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Disease on EC 3.4.21.39 - chymase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Acute Coronary Syndrome
Anaphylactic cardiovascular collapse and Kounis syndrome: systemic vasodilation or coronary vasoconstriction?
Acute Kidney Injury
Cisplatin-induced acute renal failure in mice is mediated by chymase-activated angiotensin-aldosterone system and interleukin-18.
Mast cell chymase protects against acute ischemic kidney injury by limiting neutrophil hyperactivation and recruitment.
Adenocarcinoma
The relationship of tryptase- and chymase-positive mast cells to angiogenesis in stage I non-small cell lung cancer.
Adenocarcinoma of Lung
Chymase-positive mast cells in small sized adenocarcinoma of the lung.
Airway Obstruction
Association of mast cells with lung function in chronic obstructive pulmonary disease.
Albuminuria
Chymase inhibition retards albuminuria in type 2 diabetes.
Effects of the chymase inhibitor fulacimstat in diabetic kidney disease-results from the CADA DIA trial.
Mechanism of Albuminuria Reduction by Chymase Inhibition in Diabetic Mice.
Alveolitis, Extrinsic Allergic
Disruption in the balance between apolipoprotein A-I and mast cell chymase in chronic hypersensitivity pneumonitis.
Lung mast cell density defines a subpopulation of patients with idiopathic pulmonary fibrosis.
Alzheimer Disease
Clipsin, a chymotrypsin-like protease in rat brain which is irreversibly inhibited by alpha-1-antichymotrypsin.
Identification of a chymotrypsin-like mast cell protease in rat brain capable of generating the N-terminus of the Alzheimer amyloid beta-protein.
Amyloidosis
A Preliminary Study of Cu Exposure Effects upon Alzheimer's Amyloid Pathology.
Identification of a chymotrypsin-like mast cell protease in rat brain capable of generating the N-terminus of the Alzheimer amyloid beta-protein.
Anaphylaxis
A mouse model of lupin allergy.
A multi-center assessment to compare residual allergenicity of partial hydrolyzed whey proteins in a murine model for cow's milk allergy - Comparison to the single parameter guinea pig model.
Anaphylactic cardiovascular collapse and Kounis syndrome: systemic vasodilation or coronary vasoconstriction?
Biomarkers in Human Anaphylaxis: A Critical Appraisal of Current Evidence and Perspectives.
Chickpea (Cicer arietinum) proteins induce allergic responses in nasobronchial allergic patients and BALB/c mice.
Chronic infection with a tissue-invasive helminth attenuates sublethal anaphylaxis and reduces granularity and number of mast cells.
Depletion of mucosal mast cell protease by corticosteroids: effect on intestinal anaphylaxis in the rat.
Differential roles for the IL-9/IL-9 receptor alpha-chain pathway in systemic and oral antigen-induced anaphylaxis.
Early life exposure to bisphenol A investigated in mouse models of airway allergy, food allergy and oral tolerance.
Electromagnetic field induced biological effects in humans.
Genetic diversity between mouse strains allows identification of the CC027/GeniUnc strain as an orally reactive model of peanut allergy.
Helicobacter pylori and its secreted immunomodulator VacA protect against anaphylaxis in experimental models of food allergy.
IgE-Mediated Systemic Anaphylaxis And Its Association With Gene Polymorphisms Of ACE, Angiotensinogen And Chymase.
IL-10 Receptor or TGF-? Neutralization Abrogates the Protective Effect of a Specific Nondigestible Oligosaccharide Mixture in Cow-Milk-Allergic Mice.
In vitro diagnosis of anaphylaxis.
Interlaboratory evaluation of a cow's milk allergy mouse model to assess the allergenicity of hydrolysed cow's milk based infant formulas.
Mast cell heterogeneity underlies different manifestations of food allergy in mice.
Mast cell protease release and mucosal ultrastructure during intestinal anaphylaxis in the rat.
Mast cells in cutaneous mastocytosis: accumulation of the MCTC type.
Matriptase expression in the normal and neoplastic mast cells.
Motor activity as an unbiased variable to assess anaphylaxis in allergic rats.
Nitration of ?-Lactoglobulin but Not of Ovomucoid Enhances Anaphylactic Responses in Food Allergic Mice.
Oral exposure to the free amino acid glycine inhibits the acute allergic response in a model of cow's milk allergy in mice.
Post-sensitization administration of non-digestible oligosaccharides and Bifidobacterium breve M-16V reduces allergic symptoms in mice.
Promoted expression of mast cell-specific proteases in IgE-dependent passive cutaneous anaphylaxis responses.
Release of the mucosal mast cell granule chymase, rat mast cell protease-II, during anaphylaxis is associated with the rapid development of paracellular permeability to macromolecules in rat jejunum.
Sensitizing capacity and allergenicity of enzymatically cross-linked sodium caseinate in comparison to sodium caseinate in a mouse model for cow's milk allergy.
The effect of protein deficiency on systemic release of rat mucosal mast cell protease II during Nippostrongylus brasiliensis infection and following systemic anaphylaxis.
The presence in blood of both glycosaminoglycan and mucosal mast cell protease following systemic anaphylaxis in the rat.
Type B CpG oligodeoxynucleotides induce Th1 responses to peanut antigens: Modulation of sensitization and utility in a truncated immunotherapy regimen in mice.
Usefulness of serum mast cell-specific chymase levels for postmortem diagnosis of anaphylaxis.
[Application of serum total IgE, tryptase and chymase in the identification of death caused by drug anaphylactic shock].
[Biochemical indicators of anaphylactic shock and the application in forensic medicine].
[Expression of tryptase and chymase in human lung tissue of anaphylactic shock]
Aneurysm
Chronic chymase inhibition preserves cardiac function after left ventricular repair in rats.
Pathological roles of angiotensin II produced by mast cell chymase and the effects of chymase inhibition in animal models.
Serine proteases and cardiac function.
Aortic Aneurysm
Chymase as a novel target for the prevention of vascular diseases.
Aortic Aneurysm, Abdominal
A specific chymase inhibitor, 2-(5-formylamino-6-oxo-2-phenyl-1,6-dihydropyrimidine-1-yl)-N-[[3,4-dioxo-1-phenyl-7-(2-pyridyloxy)]-2-heptyl]acetamide (NK3201), suppresses development of abdominal aortic aneurysm in hamsters.
ASB17061, a novel chymase inhibitor, prevented the development of angiotensin II-induced abdominal aortic aneurysm in apolipoprotein E-deficient mice.
Chymase activates promatrix metalloproteinase-9 in human abdominal aortic aneurysm.
Chymase as a novel target for the prevention of vascular diseases.
Critical role of mast cell chymase in mouse abdominal aortic aneurysm formation.
Effects of chymase inhibitor on angiotensin II-induced abdominal aortic aneurysm development in apolipoprotein E-deficient mice.
Immune cells and molecular mediators in the pathogenesis of the abdominal aortic aneurysm.
Mast Cell Chymase and Tryptase in Abdominal Aortic Aneurysm Formation.
New approaches to blockade of the renin-angiotensin-aldosterone system: chymase as an important target to prevent organ damage.
Targets of chymase inhibitors.
The significance of chymase in the progression of abdominal aortic aneurysms in dogs.
Aortic Valve Stenosis
Activation of the cardiac renin-angiotensin system and increased myocardial collagen expression in human aortic valve disease.
Association of the common genetic polymorphisms and haplotypes of the chymase gene with left ventricular mass in male patients with symptomatic aortic stenosis.
Arrhythmias, Cardiac
Angiotensin-(1-12): A Chymase-Mediated Cellular Angiotensin II Substrate.
Arteriosclerosis
Prospective single-arm observational study of human chymase inhibitor Polygonum hydropiper L in subjects with hypertension.
[Angiotensin II in organ organopathy]
Arteriovenous Fistula
Effect of chymase inhibition on the arteriovenous fistula stenosis in dogs.
Arthritis
Caspase 1-independent activation of interleukin-1beta in neutrophil-predominant inflammation.
Chemerin 156F, generated by chymase cleavage of prochemerin, is elevated in joint fluids of arthritis patients.
Increases in mast cells and chymase in fibroproliferative paws of collagen-induced arthritic mice.
Mast cell chymase contributes to the antibody response and the severity of autoimmune arthritis.
Mast cell-restricted, tetramer-forming tryptases induce aggrecanolysis in articular cartilage by activating matrix metalloproteinase-3 and -13 zymogens.
The activation of synovial mast cells: modulation of histamine release by tryptase and chymase and their inhibitors.
The anti-allergic compound tranilast attenuates inflammation and inhibits bone destruction in collagen-induced arthritis in mice.
Arthritis, Juvenile
Mast cells enhance sterile inflammation in chronic nonbacterial osteomyelitis.
Arthritis, Rheumatoid
Mast cell responses in rheumatoid synovium. Association of the MCTC subset with matrix turnover and clinical progression.
Recent chymase inhibitors and their effects in in vivo models.
Significant correlation between thrombospondin 1 and serine proteinase expression in rheumatoid synovium.
[Pathophysiological roles of human chymase]
Asthma
A novel (TG)n(GA)m repeat polymorphism 254 bp downstream of the mast cell chymase (CMA1) gene is associated with atopic asthma and total serum IgE levels.
A novel, potent dual inhibitor of the leukocyte proteases cathepsin G and chymase: molecular mechanisms and anti-inflammatory activity in vivo.
Accumulation of intraepithelial mast cells with a unique protease phenotype in T(H)2-high asthma.
Airway Mast Cells in a Rhesus Model of Childhood Allergic Airways Disease.
Are chemokines essential or secondary participants in allergic responses?
Association of mast cells with lung function in chronic obstructive pulmonary disease.
Association of polymorphisms in the mast cell chymase gene promoter region (-1903 g/A) and (TG)n(GA)m repeat downstream of the gene with bronchial asthma in children.
Association of STR polymorphisms in CMA1 and IL-4 with asthma and atopy: the SAPALDIA cohort.
Attenuating Effect of Peruvian Cocoa Populations on the Acute Asthmatic Response in Brown Norway Rats.
Cleaved secretory leucocyte protease inhibitor as a biomarker of chymase activity in allergic airway disease.
COL4A3 is degraded in allergic asthma and degradation predicts response to anti-IgE therapy.
Contribution of opioid and neurotensin receptors in the anti-inflammatory activity of PK20 hybrid compound in murine airways.
Discriminating between the activities of human cathepsin G and chymase using fluorogenic substrates.
Dual Inhibition of Cathepsin G and Chymase is Effective in Animal Models of Pulmonary Inflammation.
Eotaxin and monocyte chemotactic protein-4 mRNA expression in small airways of asthmatic and nonasthmatic individuals.
Mast cell chymase affects the functional properties of primary human airway fibroblasts: Implications for asthma.
Mast cell chymase impairs bronchial epithelium integrity by degrading cell junction molecules of epithelial cells.
Mast cell peptidases: chameleons of innate immunity and host defense.
Mast Cell-Mediated Orchestration of the Immune Responses in Human Allergic Asthma: Current Insights.
Mast cells, their subtypes, and relation to asthma phenotypes.
Monocyte chemoattractant protein (MCP)-4 expression in the airways of patients with asthma. Induction in epithelial cells and mononuclear cells by proinflammatory cytokines.
Monocyte chemotactic protein-4 (MCP-4; CCL-13): a biomarker of asthma.
Multidimensional endotypes of asthma: topological data analysis of cross-sectional clinical, pathological, and immunological data.
Polymorphism of the mast cell chymase gene (CMA1) promoter region: lack of association with asthma but association with serum total immunoglobulin E levels in adult atopic dermatitis.
The ?v?6 integrin modulates airway hyperresponsiveness in mice by regulating intraepithelial mast cells.
Ataxia
Activation of MIP-2 and MCP-5 Expression in Methylmercury-Exposed Mice and Their Suppression by N-Acetyl-L-Cysteine.
Atherosclerosis
A chymase gene variant is associated with atherosclerosis in venous coronary artery bypass grafts.
Aging increases aortic MMP-2 activity and angiotensin II in nonhuman primates.
Chymase activity is closely related with plaque vulnerability in a hamster model of atherosclerosis.
Chymase as a novel target for the prevention of vascular diseases.
Chymase as an important target for preventing complications of metabolic syndrome.
Chymase inhibition suppresses high-cholesterol diet-induced lipid accumulation in the hamster aorta.
Chymase-containing mast cells in human arterial intima: implications for atherosclerotic disease.
Circulating Levels of the Adipokines Monocyte Chemotactic Protein-4 (MCP-4), Macrophage Inflammatory Protein-1? (MIP-1?), and Eotaxin-3 in Severe Obesity and Following Bariatric Surgery.
