3.1.6.8: cerebroside-sulfatase

This is an abbreviated version!
For detailed information about cerebroside-sulfatase, go to the full flat file.

Word Map on EC 3.1.6.8

Reaction

a cerebroside 3-sulfate
+
H2O
=
a cerebroside
+
sulfate

Synonyms

ARS, arylsulfatase A, sulfatase, cerebroside, cerebroside sulfatase, cerebroside sulfate sulfatase, arylsulfatase E, ASA, Cerebroside-sulfatase, ARSA, AS-A, arylsulfatase-A

ECTree

     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.6 Sulfuric-ester hydrolases
                3.1.6.8 cerebroside-sulfatase

Inhibitors

Inhibitors on EC 3.1.6.8 - cerebroside-sulfatase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
4-methylumbelliferyl phosphate
AgNO3
-
50% decreased activity in milt plasma with 60 nM AgNO3 and 50% decreased activity in spermatozoon with 4 nM AgNO3
anti-AS-A IgG
-
dispersion of cumulus layers of cumulus oocyte complexes does not occurr in co-incubates with anti-AS-A IgG treated sperm and in the presence of apigenin
-
ascorbate
barium acetate
-
-
Cd2+
-
-
ceramide
-
inhibition or activation depends on substrate
cerebroside
-
inhibition or activation depends on substrate
Cerebroside 6-sulfate
-
-
cerebroside sulfate
estradiol
-
significantly declines ASA in myoepithelial, MCF7, and T47D cells
estrone
-
significant declines ASA in myoepithelial, MCF7, and T47D cells
ethanol
-
decreases ASA activity levels in the liver, but not in the cerebral cortex and kidney
Galactose 3-sulfate
-
-
Galactose 6-sulfate
-
-
H2SO4
-
50% decreased activity in milt plasma with 25 mM H2SO4 and 26% decreased activity in spermatozoon with 25 mM H2SO4
H3PO4
-
56% decreased activity in milt plasma with 1 mM H3PO4 and 43% decreased activity in spermatozoon with 1 mM H2SO4
Hg2+
-
-
hydrazine
hydroxylamine
K2HPO4
K2SO4
-
-
N-ethylmaleimide
-
no inhibition at pH 5.5, but at pH 5.0
Na+
-
enzymatic activity is inhibited at NaCl concentrations exceeding 20 mM, at 50 and 200 mM the rate of sulfatide hydrolysis is diminished by about 50 and 75%, respectively
Na2SO4
nitrocatechol sulfate
p-hydroxymercuribenzoate
phophatidylinositol
-
inhibition or activation depends on substrate
phosphate
-
competitive inhibitor
phosphatidylcholine
-
inhibition or activation depends on substrate
PO43-
psychosine
-
inhibition or activation is substrate-dependent
Semicarbazide
-
-
Sn2+
-
-
SO32-
sphingomyelin
-
inhibition or activation depends on substrate
sulfite
-
competitive inhibitor
thiol reagents
-
-
additional information
-