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Literature summary for 4.1.1.28 extracted from

  • Zhou, Z.; Yang, J.; Wang, L.; Zhang, H.; Gao, Y.; Shi, X.; Wang, M.; Kong, P.; Qiu, L.; Song, L.
    A Dopa decarboxylase modulating the immune response of scallop Chlamys farreri (2011), PLoS ONE, 6, e18596.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21 (DE3)-Transetta cells Azumapecten farreri

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
63380
-
x * 63380, calculated from amino acid sequence Azumapecten farreri

Organism

Organism UniProt Comment Textmining
Azumapecten farreri F8QPW5
-
-

Purification (Commentary)

Purification (Comment) Organism
Ni2+ chelating Sepharose column chromatography Azumapecten farreri

Source Tissue

Source Tissue Comment Organism Textmining
adductor muscle
-
Azumapecten farreri
-
gill
-
Azumapecten farreri
-
gonad
-
Azumapecten farreri
-
hemocyte
-
Azumapecten farreri
-
hepatopancreas highest expression of DDC mRNA Azumapecten farreri
-
kidney
-
Azumapecten farreri
-
mantle
-
Azumapecten farreri
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-Dopa
-
Azumapecten farreri dopamine + CO2
-
?

Subunits

Subunits Comment Organism
? x * 63380, calculated from amino acid sequence Azumapecten farreri

Synonyms

Synonyms Comment Organism
AADC
-
Azumapecten farreri
DDC
-
Azumapecten farreri
DOPA decarboxylase
-
Azumapecten farreri
L-DOPA decarboxylase
-
Azumapecten farreri

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
Azumapecten farreri

pI Value

Organism Comment pI Value Maximum pI Value
Azumapecten farreri calculated from amino acid sequence
-
6.1

Expression

Organism Comment Expression
Azumapecten farreri after treatment with lipopolysaccharide stimulation, the mRNA expression level of DDC in hemocytes increases 5.5fold at 3 h and 9.8fold at 12 h and then recovers to the baseline level up

General Information

General Information Comment Organism
physiological function DDC modulates the immune responses such as hemocytes encapsulation as well as the reactive oxygen species level through its catalytic activity, functioning as an indispensable immunomodulating enzyme in the neuroendocrine-immune regulatory network of mollusk Azumapecten farreri