4.2.2.1: hyaluronate lyase

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For detailed information about hyaluronate lyase, go to the full flat file.

Word Map on EC 4.2.2.1

4.2.2.1

streptococcus

chondroitin

disaccharide

glycosaminoglycans

agalactiae

chondroitinase

enteroaggregative

hyaluronidases

medicine

hyals

hyalurolyticus

pharmacology

autotransporter

degradation

synthesis

analysis

Reaction

(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine-[hyaluronate]n-m-1

+ 2 3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine +

Synonyms

acidic hyase, bacterial HAse, bacterial hyaluronidase, bacterial spreading factor, bacteriophage-associated hyaluronate lyase, Cumulase, EC 4.2.99.1, GBS HA lyase, GBS hyase, glucuronoglycosaminoglycan lyase, h-SD, h-SH, HA lyase, HL, Hyal, Hyal-1, Hyal-2, HYAL1, Hyal2, HYAL3, hyaluronan lyase, hyaluronate lyase, hyaluronate lyase HylA, hyaluronate lyase HylP2, hyaluronidase, hyaluronidase 3, hyaluronidase SD, hyaluronidase SH, hyaluronidase-1, hyaluronidase-2, hyaluronoglucosaminidase-1, hyaluronoglucosaminidase-2, HYase, HylA7, hylB, hylB4755, HylP, Hylp2, LUCA-1, LUCA-2, lyase, glucuronoglycosaminoglycan, lyase, hyaluronate, More, mucinase, protein SEQ2045, rHuPH20, SagHL, SagHyal, spnHL, SpnHyal, spreading factor, SP_0314

ECTree

4 Lyases

4.2 Carbon-oxygen lyases

4.2.2 Acting on polysaccharides

4.2.2.1 hyaluronate lyase

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Results	in table
5	Activating Compound
415	AA Sequence
16	Application
1	CAS Registry Number
42	Cloned(Commentary)
17	Crystallization (Commentary)
119	Disease/ Diagnostics
1	Expression
18	General Information
4	General Stability
45	IC50 Value
153	Inhibitors
2	Ki Value [mM]
24	KM Value [mM]
26	Localization
17	Metals/Ions
44	Molecular Weight [Da]
66	Natural Substrates/ Products (Substrates)
221	Organism
1	Oxidation Stability
1	Pathway
48	PDB ID
34	pH Optimum
8	pH Range
13	pH Stability
1	pI Value
8	Posttranslational Modification
91	Protein Variants
28	Purification (Commentary)
63	Reaction
6	Reaction Type
160	Reference
16	Source Tissue
20	Specific Activity [micromol/min/mg]
5	Storage Stability
206	Substrates and Products (Substrate)
44	Subunits
147	Synonyms
1	Systematic Name
23	Temperature Optimum [°C]
4	Temperature Range [°C]
19	Temperature Stability [°C]
8	Turnover Number [1/s]

Localization

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Localization on EC 4.2.2.1 - hyaluronate lyase

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Streptococcus pneumoniae

Q54873

the enzyme is anchored via its carboxy-terminal part to the pneumococcal cell wall by a covalent linkage with peptidoglycan structures

5618

210749

cytosol

Streptococcus pneumoniae

Q54873

enzyme is relaesed only when the pneumolysin causes lysis of the pneumococci

additional information

3 entries