Effect of endothelin-1 (1-31) on extracellular signal-regulated kinase and proliferation of human coronary artery smooth muscle cells.
Endothelin receptor antagonist macitentan or deletion of mouse mast cell protease 4 delays lesion development in atherosclerotic mice.
Endothelin-1-(1-31), a novel vasoactive peptide, increases [Ca2+]i in human coronary artery smooth muscle cells.
Estrogen receptors in mast cells from arterial walls.
Homocysteine-induced oxidative stress upregulates chymase in mouse mastocytoma cells.
Hypothesis regarding the pathophysiological role of alternative pathways of angiotensin II formation in atherosclerosis.
Impact of the Renin-Angiotensin-Aldosterone-System on Cardiovascular and Renal Complications in Diabetes Mellitus.
Induction of chymase that forms angiotensin II in the monkey atherosclerotic aorta.
Lentivirus-mediated RNA interference of chymase increases the plaque stability in atherosclerosis in vivo.
Mast cell chymase in the ischemic kidney of severe unilateral renovascular hypertension.
Mast cell-mediated inhibition of reverse cholesterol transport.
Mast cells induce vascular smooth muscle cell apoptosis via a toll-like receptor 4 activation pathway.
Mast cells of two types differing in neutral protease composition in the human aortic intima. Demonstration of tryptase- and tryptase/chymase-containing mast cells in normal intimas, fatty streaks, and the shoulder region of atheromas.
Morphological and histopathological study of autopsied patients with atherosclerosis and HIV.
Pathological involvement of chymase-dependent angiotensin II formation in the development of cardiovascular disease.
Recent chymase inhibitors and their effects in in vivo models.
Role of mast cell chymase and tryptase in the progression of atherosclerosis: study in 44 autopsied cases.
Usefulness of serum tryptase level as an independent biomarker for coronary plaque instability in a Chinese population.
Vascular chymase: pathophysiological role and therapeutic potential of inhibition.
[Pathophysiological roles of human chymase]
Atrial Fibrillation
An evolving story of angiotensin-II-forming pathways in rodents and humans.
Association between chymase gene polymorphisms and atrial fibrillation in Chinese Han population.
Atrial angiotensin-(1-12)/chymase expression data in patient of heart diseases.
Differential expression of the angiotensin-(1-12)/chymase axis in human atrial tissue.
Differential Expression of the Angiotensin-(1-12)/Chymase Axis in Human Atrial Tissue.
Autoimmune Diseases
Increased chymase in livers with autoimmune disease: colocalization with fibrosis.
Azoospermia
Significance of human testicular mast cells and their subtypes in male infertility.
Bacteremia
Non-lethal Plasmodium yoelii infection drives complex patterns of Th2-type host immunity and mast cell-dependent bacteremia.
Bacterial Infections
Granzyme D is a novel murine mast cell protease, highly induced by multiple pathways of mast cell activation.
The MCP-8 gene and its possible association with resistance to Streptococcus agalactiae in tilapia.
Blister
Release of soluble tryptase but only minor amounts of chymase activity from cutaneous mast cells.
Breast Neoplasms
Mast cell inhibitor cromolyn increases blood clotting and hypoxia in murine breast cancer.
Bronchitis
Comparative analysis of complete genome sequences of three avian coronaviruses reveals a novel group 3c coronavirus.
Carcinogenesis
Mast cell chymase: morphofunctional characteristics.
Polymorphisms of matrix metalloproteinase-7 and chymase are associated with susceptibility to and progression of gastric cancer in Japan.
Carcinoma
Altered immunohistochemical expression of mast cell tryptase and chymase in the pathogenesis of oral submucous fibrosis and malignant transformation of the overlying epithelium.
High density of tryptase-positive mast cells in patients with renal cell carcinoma on hemodialysis: correlation with expression of stem cell factor and protease activated receptor-2.
Inflammatory mast cells up-regulate angiogenesis during squamous epithelial carcinogenesis.
Intensity of angiogenesis and mast cell infiltration in cervical intraepithelial and invasive lesions - are they correlated?
Mast cell chymase affects the proliferation and metastasis of lung carcinoma cells in vitro.
Mast cell chymase is present in uterine cervical carcinoma and it detaches viable and growing cervical squamous carcinoma cells from substratum in vitro.
Mast cell chymase promotes angiogenesis and lymphangiogenesis mediated by activation of melanoma inhibitory activity gene family members in oral squamous cell carcinoma.
Squamous cell carcinoma antigen 2 is a novel serpin that inhibits the chymotrypsin-like proteinases cathepsin G and mast cell chymase.
The increase in tryptase- and chymase-positive mast cells is associated with partial inactivation of chymase and increase in protease inhibitors in basal cell carcinoma.
The relationship of tryptase- and chymase-positive mast cells to angiogenesis in stage I non-small cell lung cancer.
Treponema denticola chymotrypsin-like protease as associated with HPV-negative oropharyngeal squamous cell carcinoma.
Carcinoma, Basal Cell
The increase in tryptase- and chymase-positive mast cells is associated with partial inactivation of chymase and increase in protease inhibitors in basal cell carcinoma.
Carcinoma, Renal Cell
High density of tryptase-positive mast cells in patients with renal cell carcinoma on hemodialysis: correlation with expression of stem cell factor and protease activated receptor-2.
Carcinoma, Squamous Cell
Mast cell chymase is present in uterine cervical carcinoma and it detaches viable and growing cervical squamous carcinoma cells from substratum in vitro.
Squamous cell carcinoma antigen 2 is a novel serpin that inhibits the chymotrypsin-like proteinases cathepsin G and mast cell chymase.
The increase in tryptase- and chymase-positive mast cells is associated with partial inactivation of chymase and increase in protease inhibitors in basal cell carcinoma.
The relationship of tryptase- and chymase-positive mast cells to angiogenesis in stage I non-small cell lung cancer.
Cardiomegaly
Angiotensin-converting enzyme and heart chymase gene polymorphisms in hypertrophic cardiomyopathy.
Chymase inhibitor improves survival in hamsters with myocardial infarction.
Evaluation of the renin-angiotensin system in cardiac tissues of cats with pressure-overload cardiac hypertrophy.
Lys40 but not Arg143 influences selectivity of angiotensin conversion by human alpha-chymase.
Serine proteases and cardiac function.
Time course sequences of angiotensin converting enzyme and chymase-like activities during development of right ventricular hypertrophy induced by pulmonary artery constriction in dogs.
Time-dependent expression of chymase and angiotensin converting enzyme in the hamster heart under pressure overload.
Cardiomyopathies
A novel chymase inhibitor, 4-[1-([bis-(4-methyl-phenyl)-methyl]-carbamoyl)3-(2-ethoxy-benzyl)-4-oxo-azetidine-2-yloxy]-benzoic acid (BCEAB), suppressed cardiac fibrosis in cardiomyopathic hamsters.
Activation of angiotensin II-forming chymase in the cardiomyopathic hamster heart.
Beneficial effects of angiotensin-converting enzyme inhibition in adriamycin-induced cardiomyopathy in hamsters.
Beneficial effects of astragalus polysaccharides treatment on cardiac chymase activities and cardiomyopathy in diabetic hamsters.
Cardiac chymase: pathophysiological role and therapeutic potential of chymase inhibitors.
Cellular localization and regional distribution of an angiotensin II-forming chymase in the heart.
Cloning of the gene and cDNA for hamster chymase 2, and expression of chymase 1, chymase 2 and angiotensin-converting enzyme in the terminal stage of cardiomyopathic hearts.
Pathological roles of angiotensin II produced by mast cell chymase and the effects of chymase inhibition in animal models.
Renin: at the heart of the mast cell.
Targets of chymase inhibitors.
Will chymase inhibitors be the next major development for the treatment of cardiovascular disorders?
[Angiotensin II formation by chymase in the cardiovascular tissue]
[Pathophysiological roles of human chymase]
Cardiomyopathy, Dilated
Chymase inhibition reduces the progression to heart failure after autoimmune myocarditis in rats.
Roles of Angiotensin Peptides and Recombinant Human ACE2 in Heart Failure.
Cardiomyopathy, Hypertrophic
Angiotensin-converting enzyme and heart chymase gene polymorphisms in hypertrophic cardiomyopathy.
Cardiovascular Diseases
3D QSAR Pharmacophore Modeling, in Silico Screening, and Density Functional Theory (DFT) Approaches for Identification of Human Chymase Inhibitors.
A combination of receptor-based pharmacophore modeling & QM techniques for identification of human chymase inhibitors.
Activation of angiotensin II-forming chymase in the cardiomyopathic hamster heart.
Chymase inhibition and cardiovascular protection.
Chymase inhibition as a pharmacological target: A role in inflammatory and functional gastrointestinal disorders?
Chymase inhibitors.
Chymase plays an important role in left ventricular remodeling induced by intermittent hypoxia in mice.
Chymase: a new pharmacologic target in cardiovascular disease.
Cloning of the gene and cDNA for hamster chymase 2, and expression of chymase 1, chymase 2 and angiotensin-converting enzyme in the terminal stage of cardiomyopathic hearts.
Cysteinyl cathepsins and mast cell proteases in the pathogenesis and therapeutics of cardiovascular diseases.
Deficiency of mouse mast cell protease 4 mitigates cardiac dysfunctions in mice after myocardium infarction.
Dissecting the role of chymase in angiotensin II formation and heart and blood vessel diseases.
Elevated chymase-dependent angiotensin II-forming activity in circulating mononuclear leukocytes was observed in the patient of atrial fibrillation.
Endothelin-1 (1-31): From chymase-dependent synthesis to cardiovascular pathologies.
Improvement of cardiovascular remodelling by chymase inhibitor.
In silico approach to find chymase inhibitors among biogenic compounds.
Interaction of human chymase with ginkgolides, terpene trilactones of Ginkgo biloba investigated by molecular docking simulations.
Interactions of angiotensin-converting enzyme, kinins and nitric oxide in circulation and the beneficial effects of ACE inhibitors in cardiovascular diseases.
Mast cell peptidases: chameleons of innate immunity and host defense.
Recent chymase inhibitors and their effects in in vivo models.
Searching for Chymase Inhibitors among Chamomile Compounds Using a Computational-Based Approach.
Serine proteases and cardiac function.
Structure-based virtual screening for novel chymase inhibitors by in silico fragment mapping.
Therapeutic applications of chymase inhibitors in cardiovascular diseases and fibrosis.
[Angiotensin II formation by chymase in the cardiovascular tissue]
[Chymase in ischemic cardiovascular diseases]
[involvement of chymase in pathogenesis of cardiovascular diseases]
[Pathophysiological roles of human chymase]
[Role of angiotensin II-forming enzymes, angiotensin-converting enzyme and chymase]
Carotid Artery Diseases
Raised MCP-4 levels in symptomatic carotid atherosclerosis: an inflammatory link between platelet and monocyte activation.
Carotid Stenosis
Raised MCP-4 levels in symptomatic carotid atherosclerosis: an inflammatory link between platelet and monocyte activation.
Cerebral Amyloid Angiopathy, Familial
Identification of a chymotrypsin-like mast cell protease in rat brain capable of generating the N-terminus of the Alzheimer amyloid beta-protein.
Cerebral Hemorrhage
Identification of a chymotrypsin-like mast cell protease in rat brain capable of generating the N-terminus of the Alzheimer amyloid beta-protein.
Cheilitis
Increased mast cell density and protease content in actinic cheilitis.
Cholesteatoma
Isolation and characterization of trypsin-like and chymotrypsin-like proteinases from human cholesteatoma.
Chronic Periodontitis
Correlation of MCP-4 and high-sensitivity C-reactive protein as a marker of inflammation in obesity and chronic periodontitis.
chymase deficiency
Approaches for analyzing the roles of mast cells and their proteases in vivo.
Mouse connective tissue mast cell proteases tryptase and carboxypeptidase A3 play protective roles in itch induced by endothelin-1.
Proteome analysis of mast cell releasates reveals a role for chymase in the regulation of coagulation factor XIIIA levels via proteolytic degradation.
The combined action of mast cell chymase, tryptase and carboxypeptidase A3 protects against melanoma colonization of the lung.
Coinfection
Functional correlations between mucosal mast cell activity and immunity to Trichinella spiralis in high and low responder mice.
Colitis
Chymase inhibitor TY-51469 in therapy of inflammatory bowel disease.
Glutathione peroxidase 2 and aquaporin 8 as new markers for colonic inflammation in experimental colitis and inflammatory bowel diseases: an important role for H2O2?
Inhibition of tryptase release from human colon mast cells by protease inhibitors.
Modulation of histamine release from human colon mast cells by protease inhibitors.
Nafamostat mesilate attenuates colonic inflammation and mast cell infiltration in the experimental colitis.
