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Reference on EC 4.1.1.28 - aromatic-L-amino-acid decarboxylase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Christenson, J.G.; Dairman, W.; Udenfrien, S.
On the identity of DOPA decarboxylase and 5-hydroxytryptophan decarboxylase
Proc. Natl. Acad. Sci. USA
69
343-347
1972
Oryctolagus cuniculus, Rattus norvegicus, Sus scrofa
Manually annotated by BRENDA team
Tocher, R.D.; Tocher, C.S.
DOPA decarboxylase in Cytisus scoparius
Phytochemistry
11
1661-1667
1972
Cytisus scoparius
-
Manually annotated by BRENDA team
Nakazawa, H.; Kumagai, H.; Yamada, H.
Constitutive aromatic L-amino acid decarboxylase from Micrococcus percitreus
Biochem. Biophys. Res. Commun.
61
75-82
1974
Micrococcus percitreus
Manually annotated by BRENDA team
Baxter, C.; Slaytor, M.
Partial purification and some properties of tryptophan decarboxylase from Phalaris tuberosa
Phytochemistry
11
2763-2766
1972
Phalaris aquatica
-
Manually annotated by BRENDA team
Bender, D.A.; Coulson, W.F.
Aromatic amino acid decarboxylase: pH-dependence of substrates and inhibitors
Biochem. Soc. Trans.
5
1353-1356
1977
Rattus norvegicus
Manually annotated by BRENDA team
Minelli, A.; Charteris, A.T.; Voltattorni, C.B.; John, R.A.
Reactions of DOPA (3,4-dihydroxyphenylalanine) decarboxylase with DOPA
Biochem. J.
183
361-368
1979
Sus scrofa
Manually annotated by BRENDA team
Nakazawa, H.; Kumaga, H.; Yamada, H.
Cofactor requirements of constitutive aromatic L-amino acid decarboxylase from Micrococcus percitreus
Agric. Biol. Chem.
47
1605-1609
1983
Micrococcus percitreus
-
Manually annotated by BRENDA team
Lindstrm, P.
Aromatic-L-amino-acid decarboxylase activity in mouse pancreatic islets
Biochim. Biophys. Acta
884
276-281
1986
Mus musculus
Manually annotated by BRENDA team
Nakazawa, H.; Kumagai, H.; Yamada, H.
Inhibition of aromatic L-amino acid decarboxylase from Micrococcus percitreus by substrate analogs
Agric. Biol. Chem.
51
2531-2537
1987
Micrococcus percitreus, Micrococcus percitreus AJ1065
-
Manually annotated by BRENDA team
Groen, B.W.; van der Meer, R.A.; Duine, J.A.
Evidence for PQQ as cofactor in 3,4-dihydroxyphenylalanine (dopa) decarboxylase of pig kidney
FEBS Lett.
237
98-102
1988
Sus scrofa
Manually annotated by BRENDA team
Lovenberg, W.
Aromatic L-amino acid decarboxylase (guinea pig kidney)
Methods Enzymol.
17B
652-656
1971
Cavia porcellus
-
Manually annotated by BRENDA team
Fragoulis, E.G.; Sekeris, C.E.
Purification and characteristics of DOPA-decarboxylase from the integument of Calliphora vicina larvae
Arch. Biochem. Biophys.
168
15-25
1975
Calliphora vicina
Manually annotated by BRENDA team
Clark, W.C.; Pass, P.S.; Venkataraman, B.; Hodgetts, R.B.
Dopa decarboxylase from Drosophila melanogaster. Purification, characterization and an analysis of mutants
Mol. Gen. Genet.
162
287-297
1978
Drosophila melanogaster
-
Manually annotated by BRENDA team
Srinivasan, K.; Awapara, J.
Substrate specificity and other properties of dopa decarboxylase from guinea pig kidneys
Biochim. Biophys. Acta
526
597-604
1978
Cavia porcellus
Manually annotated by BRENDA team
Voltattorni, C.B.; Minelli, A.; Vecchini, P.; Fiori, A.; Turano, C.
Purification and characterization of 3,4-dihydroxyphenylalanine decarboxylase from pig kidney
Eur. J. Biochem.
93
181-188
1979
Sus scrofa
Manually annotated by BRENDA team
Bouchard, S.; Roberge, A.G.
Biochemical properties and kinetic parameters of dihydroxyphenylalanine-5-hydroxytryptophan decarboxylase in brain, liver, and adrenals of cat
Can. J. Biochem.
57
1014-1018
1979
Felis catus
Manually annotated by BRENDA team
Nakazawa, H.; Kumagai, H.; Yamada, H.
Aromatic L-amino acid decarboxylase from Micrococcus percitreus. Purification, crystallization and properties
Agric. Biol. Chem.
45
2543-2552
1981
Micrococcus percitreus
-
Manually annotated by BRENDA team
Ando-Yamamoto, M.; Hayashi, H.; Sugiyama, H.; Fukui, H.; Watanabe, T.; Wada, H.
Purification of L-DOPA decarboxylase from rat liver and production of polyclonal and monoclonal antibodies against it
J. Biochem.
101
405-414
1987
Rattus norvegicus
Manually annotated by BRENDA team
Voltattorni, C.B.; Giartosio, A.; Turano, C.
Aromatic-L-amino acid decarboxylase from pig kidney
Methods Enzymol.
142
179-187
1987
Sus scrofa
Manually annotated by BRENDA team
Nishigaki, I.; Ichinose, H.; Tamai, K.; Nagatsu, T.
Purification of aromatic L-amino acid decarboxylase from bovine brain with a monoclonal antibody
Biochem. J.
252
331-335
1988
Bos taurus
Manually annotated by BRENDA team
Dominici, P.; Tancini, B.; Barra, D.; Voltattorni, C.B.
Purification and characterization of rat-liver 3,4-dihydroxyphenylalanine decarboxylase
Eur. J. Biochem.
169
209-213
1987
Rattus norvegicus
Manually annotated by BRENDA team
Jung, M.J.
Substrates and Inhibitors of aromatic amino acid decarboxylase
Bioorg. Chem.
14
429-443
1986
Mammalia
-
Manually annotated by BRENDA team
Zhu, M.Y.; Juorio, A.V.
Aromatic L-amino acid decarboxylase: biological characterization and functional role
Gen. Pharmacol.
