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Literature summary for 3.4.24.B15 extracted from

  • Brooks, P.C.; Silletti, S.; von Schalscha, T.L.; Friedlander, M.; Cheresh, D.A.
    Disruption of angiogenesis by PEX, a noncatalytic metalloproteinase fragment with integrin binding activity (1998), Cell, 92, 391-400.
    View publication on PubMed
Search for more literature for 3.4.24.B15

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Gallus gallus interacts with integrin alphavbeta3, natural inhibitor of matrix metalloprotease 2, i.e. MMP-2, thereby regulating the invasive behavior of new blood vessels, enzyme domain disrupts angiogenesis and tumor growth ?
-
 ?
protein + H2O Gallus gallus
-
 peptides
-
 ?

Organism

Organism UniProt Comment Textmining
Gallus gallus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification the 29 kDa hemopexin domain of MMP-2 is cleaved of its C-terminus during processing of MMP-2, as well as a 80 amino acid sequence of the N-terminus Gallus gallus

Reaction

Reaction Comment Organism Reaction ID
proteolytic degradation of proteins regulatory inhibition of matrix metalloprotease 2 Gallus gallus
a

Source Tissue

Source Tissue Comment Organism Textmining
blood vessel associated on the surface of Gallus gallus
-
chorioallantois
-
 Gallus gallus
-
embryo
-
 Gallus gallus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information enzyme domain prevents the matrix metalloprotease 2 of binding to integrin alphavbeta3 and blocks cell surface collagenolytic activity Gallus gallus ?
-
 ?
additional information interacts with integrin alphavbeta3, natural inhibitor of matrix metalloprotease 2, i.e. MMP-2, thereby regulating the invasive behavior of new blood vessels, enzyme domain disrupts angiogenesis and tumor growth Gallus gallus ?
-
 ?
protein + H2O
-
 Gallus gallus peptides
-
 ?

Synonyms

Synonyms Comment Organism
M13.091 Merops-ID Gallus gallus
matrix metalloprotease 2 C-terminal hemopexin-like domain
-
 Gallus gallus
PEX
-
 Gallus gallus