Role of chymase-dependent matrix metalloproteinase-9 activation in mice with dextran sodium sulfate-induced colitis.
Colitis, Ulcerative
Mast cell peptidases: chameleons of innate immunity and host defense.
Colorectal Neoplasms
Multiple roles of angiotensin in colorectal cancer.
Congenital Abnormalities
Application of novel tissue microarrays to investigate expression of tryptase, chymase and KIT protein in placental mast cells.
Conjunctivitis
Involvement of chymase in allergic conjunctivitis of guinea pigs.
Conjunctivitis, Allergic
Involvement of chymase in allergic conjunctivitis of guinea pigs.
Mast cell chymase decreases the barrier function and inhibits the migration of corneal epithelial cells.
Mast cell chymase induces conjunctival epithelial cell apoptosis by a mechanism involving degradation of fibronectin.
Tear chymase in vernal keratoconjunctivitis.
Coronary Disease
Association between SNP rs1800875, serum chymase and immunoglobulin E levels in patients with coronary heart disease.
Usefulness of serum tryptase level as an independent biomarker for coronary plaque instability in a Chinese population.
Cough
Three candidate genes and angiotensin-converting enzyme inhibitor-related cough: a pharmacogenetic analysis.
[Resistance to ACE inhibitors. Myth or reality?]
COVID-19
Kinins and chymase: the forgotten components of the renin-angiotensin system and their implications in COVID-19 disease.
Probing CAS database as prospective antiviral agents against SARS-CoV-2 main protease.
Unbiased Analysis of Temporal Changes in Immune Serum Markers in Acute COVID-19 Infection With Emphasis on Organ Failure, Anti-Viral Treatment, and Demographic Characteristics.
Crohn Disease
Phenotypic change and accumulation of smooth muscle cells in strictures in Crohn's disease: relevance to local angiotensin II system.
Cystitis, Interstitial
Development of the chymase inhibitor as an anti-tissue-remodeling drug: myocardial infarction and some other possibilities.
Cysts
Ultramicronized palmitoylethanolamide reduces viscerovisceral hyperalgesia in a rat model of endometriosis plus ureteral calculosis: role of mast cells.
Death, Sudden, Cardiac
An antiarrhythmic effect of a chymase inhibitor after myocardial infarction.
Dengue
Alpha tryptase allele of Tryptase 1 (TPSAB1) gene associated with Dengue Hemorrhagic Fever (DHF) and Dengue Shock Syndrome (DSS) in Vietnam and Philippines.
Assessing the Serum Chymase Level as an Early Predictor of Dengue Severity.
Association between dengue severity and plasma levels of dengue-specific IgE and chymase.
Chymase Level Is a Predictive Biomarker of Dengue Hemorrhagic Fever in Pediatric and Adult Patients.
Contributions of mast cells and vasoactive products, leukotrienes and chymase, to dengue virus-induced vascular leakage.
Mast cell mediators in relation to dengue severity: A systematic review and meta-analysis.
Serum chymase levels correlate with severe dengue warning signs and clinical fluid accumulation in hospitalized pediatric patients.
Dermatitis
Chymase inhibitor improves dermatitis in NC/Nga mice.
Chymase participates in chronic dermatitis by inducing eosinophil infiltration.
Mast cell chymase regulates dermal mast cell number in mice.
Mast cells and eosinophils in feline allergic dermatitis: a qualitative and quantitative analysis.
Oral administration of chymase inhibitor improves dermatitis in NC/Nga mice.
Oral chymase inhibitor SUN13834 ameliorates skin inflammation as well as pruritus in mouse model for atopic dermatitis.
Signalling mechanisms regulating the activation of human eosinophils by mast-cell-derived chymase: implications for mast cell-eosinophil interaction in allergic inflammation.
The effect of tamol on human mast cell chymase and plasmin.
Dermatitis Herpetiformis
Mast cells in developing subepidermal bullous diseases: emphasis on tryptase, chymase and protease inhibitors.
Dermatitis, Atopic
Absence of association between a variant of the mast cell chymase gene and atopic dermatitis in an Italian population.
Association between mast cell chymase genotype and atopic eczema: comparison between patients with atopic eczema alone and those with atopic eczema and atopic respiratory disease.
Chymase participates in chronic dermatitis by inducing eosinophil infiltration.
Decrease in chymase activity is associated with increase in IL-6 expression in mast cells in atopic dermatitis.
Epidermal Expression of Filaggrin/Profilaggrin Is Decreased in Atopic Dermatitis: Reverse Association With Mast Cell Tryptase and IL-6 but Not With Clinical Severity.
In vitro and in vivo metabolism of a novel chymase inhibitor, SUN13834, and the predictability of human metabolism using mice with humanized liver.
Mast cell chymase is increased in chronic atopic dermatitis but not in psoriasis.
No evidence for an association between a variant of the mast cell chymase gene and atopic dermatitis based on case-control and haplotype-relative-risk analyses.
Oral chymase inhibitor SUN13834 ameliorates skin inflammation as well as pruritus in mouse model for atopic dermatitis.
Pharmacokinetic/pharmacodynamic analyses of chymase inhibitor SUN13834 in NC/Nga mice and prediction of effective dosage for atopic dermatitis patients.
Polymorphism of the mast cell chymase gene (CMA1) promoter region: lack of association with asthma but association with serum total immunoglobulin E levels in adult atopic dermatitis.
Quantitative analysis of tryptase- and chymase-containing mast cells in atopic dermatitis and nummular eczema.
Recent chymase inhibitors and their effects in in vivo models.
Therapeutic potential of a specific chymase inhibitor in atopic dermatitis.
Diabetes Mellitus
Effects of the chymase inhibitor fulacimstat in diabetic kidney disease-results from the CADA DIA trial.
High Fib4 index in patients with suspected NASH is associated with elevation of chymase-dependent angiotensin II-forming activity in circulating mononuclear leucocytes.
Mast cell specific immunological biomarkers and metabolic syndrome among middle-aged and older Chinese adults.
Why is blood pressure so hard to control in patients with type 2 diabetes?
Diabetes Mellitus, Type 2
Angiotensin I-converting enzyme and chymase gene polymorphisms - relationship to left ventricular mass in type 2 diabetes patients.
Chymase inhibition retards albuminuria in type 2 diabetes.
Diabetic Angiopathies
Advanced glycation end products activate a chymase-dependent angiotensin II-generating pathway in diabetic complications.
The role of oxidative stress in the pathogenesis of diabetic vascular complications.
Diabetic Cardiomyopathies
Astragalus polysaccharides inhibited diabetic cardiomyopathy in hamsters depending on suppression of heart chymase activation.
Effects of Astragalus polysaccharides on chymase, angiotensin-converting enzyme and angiotensin II in diabetic cardiomyopathy in hamsters.
Diabetic Nephropathies
Chymase inhibition and cardiovascular protection.
Chymase is upregulated in diabetic nephropathy: implications for an alternative pathway of angiotensin II-mediated diabetic renal and vascular disease.
Effects of the chymase inhibitor fulacimstat in diabetic kidney disease-results from the CADA DIA trial.
Impact of Mast Cell Chymase on Renal Disease Progression.
Increased chymase-positive mast cells in children with crescentic glomerulonephritis.
Inhibition of chymase protects against diabetes-induced oxidative stress and renal dysfunction in hamsters.
Mechanism of Albuminuria Reduction by Chymase Inhibition in Diabetic Mice.
Role of chymase in diabetic nephropathy.
Diabetic Retinopathy
Involvement of premacular mast cells in the pathogenesis of macular diseases.
Measurement of activities in two different angiotensin II generating systems, chymase and angiotensin-converting enzyme, in the vitreous fluid of vitreoretinal diseases: a possible involvement of chymase in the pathogenesis of macular hole patients.
[Polymorphism of the chymase gene and development of retinopathy in type 2 diabetic patients]
Diphtheria
Selective ablation of basophils in mice reveals their nonredundant role in acquired immunity against ticks.
Down Syndrome
Clipsin, a chymotrypsin-like protease in rat brain which is irreversibly inhibited by alpha-1-antichymotrypsin.
Identification of a chymotrypsin-like mast cell protease in rat brain capable of generating the N-terminus of the Alzheimer amyloid beta-protein.
Dysplastic Nevus Syndrome
Low numbers of tryptase+ and chymase+ mast cells associated with reduced survival and advanced tumor stage in melanoma.
Eczema
Association between genetic variants of mast-cell chymase and eczema.
Association between variants of mast cell chymase gene and serum IgE levels in eczema.
Mast cell chymase is increased in chronic atopic dermatitis but not in psoriasis.
Quantitative analysis of tryptase- and chymase-containing mast cells in atopic dermatitis and nummular eczema.
Encephalitis
Computational identification of natural product leads that inhibit mast cell chymase: an exclusive plausible treatment for Japanese encephalitis.
Japanese encephalitis virus neuropenetrance is driven by mast cell chymase.
Mast cells protect from post-traumatic brain inflammation by the mast cell-specific chymase mouse mast cell protease-4.
Encephalitis, Japanese
Computational identification of natural product leads that inhibit mast cell chymase: an exclusive plausible treatment for Japanese encephalitis.
Japanese encephalitis virus neuropenetrance is driven by mast cell chymase.
Encephalitis, Viral
Computational identification of natural product leads that inhibit mast cell chymase: an exclusive plausible treatment for Japanese encephalitis.
Encephalomyelitis
Experimental Autoimmune Encephalomyelitis Potentiates Mouse Mast Cell Protease 4-Dependent Pressor Responses to Centrally or Systemically Administered Big Endothelin-1.
Significant Contribution of Mouse Mast Cell Protease 4 in Early Phases of Experimental Autoimmune Encephalomyelitis.
Encephalomyelitis, Autoimmune, Experimental
Experimental Autoimmune Encephalomyelitis Potentiates Mouse Mast Cell Protease 4-Dependent Pressor Responses to Centrally or Systemically Administered Big Endothelin-1.
Mast cell specific proteases in rat brain: changes in rats with experimental allergic encephalomyelitis.
Significant Contribution of Mouse Mast Cell Protease 4 in Early Phases of Experimental Autoimmune Encephalomyelitis.
Endometritis
Selective CB2 up-regulation in women affected by endometrial inflammation.
endopeptidase la deficiency
Approaches for analyzing the roles of mast cells and their proteases in vivo.
Mouse connective tissue mast cell proteases tryptase and carboxypeptidase A3 play protective roles in itch induced by endothelin-1.
The combined action of mast cell chymase, tryptase and carboxypeptidase A3 protects against melanoma colonization of the lung.
Endotoxemia
Alternative pathways for angiotensin II production as an important determinant of kidney damage in endotoxemia.
Eosinophilia
C-C chemokines in allergen-induced late-phase cutaneous responses in atopic subjects: association of eotaxin with early 6-hour eosinophils, and of eotaxin-2 and monocyte chemoattractant protein-4 with the later 24-hour tissue eosinophilia, and relationship to basophils and other C-C chemokines (monocyte chemoattractant protein-3 and RANTES).
Chymase inhibitor ameliorates eosinophilia in mice infected with Nippostrongylus brasiliensis.
Human mast cell chymase induces the accumulation of neutrophils, eosinophils and other inflammatory cells in vivo.
Mast cell chymase modulates IL-33 levels and controls allergic sensitization in dust-mite induced airway inflammation.
Epiretinal Membrane
Involvement of premacular mast cells in the pathogenesis of macular diseases.
Measurement of activities in two different angiotensin II generating systems, chymase and angiotensin-converting enzyme, in the vitreous fluid of vitreoretinal diseases: a possible involvement of chymase in the pathogenesis of macular hole patients.
Erythema
Acute exposure of human skin to ultraviolet or infrared radiation or heat stimuli increases mast cell numbers and tryptase expression in human skin in vivo.
Erythema Multiforme
Mast cells in developing subepidermal bullous diseases: emphasis on tryptase, chymase and protease inhibitors.
Essential Hypertension
A study of the relationships between angiotensin- converting enzyme gene, chymase gene polymorphisms, pharmacological treatment with ACE inhibitor and regression of left ventricular hypertrophy in essential hypertension patients treated with benazepril.
Association of polymorphisms in prolylcarboxypeptidase and chymase genes with essential hypertension in the Chinese Han population.
[Association between angiotensin converting enzyme gene, chymase gene and regression of left ventricular hypertrophy in patients treated with angiotensin converting enzyme inhibitors.]
[Association of CMA1 gene tag single nucleotide polymorphisms with essential hypertension in Yi population from Yunnan].
Fatty Liver
Chymase as a Possible Therapeutic Target for Amelioration of Non-Alcoholic Steatohepatitis.
