3.4.21.39: chymase

This is an abbreviated version!
For detailed information about chymase, go to the full flat file.

Word Map on EC 3.4.21.39

3.4.21.39

tryptase

granule

degranulation

histamine

allergic

chemokines

ige

cathepsin

cardiac

artery

fibrosis

neutrophil

angiotensin-converting

eosinophil

cardiovascular

monocyte

asthma

heparin

airway

renin-angiotensin

rantes

chemoattractant

carboxypeptidase

c-kit

eotaxin

renin

elastase

chemotactic

basophil

angiotensinogen

endothelins

anaphylaxis

anaphylactic

toluidine

granzyme

mastocytosis

tryptase-positive

atopic

exocytosed

fcepsilonri

cromolyn

anti-ige

nippostrongylus

mip-1alpha

cell-deficient

mip-1beta

medicine

3clpro

enzyme-histochemical

non-ace

ige-mediated

Reaction

preferential cleavage: Phe-/- > Tyr-/- > Trp-/- > Leu-/- =

Synonyms

alpha-chymase, beta-chymase, CAGE, Chy, chymase, chymase 1, chymostatin sensitive angiotensin generating enzyme, chymotrypsin-like protease, chymotryptic mast cell peptidase, CLP, CMA, CMA1, HAM1, mast cell chymase, mast cell chymases 4, mast cell protease, mast cell protease 1, mast cell protease 4, mast cell protease I, mast cell protease-2, mast cell protease-4, mast cell specific chymase, mast cell-derived chymase, mast-cell-derived chymase, MC chymase, MC protease 4, MC-chymase, MC-derived chymase, MC-specific chymase, MCC, MCP-1, MCP-2, MCP-4, MCP-5, MCP-8, MCP2, MCP4, Mcpt, MCPT-4, MCPT4, MMCP-1, mucosal mast cell protease, mucosal mast cell protease-1, proteinase, mast cell serine, chymase, RMCP I, skeletal muscle protease, skin chymotryptic proteinase

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.21 Serine endopeptidases

3.4.21.39 chymase

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Results	in table
8	Activating Compound
15	AA Sequence
14	Application
1	CAS Registry Number
18	Cloned(Commentary)
4	Crystallization (Commentary)
2692	Disease/ Diagnostics
11	Expression
26	General Information
1	General Stability
127	IC50 Value
396	Inhibitors
16	kcat/KM [mM/s]
98	Ki Value [mM]
107	KM Value [mM]
13	Localization
32	Molecular Weight [Da]
87	Natural Substrates/ Products (Substrates)
149	Organism
22	PDB ID
8	pH Optimum
2	pH Range
3	pH Stability
11	Posttranslational Modification
10	Protein Variants
30	Purification (Commentary)
1	Reaction
1	Reaction Type
148	Reference
150	Source Tissue
5	Specific Activity [micromol/min/mg]
1	Storage Stability
342	Substrates and Products (Substrate)
23	Subunits
133	Synonyms
3	Temperature Optimum [°C]
3	Temperature Stability [°C]
107	Turnover Number [1/s]

Engineering

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Engineering on EC 3.4.21.39 - chymase

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A216G

Cavia porcellus

A7WPL7

the partially humanized mutant acquires human-like P1 Phe- and angiotensin-cleaving capacity

680901

K192M

2 entries

L40A

Homo sapiens

mutant enzyme retains strong preference for Phe8 with angiotensin I substrate but with Tyr4 hydrolytic rates enhance 16fold compared to wild-type enzyme

654835

R143Q

3 entries

R143Q/K192M

2 entries

additional information

Mus musculus

enzyme deficient animal, lack in processing of pro-matrix metalloprotease 9 to its active form and marked defect in processing of pro-matrix metalloprotease 2. Mutant animals show an increase in collagen in the ear tissue accompanied by increased ear thickness and a higher content in hydroxyproline. Lung and ear tissue of mutant animals show increased staining for fibronectin

669431