4.2.2.1: hyaluronate lyase
This is an abbreviated version!
For detailed information about hyaluronate lyase, go to the full flat file.
Word Map on EC 4.2.2.1
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4.2.2.1
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streptococcus
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chondroitin
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disaccharide
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glycosaminoglycans
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agalactiae
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chondroitinase
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enteroaggregative
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hyaluronidases
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medicine
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hyals
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hyalurolyticus
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pharmacology
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autotransporter
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degradation
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synthesis
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analysis
- 4.2.2.1
- streptococcus
- chondroitin
- disaccharide
- glycosaminoglycans
- agalactiae
- chondroitinase
-
enteroaggregative
- hyaluronidases
- medicine
-
hyals
-
hyalurolyticus
- pharmacology
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autotransporter
- degradation
- synthesis
- analysis
Reaction
Synonyms
acidic hyase, bacterial HAse, bacterial hyaluronidase, bacterial spreading factor, bacteriophage-associated hyaluronate lyase, Cumulase, EC 4.2.99.1, GBS HA lyase, GBS hyase, glucuronoglycosaminoglycan lyase, h-SD, h-SH, HA lyase, HL, Hyal, Hyal-1, Hyal-2, HYAL1, Hyal2, HYAL3, hyaluronan lyase, hyaluronate lyase, hyaluronate lyase HylA, hyaluronate lyase HylP2, hyaluronidase, hyaluronidase 3, hyaluronidase SD, hyaluronidase SH, hyaluronidase-1, hyaluronidase-2, hyaluronoglucosaminidase-1, hyaluronoglucosaminidase-2, HYase, HylA7, hylB, hylB4755, HylP, Hylp2, LUCA-1, LUCA-2, lyase, glucuronoglycosaminoglycan, lyase, hyaluronate, More, mucinase, protein SEQ2045, rHuPH20, SagHL, SagHyal, spnHL, SpnHyal, spreading factor, SP_0314
ECTree
4.2.2.1 hyaluronate lyaseAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 4.2.2.1 - hyaluronate lyase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
hyaluronate
?
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efficient degradation of hyaluronate
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-
?
hyaluronan
3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine
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enzyme might be involved in the pathogenicity of the bacterium causing paracocidiodomycosis
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-
?
hyaluronan
3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine
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disaccharide unit
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ir
hyaluronan
3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine
elimination of the polymer in the host connective tissue
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-
?
hyaluronan
3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine
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disaccharide unit
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ir
hyaluronan
3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine
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degradation leads to increased permeability of the host tissue and therefore helps bacterial invasion
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-
?
hyaluronan
?
enzyme facilitates the invasion and spreading of the pathogenic bacterium in the host tissue by degrading the hosts' extracellular matrix component in connective tissue
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-
?
hyaluronan
?
-
extracellular enzyme facilitates the invasion and spreading of the pathogenic bacterium in the host tissue by degrading the hosts' extracellular matrix component in connective tissue
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-
?
hyaluronan
?
-
extracellular enzyme facilitates the invasion and spreading of the pathogenic bacterium in the host tissue by degrading the hosts' extracellular matrix component in connective tissue
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-
?
hyaluronan
hyaluronic acid oligomers
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absolute substrate specificity of the bacteriophage enzyme
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-
?
hyaluronan
hyaluronic acid oligomers
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absolute substrate specificity of the bacteriophage enzyme
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-
?
hyaluronic acid
hyaluronic acid oligomers
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degradation of hyaluronate in connective tissue of hosts to facilitate invasion by subcutaneous infection, the enzyme is an essential bacterial virulence factor
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-
?
hyaluronic acid
hyaluronic acid oligomers
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degradation of hyaluronate in connective tissue of hosts to facilitate invasion by subcutaneous infection, the enzyme is an essential bacterial virulence factor
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-
?
hyaluronic acid
hyaluronic acid oligomers
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degradation of hyaluronate in connective tissue of hosts to facilitate invasion
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-
?
hyaluronic acid
hyaluronic acid oligomers
degradation of hyaluronate in connective tissue of hosts to facilitate invasion
-
-
?
hyaluronic acid
hyaluronic acid oligomers
degradation of hyaluronate in connective tissue of hosts to facilitate invasion
-
-
?
hyaluronic acid
hyaluronic acid oligomers
the enzyme is essential for growth on hyaluronate as carbon source
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-
?
hyaluronic acid
hyaluronic acid oligomers
Streptomyces hyalurolyticus
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highly specific for hyaluronan, degradation, unsaturated products of varied size
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-
?
hyaluronic acid polymer
hyaluronic acid oligomers
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degradation
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-
?
hyaluronic acid polymer
hyaluronic acid oligomers
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degradation
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-
?
additional information
?