26
681-696
1995
Bos taurus, Cavia porcellus, Homo sapiens, Rattus norvegicus, Sus scrofa, Xenopus laevis
Manually annotated by BRENDA team
Facchini, P.J.; de Luca, V.
Expression in Escherichia coli and partial characterization of two tyrosine/dopa decarboxylases from opium poppy
Phytochemistry
38
1119-1126
1995
Cytisus scoparius, Hordeum vulgare, Papaver somniferum, Petroselinum crispum, Sanguinaria canadensis, Syringa vulgaris, Thalictrum rugosum
Manually annotated by BRENDA team
Dluzen, D.; Reddy, A.; McDermott, J.
The aromatic amino acid decarboxylase inhibitor, NSD-1015, increases release of dopamine: response characteristics
Neuropharmacology
31
1223-1229
1992
Rattus norvegicus
Manually annotated by BRENDA team
Nasrin, S.; Ichinose, H.; Nagatsu, T.
Comparison and characteristics of bovine aromatic L-amino acid decarboxylase with human enzyme
Biochim. Biophys. Acta
1118
318-322
1992
Bos taurus, Homo sapiens
Manually annotated by BRENDA team
Sumi, C.; Ichinose, H.; Nagatsu, T.
Characterization of recombinant human aromatic L-amino acid decarboxylase expressed in COS cells
J. Neurochem.
55
1075-1078
1990
Homo sapiens
Manually annotated by BRENDA team
Siow, Y.L.; Dakshinamurti, K.
Purification of dopa decarboxylase from bovine striatum
Mol. Cell. Biochem.
94
121-131
1990
Bos taurus
Manually annotated by BRENDA team
Mappouras, D.G.; Stiakakis, J.; Fragoulis, E.G.
Purification and characterization of L-DOPA decarboxylase from human kidney
Mol. Cell. Biochem.
94
147-156
1990
Homo sapiens
Manually annotated by BRENDA team
Bossinakou, K.S.; Fragoulis, E.G.
Purification and characterization of L-dopa decarboxylase from pharate pupae of Ceratitis capitata. A comparison with the enzyme purified from the white prepupae
Comp. Biochem. Physiol. B
113
213-220
1996
Ceratitis capitata
Manually annotated by BRENDA team
Dominici, P.; Moore, P.S.; Voltattorni, C.B.
Modified purification of L-aromatic amino acid decarboxylase from pig kidney
Protein Expr. Purif.
4
345-347
1993
Sus scrofa
Manually annotated by BRENDA team
Jebai, F.; Hanoun, N.; Hamon, M.; Thibault, J.; Peltre, G.; Gros, F.; Krieger, M.
Expression, purification, and characterization of rat aromatic L-amino acid decarboxylase in Escherichia coli
Protein Expr. Purif.
11
185-194
1997
Rattus norvegicus
Manually annotated by BRENDA team
Park, D.H.; Kim, K.T.; Choi, M.U.; Samanta, H.; Joh, T.H.
Characterization of bovine aromatic L-amino acid decarboxylase expressed in a mouse cell line: comparison with native enzyme
Mol. Brain Res.
16
232-238
1992
Bos taurus
Manually annotated by BRENDA team
Borresen, T.; Klausen, N.K.; Larsen, L.; Sorensen, H.
Purification and characterization of tyrosine decarboxylase and aromatic-L-amino-acid decarboxylase
Biochim. Biophys. Acta
993
108-115
1989
Sus scrofa
Manually annotated by BRENDA team
Tancini, B.; Dominici, P.; Simmaco, M.; Schinina, M.E.; Barra, D.; Voltattorini, C.B.
Limited tryptic proteolysis of pig kidney 3,4-dihydroxyphenylalanine decarboxylase
Arch. Biochem. Biophys.
260
569-576
1988
Sus scrofa
Manually annotated by BRENDA team
Borri Voltattorni, C.; Bertoldi, M.; Bianconi, S.; Deng, W.p.; Wong, K.; Kim, I.; Herbert, B.; Kirk, K.L.
Behavior of fluorinated analogs of L-(3,4-dihydroxyphenyl)alanine and L-threo-(3,4-dihydroxyphenyl)serine as substrates for Dopa decarboxylase
Biochem. Biophys. Res. Commun.
295
107-111
2002
Sus scrofa
Manually annotated by BRENDA team
Bertoldi, M.; Borri Voltattorni, C.
Reaction of dopa decarboxylase with L-aromatic amino acids under aerobic and anaerobic conditions
Biochem. J.
352
533-538
2000
Sus scrofa
-
Manually annotated by BRENDA team
Bertoldi, M.; Borri Voltattorni, C.
Reaction and substrate specificity of recombinant pig kidney DOPA decarboxylase under aerobic and anaerobic conditions
Biochim. Biophys. Acta
1647
42-47
2003
Sus scrofa
Manually annotated by BRENDA team
Poulikakos, P.; Vassilacopoulou, D.; Fragoulis, E.G.
A membrane-associated form of L-DOPA decarboxylase in the white prepuparium and adult eclosion developmental stages of the mediterranean fruit fly, Ceratitis capitata
Biogenic Amines
17
15-24
2002
Ceratitis capitata
-
Manually annotated by BRENDA team
Tang, L.; Frank, G.
Identification and characterization of an aromatic amino acid decarboxylase from the filarial nematode, Dirofilaria immitis
Biol. Chem.
382
115-122
2001
Dirofilaria immitis
Manually annotated by BRENDA team
Husebye, E.S.; Boe, A.S.; Rorsman, F.; Kaempe, O.; Aakvaag, A.; Rygh, T.; Flatmark, T.; Haavik, J.
Inhibition of aromatic L-amino acid decarboxylase activity by human autoantibodies
Clin. Exp. Immunol.
120
420-423
2000
Rattus norvegicus
Manually annotated by BRENDA team
Kim, M.H.; Joo, C.H.; Cho, M.Y.; Kwon, T.H.; Lee, K.M.; Natori, S.; Lee, T.H.; Lee, B.L.
Bacterial-injection-induced syntheses of N-beta-alanyldopamine and DOPA decarboxylase in the hemolymph of coleopteran insect, Tenebrio molitor larvae
Eur. J. Biochem.
267
2599-2608
2000
Tenebrio molitor
Manually annotated by BRENDA team
Ishida, Y.; Yokoyama, C.; Inatomi, T.; Yagita, K.; Dong, X.; Yan, L.; Yamaguchi, S.; Nagatsu, I.; Komori, T.; Kitahama, K.; Okamura, H.
