3.4.21.39: chymase

This is an abbreviated version!
For detailed information about chymase, go to the full flat file.

Reaction

preferential cleavage: Phe-/- > Tyr-/- > Trp-/- > Leu-/- =

Synonyms

alpha-chymase, beta-chymase, CAGE, Chy, chymase, chymase 1, chymostatin sensitive angiotensin generating enzyme, chymotrypsin-like protease, chymotryptic mast cell peptidase, CLP, CMA, CMA1, HAM1, mast cell chymase, mast cell chymases 4, mast cell protease, mast cell protease 1, mast cell protease 4, mast cell protease I, mast cell protease-2, mast cell protease-4, mast cell specific chymase, mast cell-derived chymase, mast-cell-derived chymase, MC chymase, MC protease 4, MC-chymase, MC-derived chymase, MC-specific chymase, MCC, MCP-1, MCP-2, MCP-4, MCP-5, MCP-8, MCP2, MCP4, Mcpt, MCPT-4, MCPT4, MMCP-1, mucosal mast cell protease, mucosal mast cell protease-1, proteinase, mast cell serine, chymase, RMCP I, skeletal muscle protease, skin chymotryptic proteinase

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.21 Serine endopeptidases

                3.4.21.39 chymase

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Results	in table
8	Activating Compound
15	AA Sequence
14	Application
1	CAS Registry Number
18	Cloned(Commentary)
4	Crystallization (Commentary)
2692	Disease/ Diagnostics
11	Expression
26	General Information
1	General Stability
127	IC50 Value
396	Inhibitors
16	kcat/KM [mM/s]
98	Ki Value [mM]
107	KM Value [mM]
13	Localization
32	Molecular Weight [Da]
87	Natural Substrates/ Products (Substrates)
149	Organism
22	PDB ID
8	pH Optimum
2	pH Range
3	pH Stability
11	Posttranslational Modification
10	Protein Variants
30	Purification (Commentary)
1	Reaction
1	Reaction Type
148	Reference
150	Source Tissue
5	Specific Activity [micromol/min/mg]
1	Storage Stability
342	Substrates and Products (Substrate)
23	Subunits
133	Synonyms
3	Temperature Optimum [°C]
3	Temperature Stability [°C]
107	Turnover Number [1/s]

Crystallization

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Crystallization on EC 3.4.21.39 - chymase

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CRYSTALLIZATION (Commentary)

ORGANISM

UNIPROT

LITERATURE

2.2 A crystal structure in complex with succinyl-Ala-Ala-Pro-Phe-chloromethylketone

Homo sapiens

-

81372

expression in Bacillus subtilis

Homo sapiens

-

81380

phenylmethanesulfonyl fluoride-treated enzyme

Homo sapiens

P23946

81373

-

Rattus norvegicus

-

81365