3.1.6.8: cerebroside-sulfatase
This is an abbreviated version!
For detailed information about cerebroside-sulfatase, go to the full flat file.
Word Map on EC 3.1.6.8
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3.1.6.8
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metachromatic
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leukodystrophy
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sulfatide
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medicine
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lysosomal
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asa
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demyelinate
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sural
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pseudodeficiency
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nitrocatechol
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sulfatases
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molecular biology
- 3.1.6.8
-
metachromatic
- leukodystrophy
- sulfatide
- medicine
- lysosomal
- asa
-
demyelinate
-
sural
-
pseudodeficiency
- nitrocatechol
-
sulfatases
- molecular biology
Reaction
Synonyms
ARS, ARSA, arylsulfatase A, arylsulfatase E, arylsulfatase-A, AS-A, ASA, cerebroside sulfatase, cerebroside sulfate sulfatase, Cerebroside-sulfatase, sulfatase, cerebroside
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Source Tissue
Source Tissue on EC 3.1.6.8 - cerebroside-sulfatase
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immunocytochemistry of the epididymis reveals the enzyme in narrow and apical cells in the initial segment and in clear cells in all epididymal region
additional information
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the polypeptide complexes, rather than the monomers, are subject to endoplasmic reticulum quality control and, within a heteromer, the misfolded subunit exerts a dominant negative effect on the wild-type subunit
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the mean leukocyte enzyme activity in patients with benign breast disease is slightly higher than that (14.3%) that observed in the healthy subjects. In patients with primary breast cancer the enzyme activity is significantly higher than in healthy subjects
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human fibroblasts grown in the presence of lead acetate exhibit a 65% decrease in enzyme protein
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the acquisition of enzyme on the sperm surface occurs during epididymal transit
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localized on the sperm surface, in the acrosome and postacrosomal regions
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oral cavity treatment with 7,12-dimethylbenzanthracene increases activity significantly in both sexes. Administration of 7,12-dimethylbenzanthracene plus beta-carotene decreases activity remarkably in female hamsters
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oral cavity treatment with 7,12-dimethylbenzanthrracene increases activity significantly in both sexes. Administration of 7,12-dimethylbenzanthracene plus beta-carotene decreases activity slightly