3.1.3.46: fructose-2,6-bisphosphate 2-phosphatase

This is an abbreviated version!
For detailed information about fructose-2,6-bisphosphate 2-phosphatase, go to the full flat file.

Reaction

Synonyms

6-phosphofructo-2-kinase/2,6-bisphosphatase 3, 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase, 6-phosphofructo-2-kinase/fructose-2 6-biphosphatase, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphase, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (gene PFKFB3), 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-4, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphate, 6PF2K/Fru-2,6-P2ase, D-fructose-2,6-bisphosphatase, F-2,6-P2, F26BPase, F2KP, FBPase, FBPase-2, fructose-2,6-bisphosphatase, fructose-2,6-diphosphatase, heart 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, Lm1, More, OsF2KP1, OsF2KP2, Pfk-2, PFK-2/FBPase, PFK-2/FBPase-2, PFK-2/FDPase-2, PFK-2/Fru-2,6-P2, PFK2, PFK2/FBPase2, Pfk26, Pfk27, PFKFB, PFKFB-3, PFKFB-4, PFKFB1, PFKFB2, PFKFB3, PFKFB4, phosphatase, fructose 2,6-di-, RH2K, TIGAR

ECTree

     3 Hydrolases

         3.1 Acting on ester bonds

             3.1.3 Phosphoric-monoester hydrolases

                3.1.3.46 fructose-2,6-bisphosphate 2-phosphatase

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Results	in table
57	Activating Compound
212	AA Sequence
13	Application
1	CAS Registry Number
43	Cloned(Commentary)
10	Crystallization (Commentary)
2102	Disease/ Diagnostics
5	Expression
14	General Information
22	IC50 Value
111	Inhibitors
7	Ki Value [mM]
29	KM Value [mM]
7	Localization
5	Metals/Ions
29	Molecular Weight [Da]
96	Natural Substrates/ Products (Substrates)
299	Organism
3	Pathway
41	PDB ID
12	pH Optimum
1	pH Range
1	pI Value
12	Posttranslational Modification
22	Protein Variants
21	Purification (Commentary)
55	Reaction
15	Reaction Type
123	Reference
205	Source Tissue
7	Specific Activity [micromol/min/mg]
7	Storage Stability
163	Substrates and Products (Substrate)
51	Subunits
240	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
1	Temperature Stability [°C]
2	Turnover Number [1/s]

Organism

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Organism on EC 3.1.3.46 - fructose-2,6-bisphosphate 2-phosphatase

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ORGANISM

COMMENTARY

LITERATURE

UNIPROT

SEQUENCE DB

SOURCE

Arabidopsis thaliana

4 entries

Bos taurus

6 entries

Desulfovibrio desulfuricans

-

663935

-

-

brenda

Drosophila melanogaster

6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase long form; gene Pfrx

663935

Q9VWH7

SwissProt

brenda

Escherichia coli

-

680855

-

-

brenda

Gallus gallus

3 entries

Homo sapiens

20 entries

Hordeum vulgare

-

94947

-

-

brenda

Leishmania major

2 entries

Mammalia

bifunctional 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase

650931

-

-

brenda

Mus musculus

9 entries

Mus musculus C57/BL6

C57/BL6

678087

-

-

brenda

Musa acuminata

-

94930

-

-

brenda

Oryza sativa

wild type, two mutants with suppressed expression of F2KP, Tos 17 insertion mutant of OsF2KP1, RNAi mutants of OsF2KP2

681609

-

-

brenda

Pelophylax lessonae

-

94952

-

-

brenda

Pigeon

-

94936

-

-

brenda

Rattus norvegicus

16 entries

Rattus norvegicus Wistar

Wistar

678087

-

-

brenda

Saccharomyces cerevisiae

-

94928, 94931

-

-

brenda

Schizosaccharomyces pombe

-

663935

-

-

brenda

Solanum tuberosum

-

94946

O81398

SwissProt

brenda

Spinacia oleracea

2 entries

Sus scrofa

-

680855

-

-

brenda

Trypanosoma brucei

stock 427, isozymes 1-4

661698

-

-

brenda

Trypanosoma cruzi

-

661698

-

-

brenda

Vigna radiata var. radiata

-

94937

-

-

brenda

Xenopus laevis

-

729793

-

-

brenda

Zea mays

-

94938

-

-

brenda

Arabidopsis thaliana

-

663935

Q9MB58

SwissProt

brenda

Arabidopsis thaliana

bifunctional 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase

653467

Q9MB58

SwissProt

brenda

Arabidopsis thaliana

bifunctional 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, recombinant enzyme, expressed in yeast

640338

Q9MB58

SwissProt

brenda

Arabidopsis thaliana

cv. Columbia and heterozygous mutant line F2KP-KO

675637

-

-

brenda

Bos taurus

-

94925, 94942, 94943, 94949

-

-

brenda

Bos taurus

brain isozyme PFKFB3; genes PFKFB1-4, four isozymes

663935

Q28901

SwissProt

brenda

Bos taurus

heart isozyme PFKFB2; genes PFKFB1-4, four isozymes

663935

P26285

SwissProt

brenda

Bos taurus

isoform PFKFB2, bifunctional 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, EC 2.7.1.105 and EC 3.1.3.46, respectively

752141

P26285

SwissProt

brenda

Bos taurus

liver isozyme PFKFB1; genes PFKFB1-4, four isozymes

663935

P49872

SwissProt

brenda

Bos taurus

overview

94933

-

-

brenda

Gallus gallus

-

94936, 94954

-

-

brenda

Gallus gallus

bifunctional 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase

640339

-

-

brenda

Gallus gallus

bifunctional 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, recombinant enzyme

