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3.4.21.39: chymase

This is an abbreviated version!
For detailed information about chymase, go to the full flat file.

Word Map on EC 3.4.21.39

Reaction

preferential cleavage: Phe-/- > Tyr-/- > Trp-/- > Leu-/- =

Synonyms

alpha-chymase, beta-chymase, CAGE, Chy, chymase, chymase 1, chymostatin sensitive angiotensin generating enzyme, chymotrypsin-like protease, chymotryptic mast cell peptidase, CLP, CMA, CMA1, HAM1, mast cell chymase, mast cell chymases 4, mast cell protease, mast cell protease 1, mast cell protease 4, mast cell protease I, mast cell protease-2, mast cell protease-4, mast cell specific chymase, mast cell-derived chymase, mast-cell-derived chymase, MC chymase, MC protease 4, MC-chymase, MC-derived chymase, MC-specific chymase, MCC, MCP-1, MCP-2, MCP-4, MCP-5, MCP-8, MCP2, MCP4, Mcpt, MCPT-4, MCPT4, MMCP-1, mucosal mast cell protease, mucosal mast cell protease-1, proteinase, mast cell serine, chymase, RMCP I, skeletal muscle protease, skin chymotryptic proteinase

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.39 chymase

KCat KM Value

KCat KM Value on EC 3.4.21.39 - chymase

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kcat/KM VALUE [1/mMs-1]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1963
Abz-GIAPFCDLMPEQ-EDDnp
-
pH 7.4, 37°C
1035
Abz-GIATFCDLMPEQ-EDDnp
-
pH 7.4, 37°C
238
Abz-GIATFCMLMPEQ-EDDnp
-
pH 7.4, 37°C
287
Abz-GIATFCPLMPEQ-EDDnp
-
pH 7.4, 37°C
144
Abz-GIATFCRLMPEQ-EDDnp
-
pH 7.4, 37°C
221
Abz-GIATFDMLMPEQ-EDDnp
-
pH 7.4, 37°C
203
Abz-GIATFRMLMPEQ-EDDnp
-
pH 7.4, 37°C
209
Abz-GIATFSMLMPEQ-EDDnp
-
pH 7.4, 37°C
96
Abz-GIATFWMLMPEQ-EDDnp
-
pH 7.4, 37°C
1648
Abz-GIEPFSDPMPEQ-EDDnp
-
pH 7.4, 37°C
136
Abz-TPFSALQ-EDDnp
-
pH 7.4, 37°C
97
Abz-TPWSALQ-YNO2
-
pH 7.4, 37°C
3.85 - 4.86
succinyl-L-Ala-L-Ala-L-Pro-L-Phe-4-nitroanilide
355 - 1130
succinyl-L-Ala-L-Ala-L-Pro-L-Phe-thiobenzyl ester