Circadian rhythm of aromatic L-amino acid decarboxylase in the rat suprachiasmatic nucleus: gene expression and decarboxylating activity in clock oscillating cells
Genes Cells
7
447-459
2002
Rattus norvegicus
Manually annotated by BRENDA team
Niedens, B.R.; Parker, S.R.; Stierle, D.B.; Stierle, A.A.
First fungal aromatic L-amino acid decarboxylase from a paclitaxel-producing Penicillium raistrickii
Mycologia
91
619-626
1999
no activity in Penicillium raistrickii, Penicillium raistrickii, Penicillium raistrickii H10BA2
Manually annotated by BRENDA team
Nagy, L.; Hiripi, L.
Role of tyrosine, DOPA and decarboxylase enzymes in the synthesis of monoamines in the brain of the locust
Neurochem. Int.
41
9-16
2002
Locusta migratoria
Manually annotated by BRENDA team
Poulikakos, P.; Vassilacopoulou, D.; Fragoulis, E.G.
L-DOPA decarboxylase association with membranes in mouse brain
Neurochem. Res.
26
479-485
2001
Mus musculus
Manually annotated by BRENDA team
Siaterli, M.Z.; Vassilacopoulou, D.; Fragoulis, E.G.
Cloning and expression of human placental L-Dopa decarboxylase
Neurochem. Res.
28
797-803
2003
Homo sapiens
Manually annotated by BRENDA team
Mura, A.; Linder, J.C.; Young, S.J.; Groves, P.M.
Striatal cells containing aromatic L-amino acid decarboxylase: an immunohistochemical comparison with other classes of striatal neurons
Neuroscience
98
501-511
2000
Rattus norvegicus
Manually annotated by BRENDA team
Facchini, P.J.; Huber-Allanach, K.L.; Tari, L.W.
Plant aromatic L-amino acid decarboxylases: evolution, biochemistry, regulation, and metabolic engineering applications
Phytochemistry
54
121-138
2000
Camptotheca acuminata (P93082), Catharanthus roseus (P17770), Cinchona calisaya, Cinchona officinalis, Drosophila melanogaster, Homo sapiens (P20711), Solanum lycopersicum, Sus scrofa
Manually annotated by BRENDA team
Di Fiore, S.; Li, Q.; Leech, M.J.; Schuster, F.; Emans, N.; Fischer, R.; Schillberg, S.
Targeting tryptophan decarboxylase to selected subcellular compartments of tobacco plants affects enzyme stability and in vivo function and leads to a lesion-mimic phenotype
Plant Physiol.
129
1160-1169
2002
Nicotiana tabacum
Manually annotated by BRENDA team
Chang, Y.T.; Sharma, R.; Marsh, J.L.; McPherson, J.D.; Bedell, J.A.; Knust, A.; Brautigam, C.; Hoffmann, G.F.; Hyland, K.
Levodopa-responsive aromatic L-amino acid decarboxylase deficiency
Ann. Neurol.
55
435-438
2004
Homo sapiens
Manually annotated by BRENDA team
Hare, E.E.; Loer, C.M.
Function and evolution of the serotonin-synthetic bas-1 gene and other aromatic amino acid decarboxylase genes in Caenorhabditis
BMC Evol. Biol.
4
24
2004
Caenorhabditis elegans
Manually annotated by BRENDA team
DeJesus, O.T.; Flores, L.G.; Murali, D.; Converse, A.K.; Bartlett, R.M.; Barnhart, T.E.; Oakes, T.R.; Nickles, R.J.
Aromatic L-amino acid decarboxylase turnover in vivo in rhesus macaque striatum: a microPET study
Brain Res.
1054
55-60
2005
Macaca mulatta
Manually annotated by BRENDA team
Sun, M.; Kong, L.; Wang, X.; Holmes, C.; Gao, Q.; Zhang, G.R.; Pfeilschifter, J.; Goldstein, D.S.; Geller, A.I.
Coexpression of tyrosine hydroxylase, GTP cyclohydrolase I, aromatic amino acid decarboxylase, and vesicular monoamine transporter 2 from a helper virus-free herpes simplex virus type 1 vector supports high-level, long-term biochemical and behavioral correction of a rat model of Parkinson's disease
Hum. Gene Ther.
15
1177-1196
2004
Homo sapiens
Manually annotated by BRENDA team
Matsuda, N.; Hayashi, H.; Miyatake, S.; Kuroiwa, T.; Kagamiyama, H.
Instability of the apo form of aromatic L-amino acid decarboxylase in vivo and in vitro: implications for the involvement of the flexible loop that covers the active site
J. Biochem.
135
33-42
2004
Rattus norvegicus
Manually annotated by BRENDA team
Doroudchi, M.M.; Liauw, J.; Heaton, K.; Zhen, Z.; Forsayeth, J.R.
Adeno-associated virus-mediated gene transfer of human aromatic L-amino acid decarboxylase protects mixed striatal primary cultures from L-DOPA toxicity
J. Neurochem.
93
634-640
2005
Homo sapiens
Manually annotated by BRENDA team
Neff, N.H.; Wemlinger, T.A.; Duchemin, A.M.; Hadjiconstantinou, M.
Clozapine modulates aromatic L-amino acid decarboxylase activity in mouse striatum
J. Pharmacol. Exp. Ther.
317
480-487
2006
Mus musculus
Manually annotated by BRENDA team
Vassilacopoulou, D.; Sideris, D.C.; Vassiliou, A.G.; Fragoulis, E.G.
Identification and characterization of a novel form of the human L-dopa decarboxylase mRNA
Neurochem. Res.
29
1817-1823
2004
Homo sapiens
Manually annotated by BRENDA team
Brust, P.; Walter, B.; Hinz, R.; Fuchtner, F.; Muller, M.; Steinbach, J.; Bauer, R.
Developmental changes in the activities of aromatic amino acid decarboxylase and catechol-O-methyl transferase in the porcine brain: a positron emission tomography study
Neurosci. Lett.
364
159-163
2004
Sus scrofa
Manually annotated by BRENDA team
Kubovcakova, L.; Krizanova, O.; Kvetnansky, R.