Chymase inhibitor ameliorates hepatic steatosis and fibrosis on established non-alcoholic steatohepatitis in hamsters fed a methionine- and choline-deficient diet.
Chymase Inhibitor as a Novel Therapeutic Agent for Non-alcoholic Steatohepatitis.
Chymase inhibitor prevents the development and progression of non-alcoholic steatohepatitis in rats fed a high-fat and high-cholesterol diet.
Fibrosarcoma
Immunohistochemical evaluation of mast cells and mark activity tryptase and chymase in experimental fibrosarcoma.
Rat mast cell protease I alters cell metabolism.
Food Hypersensitivity
Early life exposure to bisphenol A investigated in mouse models of airway allergy, food allergy and oral tolerance.
IL-25 and CD4(+) TH2 cells enhance type 2 innate lymphoid cell-derived IL-13 production, which promotes IgE-mediated experimental food allergy.
Murine model of food allergy after epicutaneous sensitization: role of mucosal mast cell protease-1.
Piper nigrum extract attenuates food allergy by decreasing Th2 cell response and regulating the Th17/Treg balance.
Gastritis
Mast cell chymase expression in Helicobacter pylori-associated gastritis.
Gastrointestinal Diseases
Chymase inhibition as a pharmacological target: A role in inflammatory and functional gastrointestinal disorders?
Gingival Overgrowth
The possible potential therapeutic targets for drug induced gingival overgrowth.
Gingivitis
Ketotifen fumarate attenuates feline gingivitis related with gingival microenvironment modulation.
Glaucoma
Chymase and angiotensin converting enzyme activities in a hamster model of glaucoma filtering surgery.
Effects of Gelatin Hydrogel containing Chymase Inhibitor on Scarring in a Canine Filtration Surgery Model.
Role of chymase on growth of cultured canine Tenon's capsule fibroblasts and scarring in a canine conjunctival flap model.
Glomerulonephritis
Increased chymase-positive mast cells in children with crescentic glomerulonephritis.
Mouse mast cell protease-4 deteriorates renal function by contributing to inflammation and fibrosis in immune complex-mediated glomerulonephritis.
Potential role for monocyte chemotactic protein-4 (MCP-4) in monocyte/macrophage recruitment in acute renal inflammation.
Tissue-specific expression of renin-angiotensin system components in IgA nephropathy.
Glomerulonephritis, IGA
Increased chymase-positive mast cells in children with crescentic glomerulonephritis.
Glomerulonephritis, Membranoproliferative
Increased chymase-positive mast cells in children with crescentic glomerulonephritis.
Glomerulonephritis, Membranous
Tissue-specific expression of renin-angiotensin system components in IgA nephropathy.
Granuloma
Chymase as a proangiogenic factor. A possible involvement of chymase-angiotensin-dependent pathway in the hamster sponge angiogenesis model.
Chymase mediates mast cell-induced angiogenesis in hamster sponge granulomas.
Development of a chymase inhibitor: pharmacological characterization of a chymase inhibitor in inflamed tissue remodeling and fibrosis.
High resolution mapping of chromosomal regions controlling resistance to gastrointestinal nematode infections in an advanced intercross line of mice.
Mapping of chromosomal regions influencing immunological responses to gastrointestinal nematode infections in mice.
Palmitoylethanolamide inhibits rMCP-5 expression by regulating MITF activation in rat chronic granulomatous inflammation.
Suppression of basic fibroblast growth factor-induced angiogenesis by a specific chymase inhibitor, BCEAB, through the chymase-angiotensin-dependent pathway in hamster sponge granulomas.
[Involvement of chymase in angiogenesis in hamster sponge granulomas]
Heart Defects, Congenital
Increased expression of mast cell chymase in the lungs of patients with congenital heart disease associated with early pulmonary vascular disease.
Heart Diseases
Angiotensin-converting enzyme and heart chymase gene polymorphisms in hypertrophic cardiomyopathy.
Assessment of the angiotensin II-forming pathway in human atria.
Atrial angiotensin-(1-12)/chymase expression data in patient of heart diseases.
Cardiac chymase: pathophysiological role and therapeutic potential of chymase inhibitors.
Chymase gene locus is not associated with myocardial infarction and is not linked to heart size or blood pressure.
Chymase inhibitors for the treatment of cardiac diseases: a patent review (2010-2018).
Differential expression of the angiotensin-(1-12)/chymase axis in human atrial tissue.
Differential Expression of the Angiotensin-(1-12)/Chymase Axis in Human Atrial Tissue.
IGF-1 degradation by mouse mast cell protease 4 promotes cell death and adverse cardiac remodeling days after a myocardial infarction.
Novel Cardiac Intracrine Mechanisms Based on Ang-(1-12)/Chymase Axis Require a Revision of Therapeutic Approaches in Human Heart Disease.
Tranilast prevents doxorubicin-induced myocardial hypertrophy and angiotensin II synthesis in rats.
Heart Failure
Angiotensin II receptor blockers: novel therapy for heart failure?
Atrial angiotensin-(1-12)/chymase expression data in patient of heart diseases.
Changes of chymase, angiotensin converting enzyme and angiotensin II type 1 receptor expressions in the hamster heart during the development of heart failure.
Chymase inhibition prevents cardiac fibrosis and improves diastolic dysfunction in the progression of heart failure.
Chymase inhibition reduces the progression to heart failure after autoimmune myocarditis in rats.
Differential expression of angiotensin-converting enzyme and chymase in dogs with chronic mitral regurgitation.
Dissecting the role of chymase in angiotensin II formation and heart and blood vessel diseases.
Endothelin-1[1-31] is Not Elevated in Men with Chronic Heart Failure.
Finding off-targets, biological pathways, and target diseases for chymase inhibitors via structure-based systems biology approach.
Gene expression of cardiac mast cell chymase and tryptase in a murine model of heart failure caused by viral myocarditis.
Genotype-phenotype associations between chymase and angiotensin-converting enzyme gene polymorphisms in chronic systolic heart failure patients.
Increased angiotensin-I converting enzyme gene expression in the failing human heart. Quantification by competitive RNA polymerase chain reaction.
Mast cell chymase limits the cardiac efficacy of Ang I-converting enzyme inhibitor therapy in rodents.
Mast cells cause apoptosis of cardiomyocytes and proliferation of other intramyocardial cells in vitro.
Renin: at the heart of the mast cell.
Role for chymase in heart failure: angiotensin II-dependent or -independent mechanisms?
Serine proteases and cardiac function.
The role of the renin-angiotensin-aldosterone system in heart failure.
Heart Failure, Systolic
Genotype-phenotype associations between chymase and angiotensin-converting enzyme gene polymorphisms in chronic systolic heart failure patients.
Heart Valve Diseases
Differential expression of the angiotensin-(1-12)/chymase axis in human atrial tissue.
Hemangioma
Mast cells and hemangioma.
Hemangiosarcoma
Angiosarcoma of bone marrow with unusual expression of chymase: diagnosis in a trephine biopsy specimen.
Hepatic Veno-Occlusive Disease
Chymase Inhibition Attenuates Monocrotaline-Induced Sinusoidal Obstruction Syndrome in Hamsters.
Hepatitis
Increased chymase in livers with autoimmune disease: colocalization with fibrosis.
Hepatitis B, Chronic
Mast cell subpopulations in chronic inflammatory hepatobiliary diseases.
Hepatitis C
NS3-4A of hepatitis C virus is a chymotrypsin-like protease.
Hepatitis C, Chronic
Mast cell subpopulations in chronic inflammatory hepatobiliary diseases.
Hepatitis, Autoimmune
Increased chymase in livers with autoimmune disease: colocalization with fibrosis.
Mast cell subpopulations in chronic inflammatory hepatobiliary diseases.
Hepatitis, Chronic
Establishment of an assay method for human mast cell chymase.
Hepatic chymase level in chronic hepatitis: co-localization of chymase with fibrosis.
Increased chymase in livers with autoimmune disease: colocalization with fibrosis.
Herpes Zoster
Effect of azorellanone, a diterpene from Azorella yareta Hauman, on human sperm physiology.
Histiocytoma
Immunohistochemical and histochemical stains for differentiating canine cutaneous round cell tumors.
Hyperaldosteronism
A case of Gitelman's syndrome with decreased angiotensin II-forming activity.
Hypercholesterolemia
Increased chymase activity in internal thoracic artery of patients with hypercholesterolemia.
Positive correlation between chymase-like angiotensin II-forming activity in mononuclear cells and serum cholesterol level.
Hypereosinophilic Syndrome
Eosinophil migration induced by mast cell chymase is mediated by extracellular signal-regulated kinase pathway.
Hyperlipidemias
Large Accumulation of Collagen and Increased Activation of Mast Cells in Hearts of Mice with Hyperlipidemia.
Hypersensitivity
Are chemokines essential or secondary participants in allergic responses?
C-C chemokines in allergen-induced late-phase cutaneous responses in atopic subjects: association of eotaxin with early 6-hour eosinophils, and of eotaxin-2 and monocyte chemoattractant protein-4 with the later 24-hour tissue eosinophilia, and relationship to basophils and other C-C chemokines (monocyte chemoattractant protein-3 and RANTES).
Generation, characterization and structural data of chymase binding proteins based on the human Fyn kinase SH3 domain.
Granzyme D is a novel murine mast cell protease, highly induced by multiple pathways of mast cell activation.
High dietary fat intake induces a microbiota signature that promotes food allergy.
Human chymase, an enzyme forming novel bioactive 31-amino acid length endothelins.
Mast cell chymase: morphofunctional characteristics.
Mast cells in human fatty streaks and atheromas: implications for intimal lipid accumulation.
Monocyte chemotactic protein expression in allergy and non-allergy-associated chronic sinusitis.
Oral exposure to the free amino acid glycine inhibits the acute allergic response in a model of cow's milk allergy in mice.
Oral tolerance and Treg cells are induced in BALB/c mice after gavage with bovine ?-lactoglobulin.
Protease-induced leukocyte chemotaxis and activation: roles in host defense and inflammation.
The effect of immediate-hypersensitivity reactions on the level of SLPI, granulocyte elastase, alpha1-antitrypsin, and albumin in nasal secretions, by the method of unilateral antigen challenge.
The induction of a prolonged increase in microvascular permeability by human mast cell chymase.
Hypersensitivity, Immediate
Matriptase expression in the normal and neoplastic mast cells.
Hypertension
A novel vascular smooth muscle chymase is upregulated in hypertensive rats.
Advanced glycation end products activate a chymase-dependent angiotensin II-generating pathway in diabetic complications.
Analysis of genes causing hypertension and stroke in spontaneously hypertensive rats: gene expression profiles in the brain.
Association of a mast cell chymase gene variant with HDL cholesterol, but not with blood pressure in the Ohasama study.
Chymase Dependent Pathway of Angiotensin II Generation and Rapeseed Derived Peptides for Antihypertensive Treatment of Spontaneously Hypertensive Rats.
Chymase inhibition improves vascular dysfunction and survival in stroke-prone spontaneously hypertensive rats.
Chymase is activated in the hamster heart following ventricular fibrosis during the chronic stage of hypertension.
Chymase is upregulated in diabetic nephropathy: implications for an alternative pathway of angiotensin II-mediated diabetic renal and vascular disease.
Conditional and targeted overexpression of vascular chymase causes hypertension in transgenic mice.
Depressor effect of chymase inhibitor in mice with high salt-induced moderate hypertension.
Depressor effect of the young leaves of Polygonum hydropiper Linn. in high-salt induced hypertensive mice.
Dissecting the role of chymase in angiotensin II formation and heart and blood vessel diseases.
Effects of chymostatin, a chymase inhibitor, on blood pressure, plasma and tissue angiotensin II, renal haemodynamics and renal excretion in two models of hypertension in the rat.
Effects of maternal undernutrition on renal angiotensin II and chymase in hypertensive offspring.
Effects of the selective chymase inhibitor TEI-F00806 on the intrarenal renin-angiotensin system in salt-treated angiotensin I-infused hypertensive mice.
Heterozygous disruption of CMA1 does not affect blood pressure.
Human chymase expression in a mice induces mild hypertension with left ventricular hypertrophy.
Improvement of cardiovascular remodelling by chymase inhibitor.
Local angiotensin II-generating system in vascular tissues: the roles of chymase.
Lys40 but not Arg143 influences selectivity of angiotensin conversion by human alpha-chymase.
OS 28-05 ANTIHYPERTENSIVE EFFECT OF CHYMASE INHIBITORY JAPANESE WATER PEPPER INTAKE IN SALT-DEPENDENT MODERATE HYPERTENSION MOUSE MODEL AND IN HUMAN.
Positive correlation between blood pressure or heart rate and chymase-dependent angiotensin II-forming activity in circulating mononuclear leukocytes measured by new ELISA.
