nephron. Physiol.
116
17-21
2010
Homo sapiens
David, V.; Martin, A.; Hedge, A.M.; Drezner, M.K.; Rowe, P.S.
ASARM peptides: PHEX-dependent and -independent regulation of serum phosphate
Am. J. Physiol. Renal Physiol.
300
F783-F791
2011
Mus musculus
Martin, A.; Liu, S.; David, V.; Li, H.; Karydis, A.; Feng, J.Q.; Quarles, L.D.
Bone proteins PHEX and DMP1 regulate fibroblastic growth factor Fgf23 expression in osteocytes through a common pathway involving FGF receptor (FGFR) signaling
FASEB J.
25
2551-2562
2011
Mus musculus
Rowe, P.S.
The chicken or the egg: PHEX, FGF23 and SIBLINGs unscrambled
Cell Biochem. Funct.
30
355-375
2012
Homo sapiens (P78562)
Rowe, P.S.
Regulation of bone-renal mineral and energy metabolism: the PHEX, FGF23, DMP1, MEPE ASARM pathway
Crit. Rev. Eukaryot. Gene Expr.
22
61-86
2012
Homo sapiens (P78562)
Ichikawa, S.; Austin, A.; Gray, A.; Econs, M.
A Phex mutation in a murine model of X-linked hypophosphatemia alters phosphate responsiveness of bone cells
J. Bone Miner. Res.
27
453-460
2012
Mus musculus (P70669)
Owen, C.; Chen, F.; Flenniken, A.M.; Osborne, L.R.; Ichikawa, S.; Adamson, S.L.; Rossant, J.; Aubin, J.E.
A novel Phex mutation in a new mouse model of hypophosphatemic rickets
J. Cell. Biochem.
113
2432-2441
2012
Mus musculus (P70669)
BinEssa, H.; Zou, M.; Al-Enezi, A.; Alomrani, B.; Al-Faham, M.; Al-Rijjal, R.; Meyer, B.; Shi, Y.
Functional analysis of 22 splice-site mutations in the PHEX, the causative gene in X-linked dominant hypophosphatemic rickets
Bone
125
186-193
2019
Homo sapiens (P78562)
Neves, R.L.; Chiarantin, G.M.D.; Nascimento, F.D.; Pesquero, J.B.; Nader, H.B.; Tersariol, I.L.S.; McKee, M.D.; Carmona, A.K.; Barros, N.M.T.
Expression and inactivation of osteopontin-degrading PHEX enzyme in squamous cell carcinoma
Int. J. Biochem. Cell Biol.
77
155-164
2016
Homo sapiens (P78562), Homo sapiens
Ma, S.; Vega-Warner, V.; Gillies, C.; Sampson, M.; Kher, V.; Sethi, S.; Otto, E.
Whole exome sequencing reveals novel PHEX splice site mutations in patients with hypophosphatemic rickets
PLoS ONE
10
e0130729
2015
Homo sapiens (P78562)
Acar, S.; BinEssa, H.; Demir, K.; Al-Rijjal, R.; Zou, M.; Catli, G.; Anik, A.; Al-Enezi, A.; Oezisik, S.; Al-Faham, M.; Abaci, A.; Duendar, B.; Kattan, W.; Alsagob, M.; Kavukcu, S.; Tamimi, H.; Meyer, B.; Boeber, E.; Shi, Y.
Clinical and genetic characteristics of 15 families with hereditary hypophosphatemia Novel mutations in PHEX and SLC34A3
PLoS ONE
13
e0193388
2018
Homo sapiens (P78562)
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