3.1.3.46: fructose-2,6-bisphosphate 2-phosphatase

This is an abbreviated version!
For detailed information about fructose-2,6-bisphosphate 2-phosphatase, go to the full flat file.

Reaction

Synonyms

6-phosphofructo-2-kinase/2,6-bisphosphatase 3, 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase, 6-phosphofructo-2-kinase/fructose-2 6-biphosphatase, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphase, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (gene PFKFB3), 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-4, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphate, 6PF2K/Fru-2,6-P2ase, D-fructose-2,6-bisphosphatase, F-2,6-P2, F26BPase, F2KP, FBPase, FBPase-2, fructose-2,6-bisphosphatase, fructose-2,6-diphosphatase, heart 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, Lm1, More, OsF2KP1, OsF2KP2, Pfk-2, PFK-2/FBPase, PFK-2/FBPase-2, PFK-2/FDPase-2, PFK-2/Fru-2,6-P2, PFK2, PFK2/FBPase2, Pfk26, Pfk27, PFKFB, PFKFB-3, PFKFB-4, PFKFB1, PFKFB2, PFKFB3, PFKFB4, phosphatase, fructose 2,6-di-, RH2K, TIGAR

ECTree

     3 Hydrolases

         3.1 Acting on ester bonds

             3.1.3 Phosphoric-monoester hydrolases

                3.1.3.46 fructose-2,6-bisphosphate 2-phosphatase

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Results	in table
57	Activating Compound
212	AA Sequence
13	Application
1	CAS Registry Number
43	Cloned(Commentary)
10	Crystallization (Commentary)
2102	Disease/ Diagnostics
5	Expression
14	General Information
22	IC50 Value
111	Inhibitors
7	Ki Value [mM]
29	KM Value [mM]
7	Localization
5	Metals/Ions
29	Molecular Weight [Da]
96	Natural Substrates/ Products (Substrates)
299	Organism
3	Pathway
41	PDB ID
12	pH Optimum
1	pH Range
1	pI Value
12	Posttranslational Modification
22	Protein Variants
21	Purification (Commentary)
55	Reaction
15	Reaction Type
123	Reference
205	Source Tissue
7	Specific Activity [micromol/min/mg]
7	Storage Stability
163	Substrates and Products (Substrate)
51	Subunits
240	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
1	Temperature Stability [°C]
2	Turnover Number [1/s]

IC50 Value

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IC50 Value on EC 3.1.3.46 - fructose-2,6-bisphosphate 2-phosphatase

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IC50 VALUE [mM]

INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

1

2-((5-bromo-6-oxo-1-phenyl-1,6-dihydropyridazin-4-yl)amino)acetamide

Homo sapiens

-

IC50 above 1.0 mM, in 40 mM Tris pH 7.5, 20 mM MgCl2, 0.1 mg/ml bovine serum albumin, at 30°C

729389

0.5

2-(5-bromo-6-oxo-1-phenyl-1,6-dihydropyridazin-4-yl)-1,2,3,4-tetrahydroisoquinoline-5-carbonitrile

Homo sapiens

-

IC50 above 0.5 mM,in 40 mM Tris pH 7.5, 20 mM MgCl2, 0.1 mg/ml bovine serum albumin, at 30°C

729389

0.026

3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one

Homo sapiens

-

in 40 mM Tris pH 7.5, 20 mM MgCl2, 0.1 mg/ml bovine serum albumin, at 30°C

729389

0.0084

4-(4-(4-acetyl-5-methyl-1H-1,2,3-triazol-1-yl)-5-bromo-6-oxopyridazin-1(6H)-yl)benzonitrile

Homo sapiens

-

in 40 mM Tris pH 7.5, 20 mM MgCl2, 0.1 mg/ml bovine serum albumin, at 30°C

729389

1

4-bromo-2-phenyl-5-(((tetrahydrofuran-2-yl)methyl)amino)pyridazin-3(2H)-one

Homo sapiens

-

IC50 above 1.0 mM, in 40 mM Tris pH 7.5, 20 mM MgCl2, 0.1 mg/ml bovine serum albumin, at 30°C

729389

1

4-bromo-2-phenyl-5-(2-oxa-6-azaspiro[3.3]heptan-6-yl)pyridazin-3(2H)-one

Homo sapiens

-

IC50 above 1.0 mM, in 40 mM Tris pH 7.5, 20 mM MgCl2, 0.1 mg/ml bovine serum albumin, at 30°C

729389

1

4-bromo-5-morpholino-2-phenylpyridazin-3(2H)-one

Homo sapiens

-

IC50 above 1.0 mM,in 40 mM Tris pH 7.5, 20 mM MgCl2, 0.1 mg/ml bovine serum albumin, at 30°C