Positive correlation between chymase-like angiotensin II-forming activity in mononuclear cells and serum cholesterol level.
Prospective single-arm observational study of human chymase inhibitor Polygonum hydropiper L in subjects with hypertension.
Role of chymase in blood pressure control, plasma and tissue angiotensin II, renal Haemodynamics, and excretion in spontaneously hypertensive rats.
Roles of vascular angiotensin converting enzyme and chymase in two-kidney, one clip hypertensive hamsters.
Serine proteases and cardiac function.
Serum cytokine profiles in patients with chronic obstructive pulmonary disease associated pulmonary hypertension identified using protein array.
Structure of human pro-chymase: a model for the activating transition of granule-associated proteases.
Vascular chymase: pathophysiological role and therapeutic potential of inhibition.
Why is blood pressure so hard to control in patients with type 2 diabetes?
[Angiotensin II in organ organopathy]
[Chymase in the system proteinase-proteinase inhibitor in pathogenesis of hypertension]
[Pathophysiological roles of chymase and effects of chymase inhibitor]
[Role of angiotensin II-forming enzymes, angiotensin-converting enzyme and chymase]
Hypertension, Portal
Expression of angiotensin II type 1 receptor in human cirrhotic livers: Its relation to fibrosis and portal hypertension.
Hypertension, Pulmonary
Chymase: a multifunctional player in pulmonary hypertension associated with lung fibrosis.
Histological characterization of mast cell chymase in patients with pulmonary hypertension and chronic obstructive pulmonary disease.
Mast cell chymase in pulmonary hypertension.
Mast cell peptidases: chameleons of innate immunity and host defense.
Role of chymase in cigarette smoke-induced pulmonary artery remodeling and pulmonary hypertension in hamsters.
Serum cytokine profiles in patients with chronic obstructive pulmonary disease associated pulmonary hypertension identified using protein array.
Hypertension, Renovascular
Angiotensin converting enzyme-independent angiotensin ii production by chymase is up-regulated in the ischemic kidney in renovascular hypertension.
Mast cell chymase in the ischemic kidney of severe unilateral renovascular hypertension.
Hypertrophy, Left Ventricular
A study of the relationships between angiotensin- converting enzyme gene, chymase gene polymorphisms, pharmacological treatment with ACE inhibitor and regression of left ventricular hypertrophy in essential hypertension patients treated with benazepril.
Human chymase expression in a mice induces mild hypertension with left ventricular hypertrophy.
[Association between angiotensin converting enzyme gene, chymase gene and regression of left ventricular hypertrophy in patients treated with angiotensin converting enzyme inhibitors.]
Hypotension
Mast cell activation and arterial hypotension during proximal aortic repair requiring hypothermic circulatory arrest.
Idiopathic Interstitial Pneumonias
Enhanced mast cell chymase expression in human idiopathic interstitial pneumonia.
Idiopathic Pulmonary Fibrosis
Lung mast cell density defines a subpopulation of patients with idiopathic pulmonary fibrosis.
Infections
A kinetic analysis of the expression of mast cell protease mRNA in the intestines of Nippostrongylus brasiliensis-infected rats.
Aberrant mucosal mast cell protease expression in the enteric epithelium of nematode-infected mice lacking the integrin alphavbeta6, a transforming growth factor-beta1 activator.
Altered expression of mast cell proteases in the rat. Quantitative and immunohistochemical analysis of the distribution of rat mast cell proteases I and II during helminth infection.
Anaphylactic release of mucosal mast cell granule proteases: role of serpins in the differential clearance of mouse mast cell proteases-1 and -2.
Changes in inflammatory mediators and larval inhibitory activity in intestinal contents and mucus during primary and challenge infections of sheep with Trichostrongylus colubriformis.
Chymase inhibitor ameliorates eosinophilia in mice infected with Nippostrongylus brasiliensis.
Constitutive expression of mouse mast cell protease-1 in normal BALB/c mice and its up-regulation during intestinal nematode infection.
Contributions of mast cells and vasoactive products, leukotrienes and chymase, to dengue virus-induced vascular leakage.
Dengue vascular leak syndrome: insights into potentially new treatment modalities.
Enteric expression of the integrin alpha(v)beta(6) is essential for nematode-induced mucosal mast cell hyperplasia and expression of the granule chymase, mouse mast cell protease-1.
Histochemical and ultrastructural modification of mucosal mast cell granules in parasitized mice lacking the beta-chymase, mouse mast cell protease-1.
J774 macrophage-like cell line cytokine and chemokine patterns are modulated by Francisella tularensis LVS strain infection.
Japanese encephalitis virus neuropenetrance is driven by mast cell chymase.
Local eosinophil- and mast cell-related responses in abomasal nematode infections of lambs.
Lung granulomatous response induced by infection with the intestinal nematode Nippostrongylus brasiliensis is suppressed in mast cell-deficient Ws/Ws rats.
Mapping of chromosomal regions influencing immunological responses to gastrointestinal nematode infections in mice.
Mast Cell Chymase Decreases The Severity Of Group B Streptococcus Infections.
Mast cell granule composition and tissue location--a close correlation.
Mast cell heterogeneity in the gastrointestinal tract: variable expression of mouse mast cell protease-1 (mMCP-1) in intraepithelial mucosal mast cells in nematode-infected and normal BALB/c mice.
Mast cell mediators in relation to dengue severity: A systematic review and meta-analysis.
Mast cell-dependent control of Giardia lamblia infections in mice.
Mast cells that reside at different locations in the jejunum of mice infected with Trichinella spiralis exhibit sequential changes in their granule ultrastructure and chymase phenotype.
Mucosal defense against gastrointestinal nematodes: responses of mucosal mast cells and mouse mast cell protease 1 during primary strongyloides venezuelensis infection in FcRgamma-knockout mice.
Murine monocyte chemoattractant protein (MCP)-5: a novel CC chemokine that is a structural and functional homologue of human MCP-1.
Plasma cytokines eotaxin, MIP-1?, MCP-4, and vascular endothelial growth factor in acute lower respiratory tract infection.
Purification and characterization of mouse mast cell proteinase-2 and the differential expression and release of mouse mast cell proteinase-1 and -2 in vivo.
Quantitative analysis of mucosal mast cell protease in the intestines of Nippostrongylus-infected rats.
Respiratory Syncytial Virus Infection of Human Lung Fibroblasts Induces a Hyaluronan-Enriched Extracellular Matrix That Binds Mast Cells and Enhances Expression of Mast Cell Proteases.
Rhinovirus infection up-regulates eotaxin and eotaxin-2 expression in bronchial epithelial cells.
Roles Played by Toll-like Receptor-9 in Corneal Endothelial Cells after Herpes Simplex Virus Type 1 Infection.
Systemic release of mucosal mast cell protease during infection with the intestinal protozoal parasite, Eimeria nieschulzi. Studies in normal and nude rats.
The Chymase Mouse Mast Cell Protease-4 Regulates Intestinal Cytokine Expression in Mature Adult Mice Infected with Giardiaintestinalis.
The effect of protein deficiency on systemic release of rat mucosal mast cell protease II during Nippostrongylus brasiliensis infection and following systemic anaphylaxis.
The scope and activation mechanisms of chemokine gene expression in primary astrocytes following infection with Theiler's virus.
The sensitization of mucosal mast cells during infections with Trichostrongylus colubriformis or Haemonchus contortus in sheep.
Viral persistence and chronic immunopathology in the adult central nervous system following Coxsackievirus infection during the neonatal period.
[Preliminary Genetic and Functional Analyses of Schistosoma japonicum Chymotrypsin-like Protease].
Inflammatory Bowel Diseases
Chymase inhibition as a pharmacological target: A role in inflammatory and functional gastrointestinal disorders?
Chymase inhibitor TY-51469 in therapy of inflammatory bowel disease.
Immunohistochemical study of chymase-positive mast cells in inflammatory bowel disease.
Insulin Resistance
Elevated serum monocyte chemoattractant protein-4 and chronic inflammation in overweight subjects.
Intervertebral Disc Displacement
Chemokine profile of herniated intervertebral discs infiltrated with monocytes and macrophages.
Intestinal Diseases
Targets of chymase inhibitors.
Intestinal Volvulus
Inflammatory and regulatory CCL and CXCL chemokine and cytokine cellular responses in patients with patent Mansonella perstans filariasis.
Keloid
Mast cell chymase in keloid induces profibrotic response via transforming growth factor-?1/Smad activation in keloid fibroblasts.
Role of chymase in the local renin-angiotensin system in keloids: inhibition of chymase may be an effective therapeutic approach to treat keloids.
Kidney Diseases
Impact of Mast Cell Chymase on Renal Disease Progression.
Increased chymase-positive mast cells in children with crescentic glomerulonephritis.
Mast Cell Chymase and Kidney Disease.
Renal chymase-dependent pathway for angiotensin II formation mediated acute kidney injury in a mouse model of aristolochic acid I-induced acute nephropathy.
Kidney Diseases, Cystic
Chymase-like angiotensin II-generating activity in end-stage human autosomal dominant polycystic kidney disease.
Kidney Failure, Chronic
Endothelin-converting enzyme-1 inhibition and renoprotection in end-stage renal disease.
Increased Plasma Chymase Concentration and Mast Cell Chymase Expression in Venous Neointimal Lesions of Patients with CKD and ESRD.
Kounis Syndrome
Anaphylactic cardiovascular collapse and Kounis syndrome: systemic vasodilation or coronary vasoconstriction?
Laboratory Infection
Mucosal mast cell responses and release of mast cell protease-I in infections of mice with Hymenolepis diminuta and H. microstoma: modulation by cyclosporin A.
Leg Ulcer
Mast cell tryptase and chymase in chronic leg ulcers: chymase is potentially destructive to epithelium and is controlled by proteinase inhibitors.
Leukemia
A chymotrypsin-type serine protease in rat basophilic leukemia cells: evidence for its immunologic identity with atypical mast cell protease.
Enhanced natural-killer cell and erythropoietic activities in VEGF-A-overexpressing mice delay F-MuLV-induced erythroleukemia.
Linear IgA Bullous Dermatosis
Mast cells in developing subepidermal bullous diseases: emphasis on tryptase, chymase and protease inhibitors.
Lipidoses
Role of mast cell chymase and tryptase in the progression of atherosclerosis: study in 44 autopsied cases.
Liver Cirrhosis
Chymase inhibition attenuates tetrachloride-induced liver fibrosis in hamsters.
Chymase inhibitor ameliorates hepatic steatosis and fibrosis on established non-alcoholic steatohepatitis in hamsters fed a methionine- and choline-deficient diet.
Chymase inhibitor prevents the nonalcoholic steatohepatitis in hamsters fed a methionine- and choline-deficient diet.
Effect of Mast Cell Chymase on Activation, Proliferation and Transdifferentiation of Hepatic Stellate Cells.
Establishment of an assay method for human mast cell chymase.
Expression of angiotensin II type 1 receptor in human cirrhotic livers: Its relation to fibrosis and portal hypertension.
Hepatic chymase level in chronic hepatitis: co-localization of chymase with fibrosis.
Role of Chymase in the Development of Liver Cirrhosis and Its Complications: Experimental and Human Data.
Liver Cirrhosis, Biliary
Increased chymase in livers with autoimmune disease: colocalization with fibrosis.
Mast cell subpopulations in chronic inflammatory hepatobiliary diseases.
Liver Diseases
Hepatic chymase level in chronic hepatitis: co-localization of chymase with fibrosis.
Role of Chymase in the Development of Liver Cirrhosis and Its Complications: Experimental and Human Data.
Liver Diseases, Alcoholic
Mast cell subpopulations in chronic inflammatory hepatobiliary diseases.
Liver Failure, Acute
Chymase inhibition attenuates lipopolysaccharide/ d-galactosamine-induced acute liver failure in hamsters.
Lung Diseases
Expression of IFN-gamma-inducible protein; monocyte chemotactic proteins 1, 3, and 4; and eotaxin in TH1- and TH2-mediated lung diseases.
Histological characterization of mast cell chymase in patients with pulmonary hypertension and chronic obstructive pulmonary disease.
Lung Diseases, Interstitial
Lung mast cell density defines a subpopulation of patients with idiopathic pulmonary fibrosis.
Lung Injury
Mast cell mediation of muscle and pulmonary injury following hindlimb ischemia-reperfusion.
Mast cells contribute to bleomycin-induced lung inflammation and injury in mice through a chymase/mast cell protease 4-dependent mechanism.
Lymphatic Metastasis
Low numbers of tryptase+ and chymase+ mast cells associated with reduced survival and advanced tumor stage in melanoma.