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phylogenetic analysis, enzyme may play a role in releasing nutrients thereby promoting establishment of the organism in the gut
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-
?
additional information
?
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phylogenetic analysis, enzyme is the non-lethal Mu toxin, causes gas gangrene, produces many extracellular proteins during infection that are potetial virulence factors
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-
?
additional information
?
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global regulators sar and agr are involved in enzyme regulation
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?
additional information
?
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global regulators sar and agr are involved in enzyme regulation
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?
additional information
?
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enzyme is a virulence factor that helps the pathogen to brake through the biophysical barrier of the host tissues
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?
additional information
?
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enzyme is a virulence factor that helps the pathogen to brake through the biophysical barrier of the host tissues
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?
additional information
?
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the enzyme contributes to the invasive capacity of the pathogenic organism by degrading hyaluronan and chondroitin sulfates of the extracellular matrix of host tissues
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?
additional information
?
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the enzyme is involved in degradation of hyaluronate from connective host tissues to facilitate the host and specific tissue invasion by the bacterium, overview
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?
additional information
?
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phylogenetic analysis, enzyme causes mastitis, may have an important role in promoting dissemination of the producing organism into host tissue
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?
additional information
?
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phylogenetic analysis, strong association between the production of purulent abscesses and enzyme during infections
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?
additional information
?
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phylogenetic analysis, causes a number of different infections, including meningitis and pneumoniae, where the enzyme may function as a spreading factor, while pneumolysin acts as a toxin
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?
additional information
?
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the enzyme is involved in degradation of hyaluronate from connective host tissues to facilitate the host and specific tissue invasion by the bacterium, overview
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-
?
additional information
?
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phylogenetic analysis, anti-phagocytic factors, such as M-protein, might provide sufficient protection for Streptococcus pyogenes infection during enzyme production
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-
?
additional information
?
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the enzyme is a virulence factor of the animal pathogen, relation between enzyme activity, serotype, and disease state, overview
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-
?
additional information
?
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the enzyme is a virulence factor of the animal pathogen, relation between enzyme activity, serotype, and disease state, overview
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-
?
additional information
?
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the enzyme is a virulence factor of the animal pathogen, relation between enzyme activity, serotype, and disease state, overview
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-
?
additional information
?
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the enzyme is a virulence factor of the animal pathogen, relation between enzyme activity, serotype, and disease state, overview
-
-
?
additional information
?
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the enzyme is a virulence factor of the animal pathogen, relation between enzyme activity, serotype, and disease state, overview
-
-
?
additional information
?
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the enzyme is a virulence factor of the animal pathogen, relation between enzyme activity, serotype, and disease state, overview
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-
?
additional information
?
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the enzyme is a virulence factor of the animal pathogen, relation between enzyme activity, serotype, and disease state, overview
-
-
?
additional information
?
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the enzyme is a virulence factor of the animal pathogen, relation between enzyme activity, serotype, and disease state, overview
-
-
?
additional information
?
-
the enzyme is a virulence factor of the animal pathogen, relation between enzyme activity, serotype, and disease state, overview
-
-
?
additional information
?
-
the enzyme is a virulence factor of the animal pathogen, relation between enzyme activity, serotype, and disease state, overview
-
-
?
additional information
?
-
the enzyme is a virulence factor of the animal pathogen, relation between enzyme activity, serotype, and disease state, overview
-
-
?
additional information
?
-
the enzyme is a virulence factor of the animal pathogen, relation between enzyme activity, serotype, and disease state, overview
-
-
?
additional information
?
-
the enzyme is a virulence factor of the animal pathogen, relation between enzyme activity, serotype, and disease state, overview
-
-
?
additional information
?
-
the enzyme is a virulence factor of the animal pathogen, relation between enzyme activity, serotype, and disease state, overview
-
-
?
additional information
?
-
the enzyme is a virulence factor of the animal pathogen, relation between enzyme activity, serotype, and disease state, overview
-
-
?
additional information
?
-
the enzyme is a virulence factor of the animal pathogen, relation between enzyme activity, serotype, and disease state, overview
-
-
?
additional information
?
-
the enzyme is a virulence factor of the animal pathogen, relation between enzyme activity, serotype, and disease state, overview
-
-
?
additional information
?
-
-
the enzyme is a virulence factor of the animal pathogen, relation between enzyme activity, serotype, and disease state, overview
-
-
?
additional information
?
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the enzyme is involved in development of meningitis in infected pigs
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?
additional information
?
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the enzyme is involved in development of meningitis in infected pigs
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?
additional information
?
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phylogenetic analysis, enzyme causes mastitis, may have an important role in promoting dissemination of the producing organism into host tissue, anti-phagocytic factors in the capsule, such as M-protein, might provide sufficient protection for Streptococcus pyogenes infection during enzyme production
-
-
?
