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4.1.1.28: aromatic-L-amino-acid decarboxylase

This is an abbreviated version!
For detailed information about aromatic-L-amino-acid decarboxylase, go to the full flat file.

Word Map on EC 4.1.1.28

Reaction

5-hydroxy-L-tryptophan
=
5-hydroxytryptamine
 +
CO2

Synonyms

3,4-dihydroxyphenylalanine carboxylase, 3,4-Dihydroxyphenylalanine decarboxylase, 5-Hydroxy-L-tryptophan decarboxylase, 5-Hydroxytryptophan decarboxylase, 5-hydroxytryptophan hydroxylase, 5HTP decarboxylase, AAAC, AAAD, AACD, AADC, AADC1A, AADC1B, AADC393, AADC438, AADC486, Alt-DDC, aromatic acid acid decarboxylase, Aromatic amino acid decarboxylase, aromatic amino acid decarboxylase 1A, aromatic amino acid decarboxylase 1B, Aromatic L-amino acid decarboxylase, aromatic L-aminoacid decarboxylase, aromatic-L-amino-acid decarboxylase, CrTDC, DDC, Decarboxylase, aromatic amino acid, Di-ADC, Dihydroxyphenylalanine-5-hydroxytryptophan decarboxylase, DOPA DC, dopa decarboxilase, DOPA decarboxylase, DOPA-5-hydroxytryptophan decarboxylase, DOPA/5HTP decarboxylase, dopamine decarboxylase, EC 4.1.1.26, EC 4.1.1.27, HsDDC, Hydroxytryptophan decarboxylase, L-3,4-Dihydroxyphenylalanine decarboxylase, L-5-Hydroxytryptophan decarboxylase, L-amino acid decarboxylase, L-amino-acid decarboxylase, L-Aromatic amino acid decarboxylase, L-aromatic aminoacid decarboxylase, L-DOPA decarboxylase, L-Tryptophan decarboxylase, neural-type DDC, non-neural DDC, PP_2552, TDC, TDC2, Tenebrio Dopa decarboxylase, Trp decarboxylase, Tryptophan decarboxylase, tryptophan decarboxylase-1, tryptophan decarboxylase-2, TYDC, Tydc9, Tyrosine/Dopa decarboxylase

ECTree

     4 Lyases
         4.1 Carbon-carbon lyases
             4.1.1 Carboxy-lyases
                4.1.1.28 aromatic-L-amino-acid decarboxylase

Expression

Expression on EC 4.1.1.28 - aromatic-L-amino-acid decarboxylase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
4-deoxypyridoxine reduces aromatic L-amino acid decarboxylase mRNA levels
-
AADC expression in the L-DOPA naive 6-hydroxydopamine-lesioned rats does decrease significantly as compared with intact striata
-
AADC transcript abundance presents a small peak at 110 days after full bloom and then a continuous increase at the berry post-ripening stage
-
after treatment with lipopolysaccharide stimulation, the mRNA expression level of DDC in hemocytes increases 5.5fold at 3 h and 9.8fold at 12 h and then recovers to the baseline level
artemisinic acid is able to upregulate the transcriptions of geraniol 10-hydroxylase
bacterium Vibrio anguillarum challenge can induce the mRNA expression of dopa decarboxylase and dopamine beta hydroxylase in different developmental stages. A significant increase of dopa decarboxylase mRNA is observed in the trochophore larvae at 12 h and in late D-hinged larvae at 24 h post challenge
both 20-hydroxyecdysone and juvenile hormone regulate DDC expression in the epidermis
-
DDC mRNA is transcribed in two different forms, neural and non-neural, due to alternative promoter usage and alternative splicing within the 5'-untranslated region
-
ecdysone cascades regulate DDC expression in the epidermis
-
gene expression is induced by L-dopa
in lung, DDC expression in neuroendocrine differentiated cells is upregulated by Notch-1 receptor-elicited signaling
pyridoxal 5'-phosphate-deficient human SH-SY5Y neuroblastoma cells exhibit reduced levels of aromatic L-amino acid decarboxylase activity and protein but with no alteration in expression
-
significant upregulation in salicylic acid treatment (foliar application of 0.01 and 0.1 mM salicylic acid). Upregulation can result in a higher production rate of vinblastine and vincristine alkaloids
silkworm larvae fed with ecdysone hormone show significantly elevatd expression of dopa decarboxylase
-
the expression of dopa decarboxylase in silkworm is higher during molting stage, and decreases after molting
-
upregulated in plants inoculated with endophytes