4.2.2.1: hyaluronate lyase

This is an abbreviated version!
For detailed information about hyaluronate lyase, go to the full flat file.

Word Map on EC 4.2.2.1

4.2.2.1

streptococcus

chondroitin

disaccharide

glycosaminoglycans

agalactiae

chondroitinase

enteroaggregative

hyaluronidases

medicine

hyals

hyalurolyticus

pharmacology

autotransporter

degradation

synthesis

analysis

Reaction

(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine-[hyaluronate]n-m-1

+ 2 3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine +

Synonyms

acidic hyase, bacterial HAse, bacterial hyaluronidase, bacterial spreading factor, bacteriophage-associated hyaluronate lyase, Cumulase, EC 4.2.99.1, GBS HA lyase, GBS hyase, glucuronoglycosaminoglycan lyase, h-SD, h-SH, HA lyase, HL, Hyal, Hyal-1, Hyal-2, HYAL1, Hyal2, HYAL3, hyaluronan lyase, hyaluronate lyase, hyaluronate lyase HylA, hyaluronate lyase HylP2, hyaluronidase, hyaluronidase 3, hyaluronidase SD, hyaluronidase SH, hyaluronidase-1, hyaluronidase-2, hyaluronoglucosaminidase-1, hyaluronoglucosaminidase-2, HYase, HylA7, hylB, hylB4755, HylP, Hylp2, LUCA-1, LUCA-2, lyase, glucuronoglycosaminoglycan, lyase, hyaluronate, More, mucinase, protein SEQ2045, rHuPH20, SagHL, SagHyal, spnHL, SpnHyal, spreading factor, SP_0314

ECTree

4 Lyases

4.2 Carbon-oxygen lyases

4.2.2 Acting on polysaccharides

4.2.2.1 hyaluronate lyase

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Results	in table
5	Activating Compound
415	AA Sequence
16	Application
1	CAS Registry Number
42	Cloned(Commentary)
17	Crystallization (Commentary)
119	Disease/ Diagnostics
1	Expression
18	General Information
4	General Stability
45	IC50 Value
153	Inhibitors
2	Ki Value [mM]
24	KM Value [mM]
26	Localization
17	Metals/Ions
44	Molecular Weight [Da]
66	Natural Substrates/ Products (Substrates)
221	Organism
1	Oxidation Stability
1	Pathway
48	PDB ID
34	pH Optimum
8	pH Range
13	pH Stability
1	pI Value
8	Posttranslational Modification
91	Protein Variants
28	Purification (Commentary)
63	Reaction
6	Reaction Type
160	Reference
16	Source Tissue
20	Specific Activity [micromol/min/mg]
5	Storage Stability
206	Substrates and Products (Substrate)
44	Subunits
147	Synonyms
1	Systematic Name
23	Temperature Optimum [°C]
4	Temperature Range [°C]
19	Temperature Stability [°C]
8	Turnover Number [1/s]

IC50 Value

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IC50 Value on EC 4.2.2.1 - hyaluronate lyase

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0.0035

(25S)-(+)-12alpha-hydroxy-3alpha-methylcarboxyacetate-24-methyllanosta-8,24(31)-diene-26-oic acid

Streptococcus agalactiae

from Piptoporus betulinus inhibiting bacterial hyaluronate lyase, structure determination by NMR, IC50 is 0.0035 mM

