4.2.2.1: hyaluronate lyase

This is an abbreviated version!
For detailed information about hyaluronate lyase, go to the full flat file.

Word Map on EC 4.2.2.1

4.2.2.1

streptococcus

chondroitin

disaccharide

glycosaminoglycans

agalactiae

chondroitinase

enteroaggregative

hyaluronidases

medicine

hyals

hyalurolyticus

pharmacology

autotransporter

degradation

synthesis

analysis

Reaction

[hyaluronate]n

=

(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine-[hyaluronate]n-m-1

+ 2 3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine +

hyaluronate

Synonyms

acidic hyase, bacterial HAse, bacterial hyaluronidase, bacterial spreading factor, bacteriophage-associated hyaluronate lyase, Cumulase, EC 4.2.99.1, GBS HA lyase, GBS hyase, glucuronoglycosaminoglycan lyase, h-SD, h-SH, HA lyase, HL, Hyal, Hyal-1, Hyal-2, HYAL1, Hyal2, HYAL3, hyaluronan lyase, hyaluronate lyase, hyaluronate lyase HylA, hyaluronate lyase HylP2, hyaluronidase, hyaluronidase 3, hyaluronidase SD, hyaluronidase SH, hyaluronidase-1, hyaluronidase-2, hyaluronoglucosaminidase-1, hyaluronoglucosaminidase-2, HYase, HylA7, hylB, hylB4755, HylP, Hylp2, LUCA-1, LUCA-2, lyase, glucuronoglycosaminoglycan, lyase, hyaluronate, More, mucinase, protein SEQ2045, rHuPH20, SagHL, SagHyal, spnHL, SpnHyal, spreading factor, SP_0314

ECTree

4.2 Carbon-oxygen lyases

4.2.2 Acting on polysaccharides

4.2.2.1 hyaluronate lyase

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Results	in table
5	Activating Compound
415	AA Sequence
16	Application
1	CAS Registry Number
42	Cloned(Commentary)
17	Crystallization (Commentary)
119	Disease/ Diagnostics
1	Expression
18	General Information
4	General Stability
45	IC50 Value
153	Inhibitors
2	Ki Value [mM]
24	KM Value [mM]
26	Localization
17	Metals/Ions
44	Molecular Weight [Da]
66	Natural Substrates/ Products (Substrates)
221	Organism
1	Oxidation Stability
1	Pathway
48	PDB ID
34	pH Optimum
8	pH Range
13	pH Stability
1	pI Value
8	Posttranslational Modification
91	Protein Variants
28	Purification (Commentary)
63	Reaction
6	Reaction Type
160	Reference
16	Source Tissue
20	Specific Activity [micromol/min/mg]
5	Storage Stability
206	Substrates and Products (Substrate)
44	Subunits
147	Synonyms
1	Systematic Name
23	Temperature Optimum [°C]
4	Temperature Range [°C]
19	Temperature Stability [°C]
8	Turnover Number [1/s]

Organism

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Organism on EC 4.2.2.1 - hyaluronate lyase

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Manually annotated by BRENDA team

Arthrobacter globiformis

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Manually annotated by BRENDA team

Arthrobacter globiformis A152

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Manually annotated by BRENDA team

Bacteroides fragilis

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Manually annotated by BRENDA team

Bacteroides ovatus

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Manually annotated by BRENDA team

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Manually annotated by BRENDA team

Candida albicans

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Manually annotated by BRENDA team

Candida parapsilosis

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Manually annotated by BRENDA team

Candida tropicalis

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Manually annotated by BRENDA team

Clostridioides difficile

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Manually annotated by BRENDA team

Clostridium chauvoei

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Manually annotated by BRENDA team

Clostridium perfringens

-

SwissProt

Manually annotated by BRENDA team

Clostridium septicum

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Manually annotated by BRENDA team

Cutibacterium acnes

show

Cutibacterium granulosum

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Manually annotated by BRENDA team

Fusobacterium mortiferum

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Manually annotated by BRENDA team

show

Meyerozyma guilliermondii

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Manually annotated by BRENDA team

several different isozymes

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Manually annotated by BRENDA team

Neobacillus niacini

-

UniProt

Manually annotated by BRENDA team

Neobacillus niacini JAM F8

-

UniProt

Manually annotated by BRENDA team

Paracoccidioides brasiliensis

different strains isolated from different host organisms, e.g. human, penguin, armadillo, and from dog food

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-

Manually annotated by BRENDA team

Pedobacter heparinus

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Manually annotated by BRENDA team

Phocaeicola vulgatus

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Manually annotated by BRENDA team

Pichia kudriavzevii

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Manually annotated by BRENDA team