Identification of the aromatic L-amino acid decarboxylase gene expression in various mice tissues and its modulation by immobilization stress in stellate ganglia
Neuroscience
126
375-380
2004
Mus musculus, Mus musculus C57BL / 129SV
Manually annotated by BRENDA team
Hodgetts, R.B.; OKeefe, S.L.
Dopa decarboxylase: a model gene-enzyme system for studying development, behavior, and systematics
Annu. Rev. Entomol.
51
259-284
2006
Ceratitis capitata (O96937), Drosophila melanogaster (P05031), Manduca sexta (P48861), Aedes aegypti (Q16895), Mythimna separata (Q95YG8), Mamestra brassicae (Q95YG9), Bombyx mori (Q967Q9), Tenebrio molitor (Q9NL84)
Manually annotated by BRENDA team
Bratland, E.; Wolff, A.S.; Haavik, J.; Kaempe, O.; Skoeldberg, F.; Perheentupa, J.; Bredholt, G.; Knappskog, P.M.; Husebye, E.S.
Epitope mapping of human aromatic L-amino acid decarboxylase
Biochem. Biophys. Res. Commun.
353
692-698
2007
Homo sapiens
Manually annotated by BRENDA team
Kitahama, K.; Geffard, M.; Araneda, S.; Arai, R.; Ogawa, K.; Nagatsu, I.; Pequignot, J.M.
Localization of L-DOPA uptake and decarboxylating neuronal structures in the cat brain using dopamine immunohistochemistry
Brain Res.
1167
56-70
2007
Felis catus
Manually annotated by BRENDA team
Weihe, E.; Depboylu, C.; Schuetz, B.; Schaefer, M.K.; Eiden, L.E.
Three types of tyrosine hydroxylase-positive CNS neurons distinguished by Dopa decarboxylase and VMAT2 co-expression
Cell. Mol. Neurobiol.
26
659-678
2006
Macaca mulatta
Manually annotated by BRENDA team
Seta, Y.; Kataoka, S.; Toyono, T.; Toyoshima, K.
Immunohistochemical localization of aromatic L-amino acid decarboxylase in mouse taste buds and developing taste papillae
Histochem. Cell Biol.
127
415-422
2007
Mus musculus
Manually annotated by BRENDA team
Wafa, L.A.; Palmer, J.; Fazli, L.; Hurtado-Coll, A.; Bell, R.H.; Nelson, C.C.; Gleave, M.E.; Cox, M.E.; Rennie, P.S.
Comprehensive expression analysis of L-dopa decarboxylase and established neuroendocrine markers in neoadjuvant hormone-treated versus varying Gleason grade prostate tumors
Hum. Pathol.
38
161-170
2007
Homo sapiens
Manually annotated by BRENDA team
Candeloro, P.; Voltattorni, C.B.; Perniola, R.; Bertoldi, M.; Betterle, C.; Mannelli, M.; Giordano, R.; De Bellis, A.; Tiberti, C.; Laureti, S.; Santeusanio, F.; Falorni, A.
Mapping of human autoantibody epitopes on aromatic L-amino acid decarboxylase
J. Clin. Endocrinol. Metab.
92
1096-1105
2007
Homo sapiens
Manually annotated by BRENDA team
Uccella, S.; Cerutti, R.; Vigetti, D.; Furlan, D.; Oldrini, R.; Carnevali, I.; Pelosi, G.; La Rosa, S.; Passi, A.; Capella, C.
Histidine decarboxylase, DOPA decarboxylase, and vesicular monoamine transporter 2 expression in neuroendocrine tumors: immunohistochemical study and gene expression analysis
J. Histochem. Cytochem.
54
863-875
2006
Homo sapiens
Manually annotated by BRENDA team
Tehranian, R.; Montoya, S.E.; Van Laar, A.D.; Hastings, T.G.; Perez, R.G.
Alpha-synuclein inhibits aromatic amino acid decarboxylase activity in dopaminergic cells
J. Neurochem.
99
1188-1196
2006
Rattus norvegicus
Manually annotated by BRENDA team
Margiotti, K.; Wafa, L.A.; Cheng, H.; Novelli, G.; Nelson, C.C.; Rennie, P.S.
Androgen-regulated genes differentially modulated by the androgen receptor coactivator L-dopa decarboxylase in human prostate cancer cells
Mol. Cancer
6
38
2007
Homo sapiens
Manually annotated by BRENDA team
Verbeek, M.M.; Geurtz, P.B.; Willemsen, M.A.; Wevers, R.A.
Aromatic L-amino acid decarboxylase enzyme activity in deficient patients and heterozygotes
Mol. Genet. Metab.
90
363-369
2007
Homo sapiens
Manually annotated by BRENDA team
Tieman, D.; Taylor, M.; Schauer, N.; Fernie, A.R.; Hanson, A.D.; Klee, H.J.
Tomato aromatic amino acid decarboxylases participate in synthesis of the flavor volatiles 2-phenylethanol and 2-phenylacetaldehyde
Proc. Natl. Acad. Sci. USA
103
8287-8292
2006
Solanum lycopersicum (Q1KSC5), Solanum lycopersicum (Q1KSC6)
Manually annotated by BRENDA team
Campos-Tamayo, F.; Hernandez-Dominguez, E.; Vazquez-Flota, F.
Vindoline formation in shoot cultures of Catharanthus roseus is synchronously activated with morphogenesis through the last biosynthetic step
Ann. Bot.
102
409-415
2008
Catharanthus roseus (P17770), Catharanthus roseus
Manually annotated by BRENDA team
Bertoldi, M.; Cellini, B.; Montioli, R.; Borri Voltattorni, C.
Insights into the mechanism of oxidative deamination catalyzed by DOPA decarboxylase
Biochemistry
47
7187-7195
2008
Sus scrofa (P80041)
Manually annotated by BRENDA team
Kokkinou, I.; Nikolouzou, E.; Hatzimanolis, A.; Fragoulis, E.G.; Vassilacopoulou, D.
Expression of enzymatically active L-DOPA decarboxylase in human peripheral leukocytes
Blood Cells Mol. Dis.
42
92-98
2008
Homo sapiens
Manually annotated by BRENDA team
Avgeris, M.; Koutalellis, G.; Fragoulis, E.G.; Scorilas, A.
Expression analysis and clinical utility of L-Dopa decarboxylase (DDC) inprostate cancer
Clin. Biochem.
41
1140-1149
2008
Homo sapiens
Manually annotated by BRENDA team
Hadjiconstantinou, M.; Neff, N.H.
