Literature summary for 3.4.24.B15 extracted from

Neves, R.L.; Chiarantin, G.M.D.; Nascimento, F.D.; Pesquero, J.B.; Nader, H.B.; Tersariol, I.L.S.; McKee, M.D.; Carmona, A.K.; Barros, N.M.T.
Expression and inactivation of osteopontin-degrading PHEX enzyme in squamous cell carcinoma (2016), Int. J. Biochem. Cell Biol., 77, 155-164 .

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Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
intracellular	in squamous cell carcinoma cells	Homo sapiens	5622	-
additional information	OHEX is not prominentat the squamous cell carcinoma cell membrane	Homo sapiens	-	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P78562	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
MG-63 cell	-	Homo sapiens	-
UM-SCC-22A cell	PHEX and osteopontin are coexpressed in squamous cell carcinoma. Metastatic SCC-22B cells express 2fold more PHEX than primary tumor SCC-22A cells	Homo sapiens	-
UM-SCC-22B cell	PHEX and osteopontin are coexpressed in squamous cell carcinoma. Metastatic SCC-22B cells express 2fold more PHEX than primary tumor SCC-22A cells	Homo sapiens	-

General Information

General Information	Comment	Organism
metabolism	in squamous cell carcinoma cells, PHEX is degraded by endogenous cysteine proteases. Inhibition of cysteine proteases rescues membrane PHEX and osteopontin processing	Homo sapiens

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Release 2023.1 (January 2023)