3.1.6.8: cerebroside-sulfatase
This is an abbreviated version!
For detailed information about cerebroside-sulfatase, go to the full flat file.
Word Map on EC 3.1.6.8
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3.1.6.8
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metachromatic
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leukodystrophy
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sulfatide
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medicine
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lysosomal
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asa
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demyelinate
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sural
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pseudodeficiency
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nitrocatechol
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sulfatases
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molecular biology
- 3.1.6.8
-
metachromatic
- leukodystrophy
- sulfatide
- medicine
- lysosomal
- asa
-
demyelinate
-
sural
-
pseudodeficiency
- nitrocatechol
-
sulfatases
- molecular biology
Reaction
Synonyms
ARS, ARSA, arylsulfatase A, arylsulfatase E, arylsulfatase-A, AS-A, ASA, cerebroside sulfatase, cerebroside sulfate sulfatase, Cerebroside-sulfatase, sulfatase, cerebroside
ECTree
3.1.6.8 cerebroside-sulfataseAdvanced search results
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results (Substrates Products
Substrates Products on EC 3.1.6.8 - cerebroside-sulfatase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
1-O-alkyl-2-O-acyl-3-(beta-3'-sulfogalactosyl)glycerol + H2O
1-O-alkyl-2-O-acyl-3-O-(beta-galactosyl)glycerol + sulfate
1-O-alkyl-2-O-acyl-3-O-(beta-D-galactopyranoside-3'-sulfate)-glycerol + H2O
1-O-alkyl-2-O-acyl-3-O-beta-D-galactopyranoside-glycerol + sulfate
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-
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?
1-O-hexadecyl-2-O-hexadecanoyl-3-O-(beta-3'-sulfogalactosyl)glycerol + H2O
1-O-hexadecyl-2-O-hexadecanoyl-3-O-(beta-galactosyl)glycerol + sulfate
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-
-
-
?
5,6,7,8-tetrahydro-2-naphthyl sulfate + H2O
5,6,7,8-tetrahydro-2-naphthol + sulfate
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-
-
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?
cerebroside 3-sulphate + H2O
cerebroside + sulfate
the enzyme catalyzes the first step in the degradation of the glycolipid cerebroside sulfate
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?
dehydroisoandrosterone sulfate + H2O
dehydroisoandrosterone + sulfate
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-
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?
galactose(3-sulfate)beta1-1'(N-2-hydroxy-acyl)sphingosine + H2O
galactose beta1-1'(N-2-hydroxy-acyl)sphingosine + sulfate
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-
-
-
?
lysoseminolipid sulfate + H2O
lysoseminolipid + sulfate
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deacylated seminolipid
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-
?
N-acyl-1-O-(beta-3-sulfogalactosyl)sphingosine + H2O
(N-acyl-1-O-galactosyl) sphingosine + sulfate
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sulfosphingolipids
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-
?
N-lissamine rhodaminyl-(12-aminododecanoyl)cerebroside 3-sulfate + H2O
?
-
-
-
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?
1-O-alkyl-2-O-acyl-3-(beta-3'-sulfogalactosyl)glycerol + H2O
1-O-alkyl-2-O-acyl-3-O-(beta-galactosyl)glycerol + sulfate
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-
-
-
?
1-O-alkyl-2-O-acyl-3-(beta-3'-sulfogalactosyl)glycerol + H2O
1-O-alkyl-2-O-acyl-3-O-(beta-galactosyl)glycerol + sulfate
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seminolipid, sulfoglycerolipids
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-
?
2-hydroxy-5-nitrophenyl sulfate + H2O
2-hydroxy-5-nitrophenol + sulfate
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-
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?
4-nitrocatechol sulfate + H2O
4-nitrocatechol + sulfate
artificial substrate, Cys69 is the catalytic residue, and Lys302 and Lys123 act as residues anchoring the sulfate group to the active site, interaction with the enzyme active site, overview
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-
?