Enhancing aromatic L-amino acid decarboxylase activity: implications for L-DOPA treatment in Parkinsons disease
CNS Neurosci. Ther.
14
340-351
2008
Homo sapiens, Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Paskewitz, S.M.; Andreev, O.
Silencing the genes for dopa decarboxylase or dopachrome conversion enzyme reduces melanization of foreign targets in Anopheles gambiae
Comp. Biochem. Physiol. B
150
403-408
2008
Anopheles gambiae (O61717), Anopheles gambiae (O61718), Anopheles gambiae
Manually annotated by BRENDA team
Ito, S.; Nakayama, T.; Ide, S.; Ito, Y.; Oguni, H.; Goto, Y.; Osawa, M.
Aromatic L-amino acid decarboxylase deficiency associated with epilepsy mimicking non-epileptic involuntary movements
Dev. Med. Child Neurol.
50
876-878
2008
Homo sapiens
Manually annotated by BRENDA team
Lee, H.F.; Tsai, C.R.; Chi, C.S.; Chang, T.M.; Lee, H.J.
Aromatic l-amino acid decarboxylase deficiency in Taiwan
Eur. J. Paediatr. Neurol.
13
135-140
2008
Homo sapiens
Manually annotated by BRENDA team
Jin, C.M.; Yang, Y.J.; Huang, H.S.; Lim, S.C.; Kai, M.; Lee, M.K.
Induction of dopamine biosynthesis by l-DOPA in PC12 cells: implications of L-DOPA influx and cyclic AMP
Eur. J. Pharmacol.
591
88-95
2008
Rattus norvegicus
Manually annotated by BRENDA team
Matsushita, N.; Misu, Y.; Goshima, Y.
In vivo antagonism of the behavioral responses to L-3-,4-dihydroxyphenylalanine by L-3-,4-dihydroxyphenylalanine cyclohexyl ester in conscious rats
Eur. J. Pharmacol.
605
109-113
2009
Rattus norvegicus
Manually annotated by BRENDA team
Sideri, M.; Tsakas, S.; Markoutsa, E.; Lampropoulou, M.; Marmaras, V.J.
Innate immunity in insects: surface-associated dopa decarboxylase-dependent pathways regulate phagocytosis, nodulation and melanization in medfly haemocytes
Immunology
123
528-537
2008
Ceratitis capitata (O45216), Ceratitis capitata
Manually annotated by BRENDA team
Traeger, C.; Vernby, A.; Kullman, A.; Ora, I.; Kogner, P.; Kagedal, B.
mRNAs of tyrosine hydroxylase and dopa decarboxylase but not of GD2 synthase are specific for neuroblastoma minimal disease and predicts outcome for children with high-risk disease when measured at diagnosis
Int. J. Cancer
123
2849-2855
2008
Homo sapiens
Manually annotated by BRENDA team
Hofto, L.R.; Lee, C.E.; Cafiero, M.
The importance of aromatic-type interactions in serotonin synthesis: Protein-ligand interactionsin tryptophan hydroxylase and aromatic amino acid decarboxylase
J. Comput. Chem.
30
1111-1115
2008
Homo sapiens
Manually annotated by BRENDA team
Lopez-Contreras, A.J.; Galindo, J.D.; Lopez-Garcia, C.; Castells, M.T.; Cremades, A.; Penafiel, R.
Opposite sexual dimorphism of 3,4-dihydroxyphenylalanine decarboxylase in the kidney and small intestine of mice
J. Endocrinol.
196
615-624
2008
Mus musculus
Manually annotated by BRENDA team
Manegold, C.; Hoffmann, G.F.; Degen, I.; Ikonomidou, H.; Knust, A.; Laass, M.W.; Pritsch, M.; Wilichowski, E.; Hoerster, F.
Aromatic L-amino acid decarboxylase deficiency: clinical features, drug therapy and follow-up
J. Inherit. Metab. Dis.
32
371-380
2009
Homo sapiens
Manually annotated by BRENDA team
Moreira-Rodrigues, M.; Sampaio-Maia, B.; Pestana, M.
Renal dopaminergic system activity in rat remnant kidney up to twenty-six weeks after surgery
Life Sci.
84
409-414
2009
Rattus norvegicus
Manually annotated by BRENDA team
Fujimori, K.E.
Characterization of the regulatory region of the dopa decarboxylase dene in Medaka: an in vivo green fluorescent protein reporter assay combined with a simple TA-cloning method
Mol. Biotechnol.
41
224-235
2009
Oryzias latipes (C0SQJ0), Oryzias latipes
Manually annotated by BRENDA team
Menheniott, T.R.; Woodfine, K.; Schulz, R.; Wood, A.J.; Monk, D.; Giraud, A.S.; Baldwin, H.S.; Moore, G.E.; Oakey, R.J.
Genomic imprinting of Dopa decarboxylase in heart and reciprocal allelic expression with neighboring Grb10
Mol. Cell. Biol.
28
386-396
2008
Mus musculus (O88533), Mus musculus
Manually annotated by BRENDA team
Davis, M.M.; Primrose, D.A.; Hodgetts, R.B.
A member of the p38 mitogen-activated protein kinase family is responsible for transcriptional induction of Dopa decarboxylase in the epidermis of Drosophila melanogaster during the innate immune response
Mol. Cell. Biol.
28
4883-4895
2008
Drosophila melanogaster
Manually annotated by BRENDA team
Cunningham, J.; Pivirotto, P.; Bringas, J.; Suzuki, B.; Vijay, S.; Sanftner, L.; Kitamura, M.; Chan, C.; Bankiewicz, K.S.
Biodistribution of adeno-associated virus type-2 in nonhuman primates after convection-enhanced delivery to brain
Mol. Ther.
16
1267-1275
2008
Homo sapiens
Manually annotated by BRENDA team
Buck, K.; Ferger, B.
Intrastriatal inhibition of aromatic amino acid decarboxylase prevents L-DOPA-induced dyskinesia: A bilateral reverse in vivo microdialysis study in 6-hydroxydopamine lesioned rats
Neurobiol. Dis.
29
210-220
2008
Rattus norvegicus
Manually annotated by BRENDA team
Vassiliou, A.G.; Fragoulis, E.G.; Vassilacopoulou, D.
Detection, purification and identification of an endogenous inhibitor of L-dopa decarboxylase activity from human placenta
Neurochem. Res.