Lymphocytosis
An unusual case of systemic mastocytosis associated with chronic lymphocytic leukaemia (SM-CLL).
Lymphoma
Production of the novel C-C chemokine MCP-4 by airway cells and comparison of its biological activity to other C-C chemokines.
Lymphoma, Non-Hodgkin
Demonstration of tryptase in bovine cutaneous and tumor mast cells.
Immunohistochemical and histochemical stains for differentiating canine cutaneous round cell tumors.
Malnutrition
Effects of maternal undernutrition on renal angiotensin II and chymase in hypertensive offspring.
Mastocytoma
Characterisation of tryptase and a granzyme H-like chymase isolated from equine mastocytoma tissue.
Chymase and tryptase in dog mastocytoma cells: asynchronous expression as revealed by enzyme cytochemical staining.
Cloning and expression of the dog mast cell alpha-chymase gene.
Dog mast cell alpha-chymase activates progelatinase B by cleaving the Phe88-Gln89 and Phe91-Glu92 bonds of the catalytic domain.
Dog mast cell chymase: molecular cloning and characterization.
Dog mastocytoma cells secrete a 92-kD gelatinase activated extracellularly by mast cell chymase.
Dog mastocytoma tryptase: affinity purification, characterization, and amino-terminal sequence.
Effect of adenosine 3',5'-monophosphate on growth and several functions of cultured mastocytoma P-815 cells.
Homocysteine-induced oxidative stress upregulates chymase in mouse mastocytoma cells.
Interaction and cooperation of mi transcription factor (MITF) and myc-associated zinc-finger protein-related factor (MAZR) for transcription of mouse mast cell protease 6 gene.
Mast cell alpha-chymase reduces IgE recognition of birch pollen profilin by cleaving antibody-binding epitopes.
Mast cell chymase. A potent secretagogue for airway gland serous cells.
Mast cell tryptase and chymase reverse airway smooth muscle relaxation induced by vasoactive intestinal peptide in the ferret.
Mast cells and cell-to-cell interactions in airways.
Purification and characterization of dog mastocytoma chymase: identification of an octapeptide conserved in chymotryptic leukocyte proteinases.
Tryptase and chymase: comparison of extraction and release in two dog mastocytoma lines.
Mastocytosis
A critical role for stem cell factor and c-kit in host protective immunity to an intestinal helminth.
Chymase expressing bone marrow mast cells in mastocytosis and myelodysplastic syndromes: an immunohistochemical and morphometric study.
Conditioned media obtained from a human mastocytosis cell strain induce mast cells expressing chymase but not tryptase from human progenitors.
Curcumin Ingestion Inhibits Mastocytosis and Suppresses Intestinal Anaphylaxis in a Murine Model of Food Allergy.
Differential roles for the IL-9/IL-9 receptor alpha-chain pathway in systemic and oral antigen-induced anaphylaxis.
Immunological relationships during primary infection with Heligmosomoides polygyrus (Nematospiroides dubius): downregulation of specific cytokine secretion (IL-9 and IL-10) correlates with poor mastocytosis and chronic survival of adult worms.
Immunological relationships during primary infection with Heligmosomoides polygyrus: Th2 cytokines and primary response phenotype.
Mast cells expressing chymase but not tryptase can be derived by culturing human progenitors in conditioned medium obtained from a human mastocytosis cell strain with c-kit ligand.
Mast cells in cutaneous mastocytosis: accumulation of the MCTC type.
Mast-cell phenotype in indolent forms of mastocytosis. Ultrastructural features, fluorescence detection of avidin binding, and immunofluorescent determination of chymase, tryptase, and carboxypeptidase.
Mucosal defense against gastrointestinal nematodes: responses of mucosal mast cells and mouse mast cell protease 1 during primary strongyloides venezuelensis infection in FcRgamma-knockout mice.
Non-lethal Plasmodium yoelii infection drives complex patterns of Th2-type host immunity and mast cell-dependent bacteremia.
Mastocytosis, Systemic
Chronically KIT-stimulated clonally-derived human mast cells show heterogeneity in different tissue microenvironments.
Megacolon
Mast cell-nerve interaction in the colon of Trypanosoma cruzi-infected individuals with chagasic megacolon.
Melanoma
Low numbers of tryptase+ and chymase+ mast cells associated with reduced survival and advanced tumor stage in melanoma.
Mast cell chymase promotes angiogenesis and lymphangiogenesis mediated by activation of melanoma inhibitory activity gene family members in oral squamous cell carcinoma.
The combined action of mast cell chymase, tryptase and carboxypeptidase A3 protects against melanoma colonization of the lung.
Mesothelioma
Tryptase mast cells in malignant pleural mesothelioma as an independent favorable prognostic factor.
Metabolic Diseases
Mast cell chymase and tryptase as targets for cardiovascular and metabolic diseases.
Metabolic Syndrome
Chymase as an important target for preventing complications of metabolic syndrome.
High Fib4 index in patients with suspected NASH is associated with elevation of chymase-dependent angiotensin II-forming activity in circulating mononuclear leucocytes.
The contribution of chymase-dependent formation of AngII to cardiac dysfunction in metabolic syndrome of young rats: roles of fructose and EETs.
Mitral Valve Insufficiency
Cardiac mast cell- and chymase-mediated matrix metalloproteinase activity and left ventricular remodeling in mitral regurgitation in the dog.
Chymase inhibition prevents fibronectin and myofibrillar loss and improves cardiomyocyte function and LV torsion angle in dogs with isolated mitral regurgitation.
Differential expression of angiotensin-converting enzyme and chymase in dogs with chronic mitral regurgitation.
Modulation of the tissue reninangiotensin-aldosterone system in dogs with chronic mild regurgitation through the mitral valve.
Mouth Neoplasms
Mast cell chymase promotes angiogenesis and lymphangiogenesis mediated by activation of melanoma inhibitory activity gene family members in oral squamous cell carcinoma.
Muscular Dystrophies
Skeletal muscle protease and glucocorticoid hormone receptors in muscle wasting conditions and muscular dystrophy.
Myelodysplastic Syndromes
Chymase expressing bone marrow mast cells in mastocytosis and myelodysplastic syndromes: an immunohistochemical and morphometric study.
Myocardial Infarction
A Chymase Inhibitory RNA Aptamer Improves Cardiac Function and Survival after Myocardial Infarction.
An antiarrhythmic effect of a chymase inhibitor after myocardial infarction.
Beneficial effects of cardiac chymase inhibition during the acute phase of myocardial infarction.
Cardiac chymase: pathophysiological role and therapeutic potential of chymase inhibitors.
Chymase as an important target for preventing complications of metabolic syndrome.
Chymase gene locus is not associated with myocardial infarction and is not linked to heart size or blood pressure.
Chymase inhibition prevents cardiac fibrosis and dysfunction after myocardial infarction in rats.
Chymase inhibitor improves survival in hamsters with myocardial infarction.
Chymase-derived angiotensin II and arrhythmias after myocardial infarction.
Deficiency of mouse mast cell protease 4 mitigates cardiac dysfunctions in mice after myocardium infarction.
Development of the chymase inhibitor as an anti-tissue-remodeling drug: myocardial infarction and some other possibilities.
Effects of the chymase inhibitor fulacimstat on adverse cardiac remodeling after acute myocardial infarction-Results of the Chymase Inhibitor in Adverse Remodeling after Myocardial Infarction (CHIARA MIA) 2 trial.
Exploration of the effect of salvianolate on myocardial infarction in rats based on tandem mass tags.
Healing human myocardial infarction associated with increased chymase immunoreactivity.
Hypothesis regarding the pathophysiological role of alternative pathways of angiotensin II formation in atherosclerosis.
IGF-1 degradation by mouse mast cell protease 4 promotes cell death and adverse cardiac remodeling days after a myocardial infarction.
Impact of chymase inhibitor on cardiac function and survival after myocardial infarction.
Increase of chymase-dependent angiotensin II-forming activity in circulating mononuclear leukocytes after acute myocardial infarction chymase activity after acute myocardial infarction.
Mast cell chymase limits the cardiac efficacy of Ang I-converting enzyme inhibitor therapy in rodents.
Mouse Mast Cell Protease 4 Deletion Protects Heart Function and Survival After Permanent Myocardial Infarction.
Pathological roles of angiotensin II produced by mast cell chymase and the effects of chymase inhibition in animal models.
Pharmacokinetics, Safety, and Tolerability of the Novel Chymase Inhibitor BAY 1142524 in Healthy Male Volunteers.
Possible roles of cardiac chymase after myocardial infarction in hamster hearts.
Prospective single-arm observational study of human chymase inhibitor Polygonum hydropiper L in subjects with hypertension.
Recent chymase inhibitors and their effects in in vivo models.
Safety and Tolerability of the Chymase Inhibitor Fulacimstat in Patients With Left Ventricular Dysfunction After Myocardial Infarction-Results of the CHIARA MIA 1 Trial.
Myocardial Ischemia
Differential expression of the angiotensin-(1-12)/chymase axis in human atrial tissue.
Dual inhibition of cathepsin G and chymase reduces myocyte death and improves cardiac remodeling after myocardial ischemia reperfusion injury.
Myocarditis
Chymase inhibition reduces the progression to heart failure after autoimmune myocarditis in rats.
Gene expression of cardiac mast cell chymase and tryptase in a murine model of heart failure caused by viral myocarditis.
Renin: at the heart of the mast cell.
Myositis
[Immunohistochemical localization of chymase; a mast cell marker and clinical significance in diseased human skeletal muscle]
Nasal Polyps
Expression of MCP-4 by TLR ligand-stimulated nasal polyp fibroblasts.
Histochemical and immunohistochemical characteristics of mast cells in nasal polyps.
Nematode Infections
Anaphylactic release of mucosal mast cell granule proteases: role of serpins in the differential clearance of mouse mast cell proteases-1 and -2.
Constitutive expression of mouse mast cell protease-1 in normal BALB/c mice and its up-regulation during intestinal nematode infection.
Constitutive secretion of the granule chymase mouse mast cell protease-1 and the chemokine, CCL2, by mucosal mast cell homologues.
Extended cleavage specificity of mMCP-1, the major mucosal mast cell protease in mouse-High specificity indicates high substrate selectivity.
Functional relationships between sensory nerve fibers and mast cells of dura mater in normal and inflammatory conditions.
Neoplasm Metastasis
Anti-Angiotensin and Hypoglycemic Treatments Suppress Liver Metastasis of Colon Cancer Cells.
Elevated serum concentration of monocyte chemotactic protein 4 (MCP-4) as a novel non-invasive prognostic and predictive biomarker for detection of metastasis in colorectal cancer.
Identification of genes that may play critical roles in phenobarbital (PB)-induced liver tumorigenesis due to altered DNA methylation.
Low numbers of tryptase+ and chymase+ mast cells associated with reduced survival and advanced tumor stage in melanoma.
Mast cell chymase affects the proliferation and metastasis of lung carcinoma cells in vitro.
Neoplasms
A Novel Cytological Model of B-Cell/Macrophage Biphenotypic Cell Hodgkin Lymphoma in Ganp-Transgenic Mice.
A time-course analysis of mRNA expression during injury healing in human dermal injuries.
Activated mast cells induce endothelial cell apoptosis by a combined action of chymase and tumor necrosis factor-alpha.
Acute dehydrating disease caused by Vibrio cholerae serogroups O1 and O139 induce increases in innate cells and inflammatory mediators at the mucosal surface of the gut.
Airway mucosal immune-suppression in neonates of mothers receiving A(H1N1)pnd09 vaccination during pregnancy.
Association between mast cells of different phenotypes and angiogenesis in colorectal cancer.
Association of STR polymorphisms in CMA1 and IL-4 with asthma and atopy: the SAPALDIA cohort.
Bile and urine peptide marker profiles: access keys to molecular pathways and biological processes in cholangiocarcinoma.
Chymase and tryptase in dog mastocytoma cells: asynchronous expression as revealed by enzyme cytochemical staining.
Chymase inhibition attenuates lipopolysaccharide/ d-galactosamine-induced acute liver failure in hamsters.
Comparative Analysis of Bone Marrow-derived Mast Cell Differentiation in C57BL/6 and BALB/c Mice.
Correlations Between the Density of Tryptase Positive Mast Cells (DMCT) and that of New Blood Vessels (CD105+) in Patients with Gastric Cancer.
Cutaneous mast cell tumours in a lion (Panthera leo): a light and transmission electron microscopical study.
Demonstration of tryptase in bovine cutaneous and tumor mast cells.
Dysregulated inflammatory response to Candida albicans in a C5-deficient mouse strain.
Enhanced susceptibility to endotoxic shock and impaired STAT3 signaling in CD31-deficient mice.
