4.1.1.28: aromatic-L-amino-acid decarboxylase

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For detailed information about aromatic-L-amino-acid decarboxylase, go to the full flat file.

Reaction

Synonyms

3,4-dihydroxyphenylalanine carboxylase, 3,4-Dihydroxyphenylalanine decarboxylase, 5-Hydroxy-L-tryptophan decarboxylase, 5-Hydroxytryptophan decarboxylase, 5-hydroxytryptophan hydroxylase, 5HTP decarboxylase, AAAC, AAAD, AACD, AADC, AADC1A, AADC1B, AADC393, AADC438, AADC486, Alt-DDC, aromatic acid acid decarboxylase, Aromatic amino acid decarboxylase, aromatic amino acid decarboxylase 1A, aromatic amino acid decarboxylase 1B, Aromatic L-amino acid decarboxylase, aromatic L-aminoacid decarboxylase, aromatic-L-amino-acid decarboxylase, CrTDC, DDC, Decarboxylase, aromatic amino acid, Di-ADC, Dihydroxyphenylalanine-5-hydroxytryptophan decarboxylase, DOPA DC, dopa decarboxilase, DOPA decarboxylase, DOPA-5-hydroxytryptophan decarboxylase, DOPA/5HTP decarboxylase, dopamine decarboxylase, EC 4.1.1.26, EC 4.1.1.27, HsDDC, Hydroxytryptophan decarboxylase, L-3,4-Dihydroxyphenylalanine decarboxylase, L-5-Hydroxytryptophan decarboxylase, L-amino acid decarboxylase, L-amino-acid decarboxylase, L-Aromatic amino acid decarboxylase, L-aromatic aminoacid decarboxylase, L-DOPA decarboxylase, L-Tryptophan decarboxylase, neural-type DDC, non-neural DDC, PP_2552, TDC, TDC2, Tenebrio Dopa decarboxylase, Trp decarboxylase, Tryptophan decarboxylase, tryptophan decarboxylase-1, tryptophan decarboxylase-2, TYDC, Tydc9, Tyrosine/Dopa decarboxylase

ECTree

     4 Lyases

         4.1 Carbon-carbon lyases

             4.1.1 Carboxy-lyases

                4.1.1.28 aromatic-L-amino-acid decarboxylase

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Results	in table
54	Activating Compound
437	AA Sequence
29	Application
1	CAS Registry Number
50	Cloned(Commentary)
79	Cofactor
5	Crystallization (Commentary)
1429	Disease/ Diagnostics
17	Expression
24	General Information
6	General Stability
7	IC50 Value
205	Inhibitors
1	kcat/KM [mM/s]
11	Ki Value [mM]
93	KM Value [mM]
17	Localization
5	Metals/Ions
57	Molecular Weight [Da]
137	Natural Substrates/ Products (Substrates)
204	Organism
1	Oxidation Stability
36	Pathway
30	PDB ID
24	pH Optimum
4	pH Range
7	pH Stability
7	pI Value
4	Posttranslational Modification
26	Protein Variants
42	Purification (Commentary)
6	Reaction
30	Reaction Type
192	Reference
275	Source Tissue
93	Specific Activity [micromol/min/mg]
6	Storage Stability
396	Substrates and Products (Substrate)
37	Subunits
326	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]
5	Temperature Stability [°C]
28	Turnover Number [1/s]

Storage Stability

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Storage Stability on EC 4.1.1.28 - aromatic-L-amino-acid decarboxylase

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STORAGE STABILITY

ORGANISM

UNIPROT

LITERATURE

-20°C, 0.1 M potassium phosphate buffer, 0.1 mM dithiothreitol, stable for at least 2 months

Sus scrofa

-

4218

-20°C, stable for at least 2 months

Sus scrofa

-

4214

0°C, 0.05-0.01 M sodium phosphate buffer, pH 7.2, 1 mM dithiothreitol, stable for 6 weeks

Drosophila melanogaster

-

4212

4°C, 40% loss of activity after 10 days

Cavia porcellus

-

4210

5°C, 0.5 M potassium phosphate buffer pH 7.0 containing 20% (v/v) glycerol and 10 mM pyridoxal phosphate, more than 10 months, no loss of activity

Micrococcus percitreus

-

743976

5°C, in 0.5 M potassium phosphate buffer, pH 7.0, 20% glycerol, 1 mM pyridoxal phosphate and 19 mM 2-mercaptoethanol, stable for more than 10 months

Micrococcus percitreus

-

4216