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Literature summary for 3.1.6.8 extracted from
- Steroid sulfatase, arylsulfatases A and B, galactose-6-sulfatase, and iduronate sulfatase in mammary cells and effects of sulfated and non-sulfated estrogens on sulfatase activity (2007), J. Steroid Biochem. Mol. Biol., 103, 20-34.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| estradiol | significantly declines ASA in myoepithelial, MCF7, and T47D cells | Homo sapiens |  |
| estrone | significant declines ASA in myoepithelial, MCF7, and T47D cells | Homo sapiens | |
| additional information | estrogens do not significantly change ASA activity in epithelial, HCC1937, or MCF10A cells. Estrone 3-sulfate and estradiol sulfate do not significantly decline ASA in myoepithelial, MCF7, and T47D cells | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| epithelial cell | highest activity of ASA | Homo sapiens | - |
| HCC-1937 cell | - |
Homo sapiens | - |
| MCF-10A cell | lowest activity of ASA | Homo sapiens | - |
| MCF-7 cell | - |
Homo sapiens | - |
| myoepithelial cell | - |
Homo sapiens | - |
| T-47D cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| p-nitrocatechol sulfate + H2O | - |
Homo sapiens | p-nitrocatechol + sulfate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| arylsulfatase A | - |
Homo sapiens |
| ASA | - |
Homo sapiens |
| cerebroside sulfatase | - |
Homo sapiens |
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