3.4.21.39: chymase

This is an abbreviated version!
For detailed information about chymase, go to the full flat file.

Reaction

preferential cleavage: Phe-/- > Tyr-/- > Trp-/- > Leu-/- =

Synonyms

alpha-chymase, beta-chymase, CAGE, Chy, chymase, chymase 1, chymostatin sensitive angiotensin generating enzyme, chymotrypsin-like protease, chymotryptic mast cell peptidase, CLP, CMA, CMA1, HAM1, mast cell chymase, mast cell chymases 4, mast cell protease, mast cell protease 1, mast cell protease 4, mast cell protease I, mast cell protease-2, mast cell protease-4, mast cell specific chymase, mast cell-derived chymase, mast-cell-derived chymase, MC chymase, MC protease 4, MC-chymase, MC-derived chymase, MC-specific chymase, MCC, MCP-1, MCP-2, MCP-4, MCP-5, MCP-8, MCP2, MCP4, Mcpt, MCPT-4, MCPT4, MMCP-1, mucosal mast cell protease, mucosal mast cell protease-1, proteinase, mast cell serine, chymase, RMCP I, skeletal muscle protease, skin chymotryptic proteinase

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.21 Serine endopeptidases

                3.4.21.39 chymase

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Results	in table
8	Activating Compound
15	AA Sequence
14	Application
1	CAS Registry Number
18	Cloned(Commentary)
4	Crystallization (Commentary)
2692	Disease/ Diagnostics
11	Expression
26	General Information
1	General Stability
127	IC50 Value
396	Inhibitors
16	kcat/KM [mM/s]
98	Ki Value [mM]
107	KM Value [mM]
13	Localization
32	Molecular Weight [Da]
87	Natural Substrates/ Products (Substrates)
149	Organism
22	PDB ID
8	pH Optimum
2	pH Range
3	pH Stability
11	Posttranslational Modification
10	Protein Variants
30	Purification (Commentary)
1	Reaction
1	Reaction Type
148	Reference
150	Source Tissue
5	Specific Activity [micromol/min/mg]
1	Storage Stability
342	Substrates and Products (Substrate)
23	Subunits
133	Synonyms
3	Temperature Optimum [°C]
3	Temperature Stability [°C]
107	Turnover Number [1/s]

Organism

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Organism on EC 3.4.21.39 - chymase

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ORGANISM

COMMENTARY

LITERATURE

UNIPROT

SEQUENCE DB

SOURCE

Canis lupus familiaris

-

29385, 81384, 656450, 656451, 680106, 681726, 682260, 709741, 717668

-

-

brenda

Cavia porcellus

2 entries

Cricetinae

2 entries

Homo sapiens

11 entries

Meriones unguiculatus

chymases with Val199 are found only in animals expressing multiple chymases, consistent with the premise that their substrate specificity differs from that of chymases with Gly199

655550

-

-

brenda

Mesocricetus auratus

-

81383, 670951, 682260, 695395, 699923, 708640, 709290, 709684, 755179

-

-

brenda

Monodelphis domestica

short-tailed opossum

681970

-

-

brenda

Mus musculus

7 entries

Ovis aries

-

753380

P79204

UniProt

brenda

Rattus norvegicus

2 entries

Sus scrofa

-

81364

-

-

brenda

Cavia porcellus

-

731764

A7WPL7

UniProt

brenda

Cavia porcellus

precursor

680901

A7WPL7

UniProt

brenda

Cricetinae

-

654809

-

-

brenda

Cricetinae

chymases with Val199 are found only in animals expressing multiple chymases, consistent with the premise that their substrate specificity differs from that of chymases with Gly199

655550

-

-

brenda

Homo sapiens

-

29385, 81361, 81366, 81372

-

-

brenda

Homo sapiens

-

81373

P23946

Uniprot

brenda

Homo sapiens

-

81374, 81375, 81377, 81379, 81380, 81381, 81382, 654835, 654961, 654963, 655319, 655425, 655803, 656450, 656451, 668033, 668072, 677877, 678669, 678670, 679069, 679291, 679660, 680106, 680108, 680237, 680336, 680901, 681201, 681272, 681301, 681586, 682260, 682307, 696528, 697785, 698223, 698296, 698854, 699284, 699404, 699406, 700007, 700577, 701374, 708180, 717452, 717585, 717592, 731944

-

-

brenda

Homo sapiens

-

732148, 732379, 732525, 732730

P23946

Uniprot

brenda

Homo sapiens

-

732860

-

-

brenda

Homo sapiens

-

732957, 752661

P23946

Uniprot

brenda

Homo sapiens

-

752910

-

-

brenda

Homo sapiens

-

753007

P23946

Uniprot

brenda

Homo sapiens

-

753116, 755130, 755386

-

-

brenda

Homo sapiens

patients treated for breast cancer with surgery and radiotherapy

668506

-

-

brenda

Homo sapiens

patients with macular holes, proliferative diabetic retinopathy, idiopathic epiretinal membrane, or rhegmatogenous retinal detachment

668338

-

-

brenda

Mus musculus

-

656450, 656451, 669431, 679660, 680106, 680107, 680108, 681972, 681974, 682851, 695966, 697768, 697863, 699756, 701374, 709272, 717909

-

-

brenda

Mus musculus

-

731102, 732148, 732267, 732378, 732427, 732552

P21812

UniProt

brenda

Mus musculus

-

732700

-

-

brenda

Mus musculus

-

732700

P21812

UniProt

brenda

Mus musculus

-

752910, 753962

-

-

brenda

Mus musculus

5 enzyme forms: MMCP-1A to MMCP-1E

81378

-

-

brenda

Mus musculus

chymases with Val199 are found only in animals expressing multiple chymases, consistent with the premise that their substrate specificity differs from that of chymases with Gly199

655550

-

-

brenda

Rattus norvegicus

-

29374, 29385, 29386, 81360, 81362, 81363, 81365, 81368, 81370, 81376, 81385, 656450, 656451, 668245, 679679, 680106, 680107, 681895, 681903, 681974, 697152, 731891, 752688, 755130

-

-

brenda

Rattus norvegicus

chymases with Val199 are found only in animals expressing multiple chymases, consistent with the premise that their substrate specificity differs from that of chymases with Gly199

655550

-

-

brenda