4.1.1.28: aromatic-L-amino-acid decarboxylase
This is an abbreviated version!
For detailed information about aromatic-L-amino-acid decarboxylase, go to the full flat file.
Word Map on EC 4.1.1.28
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4.1.1.28
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dopaminergic
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serotonin
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parkinsonism
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monoamine
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striatum
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catecholamine
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neurotransmitter
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carbidopa
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noradrenaline
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levodopa
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norepinephrine
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benserazide
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5-hydroxytryptamine
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substantia
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dopac
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serotonergic
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tryptamine
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nigrostriatal
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catharanthus
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catechol-o-methyltransferase
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roseus
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beta-hydroxylase
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5-hydroxyindoleacetic
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homovanillic
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3,4-dihydroxyphenylacetic
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catecholaminergic
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dyskinesia
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dopamine-beta-hydroxylase
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alpha-methyl-p-tyrosine
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5-hiaa
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pargyline
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strictosidine
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monoaminergic
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raphe
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l-dopa-induced
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l-dihydroxyphenylalanine
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apomorphine
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antiparkinsonian
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gamma-butyrolactone
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tuberoinfundibular
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autoreceptors
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3-methoxytyramine
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quinpirole
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entacapone
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catecholamine-synthesizing
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dihydroxyphenylacetic
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non-dopaminergic
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phenylethanolamine
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pharmacology
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analysis
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6-hydroxydopamine-lesioned
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medicine
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drug development
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synthesis
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tolcapone
- 4.1.1.28
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dopaminergic
- serotonin
- parkinsonism
-
monoamine
- striatum
- catecholamine
-
neurotransmitter
- carbidopa
- noradrenaline
- levodopa
- norepinephrine
- benserazide
- 5-hydroxytryptamine
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substantia
-
dopac
-
serotonergic
- tryptamine
-
nigrostriatal
- catharanthus
- catechol-o-methyltransferase
- roseus
- beta-hydroxylase
-
5-hydroxyindoleacetic
-
homovanillic
-
3,4-dihydroxyphenylacetic
-
catecholaminergic
- dyskinesia
- dopamine-beta-hydroxylase
- alpha-methyl-p-tyrosine
-
5-hiaa
- pargyline
- strictosidine
-
monoaminergic
-
raphe
-
l-dopa-induced
- l-dihydroxyphenylalanine
- apomorphine
-
antiparkinsonian
- gamma-butyrolactone
-
tuberoinfundibular
-
autoreceptors
- 3-methoxytyramine
- quinpirole
- entacapone
-
catecholamine-synthesizing
-
dihydroxyphenylacetic
-
non-dopaminergic
- phenylethanolamine
- pharmacology
- analysis
-
6-hydroxydopamine-lesioned
- medicine
- drug development
- synthesis
- tolcapone
Reaction
Synonyms
3,4-dihydroxyphenylalanine carboxylase, 3,4-Dihydroxyphenylalanine decarboxylase, 5-Hydroxy-L-tryptophan decarboxylase, 5-Hydroxytryptophan decarboxylase, 5-hydroxytryptophan hydroxylase, 5HTP decarboxylase, AAAC, AAAD, AACD, AADC, AADC1A, AADC1B, AADC393, AADC438, AADC486, Alt-DDC, aromatic acid acid decarboxylase, Aromatic amino acid decarboxylase, aromatic amino acid decarboxylase 1A, aromatic amino acid decarboxylase 1B, Aromatic L-amino acid decarboxylase, aromatic L-aminoacid decarboxylase, aromatic-L-amino-acid decarboxylase, CrTDC, DDC, Decarboxylase, aromatic amino acid, Di-ADC, Dihydroxyphenylalanine-5-hydroxytryptophan decarboxylase, DOPA DC, dopa decarboxilase, DOPA decarboxylase, DOPA-5-hydroxytryptophan decarboxylase, DOPA/5HTP decarboxylase, dopamine decarboxylase, EC 4.1.1.26, EC 4.1.1.27, HsDDC, Hydroxytryptophan decarboxylase, L-3,4-Dihydroxyphenylalanine decarboxylase, L-5-Hydroxytryptophan decarboxylase, L-amino acid decarboxylase, L-amino-acid decarboxylase, L-Aromatic amino acid decarboxylase, L-aromatic aminoacid decarboxylase, L-DOPA decarboxylase, L-Tryptophan decarboxylase, neural-type DDC, non-neural DDC, PP_2552, TDC, TDC2, Tenebrio Dopa decarboxylase, Trp decarboxylase, Tryptophan decarboxylase, tryptophan decarboxylase-1, tryptophan decarboxylase-2, TYDC, Tydc9, Tyrosine/Dopa decarboxylase
ECTree
4.1.1.28 aromatic-L-amino-acid decarboxylaseAdvanced search results
results (
results (KM Value
KM Value on EC 4.1.1.28 - aromatic-L-amino-acid decarboxylase
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KM VALUE [mM] 
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
0.62
3,4-dihydroxyphenylalanine
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in 167 mM phosphate buffer, pH 7.0, containing 39 mM dithiotreitol and 0.167 mM NaEDTA, for 2 h at 37°C
0.49
5-hydroxy-L-tryptophan
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in 167 mM phosphate buffer, pH 7.0, containing 39 mM dithiotreitol and 0.167 mM NaEDTA, for 2 h at 37°C
2.2
L-3,4-dihydroxyphenylalanine
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determined in homogenates of renal cortex of 3/4 nephrectomized rats after 26 weeks
2.6
L-3,4-dihydroxyphenylalanine
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determined in homogenates of renal cortex of sham surgery rats (control) after 10 weeks
2.6
L-3,4-dihydroxyphenylalanine
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determined in homogenates of renal cortex of sham surgery rats (control) after 26 weeks
2.9
L-3,4-dihydroxyphenylalanine
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determined in homogenates of renal cortex of 3/4 nephrectomized rats after 10 weeks
0.047
L-5-hydroxytryptophan
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in the presence of 0.07 mM pyridoxal 5'-phosphate, in 167 mM sodium phosphate pH 8.0, at 37°C
0.000095
L-Dopa
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dopamine formation, mutant enzyme K303A, in 50 mM HEPES, pH 7.5, at 25°C
0.00092
L-Dopa
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aldehyde formation, mutant enzyme K303A, in 50 mM HEPES, pH 7.5, at 25°C
0.028
L-Dopa
decarboxylation reaction, pH and temperature not specified in the publication
0.034
L-Dopa
in 50 mM sodium phosphate buffer, pH 7.2, 0.1 mM pargyline, 0.17 mM ascorbic acid, 0.1 mM EDTA, 1 mM beta-mercaptoethanol, 0.01 mMM pyridoxal 5'-phosphate and 0.5 mM L-Dopa, at 30°C
0.07
L-Dopa
decarboxylation reaction, pH and temperature not specified in the publication
0.086
L-Dopa
decarboxylation reaction, pH and temperature not specified in the publication
0.307
L-Dopa
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in the absence of pyridoxal 5'-phosphate, in 500 mM sodium phosphate pH 7.0, at 37°C
0.333
L-Dopa
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in the presence of 0.07 mM pyridoxal 5'-phosphate, in 500 mM sodium phosphate pH 7.0, at 37°C
2.4
L-tryptophan
Micrococcus percitreus
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pH and temperature not specified in the publication
additional information
additional information
Michaelis-Menten kinetics
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additional information
additional information
Michaelis-Menten kinetics
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