3.1.6.8: cerebroside-sulfatase
This is an abbreviated version!
For detailed information about cerebroside-sulfatase, go to the full flat file.
Word Map on EC 3.1.6.8
-
3.1.6.8
-
metachromatic
-
leukodystrophy
-
sulfatide
-
medicine
-
lysosomal
-
asa
-
demyelinate
-
sural
-
pseudodeficiency
-
nitrocatechol
-
sulfatases
-
molecular biology
- 3.1.6.8
-
metachromatic
- leukodystrophy
- sulfatide
- medicine
- lysosomal
- asa
-
demyelinate
-
sural
-
pseudodeficiency
- nitrocatechol
-
sulfatases
- molecular biology
Reaction
Synonyms
ARS, ARSA, arylsulfatase A, arylsulfatase E, arylsulfatase-A, AS-A, ASA, cerebroside sulfatase, cerebroside sulfate sulfatase, Cerebroside-sulfatase, sulfatase, cerebroside
ECTree
Advanced search results
Subunits
Subunits on EC 3.1.6.8 - cerebroside-sulfatase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
dimer
monomer
octamer
oligomer
tetramer
additional information
monomer
-
1 * 140000, each monomer consists of 2 equivalent polypeptide chains
octamer
-
ar pH 5.0-5.4, the enzyme exists in solution as a dimer or as an octamer
tetramer
-
aggregation to tetramer at higher concentrations around pH 5, 2 * 49000, 2 * 55000
The dimer-octamer equilibrium is regulated by the pH and may be explained by a switch function of Glu424. Glu424 in the conformation suitable for the intramolecular hydrogen bonds to Gln460. Glu424 in the conformation suitable for the intermolecular hydrogen bonds to Phe398
additional information
-
mature lysosomal arylsulfatase A forms dimers at neutral pH, while in the early biosynthetic pathway, arylsulfatase A forms oligomers with more than two subunits. Within a heteromer, the misfolded subunit exerts a dominant negative effect on the wild-type subunit
additional information
the polypeptide complexes, rather than the monomers, are subject to endoplasmic reticulum quality control and, within a heteromer, the misfolded subunit exerts a dominant negative effect on the wild-type subunit