Expression of chymase-positive cells in gastric cancer and its correlation with the angiogenesis.
Expression of cytokines and proteases in mast cells in the lesion of subcapsular cell hyperplasia in mouse adrenal glands.
Expression of Mast Cell Proteases Correlates with Mast Cell Maturation and Angiogenesis during Tumor Progression.
Growth inhibition of different human colorectal cancer xenografts after a single intravenous injection of oncolytic vaccinia virus GLV-1 h68.
Identification of Soluble Mediators in IgG-Mediated Anaphylaxis via Fc? Receptor: A Meta-Analysis.
IL-4 differentially regulates eotaxin and MCP-4 in lung epithelium and circulating mononuclear cells.
Immunohistochemical and histochemical stains for differentiating canine cutaneous round cell tumors.
Inflammatory mast cells up-regulate angiogenesis during squamous epithelial carcinogenesis.
Inhibition of perivascular mast cell activation is involved in the atheroprotective effect of rosiglitazone in apolipoprotein E-deficient mice.
Mast cell activation and arterial hypotension during proximal aortic repair requiring hypothermic circulatory arrest.
Mast cell chymase is present in uterine cervical carcinoma and it detaches viable and growing cervical squamous carcinoma cells from substratum in vitro.
Mast cell chymase promotes angiogenesis and lymphangiogenesis mediated by activation of melanoma inhibitory activity gene family members in oral squamous cell carcinoma.
Mast cell phenotype in benign and malignant tumors of the prostate.
Mast cells and cancer: a review of literature.
Mast Cells in Human Cutaneous Neurofibromas: Density, Subtypes, and Association with Clinical Features in Neurofibromatosis 1.
Mast cells in vulnerable coronary plaques: potential mechanisms linking mast cell activation to plaque erosion and rupture.
Mechanisms Governing Anaphylaxis: Inflammatory Cells, Mediators, Endothelial Gap Junctions and Beyond.
Membrane-bound form of monocyte chemoattractant protein-1 enhances antitumor effects of suicide gene therapy in a model of hepatocellular carcinoma.
Monocyte chemoattractant protein (MCP)-4 expression in the airways of patients with asthma. Induction in epithelial cells and mononuclear cells by proinflammatory cytokines.
Monocyte chemotactic protein-4: tissue-specific expression and signaling through CC chemokine receptor-2.
Murine mast cell lines as indicators of early events in mast cell and basophil development.
NOS2-derived nitric oxide regulates the size, quantity and quality of granuloma formation in Mycobacterium avium-infected mice without affecting bacterial loads.
Potential role for monocyte chemotactic protein-4 (MCP-4) in monocyte/macrophage recruitment in acute renal inflammation.
Quercetin suppresses the chymotrypsin-like activity of proteasome via inhibition of MEK1/ERK1/2 signaling pathway in hepatocellular carcinoma HepG2 cells.
Raised MCP-4 levels in symptomatic carotid atherosclerosis: an inflammatory link between platelet and monocyte activation.
Rat mast cell protease I alters cell metabolism.
Recent Trends in the Design, Synthesis and Biological Exploration of ?-Lactams.
Reovirus Virotherapy Overrides Tumor Antigen Presentation Evasion and Promotes Protective Antitumor Immunity.
Serglycin--structure and biology.
Structural examination of tryptase- and chymase-positive mast cells in livers, containing metastases from gastrointestinal cancers.
The production of collagen and the activity of mast-cell chymase increase in human skin after irradiation therapy.
The relationship between breast cancer molecular subtypes and mast cell populations in tumor microenvironment.
The relationship between symptom burden and systemic inflammation differs between male and female athletes following concussion.
The relationship of tryptase- and chymase-positive mast cells to angiogenesis in stage I non-small cell lung cancer.
The Role of Mast Cell Specific Chymases and Tryptases in Tumor Angiogenesis.
[The phenotype of mast cells in primary adenoid liver tumours of rats and its relation to tumor cells]
Nephritis
Contribution of mast cells to the tubulointerstitial lesions in IgA nephritis.
Increased chymase-positive mast cells in children with crescentic glomerulonephritis.
Nephrotic Syndrome
Tissue-specific expression of renin-angiotensin system components in IgA nephropathy.
Neurogenic Inflammation
Mast cell tryptase and chymase are potential regulators of neurogenic inflammation in psoriatic skin.
Substance P and vasoactive intestinal peptide degradation by mast cell tryptase and chymase.
[Progress in the study of chymase]
Nevus
Low numbers of tryptase+ and chymase+ mast cells associated with reduced survival and advanced tumor stage in melanoma.
Non-alcoholic Fatty Liver Disease
Chymase as an important target for preventing complications of metabolic syndrome.
Chymase inhibitor prevents the nonalcoholic steatohepatitis in hamsters fed a methionine- and choline-deficient diet.
Multiple Mechanisms for the Action of Chymase Inhibitors.
Targets of chymase inhibitors.
Obesity
Biomarkers in biological fluids in adults with periodontitis and/or obesity: A meta-analysis.
Circulating Levels of the Adipokines Monocyte Chemotactic Protein-4 (MCP-4), Macrophage Inflammatory Protein-1? (MIP-1?), and Eotaxin-3 in Severe Obesity and Following Bariatric Surgery.
Correlation of MCP-4 and high-sensitivity C-reactive protein as a marker of inflammation in obesity and chronic periodontitis.
Elevated serum monocyte chemoattractant protein-4 and chronic inflammation in overweight subjects.
Obesity, Morbid
Circulating Levels of the Adipokines Monocyte Chemotactic Protein-4 (MCP-4), Macrophage Inflammatory Protein-1? (MIP-1?), and Eotaxin-3 in Severe Obesity and Following Bariatric Surgery.
Obstetric Labor, Premature
Blood protein profiles of infants born before 28th weeks differ by pregnancy complication.
Mast Cell Chymase Decreases The Severity Of Group B Streptococcus Infections.
Ocular Hypertension
Effect of chymase on intraocular pressure in rabbits.
Onchocerciasis
Mast cells in onchocercomas from patients with hyperreactive onchocerciasis (sowda).
Oral Submucous Fibrosis
Altered immunohistochemical expression of mast cell tryptase and chymase in the pathogenesis of oral submucous fibrosis and malignant transformation of the overlying epithelium.
Osteoarthritis
Mast cell responses in rheumatoid synovium. Association of the MCTC subset with matrix turnover and clinical progression.
Significant correlation between thrombospondin 1 and serine proteinase expression in rheumatoid synovium.
Osteolysis
Simultaneous labeling of mast cell proteases and protease mRNAs at the bone-implant interface of aseptically loosened hip implants.
Osteoporosis
Increased Bone Mass in Female Mice Lacking Mast Cell Chymase.
p-type cu2+ transporter deficiency
Production of LPS-induced inflammatory mediators in murine peritoneal macrophages: neocuproine as a broad inhibitor and ATP7A as a selective regulator.
Pancreatic Neoplasms
The stem cell factor-c-kit system and mast cells in human pancreatic cancer.
Pancreatitis
Blocking of monocyte chemoattractant protein-1 (MCP-1) activity attenuates the severity of acute pancreatitis in rats.
Loss of chymotrypsin-like protease (CTRL) alters intrapancreatic protease activation but not pancreatitis severity in mice.
Pancytopenia
High Fib4 index in patients with suspected NASH is associated with elevation of chymase-dependent angiotensin II-forming activity in circulating mononuclear leucocytes.
Pemphigoid, Bullous
Dual targets for mouse mast cell protease-4 in mediating tissue damage in experimental bullous pemphigoid.
Mast cells in developing subepidermal bullous diseases: emphasis on tryptase, chymase and protease inhibitors.
Peptic Ulcer
Influences of chymase and angiotensin I-converting enzyme gene polymorphisms on gastric cancer risks in Japan.
Periodontitis
Biomarkers in biological fluids in adults with periodontitis and/or obesity: A meta-analysis.
Peripheral Vascular Diseases
Mast cell subpopulations in the synovial tissue of patients with osteoarthritis: selective increase in numbers of tryptase-positive, chymase-negative mast cells.
Peritonitis
IL-15 constrains mast cell-dependent antibacterial defenses by suppressing chymase activities.
Inflammatory mediator profiling reveals immune properties of chemotactic gradients and macrophage mediator production inhibition during thioglycollate elicited peritoneal inflammation.
Mast cell chymase induces expression of chemokines for neutrophils in eosinophilic EoL-1 cells and mouse peritonitis eosinophils.
Protease-activated receptor 1 activation is necessary for monocyte chemoattractant protein 1-dependent leukocyte recruitment in vivo.
Plasmacytoma
Immunohistochemical and histochemical stains for differentiating canine cutaneous round cell tumors.
Pleural Effusion
Serum chymase levels correlate with severe dengue warning signs and clinical fluid accumulation in hospitalized pediatric patients.
Pneumonia
Chymase is activated in the pulmonary inflammation and fibrosis induced by paraquat in hamsters.
Dual Inhibition of Cathepsin G and Chymase is Effective in Animal Models of Pulmonary Inflammation.
Eotaxin and monocyte chemotactic protein-4 mRNA expression in small airways of asthmatic and nonasthmatic individuals.
Polycystic Kidney, Autosomal Dominant
Chymase-like angiotensin II-generating activity in end-stage human autosomal dominant polycystic kidney disease.
Pre-Eclampsia
Blood protein profiles of infants born before 28th weeks differ by pregnancy complication.
Contractility of placental vascular smooth muscle cells in response to stimuli produced by the placenta: roles of ACE vs. non-ACE and AT1 vs. AT2 in placental vessel cells.
Elevated plasma chymotrypsin-like protease (chymase) activity in women with preeclampsia.
Histone deacetylase inhibition disturbs the balance between ACE and chymase expression in endothelial cells: a potential mechanism of chymase activation in preeclampsia.
Increased chymotrypsin-like protease (chymase) expression and activity in placentas from women with preeclampsia.
PAR-2 triggers placenta-derived protease-induced altered VE-cadherin reorganization at endothelial junctions in preeclampsia.
Placenta-derived chymotrypsin-like protease (CLP) disturbs endothelial junctional structure in preeclampsia.
Production of human mast cell chymase in human myometrium and placenta in cases of normal pregnancy and preeclampsia.
Role of chymase in preeclampsia.
Upregulation of cathepsin C expression contributes to endothelial chymase activation in preeclampsia.
Premature Birth
Mast Cell Chymase Decreases The Severity Of Group B Streptococcus Infections.
Pressure Ulcer
The 3G5 antigen is expressed in dermal mast cells but not pericytes.
Protein Deficiency
The effect of protein deficiency on systemic release of rat mucosal mast cell protease II during Nippostrongylus brasiliensis infection and following systemic anaphylaxis.
Proteinuria
Chymase inhibition and cardiovascular protection.
Inhibition of chymase protects against diabetes-induced oxidative stress and renal dysfunction in hamsters.
Prurigo
Dendritic mast cells in prurigo nodularis skin.
Pruritus
Oral chymase inhibitor SUN13834 ameliorates skin inflammation as well as pruritus in mouse model for atopic dermatitis.
Therapeutic potential of a specific chymase inhibitor in atopic dermatitis.
Psoriasis
Association of cutaneous mast cells and sensory nerves with psychic stress in psoriasis.
Decreased chymase activity is associated with increased levels of protease inhibitors in mast cells of psoriatic lesions.
Mast cell chymase in experimentally induced psoriasis.
Mast cell chymase is increased in chronic atopic dermatitis but not in psoriasis.
Psoriasis pathogenesis - Pso p27 is generated from SCCA1 with chymase.
Pterygium
[Pterygium and mast cells--mast cell number, phenotype, and localization of stem cell factor]
Pulmonary Disease, Chronic Obstructive
A novel, potent dual inhibitor of the leukocyte proteases cathepsin G and chymase: molecular mechanisms and anti-inflammatory activity in vivo.
Association of mast cells with lung function in chronic obstructive pulmonary disease.
Chronic Obstructive Pulmonary Disease Patients Have Increased Levels of Plasma Inflammatory Mediators Reported Upregulated in Severe COVID-19.
Dual Inhibition of Cathepsin G and Chymase is Effective in Animal Models of Pulmonary Inflammation.
Histological characterization of mast cell chymase in patients with pulmonary hypertension and chronic obstructive pulmonary disease.
Mast cells in COPD airways: relationship to bronchodilator responsiveness and angiogenesis.
Serum cytokine profiles in patients with chronic obstructive pulmonary disease associated pulmonary hypertension identified using protein array.
[Correlations between chymase activity ,levels of tryptase, and eotaxin in the sputum of patients with chronic obstructive puhnonary disease and their clinical implications]
Pulmonary Fibrosis
A specific chymase inhibitor, NK3201, suppresses bleomycin-induced pulmonary fibrosis in hamsters.