34
1089-1100
2008
Mus musculus
Manually annotated by BRENDA team
Eberling, J.L.; Jagust, W.J.; Christine, C.W.; Starr, P.; Larson, P.; Bankiewicz, K.S.; Aminoff, M.J.
Results from a phase I safety trial of hAADC gene therapy for Parkinson disease
Neurology
70
1980-1983
2008
Homo sapiens
Manually annotated by BRENDA team
Bertoldi, M.; Voltattorni, C.B.
Multiple roles of the active site lysine of Dopa decarboxylase
Arch. Biochem. Biophys.
488
130-139
2009
Homo sapiens
Manually annotated by BRENDA team
Lin, Y.L.; Gao, J.
Internal proton transfer in the external pyridoxal 5'-phosphate Schiff base in dopa decarboxylase
Biochemistry
49
84-94
2010
Sus scrofa (P80041)
Manually annotated by BRENDA team
Ide, S.; Sasaki, M.; Kato, M.; Shiihara, T.; Kinoshita, S.; Takahashi, J.Y.; Goto, Y.
Abnormal glucose metabolism in aromatic L-amino acid decarboxylase deficiency
Brain Dev.
32
506-510
2010
Homo sapiens
Manually annotated by BRENDA team
Blechingberg, J.; Holm, I.E.; Johansen, M.G.; B?rglum, A.D.; Nielsen, A.L.
Aromatic L-amino acid decarboxylase expression profiling and isoform detection in the developing porcine brain
Brain Res.
1308
1-13
2010
Sus scrofa
Manually annotated by BRENDA team
Gil, S.; Park, C.; Lee, J.; Koh, H.
The roles of striatal serotonin and L-amino-acid decarboxylase on L-DOPA-induced dyskinesia in a hemiparkinsonian rat model
Cell. Mol. Neurobiol.
30
817-825
2010
Rattus norvegicus
Manually annotated by BRENDA team
Tayarani-Binazir, K.A.; Jackson, M.J.; Fisher, R.; Zoubiane, G.; Rose, S.; Jenner, P.
The timing of administration, dose dependence and efficacy of dopa decarboxylase inhibitors on the reversal of motor disability produced by L-DOPA in the MPTP-treated common marmoset
Eur. J. Pharmacol.
635
109-116
2010
Callithrix jacchus
Manually annotated by BRENDA team
Hiruma, K.; Riddiford, L.M.
The molecular mechanisms of cuticular melanization: the ecdysone cascade leading to dopa decarboxylase expression in Manduca sexta
Insect Biochem. Mol. Biol.
39
245-253
2009
Manduca sexta
Manually annotated by BRENDA team
da Silva, R.T.; Hokoc, J.N.; de Mello, F.G.; Gardino, P.F.
Differential immunodetection of L-DOPA decarboxylase and tyrosine hydroxylase in the vertebrate retina
Int. J. Dev. Neurosci.
27
469-476
2009
Gallus gallus, Didelphis aurita
Manually annotated by BRENDA team
Arakane, Y.; Lomakin, J.; Beeman, R.W.; Muthukrishnan, S.; Gehrke, S.H.; Kanost, M.R.; Kramer, K.J.
Molecular and functional analyses of amino acid decarboxylases involved in cuticle tanning in Tribolium castaneum
J. Biol. Chem.
284
16584-16594
2009
Tribolium castaneum (A7U8C8), Tribolium castaneum
Manually annotated by BRENDA team
Kitahama, K.; Ikemoto, K.; Jouvet, A.; Araneda, S.; Nagatsu, I.; Raynaud, B.; Nishimura, A.; Nishi, K.; Niwa, S.
Aromatic L-amino acid decarboxylase-immunoreactive structures in human midbrain, pons, and medulla
J. Chem. Neuroanat.
38
130-140
2009
Homo sapiens
Manually annotated by BRENDA team
Allen, G.F.; Neergheen, V.; Oppenheim, M.; Fitzgerald, J.C.; Footitt, E.; Hyland, K.; Clayton, P.T.; Land, J.M.; Heales, S.J.
Pyridoxal 5-phosphate deficiency causes a loss of aromatic L-amino acid decarboxylase in patients and human neuroblastoma cells, implications for aromatic L-amino acid decarboxylase and vitamin B(6) deficiency states
J. Neurochem.
114
87-96
2010
Homo sapiens
Manually annotated by BRENDA team
Kokkinou, I.; Fragoulis, E.G.; Vassilacopoulou, D.
The U937 macrophage cell line expresses enzymatically active L-Dopa decarboxylase
J. Neuroimmunol.
216
51-58
2009
Homo sapiens
Manually annotated by BRENDA team
Allen, G.F.; Land, J.M.; Heales, S.J.
A new perspective on the treatment of aromatic L-amino acid decarboxylase deficiency
Mol. Genet. Metab.
97
6-14
2009
Homo sapiens
Manually annotated by BRENDA team
Giegling, I.; Moreno-De-Luca, D.; Calati, R.; Hartmann, A.M.; Moeller, H.J.; De Ronchi, D.; Rujescu, D.; Serretti, A.
Tyrosine hydroxylase and DOPA decarboxylase gene variants in personality traits
Neuropsychobiology
59
23-27
2009
Homo sapiens
Manually annotated by BRENDA team
Kontos, C.K.; Papadopoulos, I.N.; Fragoulis, E.G.; Scorilas, A.
Quantitative expression analysis and prognostic significance of L-DOPA decarboxylase in colorectal adenocarcinoma
Br. J. Cancer
102
1384-1390
2010
Homo sapiens
Manually annotated by BRENDA team
Lin, Y.L.; Gao, J.
Kinetic isotope effects of L-Dopa decarboxylase
J. Am. Chem. Soc.
133
4398-4403
2011
Sus scrofa
Manually annotated by BRENDA team
Duchemin, A.M.; Neff, N.H.; Hadjiconstantinou, M.
Aromatic L-amino acid decarboxylase phosphorylation and activation by PKGIalpha in vitro
J. Neurochem.
114
542-552
2010
Mus musculus (O88533), Mus musculus
Manually annotated by BRENDA team
Chalatsa, I.; Nikolouzou, E.; Fragoulis, E.G.; Vassilacopoulou, D.
L-Dopa decarboxylase expression profile in human cancer cells
Mol. Biol. Rep.
