3.1.3.46: fructose-2,6-bisphosphate 2-phosphatase

This is an abbreviated version!
For detailed information about fructose-2,6-bisphosphate 2-phosphatase, go to the full flat file.

Reaction

Synonyms

6-phosphofructo-2-kinase/2,6-bisphosphatase 3, 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase, 6-phosphofructo-2-kinase/fructose-2 6-biphosphatase, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphase, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (gene PFKFB3), 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-4, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphate, 6PF2K/Fru-2,6-P2ase, D-fructose-2,6-bisphosphatase, F-2,6-P2, F26BPase, F2KP, FBPase, FBPase-2, fructose-2,6-bisphosphatase, fructose-2,6-diphosphatase, heart 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, Lm1, More, OsF2KP1, OsF2KP2, Pfk-2, PFK-2/FBPase, PFK-2/FBPase-2, PFK-2/FDPase-2, PFK-2/Fru-2,6-P2, PFK2, PFK2/FBPase2, Pfk26, Pfk27, PFKFB, PFKFB-3, PFKFB-4, PFKFB1, PFKFB2, PFKFB3, PFKFB4, phosphatase, fructose 2,6-di-, RH2K, TIGAR

ECTree

     3 Hydrolases

         3.1 Acting on ester bonds

             3.1.3 Phosphoric-monoester hydrolases

                3.1.3.46 fructose-2,6-bisphosphate 2-phosphatase

Advanced search results

Do not include text mining results

Include results (more...)

Include results (more...)

Results	in table
57	Activating Compound
212	AA Sequence
13	Application
1	CAS Registry Number
43	Cloned(Commentary)
10	Crystallization (Commentary)
2102	Disease/ Diagnostics
5	Expression
14	General Information
22	IC50 Value
111	Inhibitors
7	Ki Value [mM]
29	KM Value [mM]
7	Localization
5	Metals/Ions
29	Molecular Weight [Da]
96	Natural Substrates/ Products (Substrates)
299	Organism
3	Pathway
41	PDB ID
12	pH Optimum
1	pH Range
1	pI Value
12	Posttranslational Modification
22	Protein Variants
21	Purification (Commentary)
55	Reaction
15	Reaction Type
123	Reference
205	Source Tissue
7	Specific Activity [micromol/min/mg]
7	Storage Stability
163	Substrates and Products (Substrate)
51	Subunits
240	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
1	Temperature Stability [°C]
2	Turnover Number [1/s]

Expression

print visible entries

print all entries

Expression on EC 3.1.3.46 - fructose-2,6-bisphosphate 2-phosphatase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide Go to Expression Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

EXPRESSION

ORGANISM

UNIPROT

LITERATURE

androgen stimulates glycolysis for de novo lipid synthesis by increasing the activities of hexokinase 2 and 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2, up-regulation of PFKFB2 expression in LNCaP cells is mediated by the direct binding of ligand-activated androgen receptor to the PFKFB2 promoter. Expression of PFKFB2 gene is increased 3.0fold by treatment with methyltrienolone, i.e. R1881, a synthetic androgen

Homo sapiens

-

714090

p53 downregulates PFKFB4 expression by binding to its promoter and mediating transcriptional repression via histone deacetylases

Homo sapiens

Q16877

751761

the enzyme is induced in hypoxia and upregulated as a consequence of the transcriptional changes orchestrated by the androgen receptor in prostate cancer cells

Homo sapiens

-

729519

the enzyme isoform PFKFB4 is about 3fold overexpressed in lung adenocarcinoma compared to normal lung tissue. PFKFB4 mRNA and protein expression are also increased by hypoxia

Homo sapiens

Q16877

730530

the protein levels are markedly elevated in high-grade astrocytomas relative to low-grade astrocytomas and corresponding non-neoplastic brain tissue, whereas no significant increase of PFKFB3 mRNA is observed in high-grade astrocytomas

Homo sapiens

-

681540