Application | Comment | Organism |
---|---|---|
pharmacology | enzyme is a target for development of antimicrobial agents | Streptococcus pneumoniae |
Crystallization (Comment) | Organism |
---|---|
enzyme-disaccharide complex, X-ray diffraction structure determination and analysis at 1.7 A resolution, structure modeling | Streptococcus pneumoniae |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | activates, bridges between enzyme and substrate | Streptococcus pneumoniae |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
hyaluronan | Streptococcus pneumoniae | degradation leads to increased permeability of the host tissue and therefore helps bacterial invasion | 3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Streptococcus pneumoniae | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
[hyaluronate]n = (4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine-[hyaluronate]n-m-1 + 2 3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine + hyaluronate | enzyme-product interaction from crystal structure, catalytic mechanism, interaction with substrate binding site, Tyr408, Asn349, and His399 are involved | Streptococcus pneumoniae |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
hyaluronan | degradation leads to increased permeability of the host tissue and therefore helps bacterial invasion | Streptococcus pneumoniae | 3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine | - |
? | |
hyaluronic acid | - |
Streptococcus pneumoniae | 3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine | - |
? |