4.2.2.1: hyaluronate lyase

This is an abbreviated version!
For detailed information about hyaluronate lyase, go to the full flat file.

Reaction

Synonyms

acidic hyase, bacterial HAse, bacterial hyaluronidase, bacterial spreading factor, bacteriophage-associated hyaluronate lyase, Cumulase, EC 4.2.99.1, GBS HA lyase, GBS hyase, glucuronoglycosaminoglycan lyase, h-SD, h-SH, HA lyase, HL, Hyal, Hyal-1, Hyal-2, HYAL1, Hyal2, HYAL3, hyaluronan lyase, hyaluronate lyase, hyaluronate lyase HylA, hyaluronate lyase HylP2, hyaluronidase, hyaluronidase 3, hyaluronidase SD, hyaluronidase SH, hyaluronidase-1, hyaluronidase-2, hyaluronoglucosaminidase-1, hyaluronoglucosaminidase-2, HYase, HylA7, hylB, hylB4755, HylP, Hylp2, LUCA-1, LUCA-2, lyase, glucuronoglycosaminoglycan, lyase, hyaluronate, More, mucinase, protein SEQ2045, rHuPH20, SagHL, SagHyal, spnHL, SpnHyal, spreading factor, SP_0314

ECTree

     4 Lyases

         4.2 Carbon-oxygen lyases

             4.2.2 Acting on polysaccharides

                4.2.2.1 hyaluronate lyase

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Results	in table
5	Activating Compound
415	AA Sequence
16	Application
1	CAS Registry Number
42	Cloned(Commentary)
17	Crystallization (Commentary)
119	Disease/ Diagnostics
1	Expression
18	General Information
4	General Stability
45	IC50 Value
153	Inhibitors
2	Ki Value [mM]
24	KM Value [mM]
26	Localization
17	Metals/Ions
44	Molecular Weight [Da]
66	Natural Substrates/ Products (Substrates)
221	Organism
1	Oxidation Stability
1	Pathway
48	PDB ID
34	pH Optimum
8	pH Range
13	pH Stability
1	pI Value
8	Posttranslational Modification
91	Protein Variants
28	Purification (Commentary)
63	Reaction
6	Reaction Type
160	Reference
16	Source Tissue
20	Specific Activity [micromol/min/mg]
5	Storage Stability
206	Substrates and Products (Substrate)
44	Subunits
147	Synonyms
1	Systematic Name
23	Temperature Optimum [°C]
4	Temperature Range [°C]
19	Temperature Stability [°C]
8	Turnover Number [1/s]

pH Stability

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pH Stability on EC 4.2.2.1 - hyaluronate lyase

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pH STABILITY

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

1

Staphylococcus aureus

-

18 h, complete loss of activity

210738

14

Staphylococcus aureus

-

18 h, complete loss of activity

210738

2 - 13

Staphylococcus aureus

-

18 h, stable

210738

4 - 7

Streptococcus pyogenes phage H4489A

-

purified recombinant enzyme, stable

714651

4.2

Cutibacterium acnes

-

37°C, 1 h, 80% loss of activity

210736

5 - 10

Arthrobacter globiformis

-

1 h, 37°C, 81% residual activity

746795

5 - 5.8

Cutibacterium acnes

-

37°C, 1 h, stable

210736

5 - 9

Neobacillus niacini

X5I0R2

stable in presence of Ca2+

748522

5.5

Streptococcus sp.

-

30 min, irreversible inactivation

210737

6 - 10

Neobacillus niacini

X5I0R2

stable in absence of Ca2+

748522

7

2 entries

8.6

Streptococcus sp.

-

10 min, complete loss of activity

210737

7

Cutibacterium acnes

-

37°C, 1 h, 70% loss of activity

210736

7

Streptococcus sp.

-

above pH 7.0, 24 h, irreversible loss of activity

210737