4-nitrocatechol sulfate + H2O
4-nitrocatechol + sulfate
artificial substrate, Cys69 is the catalytic residue, and Lys302 and Lys123 act as residues anchoring the sulfate group to the active site, interaction with the enzyme active site, overview
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-
?
cerebroside 3-sulfate + H2O
cerebroside + sulfate
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-
-
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?
cerebroside 3-sulfate + H2O
cerebroside + sulfate
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135666, 135667, 135668, 135669, 135670, 135671, 135672, 135676, 135677, 135678, 135681, 135686, 135687, 135691, 135695, 649125
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-
?
cerebroside 3-sulfate + H2O
cerebroside + sulfate
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galactosyl ceramid
?
cerebroside 3-sulfate + H2O
cerebroside + sulfate
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galactosyl ceramide
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?
cerebroside 3-sulfate + H2O
cerebroside + sulfate
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activity depends on ionic strength
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-
?
cerebroside 3-sulfate + H2O
cerebroside + sulfate
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no requirement for activators when acting on cerebroside sulfate
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-
?
cerebroside 3-sulfate + H2O
cerebroside + sulfate
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3-O-sulfogalactosyl ceramide
galactosyl ceramide
?
cerebroside 3-sulfate + H2O
cerebroside + sulfate
the enzyme catalyzes the first step in the degradation of the glycolipid cerebroside sulfate. Accumulation of cerebroside sulfate is responsible for metachromatic leukodystrophy, a severe autosomal recessive inherited disorder. Good correlation between the type of mutation, deficient arylsulfatase A activity and disease severity is recognized
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-
?
cerebroside 3-sulfate + H2O
cerebroside + sulfate
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the reaction requires saposin B, a non-enzymatic proteinaceous cofactor which presents sulfatide to the catalytic site of arylsulfatase A, desulfation is negligible when Sap B is substituted by Sap A, C, or D
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-
?
cerebroside 3-sulfate + H2O
cerebroside + sulfate
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-
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?
cerebroside 3-sulfate + H2O
cerebroside + sulfate
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-
-
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?
methylumbelliferyl sulfate + H2O
methylumbelliferone + sulfate
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-
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?
methylumbelliferyl sulfate + H2O
methylumbelliferone + sulfate
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-
-
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?
nitrocatechol sulfate + H2O
nitrocatechol + sulfate
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-
-
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?
nitrocatechol sulfate + H2O
nitrocatechol + sulfate
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-
-
-
?
nitrocatechol sulfate + H2O
nitrocatechol + sulfate
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-
-
-
?
nitrocatechol sulfate + H2O
nitrocatechol + sulfate
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-
-
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?
p-nitrocatechol sulfate + H2O
p-nitrocatechol + sulfate
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-
-
-
?
sulfogalactosylceramide + H2O
?
Cys69 is the catalytic residue, and Lys302 and Lys123 act as residues anchoring the sulfate group to the active site, interaction with the enzyme active site, overview
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-
?
sulfogalactosylceramide + H2O
?
Cys69 is the catalytic residue, and Lys302 and Lys123 act as residues anchoring the sulfate group to the active site, interaction with the enzyme active site, overview
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-
?
sulfogalactosylglycerolipid + H2O
?
Cys69 is the catalytic residue, and Lys302 and Lys123 act as residues anchoring the sulfate group to the active site, interaction with the enzyme active site, overview
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-
?
sulfogalactosylglycerolipid + H2O
?
Cys69 is the catalytic residue, and Lys302 and Lys123 act as residues anchoring the sulfate group to the active site, interaction with the enzyme active site, overview
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-
?
additional information
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metachromatic leukodystrophy is a lysosomal storage disorder caused by the deficiency of enzyme
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?
additional information
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substrate binding and docking study, using crystal structures, PDB IDs 1N2K and 1E2S, overview
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?
additional information
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recombinant mouse ArsA tightly binds to sulfated polysaccharides
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?
additional information
?
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AS-A has mannose, N-acetylglucosamine and/or sialic acid residues as part of its glycosilation
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?
additional information
?
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is able to disperse cumulus layers of cumulus oocyte complexes. Chondroitin sulfate A, chondroitin sulfate C, ovalbumin and heparan sulfate do not show interaction with AS-A
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?
additional information
?
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substrate binding and docking study, using human crystal structures, PDB IDs 1N2K and 1E2S, overview
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?