Porphyromonas asaccharolytica

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Prevotella melaninogenica

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Staphylococcus aureus

show

Staphylococcus aureus 1801

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Manually annotated by BRENDA team

Staphylococcus aureus AEMC 1801

AEMC 1801

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-

Manually annotated by BRENDA team

Staphylococcus aureus M18

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Manually annotated by BRENDA team

Staphylococcus aureus NCTC 8325

strain 8325-4, gene hysA

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-

Manually annotated by BRENDA team

Staphylococcus hyicus

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-

Manually annotated by BRENDA team

Streptococcus agalactiae

show

Streptococcus agalactiae 4755

show

Streptococcus constellatus

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Manually annotated by BRENDA team

Streptococcus dysgalactiae

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Manually annotated by BRENDA team

Streptococcus dysgalactiae subsp. equisimilis

show

Streptococcus dysgalactiae subsp. equisimilis SHL-03

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Manually annotated by BRENDA team

Streptococcus equi

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Manually annotated by BRENDA team

Streptococcus equi subsp. equi 4047

prophage encoded

SwissProt

Manually annotated by BRENDA team

Streptococcus equi subsp. zooepidemicus

-

UniProt

Manually annotated by BRENDA team

Streptococcus intermedius

-

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-

Manually annotated by BRENDA team

Streptococcus pneumoniae

show

Streptococcus pyogenes

show

Streptococcus pyogenes MGAS10270

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Manually annotated by BRENDA team

Streptococcus pyogenes MGAS10394

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Manually annotated by BRENDA team

Streptococcus pyogenes MGAS10750

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Manually annotated by BRENDA team

Streptococcus pyogenes MGAS315

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Manually annotated by BRENDA team

Streptococcus pyogenes MGAS5005

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Manually annotated by BRENDA team

Streptococcus pyogenes MGAS6180

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Manually annotated by BRENDA team

Streptococcus pyogenes MGAS8232

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Manually annotated by BRENDA team

Streptococcus pyogenes MGAS9429

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Manually annotated by BRENDA team

Streptococcus pyogenes NZ131

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Manually annotated by BRENDA team

Streptococcus pyogenes phage

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Manually annotated by BRENDA team

Streptococcus pyogenes phage H10403

show

Streptococcus pyogenes phage H4489A

show

Streptococcus pyogenes serotype M1

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UniProt

Manually annotated by BRENDA team

Streptococcus pyogenes serotype M1 SF370

-

UniProt

Manually annotated by BRENDA team

Streptococcus pyogenes serotype M3

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A7XFU7, A7XFU8, A7XFU9, A7XFV3, A7XFV4, A7XFV6, A7XFV7

UniProt

Manually annotated by BRENDA team

Streptococcus pyogenes serotype M3 1020

-

UniProt

Manually annotated by BRENDA team

Streptococcus pyogenes serotype M3 1055

-

UniProt

Manually annotated by BRENDA team

Streptococcus pyogenes serotype M3 350

-

UniProt

Manually annotated by BRENDA team

Streptococcus pyogenes serotype M3 3779

-

UniProt

Manually annotated by BRENDA team

Streptococcus pyogenes serotype M3 422

-

UniProt

Manually annotated by BRENDA team

Streptococcus pyogenes serotype M3 872

-

UniProt

Manually annotated by BRENDA team

Streptococcus pyogenes serotype M3 94146

-

UniProt

Manually annotated by BRENDA team

Streptococcus pyogenes serotype M4

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A7XFU5, A7XFU6, A7XFV2, A7XFV5

UniProt

Manually annotated by BRENDA team

Streptococcus pyogenes serotype M4 2397

-

UniProt

Manually annotated by BRENDA team

Streptococcus pyogenes serotype M4 4282

-

UniProt

Manually annotated by BRENDA team

Streptococcus pyogenes serotype M4 4283

-

UniProt

Manually annotated by BRENDA team

Streptococcus pyogenes serotype M4 445

-

UniProt

Manually annotated by BRENDA team

Streptococcus pyogenes str. Manfredo

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Manually annotated by BRENDA team

Streptococcus sp.

show

Streptococcus suis

show

Streptococcus uberis

capsular and acapsular phenotype, contains 2 forms: a extracellular and a bacteriophage enzyme

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Manually annotated by BRENDA team

Streptomyces coelicolor

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Manually annotated by BRENDA team

Streptomyces griseus

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SwissProt

Manually annotated by BRENDA team

Streptomyces hyalurolytics

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Manually annotated by BRENDA team

Streptomyces hyalurolyticus

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652643, 655596, 655682, 664514, 664596

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Manually annotated by BRENDA team

Treponema pallidum

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Manually annotated by BRENDA team

Treponema pallidum subsp. pertenue

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Manually annotated by BRENDA team

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Release 2023.1 (January 2023)