650442

-

-

brenda

Homo sapiens

-

94926, 94950, 94951

-

-

brenda

Homo sapiens

-

640332

P16118

SwissProt

brenda

Homo sapiens

-

673215, 678087, 681437, 681500, 681540, 713740, 713747, 714090, 729389, 729519

-

-

brenda

Homo sapiens

-

730008

O60825

SwissProt

brenda

Homo sapiens

-

730530

Q16877

SwissProt

brenda

Homo sapiens

-

730905

Q16875

SwissProt

brenda

Homo sapiens

bifunctional 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, six different isoforms

650740

Q9BQU3

UniProt

brenda

Homo sapiens

bifunctional enzyme

663563

-

-

brenda

Homo sapiens

brain/placenta isozyme PFKFB3; genes PFKFB1-4, four isozymes

663935

Q16875

SwissProt

brenda

Homo sapiens

heart isozyme PFKFB2; genes PFKFB1-4, four isozymes

663935

O60825

SwissProt

brenda

Homo sapiens

isoform PFKFB2, bifunctional 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, EC 2.7.1.105 and EC 3.1.3.46, respectively

752141

O60825

SwissProt

brenda

Homo sapiens

isoform PFKFB3, bifunctional 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, EC 2.7.1.105 and EC 3.1.3.46, respectively

749587, 749813, 751765, 751774

Q16875

SwissProt

brenda

Homo sapiens

isoform PFKFB4, bifunctional 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, EC 2.7.1.105 and EC 3.1.3.46, respectively

751761

Q16877

SwissProt

brenda

Homo sapiens

isozymes PFKFB-4 and PFKFB-3

664248

-

-

brenda

Homo sapiens

isozymes PFKFB1-4

664718

-

-

brenda

Homo sapiens

isozymes PFKFB1-4

665727

P16118

SwissProt

brenda

Homo sapiens

liver isozyme PFKFB1; genes PFKFB1-4, four isozymes

663935

P16118

SwissProt

brenda

Homo sapiens

PFKFB4 gene, promoter region, and 5' untranslated region, partial sequence; minor splice isozyme PFKFB-4, major isozyme PFKFB-3

666334

Q16877

SwissProt

brenda

Homo sapiens

recombinant

665727

P16118

SwissProt

brenda

Homo sapiens

testis isozyme PFKFB4; genes PFKFB1-4, four isozymes

663935

Q16877

SwissProt

brenda

Leishmania major

-

661698

-

-

brenda

Leishmania major

This UniProt-ID has been deleted

663935

-

-

brenda

Mus musculus

-

695235

Q3U3S6

UniProt

brenda

Mus musculus

-

730691

-

-

brenda

Mus musculus

-

751121

Q8BZA9

UniProt

brenda

Mus musculus

C57/BL6

678087

-

-

brenda

Mus musculus

heart isozyme PFKFB2; genes PFKFB1-4, four isozymes

663935

P70265

SwissProt

brenda

Mus musculus

inducible isozyme PFKFB3; genes PFKFB1-4, four isozymes

663935

Q9ESY2

SwissProt

brenda

Mus musculus

male 129J mice

664763

-

-

brenda

Mus musculus

male and female mice

665582

-

-

brenda

Mus musculus

male C57BL7& mice, isozyme PFKFB3

664718

-

-

brenda

Rattus norvegicus

-

94925

-

-

brenda

Rattus norvegicus

-

94927

P07953

SwissProt

brenda

Rattus norvegicus

-

94932, 94933, 94934, 94935, 94939, 94940, 94941, 94942, 94944, 94945, 94948, 94952, 94955, 640344, 663563, 665854, 684366, 690361, 716226, 721553, 722278, 730008

-

-

brenda

Rattus norvegicus

bifunctional 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase

649951, 650014

-

-

brenda

Rattus norvegicus

bifunctional 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, recombinant enzyme

650947

-

-

brenda

Rattus norvegicus

bifunctional 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, recombinant enzyme expressed in Mv1Lu cell line

651270

-

-

brenda

Rattus norvegicus

bifunctional 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, recombinant enzyme expressed in Mv1Lu cells

649291

-

-

brenda

Rattus norvegicus

bifunctional 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, recombinant enzyme, liver and muscle isoform

640325

-

-

brenda

Rattus norvegicus

brain isozyme PFKFB2; genes PFKFB1-4, four isozymes

663935

O35552

SwissProt

brenda

Rattus norvegicus

heart isozyme PFKFB2; genes PFKFB1-4, four isozymes

663935

Q9JJH5

SwissProt

brenda

Rattus norvegicus

insulin-resistant Zucker fa/fa and Fa/? strains

671260

-

-

brenda

Rattus norvegicus

liver isozyme PFKFB1; genes PFKFB1-4, four isozymes

663935

P07953

SwissProt

brenda

Rattus norvegicus

splice variant

701360

B0ZTI0

UniProt

brenda

Rattus norvegicus

splice variant

701360

P25114

SwissProt

brenda

Rattus norvegicus

testis isozyme PFKFB4; genes PFKFB1-4, four isozymes

663935

P25114

SwissProt

brenda

Rattus norvegicus

Wistar

678087

-

-

brenda

Spinacia oleracea

-

94924, 94929, 94953

-

-

brenda

Spinacia oleracea

bifunctional 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, recombinant enzyme

640345

O64983

SwissProt

brenda