38
1005-1011
2011
Homo sapiens
Manually annotated by BRENDA team
Pan, Q.H.; Chen, F.; Zhu, B.Q.; Ma, L.Y.; Li, L.; Li, J.M.
Molecular cloning and expression of gene encoding aromatic amino acid decarboxylase in Vidal blanc grape berries
Mol. Biol. Rep.
39
4319-4325
2012
Vitis vinifera x Vitis riparia
Manually annotated by BRENDA team
Chalatsa, I.; Fragoulis, E.G.; Vassilacopoulou, D.
Release of membrane-associated L-dopa decarboxylase from human cells
Neurochem. Res.
36
1426-1434
2011
Homo sapiens
Manually annotated by BRENDA team
Ishihara, A.; Nakao, T.; Mashimo, Y.; Murai, M.; Ichimaru, N.; Tanaka, C.; Nakajima, H.; Wakasa, K.; Miyagawa, H.
Probing the role of tryptophan-derived secondary metabolism in defense responses against Bipolaris oryzae infection in rice leaves by a suicide substrate of tryptophan decarboxylase
Phytochemistry
72
7-13
2011
Oryza sativa
Manually annotated by BRENDA team
Zhou, Z.; Yang, J.; Wang, L.; Zhang, H.; Gao, Y.; Shi, X.; Wang, M.; Kong, P.; Qiu, L.; Song, L.
A Dopa decarboxylase modulating the immune response of scallop Chlamys farreri
PLoS ONE
6
e18596
2011
Azumapecten farreri (F8QPW5), Azumapecten farreri
Manually annotated by BRENDA team
Ren, J.; Zhang, Y.; Jin, H.; Yu, J.; Zhou, Y.; Wu, F.; Zhang, W.
Novel inhibitors of human DOPA decarboxylase extracted from Euonymus glabra Roxb.
ACS Chem. Biol.
9
897-903
2014
Homo sapiens
Manually annotated by BRENDA team
Charoonratana, T.; Wungsintaweekul, J.; Keawpradub, N.; Verpoorte, R.
Molecular cloning and expression of tryptophan decarboxylase from Mitragyna speciosa
Acta Physiol. Plant.
35
2611-2621
2013
Mitragyna speciosa (G5DF84)
-
Manually annotated by BRENDA team
Montioli, R.; Cellini, B.; Dindo, M.; Oppici, E.; Voltattorni, C.
Interaction of human Dopa decarboxylase with L-dopa: Spectroscopic and kinetic studies as a function of pH
BioMed Res. Int.
2013
161456
2013
Homo sapiens
Manually annotated by BRENDA team
Zhou, Z.; Wang, L.; Shi, X.; Yue, F.; Wang, M.; Zhang, H.; Song, L.
The expression of dopa decarboxylase and dopamine beta hydroxylase and their responding to bacterial challenge during the ontogenesis of scallop Chlamys farreri
Fish Shellfish Immunol.
33
67-74
2012
Azumapecten farreri (F8QPW5), Azumapecten farreri
Manually annotated by BRENDA team
Chakrabarty, K.; Gupta, S.N.; Das, G.K.; Roy, S.
Theoretical studies on the pyridoxal-5-phosphate dependent enzyme dopa decarboxylase: effect of Thr 246 residue on the co-factor-enzyme binding and reaction mechanism
Indian J. Biochem. Biophys.
49
155-164
2012
Sus scrofa (P80041)
Manually annotated by BRENDA team
Torrens-Spence, M.P.; Liu, P.; Ding, H.; Harich, K.; Gillaspy, G.; Li, J.
Biochemical evaluation of the decarboxylation and decarboxylation-deamination activities of plant aromatic amino acid decarboxylases
J. Biol. Chem.
288
2376-2387
2013
Papaver somniferum (O82415), Papaver somniferum, Catharanthus roseus (P17770), Catharanthus roseus
Manually annotated by BRENDA team
Ruiz-Perez, M.V.; Pino-Angeles, A.; Medina, M.A.; Sanchez-Jimenez, F.; Moya-Garcia, A.A.
Structural perspective on the direct inhibition mechanism of EGCG on mammalian histidine decarboxylase and DOPA decarboxylase
J. Chem. Inf. Model.
52
113-119
2012
Sus scrofa (P80041)
Manually annotated by BRENDA team
Koyanagi, T.; Nakagawa, A.; Sakurama, H.; Yamamoto, K.; Sakurai, N.; Takagi, Y.; Minami, H.; Katayama, T.; Kumagai, H.
Eukaryotic-type aromatic amino acid decarboxylase from the root colonizer Pseudomonas putida is highly specific for 3,4-dihydroxyphenyl-L-alanine, an allelochemical in the rhizosphere
Microbiology
158
2965-2974
2012
Pseudomonas putida (Q88JU5), Pseudomonas putida, Pseudomonas putida KT 2240 (Q88JU5)
Manually annotated by BRENDA team
Wang, M.X.; Cai, Z.Z.; Lu, Y.; Xin, H.H.; Chen, R.T.; Liang, S.; Singh, C.O.; Kim, J.N.; Niu, Y.S.; Miao, Y.G.
Expression and functions of dopa decarboxylase in the silkworm, Bombyx mori was regulated by molting hormone
Mol. Biol. Rep.
40
4115-4122
2013
Bombyx mori
Manually annotated by BRENDA team
Hoefig, C.S.; Renko, K.; Piehl, S.; Scanlan, T.S.; Bertoldi, M.; Opladen, T.; Hoffmann, G.F.; Klein, J.; Blankenstein, O.; Schweizer, U.; Koehrle, J.
Does the aromatic L-amino acid decarboxylase contribute to thyronamine biosynthesis?
Mol. Cell. Endocrinol.
349
195-201
2012
Homo sapiens (P20711), Homo sapiens
Manually annotated by BRENDA team
Daidone, F.; Montioli, R.; Paiardini, A.; Cellini, B.; Macchiarulo, A.; Giardina, G.; Bossa, F.; Borri Voltattorni, C.
Identification by virtual screening and in vitro testing of human DOPA decarboxylase inhibitors
PLoS ONE
7
e31610
2012
Homo sapiens
Manually annotated by BRENDA team
Shih, D.F.; Hsiao, C.D.; Min, M.Y.; Lai, W.S.; Yang, C.W.; Lee, W.T.; Lee, S.J.
