3.1.6.8: cerebroside-sulfatase
This is an abbreviated version!
For detailed information about cerebroside-sulfatase, go to the full flat file.
Word Map on EC 3.1.6.8
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3.1.6.8
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metachromatic
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leukodystrophy
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sulfatide
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medicine
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lysosomal
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asa
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demyelinate
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sural
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pseudodeficiency
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nitrocatechol
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sulfatases
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molecular biology
- 3.1.6.8
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metachromatic
- leukodystrophy
- sulfatide
- medicine
- lysosomal
- asa
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demyelinate
-
sural
-
pseudodeficiency
- nitrocatechol
-
sulfatases
- molecular biology
Reaction
Synonyms
ARS, ARSA, arylsulfatase A, arylsulfatase E, arylsulfatase-A, AS-A, ASA, cerebroside sulfatase, cerebroside sulfate sulfatase, Cerebroside-sulfatase, sulfatase, cerebroside
ECTree
3.1.6.8 cerebroside-sulfataseAdvanced search results
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results (Inhibitors
Inhibitors on EC 3.1.6.8 - cerebroside-sulfatase
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INHIBITOR 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
AgNO3
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50% decreased activity in milt plasma with 60 nM AgNO3 and 50% decreased activity in spermatozoon with 4 nM AgNO3
anti-AS-A IgG
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dispersion of cumulus layers of cumulus oocyte complexes does not occurr in co-incubates with anti-AS-A IgG treated sperm and in the presence of apigenin
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ethanol
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decreases ASA activity levels in the liver, but not in the cerebral cortex and kidney
H2SO4
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50% decreased activity in milt plasma with 25 mM H2SO4 and 26% decreased activity in spermatozoon with 25 mM H2SO4
H3PO4
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56% decreased activity in milt plasma with 1 mM H3PO4 and 43% decreased activity in spermatozoon with 1 mM H2SO4
Na+
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enzymatic activity is inhibited at NaCl concentrations exceeding 20 mM, at 50 and 200 mM the rate of sulfatide hydrolysis is diminished by about 50 and 75%, respectively
cerebroside sulfate
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competitive to 1-O-acyl-2-O-alkyl3-O-(beta-D-galactopyranoside-3'-sulfate)glycerol
additional information
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the lysosomal degradation of endocytosed enzymes strongly inhibited in CLN6 defective cells
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additional information
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estrogens do not significantly change ASA activity in epithelial, HCC1937, or MCF10A cells. Estrone 3-sulfate and estradiol sulfate do not significantly decline ASA in myoepithelial, MCF7, and T47D cells
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additional information
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secretion and stability of wtASA is decreased by the coexpression of defective P377L-pdASA
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additional information
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dispersion of cumulus layers of cumulus oocyte complexes still occur in co-incubates with preimmune IgG treated sperm
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additional information
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cumulus oocyte complex dispersion caused by AS-A is the same in the presence or absence of apigenin
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