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Literature summary for 3.4.24.B15 extracted from

  • Alos, N.; Ecarot, B.
    Downregulation of osteoblast Phex expression by PTH (2005), Bone, 37, 589-598.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
the gene is localized on the X chromosome Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information mutation of Phex leads to the dominant disorder hypophosphatemia which is associated with a renal waste of phosphate and defective bone mineralization Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
additional information the major regulator of bone development and turnover PTH, commercial preperation from rat, decreases osteoblastic Phex expression and matrix mineralization in vitro and in vivo, overview Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
Mus musculus 16020
-

Organism

Organism UniProt Comment Textmining
Mus musculus
-
C57BL/6J mice
-
Mus musculus C57/BL6J
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C57BL/6J mice
-

Source Tissue

Source Tissue Comment Organism Textmining
calvarium
-
Mus musculus
-
MC3T3-E1 cell osteoblastic cell line Mus musculus
-
osteoblast fully differentiated, from calvaria of newborn mice Mus musculus
-

Synonyms

Synonyms Comment Organism
PHEX
-
Mus musculus
phosphate-regulating gene with homologies to endopeptidases on the X chromosome
-
Mus musculus