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Literature summary for 3.4.21.39 extracted from

  • Muilenburg, D.J.; Raymond, W.W.; Wolters, P.J.; Caughey, G.H.
    Lys40 but not Arg143 influences selectivity of angiotensin conversion by human alpha-chymase (2002), Biochim. Biophys. Acta, 1596, 346-356.
    View publication on PubMed
Search for more literature for 3.4.21.39

Protein Variants

Protein Variants Comment Organism
L40A mutant enzyme retains strong preference for Phe8 with angiotensin I substrate but with Tyr4 hydrolytic rates enhance 16fold compared to wild-type enzyme Homo sapiens
R143Q mutant enzyme remains highly Phe8-selective with angiotensin I substrate Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
angiotensin I + H2O Homo sapiens selective hydrolysis at Phe8 to generate bioactive angiotensin II, which can promote cardiac hypertrophy, vascular stenosis, and hypertension angiotensin II + His-Leu
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
angiotensin I + H2O selective hydrolysis at Phe8 to generate bioactive angiotensin II, which can promote cardiac hypertrophy, vascular stenosis, and hypertension Homo sapiens angiotensin II + His-Leu
-
 ?
angiotensin I + H2O the enzyme cleaves Tyr4 and Phe8 at rates of 5.47 and 17800 nM/min. Selective hydrolysis at Phe8 to generate bioactive angiotensin II. Lys40 of chymase contributes to the remarkable preference for angiotensin II generation over destruction Homo sapiens angiotensin II + His-Leu
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 ?

Synonyms

Synonyms Comment Organism
alpha-chymase
-
 Homo sapiens