3.4.21.39: chymase

This is an abbreviated version!
For detailed information about chymase, go to the full flat file.

Reaction

preferential cleavage: Phe-/- > Tyr-/- > Trp-/- > Leu-/- =

Synonyms

alpha-chymase, beta-chymase, CAGE, Chy, chymase, chymase 1, chymostatin sensitive angiotensin generating enzyme, chymotrypsin-like protease, chymotryptic mast cell peptidase, CLP, CMA, CMA1, HAM1, mast cell chymase, mast cell chymases 4, mast cell protease, mast cell protease 1, mast cell protease 4, mast cell protease I, mast cell protease-2, mast cell protease-4, mast cell specific chymase, mast cell-derived chymase, mast-cell-derived chymase, MC chymase, MC protease 4, MC-chymase, MC-derived chymase, MC-specific chymase, MCC, MCP-1, MCP-2, MCP-4, MCP-5, MCP-8, MCP2, MCP4, Mcpt, MCPT-4, MCPT4, MMCP-1, mucosal mast cell protease, mucosal mast cell protease-1, proteinase, mast cell serine, chymase, RMCP I, skeletal muscle protease, skin chymotryptic proteinase

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.21 Serine endopeptidases

                3.4.21.39 chymase

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Results	in table
8	Activating Compound
15	AA Sequence
14	Application
1	CAS Registry Number
18	Cloned(Commentary)
4	Crystallization (Commentary)
2692	Disease/ Diagnostics
11	Expression
26	General Information
1	General Stability
127	IC50 Value
396	Inhibitors
16	kcat/KM [mM/s]
98	Ki Value [mM]
107	KM Value [mM]
13	Localization
32	Molecular Weight [Da]
87	Natural Substrates/ Products (Substrates)
149	Organism
22	PDB ID
8	pH Optimum
2	pH Range
3	pH Stability
11	Posttranslational Modification
10	Protein Variants
30	Purification (Commentary)
1	Reaction
1	Reaction Type
148	Reference
150	Source Tissue
5	Specific Activity [micromol/min/mg]
1	Storage Stability
342	Substrates and Products (Substrate)
23	Subunits
133	Synonyms
3	Temperature Optimum [°C]
3	Temperature Stability [°C]
107	Turnover Number [1/s]

Expression

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Expression on EC 3.4.21.39 - chymase

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EXPRESSION

ORGANISM

UNIPROT

LITERATURE

chronic angiotensin I-converting enzyme inhibition causes a marked bradykinin/B2 receptor-mediated increase in left ventricle interstitial fluid chymase activity

Mus musculus

-

709272

chymase activity is increased in ophthalmic lavage fluid immediately after the pollen challenge

Cavia porcellus

A7WPL7

731764

chymase is increased in AAA lesions, and in blood from AAA patients

Homo sapiens

P23946

732957

enzyme expression is increased in synovial tissue of collagen-induced-arthritis rats

Rattus norvegicus

-

752688

gene expression and activity of mast cell chymase in keloid are significantly higher than those in normal skin

Homo sapiens

-

731944

in liver and kidneys of G3 rats there is a larger amount of chymase than in normal rats

Rattus norvegicus

-

755130

levels of gene expression of myocardial chymase in Astragalus polysaccharide-treated diabetic hamsters are significantly lower than those in normal saline-treated diabetic hamsters

Mesocricetus auratus

-

709290

mast cells release the enzyme upon GBS exposure

Mus musculus

-

753962

the enzyme expression is increased after treatment with transforming growth factor-beta1

Homo sapiens

-

755130

the expression of isoform MCP-5 increases during tumor progression

Mus musculus

P21812

732700

there is a significant increase in the nasal lavage chymase levels in the allergen-challenged individuals as compared with placebo-exposed individuals

Homo sapiens

-

708180