Chymase gene (CMA1) polymorphisms in Dutch and Japanese sarcoidosis patients.
Chymase is activated in the pulmonary inflammation and fibrosis induced by paraquat in hamsters.
Chymase: a multifunctional player in pulmonary hypertension associated with lung fibrosis.
Disruption in the balance between apolipoprotein A-I and mast cell chymase in chronic hypersensitivity pneumonitis.
Involvement of mast cell chymase in bleomycin-induced pulmonary fibrosis in mice.
Mast cell Chymase: an indispensable instrument in the pathological symphony of idiopathic pulmonary fibrosis?
The specific chymase inhibitor TY-51469 suppresses the accumulation of neutrophils in the lung and reduces silica-induced pulmonary fibrosis in mice.
Purpura
Increased chymase-positive mast cells in children with crescentic glomerulonephritis.
Renal Artery Obstruction
Effects of chymostatin, a chymase inhibitor, on blood pressure, plasma and tissue angiotensin II, renal haemodynamics and renal excretion in two models of hypertension in the rat.
Renal Insufficiency, Chronic
Chronic renal insufficiency among Asian Indians with type 2 diabetes: I. Role of RAAS gene polymorphisms.
Reperfusion Injury
Dual inhibition of cathepsin G and chymase reduces myocyte death and improves cardiac remodeling after myocardial ischemia reperfusion injury.
Mast cell chymase protects against acute ischemic kidney injury by limiting neutrophil hyperactivation and recruitment.
Recent chymase inhibitors and their effects in in vivo models.
Respiratory Tract Infections
Plasma cytokines eotaxin, MIP-1?, MCP-4, and vascular endothelial growth factor in acute lower respiratory tract infection.
Retinal Detachment
Involvement of premacular mast cells in the pathogenesis of macular diseases.
Measurement of activities in two different angiotensin II generating systems, chymase and angiotensin-converting enzyme, in the vitreous fluid of vitreoretinal diseases: a possible involvement of chymase in the pathogenesis of macular hole patients.
Retinal Perforations
Effects of chymase on the macular region in monkeys and porcine muller cells: probable involvement of chymase in the onset of idiopathic macular holes.
Involvement of premacular mast cells in the pathogenesis of macular diseases.
Measurement of activities in two different angiotensin II generating systems, chymase and angiotensin-converting enzyme, in the vitreous fluid of vitreoretinal diseases: a possible involvement of chymase in the pathogenesis of macular hole patients.
[The pathogenesis of vitreoretinal diseases from the standpoint of molecular biology]
Rhinitis
Monocyte chemotactic proteins in allergen-induced inflammation in the nasal mucosa: effect of topical corticosteroids.
Rhinitis, Allergic
Cleaved secretory leucocyte protease inhibitor as a biomarker of chymase activity in allergic airway disease.
Monocyte chemotactic proteins in allergen-induced inflammation in the nasal mucosa: effect of topical corticosteroids.
[Differentiation and proliferation of mast cells in nasal mucosa]
Rhinitis, Allergic, Seasonal
Comparison of the nasal release of IL-4, IL-10, IL-17, CCL13/MCP-4, and CCL26/eotaxin-3 in allergic rhinitis during season and after allergen challenge.
Sarcoidosis
Chymase gene (CMA1) polymorphisms in Dutch and Japanese sarcoidosis patients.
Sarcoidosis, Pulmonary
Chymase gene (CMA1) polymorphisms in Dutch and Japanese sarcoidosis patients.
Sarcoma
Cloning of the cDNA and gene for mouse mast cell protease 4. Demonstration of its late transcription in mast cell subclasses and analysis of its homology to subclass-specific neutral proteases of the mouse and rat.
Identification and molecular cloning of a novel mouse mucosal mast cell serine protease.
Schistosomiasis
Impairment of intestinal barrier and secretory function as well as egg excretion during intestinal schistosomiasis occur independently of mouse mast cell protease-1.
Scleroderma, Systemic
Lung mast cell density defines a subpopulation of patients with idiopathic pulmonary fibrosis.
Scoliosis
Chemokine profile of herniated intervertebral discs infiltrated with monocytes and macrophages.
Sepsis
Proteome analysis of mast cell releasates reveals a role for chymase in the regulation of coagulation factor XIIIA levels via proteolytic degradation.
The Chymase Mouse Mast Cell Protease 4 Degrades TNF, Limits Inflammation, and Promotes Survival in a Model of Sepsis.
Severe Acute Respiratory Syndrome
Chalcones isolated from Angelica keiskei inhibit cysteine proteases of SARS-CoV.
Design and synthesis of peptidomimetic severe acute respiratory syndrome chymotrypsin-like protease inhibitors.
Evaluation of a non-prime site substituent and warheads combined with a decahydroisoquinolin scaffold as a SARS 3CL protease inhibitor.
Fused-ring structure of decahydroisoquinolin as a novel scaffold for SARS 3CL protease inhibitors.
Micronutrients and bioactive substances: Their potential roles in combating COVID-19.
Severe acute respiratory syndrome coronavirus papain-like protease: Structure of a viral deubiquitinating enzyme.
Structural basis for the development of SARS 3CL protease inhibitors from a peptide mimic to an aza-decaline scaffold.
Structure-based design, synthesis, and evaluation of peptide-mimetic SARS 3CL protease inhibitors.
[Studies on Functional Molecules Based on Peptide Chemistry].
Severe Dengue
Alpha tryptase allele of Tryptase 1 (TPSAB1) gene associated with Dengue Hemorrhagic Fever (DHF) and Dengue Shock Syndrome (DSS) in Vietnam and Philippines.
Assessing the Serum Chymase Level as an Early Predictor of Dengue Severity.
Chymase Level Is a Predictive Biomarker of Dengue Hemorrhagic Fever in Pediatric and Adult Patients.
Contributions of mast cells and vasoactive products, leukotrienes and chymase, to dengue virus-induced vascular leakage.
Serum chymase levels correlate with severe dengue warning signs and clinical fluid accumulation in hospitalized pediatric patients.
Shock, Septic
Therapeutic effects of the combination of two proteinase inhibitors in endotoxin shock of the pig.
Skin Diseases
Mast cells in developing subepidermal bullous diseases: emphasis on tryptase, chymase and protease inhibitors.
Skin mast cell promotion of matrix remodeling in burn wound healing in mice: relevance of chymase.
Sleep Apnea Syndromes
Why is blood pressure so hard to control in patients with type 2 diabetes?
Sparganosis
IgG antibody responses in early experimental sparganosis and IgG subclass responses in human sparganosis.
Spinal Cord Injuries
Mast cells protect from post-traumatic spinal cord damage in mice by degrading inflammation-associated cytokines via mouse mast cell protease 4.
Mouse mast cell protease 4 suppresses scar formation after traumatic spinal cord injury.
Squamous Cell Carcinoma of Head and Neck
Altered immunohistochemical expression of mast cell tryptase and chymase in the pathogenesis of oral submucous fibrosis and malignant transformation of the overlying epithelium.
Mast cell chymase promotes angiogenesis and lymphangiogenesis mediated by activation of melanoma inhibitory activity gene family members in oral squamous cell carcinoma.
Treponema denticola chymotrypsin-like protease as associated with HPV-negative oropharyngeal squamous cell carcinoma.
Stomach Neoplasms
Expression of chymase-positive cells in gastric cancer and its correlation with the angiogenesis.
Influences of chymase and angiotensin I-converting enzyme gene polymorphisms on gastric cancer risks in Japan.
Polymorphisms of matrix metalloproteinase-7 and chymase are associated with susceptibility to and progression of gastric cancer in Japan.
Role of renin-angiotensin system in gastric oncogenesis.
Stroke
Atrial angiotensin-(1-12)/chymase expression data in patient of heart diseases.
Differential Expression of the Angiotensin-(1-12)/Chymase Axis in Human Atrial Tissue.
Synovitis
Evaluating MRI-detected tenosynovitis in the hand and wrist in early arthritis.
Expression of the alphaEbeta7 integrin by mast cells in rheumatoid synovium.
Tachycardia
Chymase inhibition prevents cardiac fibrosis and improves diastolic dysfunction in the progression of heart failure.
Thrombocytopenia
Serum chymase levels correlate with severe dengue warning signs and clinical fluid accumulation in hospitalized pediatric patients.
Thrombosis
Anaphylactic cardiovascular collapse and Kounis syndrome: systemic vasodilation or coronary vasoconstriction?
Thyroiditis, Autoimmune
The effect of mast cell chymase on extracellular matrix: studies in autoimmune thyroiditis and in cultured thyroid cells.
Trauma, Nervous System
Mast cells as protectors of health.
Ureteral Obstruction
Contribution of chymase-dependent angiotensin II formation to the progression of tubulointerstitial fibrosis in obstructed kidneys in hamsters.
Mast cell chymase protects against renal fibrosis in murine unilateral ureteral obstruction.
Mast Cells and MCPT4 Chymase Promote Renal Impairment after Partial Ureteral Obstruction.
Urinary Bladder, Neurogenic
Mast cell chymase is a possible mediator of neurogenic bladder fibrosis.
Urticaria
An unusual case of systemic mastocytosis associated with chronic lymphocytic leukaemia (SM-CLL).
Heterozygous alpha 1-antichymotrypsin deficiency may be associated with cold urticaria.
Immunoglobulin E-bearing cells and mast cells in skin biopsies of horses with urticaria.
Mast cell number and phenotype in chronic idiopathic urticaria.
Urticaria Pigmentosa
Chronically KIT-stimulated clonally-derived human mast cells show heterogeneity in different tissue microenvironments.
Determination of the primary structures of human skin chymase and cathepsin G from cutaneous mast cells of urticaria pigmentosa lesions.
Heterogeneity of mast cells in mastocytosis and inhibitory effect of ketotifen and ranitidine on indolent systemic mastocytosis.
Uterine Cervical Neoplasms
[miR-520a-3p regulates the signaling pathway of cytokine secretion in cervical cancer].
Varicocele
Significance of human testicular mast cells and their subtypes in male infertility.
Vascular Diseases
Chymase as a novel target for the prevention of vascular diseases.
Chymase inhibitors for the treatment of cardiac diseases: a patent review (2010-2018).
Chymase is upregulated in diabetic nephropathy: implications for an alternative pathway of angiotensin II-mediated diabetic renal and vascular disease.
Cysteinyl cathepsins and mast cell proteases in the pathogenesis and therapeutics of cardiovascular diseases.
Dissecting the role of chymase in angiotensin II formation and heart and blood vessel diseases.
Endothelin-1 (1-31): From chymase-dependent synthesis to cardiovascular pathologies.
Human chymase, an enzyme forming novel bioactive 31-amino acid length endothelins.
Increased expression of mast cell chymase in the lungs of patients with congenital heart disease associated with early pulmonary vascular disease.
Mast cell chymase in the ischemic kidney of severe unilateral renovascular hypertension.
Mast cell granule composition and tissue location--a close correlation.
Vascular chymase: pathophysiological role and therapeutic potential of inhibition.
[Role of chymase in vascular diseases and the efficacy of chymase inhibitor]
Vascular System Injuries
Chymase: a new pharmacologic target in cardiovascular disease.
Local angiotensin II-generating system in vascular tissues: the roles of chymase.
Tranilast suppresses vascular chymase expression and neointima formation in balloon-injured dog carotid artery.
Vasculitis
Complement C3 is expressed by mast cells in cutaneous vasculitis and is degraded by chymase.
Mast cell chymase degrades fibrinogen and fibrin.
Mast cell tryptase and chymase in the progress of cutaneous vasculitis.
Vasculitis, Leukocytoclastic, Cutaneous
Complement C3 is expressed by mast cells in cutaneous vasculitis and is degraded by chymase.
Ventricular Dysfunction
Renin: at the heart of the mast cell.
Ventricular Dysfunction, Left
Safety and Tolerability of the Chymase Inhibitor Fulacimstat in Patients With Left Ventricular Dysfunction After Myocardial Infarction-Results of the CHIARA MIA 1 Trial.
Virus Diseases
Emetine, a potent alkaloid for the treatment of SARS-CoV-2 targeting papain-like protease and non-structural proteins: pharmacokinetics, molecular docking and dynamic studies.
Rhinovirus infection up-regulates eotaxin and eotaxin-2 expression in bronchial epithelial cells.
West Nile Fever
West Nile virus encephalitis: sequential histopathological and immunological events in a murine model of infection.
Whooping Cough
The monocyte chemotactic protein-4 induces oxygen radical production, actin reorganization, and CD11b up-regulation via a pertussis toxin-sensitive G-protein in human eosinophils.