665318

0.16 - 0.31

(2E)-1-furan-2-yl-3-(4-nitrophenyl)prop-2-en-1-one

Streptococcus agalactiae

Q53591

IC50 at enzyme optimum pH 5.0 is 0.31 mM, and 0.16 mM at physiological pH 7.4

666893

0.07

(3-chlorophenyl)(2-thioxo-1H-benzo[d]imidazol-1-yl)methanone

Streptococcus agalactiae

pH 7.4, 37°C

714907

2.54

1,3-benzoxazole-2(3H)-thione

Streptococcus agalactiae

pH 7.4, 37°C

714907

0.0001

1,3-diacetyl-1H-benzo[d]imidazol-2(3H)-one

Streptococcus agalactiae

pH 7.4, temperature not specified in the publication

714907

0.005 - 0.16

1,3-diacetyl-benzimidazole-2-thione

Streptococcus agalactiae

Q53591

IC50 at enzyme optimum pH 5.0 is 0.16 mM, and 0.005 mM at physiological pH 7.4

666893

0.005

1,3-diacetylbenzimidazole-2-thione

Streptococcus agalactiae

pH 7.4, temperature not specified in the publication

714907

1.86

1,3-dihydro-2H-benzimidazole-2-thione

Streptococcus agalactiae

pH 7.4, 37°C

714907

0.029

1-(2-thioxo-1H-benzo[d]imidazol-1-yl)-3-phenylpropan-1-one

Streptococcus agalactiae

pH 7.4, 37°C

714907

0.02

1-(2-thioxo-1H-benzo[d]imidazol-1-yl)butan-1-one

Streptococcus agalactiae

pH 7.4, 37°C

714907

0.017

1-(2-thioxo-1H-benzo[d]imidazol-1-yl)ethanone

Streptococcus agalactiae

pH 7.4, 37°C

714907

0.016

1-(2-thioxo-1H-benzo[d]imidazol-1-yl)hexan-1-one

Streptococcus agalactiae

pH 7.4, 37°C

714907

0.026

1-(2-thioxo-1H-benzo[d]imidazol-1-yl)propan-1one

Streptococcus agalactiae

pH 7.4, 37°C

714907

0.025

1-(2-thioxobenzo[d]oxazol-3(2H)-yl)decan-1-one

Streptococcus agalactiae

pH 7.4, 37°C

714907

0.042

1-(2-thioxobenzo[d]oxazol-3(2H)-yl)ethanone

Streptococcus agalactiae

pH 7.4, 37°C

714907

0.017

1-(2-thioxobenzo[d]oxazol-3(2H)-yl)hexadecan-1-one

Streptococcus agalactiae

pH 7.4, 37°C

714907

0.029

1-(2-thioxobenzo[d]oxazol-3(2H)-yl)hexan-1-one

Streptococcus agalactiae

pH 7.4, 37°C

714907

0.048

1-(2-thioxobenzo[d]oxazol-3(2H)-yl)propan-1-one

Streptococcus agalactiae

pH 7.4, 37°C

714907

0.012

1-(3-acetyl-1,2-dihydro-2-thioxobenzo[d]imidazol-1-yl)hexan-1-one

Streptococcus agalactiae

pH 7.4, temperature not specified in the publication

714907

0.019

1-(3-ethyl-1,2-dihydro-2-thioxobenzo[d]imidazole-1-yl)ethanone

Streptococcus agalactiae

pH 7.4, temperature not specified in the publication

714907

0.011

1-decyl-2-(4-sulfamoyloxyphenyl)-1-indol-6-yl sulfamate

Streptococcus agalactiae

pH 5.0

680038

0.9 - 0.37

2,2'-benzene-1,4-diyldiacetic acid

Streptococcus agalactiae

Q53591

IC50 at enzyme optimum pH 5.0 is 0.37 mM, and 0.90 mM at physiological pH 7.4

666893

0.062

2-phenoxy-1-(2-thioxobenzo[d]oxazol-3(2H)-yl)ethanone

Streptococcus agalactiae

pH 7.4, 37°C

714907

0.069

2-phenyl-1-(2-thioxobenzo[d]oxazol-3(2H)-yl)ethanone

Streptococcus agalactiae

pH 7.4, 37°C

714907

1.45

3-acetylbenzo[d]oxazol-2(3H)-one

Streptococcus agalactiae

pH 7.4, 37°C

714907

0.02

3-cyclohexyl-1-(2-thioxobenzo[d]oxazol-3(2H)-yl)propan-1-one

Streptococcus agalactiae

pH 7.4, 37°C

714907

0.024

3-phenyl-1-(2-thioxobenzo[d]oxazol-3(2H)-yl)propan-1-one

Streptococcus agalactiae

pH 7.4, 37°C

714907

0.04

3alpha-acetylpolyporenic acid A

Streptococcus agalactiae

from Piptoporus betulinus inhibiting bacterial hyaluronate lyase, structure determination by NMR, IC50 is 0.040 mM

665318

0.019

4-phenyl-1-(2-thioxobenzo[d]oxazol-3(2H)-yl)butan-1-one

Streptococcus agalactiae

pH 7.4, 37°C

714907

0.556

benzyl 2-thioxobenzo[d]oxazol-3(2H)-carboxylate

Streptococcus agalactiae

pH 7.4, 37°C

714907

0.7

L-ascorbate

Streptococcus pyogenes phage H4489A

P15316

pH 6.0, 25°C, recombinant wild-type enzyme

729322

6.1 - 34.8

L-ascorbic acid

2 entries

0.0042 - 0.1

L-ascorbic acid-6-hexadecanoate

2 entries

0.051

lanostanoid

Streptococcus agalactiae

from Piptoporus betulinus inhibiting bacterial hyaluronate lyase, structure determination by NMR, IC50 is 0.051 mM

665318

0.021

methyl-3-(3-phenylpropanoyl)-2,3-dihydro-2-thioxobenzo[d]oxazole-5-carboxylate

Streptococcus agalactiae

pH 7.4, 37°C

714907

0.015

N-(3-phenylpropionyl)-benzoxazole-2-thione

Streptococcus agalactiae

pH 5.0

680038

0.015 - 0.024

N-(3-phenylpropionyl)benzoxazole-2-thione

2 entries

0.015

partially sulfated planteose

Streptococcus agalactiae

the non-sulfated planteose is not inhibitory, IC50 is 0.015 mM

666687

0.03

partially sulfated verbascose

Streptococcus agalactiae

2 forms, the non-sulfated verbascose is not inhibitory, IC50 are 0.030 mM and 0.001 mM

666687

0.0125

polyporenic acid

Streptococcus agalactiae

from Piptoporus betulinus inhibiting bacterial hyaluronate lyase, structure determination by NMR, IC50 is 0.0125 mM

665318

0.35

sulfated 2-hydroxyphenyl monolactobioside

Streptococcus agalactiae

IC50 is 0.35 mM

666687

0.08

sulfated hydroquinone galactoside

Streptococcus agalactiae

IC50 is 0.080 mM

666687