Aromatic L-amino acid decarboxylase (AADC) is crucial for brain development and motor functions
PLoS ONE
8
e71741
2013
Danio rerio (Q7SZR0), Danio rerio
Manually annotated by BRENDA team
Giardina, G.; Montioli, R.; Gianni, S.; Cellini, B.; Paiardini, A.; Voltattorni, C.B.; Cutruzzola, F.
Open conformation of human DOPA decarboxylase reveals the mechanism of PLP addition to Group II decarboxylases
Proc. Natl. Acad. Sci. USA
108
20514-20519
2011
Homo sapiens (P20711), Homo sapiens
Manually annotated by BRENDA team
Yuwen, L.; Zhang, F.; Chen, Q.; Lin, S.; Zhao, Y.; Li, Z.
The role of aromatic L-amino acid decarboxylase in bacillamide C biosynthesis by Bacillus atrophaeus C89
Sci. Rep.
3
1753
2013
Bacillus atrophaeus (I0DFJ0), Bacillus atrophaeus C89 (I0DFJ0), Bacillus atrophaeus C89
Manually annotated by BRENDA team
Pandey, S.S.; Singh, S.; Babu, C.S.; Shanker, K.; Srivastava, N.K.; Shukla, A.K.; Kalra, A.
Fungal endophytes of Catharanthus roseus enhance vindoline content by modulating structural and regulatory genes related to terpenoid indole alkaloid biosynthesis
Sci. Rep.
6
26583
2016
Catharanthus roseus (P17770), Catharanthus roseus
Manually annotated by BRENDA team
Liu, J.; Zhu, J.; Tang, L.; Wen, W.; Lv, S.; Yu, R.
Enhancement of vindoline and vinblastine production in suspension-cultured cells of Catharanthus roseus by artemisinic acid elicitation
World J. Microbiol. Biotechnol.
30
175-180
2014
Catharanthus roseus (P17770), Catharanthus roseus
Manually annotated by BRENDA team
Nakazawa, H.; Kumagai, H.; Yamada, H.
Aromatic L-amino acid decarboxylase from Micrococcus percitreus purification, crystallization and properties
Agric. Biol. Chem.
45
2543-2552
1981
Micrococcus percitreus, Micrococcus percitreus AJ 1065
-
Manually annotated by BRENDA team
Nakazawa, H.
Decarboxylation reaction of alpha-methyl amino acid catalyzed by aromatic L-amino acid decarboxylase from Micrococcus percitreus
Agric. Biol. Chem.
49
159-165
1985
Micrococcus percitreus, Micrococcus percitreus AJ 1065
-
Manually annotated by BRENDA team
Nakazawa, H.
Inhibition of aromatic L-amino acid decarboxylase from Micrococcus percitreus by substrate analogs
Agric. Biol. Chem.
51
2531-2537
1987
Micrococcus percitreus, Micrococcus percitreus AJ 1065
-
Manually annotated by BRENDA team
Sangwan, R.S.; Mishra, S.; Kumar, S.
Direct fluorometry of phase-extracted tryptamine-based fast quantitative assay of L-tryptophan decarboxylase from Catharanthus roseus leaf
Anal. Biochem.
255
39-46
1998
Catharanthus roseus
Manually annotated by BRENDA team
Nakazawa, H.; Kumagai, H.; Yamada, H.
Constitutive aromatic L-amino acid decarboxylase from Micrococcus percitreus
Biochem. Biophys. Res. Commun.
61
75-82
1974
Micrococcus percitreus, Micrococcus percitreus AJ 1065
Manually annotated by BRENDA team
Barboni, E.; Borri Voltattorni, C.; DErme, M.; Fiori, A.; Minelli, A.; Rosei, M.; Turano, C.
An abnormal reaction occurring in the presence of L-aromatic aminoacid decarboxylase
Biochem. Biophys. Res. Commun.
99
576-583
1981
Sus scrofa
Manually annotated by BRENDA team
Chaudhuri, J.; Martin, R.; Donahue, M.
Tryptophan hydroxylase and aromatic l-amino acid decarboxylase activities in the tissues of adult Ascaris suum
Int. J. Parasitol.
18
341-346
1988
Ascaris suum
Manually annotated by BRENDA team
Torrens-Spence, M.P.; Liu, P.; Ding, H.; Harich, K.; Gillaspy, G.; Li, J.
Biochemical evaluation of the decarboxylation and decarboxylation-deamination activities of plant aromatic amino acid decarboxylases
J. Biol. Chem.
288
2376-2387
2013
Papaver somniferum (O82415), Papaver somniferum
Manually annotated by BRENDA team
Bertoldi, M.
Mammalian dopa decarboxylase structure, catalytic activity and inhibition
Arch. Biochem. Biophys.
546
1-7
2014
Rattus norvegicus (P14173), Homo sapiens (P20711), Sus scrofa (P80041)
Manually annotated by BRENDA team
Ren, L.Q.; Chen, M.; Hultborn, H.; Guo, S.; Zhang, Y.; Zhang, M.
Heterogenic distribution of aromatic L-amino acid decarboxylase neurons in the rat spinal cord
Front. Integr. Neurosci.
11
31
2017
Rattus norvegicus (P14173)
Manually annotated by BRENDA team
Portaro, S.; Gugliandolo, A.; Scionti, D.; Cammaroto, S.; Morabito, R.; Leonardi, S.; Fraggetta, F.; Bramanti, P.; Mazzon, E.
When dysphoria is not a primary mental state a case report of the role of the aromatic L-aminoacid decarboxylase
Medicine (Baltimore)
97
e10953
2018
Homo sapiens
Manually annotated by BRENDA team
Sanchez-Jimenez, F.; Pino-Angeles, A.; Rodriguez-Lopez, R.; Morales, M.; Urdiales, J.L.
Structural and functional analogies and differences between histidine decarboxylase and aromatic l-amino acid decarboxylase molecular networks biomedical implications
Pharmacol. Res.
114
90-102
2016
Homo sapiens (P20711), Homo sapiens
Manually annotated by BRENDA team
Soltani, N.; Nazarian-Firouzabadi, F.; Shafeinia, A.; Sadr, A.S.; Shirali, M.
The expression of terpenoid indole alkaloid (TIAs) pathway genes in Catharanthus roseus in response to salicylic acid treatment
Mol. Biol. Rep.
47
7009-7016
2020
Catharanthus roseus (P17770), Catharanthus roseus
Manually annotated by BRENDA team