729389

0.0034

5-(4-acetyl-5-methyl-1H-1,2,3-triazol-1-yl)-2-benzyl-4-bromopyridazin-3(2H)-one

Homo sapiens

-

in 40 mM Tris pH 7.5, 20 mM MgCl2, 0.1 mg/ml bovine serum albumin, at 30°C

729389

10

5-(4-acetyl-5-methyl-1H-1,2,3-triazol-1-yl)-2-benzylpyridazin-3(2H)-one

Homo sapiens

-

IC50 above 10 mM, in 40 mM Tris pH 7.5, 20 mM MgCl2, 0.1 mg/ml bovine serum albumin, at 30°C

729389

0.011

5-(4-acetyl-5-methyl-1H-1,2,3-triazol-1-yl)-4-bromo-2-(3-phenylpropyl)pyridazin-3(2H)-one

Homo sapiens

-

in 40 mM Tris pH 7.5, 20 mM MgCl2, 0.1 mg/ml bovine serum albumin, at 30°C

729389

0.5

5-(4-acetyl-5-methyl-1H-1,2,3-triazol-1-yl)-4-bromo-2-(4-((2-(dimethylamino)ethyl)-amino)benzyl)pyridazin-3(2H)-one

Homo sapiens

-

IC50 above 0.5 mM, in 40 mM Tris pH 7.5, 20 mM MgCl2, 0.1 mg/ml bovine serum albumin, at 30°C

729389

0.0091

5-(4-acetyl-5-methyl-1H-1,2,3-triazol-1-yl)-4-bromo-2-(4-(trifluoromethoxy)phenyl)-pyridazin-3(2H)-one

Homo sapiens

-

in 40 mM Tris pH 7.5, 20 mM MgCl2, 0.1 mg/ml bovine serum albumin, at 30°C

729389

0.007

5-(4-acetyl-5-methyl-1H-1,2,3-triazol-1-yl)-4-bromo-2-(4-chlorophenyl)pyridazin-3(2H)-one

Homo sapiens

-

in 40 mM Tris pH 7.5, 20 mM MgCl2, 0.1 mg/ml bovine serum albumin, at 30°C

729389

0.0087

5-(4-acetyl-5-methyl-1H-1,2,3-triazol-1-yl)-4-bromo-2-(4-iodobenzyl)pyridazin-3(2H)-one

Homo sapiens

-

in 40 mM Tris pH 7.5, 20 mM MgCl2, 0.1 mg/ml bovine serum albumin, at 30°C

729389

0.0096

5-(4-acetyl-5-methyl-1H-1,2,3-triazol-1-yl)-4-bromo-2-(pyrimidin-5-yl)pyridazin-3(2H)-one

Homo sapiens

-

in 40 mM Tris pH 7.5, 20 mM MgCl2, 0.1 mg/ml bovine serum albumin, at 30°C

729389

0.0026

5-(4-acetyl-5-methyl-1H-1,2,3-triazol-1-yl)-4-bromo-2-phenethylpyridazin-3(2H)-one

Homo sapiens

-

in 40 mM Tris pH 7.5, 20 mM MgCl2, 0.1 mg/ml bovine serum albumin, at 30°C

729389

0.0074

5-(4-acetyl-5-methyl-1H-1,2,3-triazol-1-yl)-4-bromo-2-phenylpyridazin-3(2H)-one

Homo sapiens

-

in 40 mM Tris pH 7.5, 20 mM MgCl2, 0.1 mg/ml bovine serum albumin, at 30°C

729389

0.0262

5-(4-acetyl-5-methyl-1H-1,2,3-triazol-1-yl)-4-chloro-2-phenylpyridazin-3(2H)-one

Homo sapiens

-

in 40 mM Tris pH 7.5, 20 mM MgCl2, 0.1 mg/ml bovine serum albumin, at 30°C

729389

1

5-(4-acetyl-5-methyl-1H-1,2,3-triazol-1-yl)-4-ethoxy-2-phenylpyridazin-3(2H)-one

Homo sapiens

-

IC50 above 1.0 mM, in 40 mM Tris pH 7.5, 20 mM MgCl2, 0.1 mg/ml bovine serum albumin, at 30°C

729389

0.013

5-(4-acetyl-5-methyl-1H-1,2,3-triazol-1-yl)-4-iodo-2-phenylpyridazin-3(2H)-one

Homo sapiens

-

in 40 mM Tris pH 7.5, 20 mM MgCl2, 0.1 mg/ml bovine serum albumin, at 30°C

729389

0.5

5-(4-acetyl-5-methyl-1H-1,2,3-triazol-1-yl)-4-isopropyl-2-phenylpyridazin-3(2H)-one

Homo sapiens

-

IC50 above 0.5 mM, in 40 mM Tris pH 7.5, 20 mM MgCl2, 0.1 mg/ml bovine serum albumin, at 30°C

729389

0.055

ethyl 1-(6-oxo-1-phenyl-5-(2-oxa-6-azaspiro[3.3]heptan-6-yl)-1,6-dihydropyridazin-4-yl)-1H-1,2,3-triazole-4-carboxylate

Homo sapiens

-

in 40 mM Tris pH 7.5, 20 mM MgCl2, 0.1 mg/ml bovine serum albumin, at 30°C

729389