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4.1.1.28: aromatic-L-amino-acid decarboxylase

This is an abbreviated version!
For detailed information about aromatic-L-amino-acid decarboxylase, go to the full flat file.

Word Map on EC 4.1.1.28

Reaction

5-hydroxy-L-tryptophan
=
5-hydroxytryptamine
 +
CO2

Synonyms

3,4-dihydroxyphenylalanine carboxylase, 3,4-Dihydroxyphenylalanine decarboxylase, 5-Hydroxy-L-tryptophan decarboxylase, 5-Hydroxytryptophan decarboxylase, 5-hydroxytryptophan hydroxylase, 5HTP decarboxylase, AAAC, AAAD, AACD, AADC, AADC1A, AADC1B, AADC393, AADC438, AADC486, Alt-DDC, aromatic acid acid decarboxylase, Aromatic amino acid decarboxylase, aromatic amino acid decarboxylase 1A, aromatic amino acid decarboxylase 1B, Aromatic L-amino acid decarboxylase, aromatic L-aminoacid decarboxylase, aromatic-L-amino-acid decarboxylase, CrTDC, DDC, Decarboxylase, aromatic amino acid, Di-ADC, Dihydroxyphenylalanine-5-hydroxytryptophan decarboxylase, DOPA DC, dopa decarboxilase, DOPA decarboxylase, DOPA-5-hydroxytryptophan decarboxylase, DOPA/5HTP decarboxylase, dopamine decarboxylase, EC 4.1.1.26, EC 4.1.1.27, HsDDC, Hydroxytryptophan decarboxylase, L-3,4-Dihydroxyphenylalanine decarboxylase, L-5-Hydroxytryptophan decarboxylase, L-amino acid decarboxylase, L-amino-acid decarboxylase, L-Aromatic amino acid decarboxylase, L-aromatic aminoacid decarboxylase, L-DOPA decarboxylase, L-Tryptophan decarboxylase, neural-type DDC, non-neural DDC, PP_2552, TDC, TDC2, Tenebrio Dopa decarboxylase, Trp decarboxylase, Tryptophan decarboxylase, tryptophan decarboxylase-1, tryptophan decarboxylase-2, TYDC, Tydc9, Tyrosine/Dopa decarboxylase

ECTree

     4 Lyases
         4.1 Carbon-carbon lyases
             4.1.1 Carboxy-lyases
                4.1.1.28 aromatic-L-amino-acid decarboxylase

KI Value

KI Value on EC 4.1.1.28 - aromatic-L-amino-acid decarboxylase

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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0044
2-[[(2-oxo-2,3-dihydro-1H-benzimidazol-5-yl)sulfonyl]amino]-N-phenylbenzamide
-
pH 7.4, 25°C
0.0151
4-[(E)-[(3-phenyl-5-sulfanyl-4H-1,2,4-triazol-4-yl)imino]methyl]benzene-1,2,3-triol
-
pH 7.4, 25°C
0.0018
4-[(E)-[(3-phenyl-5-sulfanyl-4H-1,2,4-triazol-4-yl)imino]methyl]benzene-1,2-diol
-
pH 7.4, 25°C
0.0023
4-[(E)-[[3-(4-chlorophenyl)-5-sulfanyl-4H-1,2,4-triazol-4-yl]imino]methyl]benzene-1,2-diol
-
pH 7.4, 25°C
5.7
5-hydroxy-L-tryptophan
wild-type enzyme, the data of initial velocity for decarboxylation of 5-hydroxy-L-tryptophan versus substrate concentration exhibit a substrate-inhibition pattern that requires a modified version of the Michaelis-Menten equation.
46
alpha-methyl-DL-phenylalanine
Micrococcus percitreus
-
pH and temperature not specified in the publication
0.0005
Amb2470350
pH and temperature not specified in the publication
0.000036
annexin 5
-
inhibitor purified from mouse kidney homogenate ddc, classical non-competitive inhibitor
-
10
L-Dopa
wild-type enzyme, the data of initial velocity for decarboxylation of L-dopa versus substrate concentration curiously exhibit a substrate-inhibition pattern that requires a modified version of the Michaelis-Menten equation.
0.31
tryptamine
-
additional information
additional information
-
Samples containing varying amounts of the purified molecule are incubated in the presence of 0.34 U Ddc from mouse kidney homogenate at room temperature for 15 min. This results in an inhibitor quantity-dependent increase of Ddc activity inhibition. The inhibitory activity reaches saturation, when 1.8 microg of purified inhibitor are added to the reaction. Samples containing 0.9 microg of the purified inhibitor are incubated in the presence of 0.34 U Ddc from mouse kidney homogenate for varying time periods at room temperature, prior to estimation of their inhibitory activity. The purified molecule causes a time-dependent inhibition of Ddc, while there is no inhibitory activity at 0 min. The inhibitory activity is seen to reach a maximum effect at 30 min, before declining.
-