3.1.3.46: fructose-2,6-bisphosphate 2-phosphatase
This is an abbreviated version!
For detailed information about fructose-2,6-bisphosphate 2-phosphatase, go to the full flat file.
Word Map on EC 3.1.3.46
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3.1.3.46
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fructose-1,6-bisphosphatase
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gluconeogenesis
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gluconeogenic
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amp
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6-phosphate
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1,6-bisphosphatase
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tp53-induced
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phosphoenolpyruvate
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isozyme
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chloroplast
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endothelial
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glycogen
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pentose
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6-phosphofructo-1-kinase
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hepatocytes
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carboxykinase
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fructose-6-phosphate
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hypoxia-inducible
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glucokinase
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camp-dependent
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warburg
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pepck
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3.1.3.11
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glucose-induced
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g6pase
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spinach
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hk2
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fructose-1
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hypoglycemia
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glucose-6-phosphatase
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hexokinase
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fru-6-p
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glycogenolysis
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calvin
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p53-inducible
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anaphase-promoting
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phosphofructokinase-1
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phosphoenzyme
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fructose-6-p
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molecular biology
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medicine
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pharmacology
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agriculture
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pentose-phosphate
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z-line
- 3.1.3.46
- fructose-1,6-bisphosphatase
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gluconeogenesis
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gluconeogenic
- amp
- 6-phosphate
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1,6-bisphosphatase
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tp53-induced
- phosphoenolpyruvate
- isozyme
- chloroplast
- endothelial
- glycogen
- pentose
- 6-phosphofructo-1-kinase
- hepatocytes
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carboxykinase
- fructose-6-phosphate
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hypoxia-inducible
- glucokinase
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camp-dependent
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warburg
- pepck
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3.1.3.11
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glucose-induced
- g6pase
- spinach
- hk2
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fructose-1
- hypoglycemia
- glucose-6-phosphatase
- hexokinase
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fru-6-p
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glycogenolysis
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calvin
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p53-inducible
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anaphase-promoting
- phosphofructokinase-1
- phosphoenzyme
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fructose-6-p
- molecular biology
- medicine
- pharmacology
- agriculture
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pentose-phosphate
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z-line
Reaction
Synonyms
6-phosphofructo-2-kinase/2,6-bisphosphatase 3, 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase, 6-phosphofructo-2-kinase/fructose-2 6-biphosphatase, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphase, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (gene PFKFB3), 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-4, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphate, 6PF2K/Fru-2,6-P2ase, D-fructose-2,6-bisphosphatase, F-2,6-P2, F26BPase, F2KP, FBPase, FBPase-2, fructose-2,6-bisphosphatase, fructose-2,6-diphosphatase, heart 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, Lm1, More, OsF2KP1, OsF2KP2, Pfk-2, PFK-2/FBPase, PFK-2/FBPase-2, PFK-2/FDPase-2, PFK-2/Fru-2,6-P2, PFK2, PFK2/FBPase2, Pfk26, Pfk27, PFKFB, PFKFB-3, PFKFB-4, PFKFB1, PFKFB2, PFKFB3, PFKFB4, phosphatase, fructose 2,6-di-, RH2K, TIGAR
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Application on EC 3.1.3.46 - fructose-2,6-bisphosphate 2-phosphatase
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APPLICATION 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
agriculture
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FK2P in rice is encoded by two genes OsF2KP1 and OsF2KP2, both are involved in the regulation of primary carbon metabolism in rice leaves during the light period
medicine
molecular biology
pharmacology
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a pharmacophore map is generated and validated to identify inhibitors of the F6PFBPase complex
medicine
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overexpression of enzyme results in increase of glucokinase activity, interaction of enzyme with glucokinase at concentrations of glucose physiologically relevant for glucokinase activation, possible site for intervention in type 2 diabetes treatment
medicine
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PFKFB3 is constitutively expressed in human leukemias and solid tumor cells, inhibitors could act as antineoplastic agents
medicine
pharmacological disruption of the PFKFB4 kinase domain may have clinical utility for the treatment of human cancers
medicine
in colonic and bladder cancer cells, additive growth inhibitory effects are seen with phenformin and with an inhibitor of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3. The increased acidification of the culture medium and glucose uptake caused by phenformin is blocked by combined treatment with PFKFB3 inhibitors
medicine
tumor suppressor p53 regulates the expression of PFKFB4 and p53-deficient cancer cells are highly dependent on the function of the enzyme. Depletion of PFKFB4 from p53-deficient cancer cells increases levels of the allosteric regulator fructose-2,6-bisphosphate, leading to increased glycolytic activity but decreased routing of metabolites through the oxidative arm of the pentose-phosphate pathway. PFKFB4 is also required to support the synthesis and regeneration of nicotinamide adenine dinucleotide phosphate (NADPH) in p53-deficient cancer cells. Depletion of PFKFB4-attenuated cellular biosynthetic activity and results in the accumulation of reactive oxygen species and cell death in the absence of p53. Silencing of PFKFB4-induces apoptosis in p53-deficient cancer cells in vivo and interferes with tumor growth
molecular biology
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overexpression alone has negligible effects on insulin secretion, only in combination with 6-phosphofructo-2-kinase, partial down-regulation of endogenous PFKFB2 and PFKFB3 in INS1 cells by siRNA decreased PFK-2/FBPase-2 protein, fructose 2,6-bisphosphate content, glucokinase activity and glucose-induced insulin secretion
molecular biology
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overexpression alone has negligible effects on insulin secretion, only in combination with 6-phosphofructo-2-kinase, partial down-regulation of endogenous PFKFB2 and PFKFB3 in INS1 cells by siRNA decreased PFK-2/FBPase-2 protein, fructose 2,6-bisphosphate content, glucokinase activity and glucose-induced insulin secretion
molecular biology
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overexpression alone has negligible effects on insulin secretion, only in combination with 6-phosphofructo-2-kinase, partial down-regulation of endogenous PFKFB2 and PFKFB3 in INS1 cells by siRNA decreased PFK-2/FBPase-2 protein, fructose 2,6-bisphosphate content, glucokinase activity and glucose-induced insulin secretion
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molecular biology
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overexpression alone has negligible effects on insulin secretion, only in combination with 6-phosphofructo-2-kinase, partial down-regulation of endogenous PFKFB2 and PFKFB3 in INS1 cells by siRNA decreased PFK-2/FBPase-2 protein, fructose 2,6-bisphosphate content, glucokinase activity and glucose-induced insulin secretion
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