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Literature summary for 3.1.6.8 extracted from
- Sperm surface arylsulfatase A can disperse the cumulus matrix of cumulus oocyte complexes (2007), J. Cell. Physiol., 213, 201-211.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | availability of AS-A on the sperm surface is important for the dispersion of cumulus layers of cumulus oocyte complexes | Mus musculus |
| medicine | availability of AS-A on the sperm surface is important for the dispersion of cumulus layers of cumulus oocyte complexes | Sus scrofa |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | sperm from AS-A null mice show a significant delay in cumulus oocyte complex dispersion, compared with wild-type sperm | Mus musculus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| anti-AS-A IgG | dispersion of cumulus layers of cumulus oocyte complexes does not occurr in co-incubates with anti-AS-A IgG treated sperm and in the presence of apigenin | Mus musculus | |
| additional information | dispersion of cumulus layers of cumulus oocyte complexes still occur in co-incubates with preimmune IgG treated sperm | Mus musculus | |
| additional information | cumulus oocyte complex dispersion caused by AS-A is the same in the presence or absence of apigenin | Sus scrofa |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 66000 | - |
1 * 66000, SDS-PAGE | Sus scrofa |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
| Sus scrofa | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| by gel filtration | Sus scrofa |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| sperm | - |
Mus musculus | - |
| sperm | - |
Sus scrofa | - |
| testis | - |
Mus musculus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 5 | - |
degraded enzyme | Sus scrofa |
| 24 | - |
66 kDa form | Sus scrofa |
| 60 | - |
purified enzyme, 66 kDa form | Sus scrofa |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| chondroitin sulfate B + H2O | - |
Sus scrofa | sulfate | - |
? |  |
| hyaluronan + H2O | - |
Sus scrofa | ? | - |
? | |
| additional information | is able to disperse cumulus layers of cumulus oocyte complexes. Chondroitin sulfate A, chondroitin sulfate C, ovalbumin and heparan sulfate do not show interaction with AS-A | Sus scrofa | ? | - |
? | |
| p-nitrocatechol sulfate + H2O | - |
Sus scrofa | p-nitrocatechol + sulfate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| monomer | 1 * 66000, SDS-PAGE | Sus scrofa |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| arylsulfatase A | - |
Mus musculus |
| arylsulfatase A | - |
Sus scrofa |
| AS-A | - |
Mus musculus |
| AS-A | - |
Sus scrofa |
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Release 2023.1 (January 2023)
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