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Literature summary for 4.2.2.1 extracted from

  • Wangun, H.V.K.; Berg, A.; Hertel, W.; Nkengfack, A.E.; Hertweck, C.
    Anti-inflammatory and anti-hyaluronate lyase activities of lanostanoids from Piptoporus betulinus (2004), J. Antibiot., 57, 755-758.
    View publication on PubMed
Search for more literature for 4.2.2.1

Inhibitors

Inhibitors Comment Organism Structure
(25S)-(+)-12alpha-hydroxy-3alpha-methylcarboxyacetate-24-methyllanosta-8,24(31)-diene-26-oic acid from Piptoporus betulinus inhibiting bacterial hyaluronate lyase, structure determination by NMR, IC50 is 0.0035 mM Streptococcus agalactiae
3alpha-acetylpolyporenic acid A from Piptoporus betulinus inhibiting bacterial hyaluronate lyase, structure determination by NMR, IC50 is 0.040 mM Streptococcus agalactiae
lanostanoid from Piptoporus betulinus inhibiting bacterial hyaluronate lyase, structure determination by NMR, IC50 is 0.051 mM Streptococcus agalactiae
polyporenic acid from Piptoporus betulinus inhibiting bacterial hyaluronate lyase, structure determination by NMR, IC50 is 0.0125 mM Streptococcus agalactiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
hyaluronic acid Streptococcus agalactiae degradation of hyaluronate in connective tissue of hosts to facilitate invasion hyaluronic acid oligomers
-
 ?

Organism

Organism UniProt Comment Textmining
Streptococcus agalactiae
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
hyaluronic acid degradation Streptococcus agalactiae hyaluronic acid oligomers
-
 ?
hyaluronic acid degradation of hyaluronate in connective tissue of hosts to facilitate invasion Streptococcus agalactiae hyaluronic acid oligomers
-
 ?

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0035
-
 from Piptoporus betulinus inhibiting bacterial hyaluronate lyase, structure determination by NMR, IC50 is 0.0035 mM Streptococcus agalactiae (25S)-(+)-12alpha-hydroxy-3alpha-methylcarboxyacetate-24-methyllanosta-8,24(31)-diene-26-oic acid
0.0125
-
 from Piptoporus betulinus inhibiting bacterial hyaluronate lyase, structure determination by NMR, IC50 is 0.0125 mM Streptococcus agalactiae polyporenic acid
0.04
-
 from Piptoporus betulinus inhibiting bacterial hyaluronate lyase, structure determination by NMR, IC50 is 0.040 mM Streptococcus agalactiae 3alpha-acetylpolyporenic acid A
0.051
-
 from Piptoporus betulinus inhibiting bacterial hyaluronate lyase, structure determination by NMR, IC50 is 0.051 mM Streptococcus agalactiae lanostanoid