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Literature summary for 3.4.21.39 extracted from

  • Tchougounova, E.; Lundequist, A.; Fajardo, I.; Winberg, J.O.; Abrink, M.; Pejler, G.
    A key role for mast cell chymase in the activation of pro-matrix metalloprotease-9 and pro-matrix metalloprotease-2 (2005), J. Biol. Chem., 280, 9291-9296.
    View publication on PubMed
Search for more literature for 3.4.21.39

Protein Variants

Protein Variants Comment Organism
additional information enzyme deficient animal, lack in processing of pro-matrix metalloprotease 9 to its active form and marked defect in processing of pro-matrix metalloprotease 2. Mutant animals show an increase in collagen in the ear tissue accompanied by increased ear thickness and a higher content in hydroxyproline. Lung and ear tissue of mutant animals show increased staining for fibronectin Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
pro-matrix metalloprotease 2 + H2O Mus musculus
-
 matrix metalloprotease 2 + propeptide
-
 ?
pro-matrix metalloprotease 9 + H2O Mus musculus
-
 matrix metalloprotease 9 + propeptide
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
pro-matrix metalloprotease 2 + H2O
-
 Mus musculus matrix metalloprotease 2 + propeptide
-
 ?
pro-matrix metalloprotease 9 + H2O
-
 Mus musculus matrix metalloprotease 9 + propeptide
-
 ?

Synonyms

Synonyms Comment Organism
mast cell protease 4
-
 Mus musculus