Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
50000 | - |
x * 50000, SDS-PAGE | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-Dopa | Homo sapiens | - |
dopamine + CO2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
astrocytoma cell | - |
Homo sapiens | - |
cervical adenocarcinoma cell | - |
Homo sapiens | - |
glioblastoma cell | - |
Homo sapiens | - |
HeLa cell | expression of neural-type and non-neural DDC isoforms, although HeLa cells express full length and the alternative Alt-DDC isoforms, they do not possess enzymatic activity towards the decarboxylation of L-Dopa | Homo sapiens | - |
J-82 cell | expression of neural-type and non-neural DDC isoform | Homo sapiens | - |
neuroblastoma cell | - |
Homo sapiens | - |
SH-SY5Y cell | expression of neural-type DDC isoform | Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.00003 | - |
enzyme from HTB-14 cells, at 37°C, pH not specified in the publication | Homo sapiens |
0.00006 | - |
enzyme from HeLa cells, at 37°C, pH not specified in the publication | Homo sapiens |
10.03 | - |
enzyme from SH-SY5Y cells, at 37°C, pH not specified in the publication | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-Dopa | - |
Homo sapiens | dopamine + CO2 | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 50000, SDS-PAGE | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
AADC | - |
Homo sapiens |
Alt-DDC | alternative DDC protein isoform | Homo sapiens |
DDC | - |
Homo sapiens |
L-DOPA decarboxylase | - |
Homo sapiens |
neural-type DDC | isoform | Homo sapiens |
non-neural DDC | isoform | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
pyridoxal 5'-phosphate | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | DDC mRNA is transcribed in two different forms, neural and non-neural, due to alternative promoter usage and alternative splicing within the 5'-untranslated region | additional information |