Reference on EC 3.1.3.46 - fructose-2,6-bisphosphate 2-phosphatase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Macdonald, F.D.; Chou, Q.; Buchanan, B.B.; Stitt, M.
Purification and characterization of fructose-2,6-bisphosphatase, a substrate-specific cytosolic enzyme from leaves
J. Biol. Chem.
264
5540-5544
1989
Spinacia oleracea
Taniyama, M.; Kitamura, K.; Thomas, H; Lawson, J.W.R.; Uyeda, K.
Isozymes of fructose 6-phosphate, 2-kinase:fructose-2,6-bisphosphatase in rat and bovine heart, liver, and skeletal muscle
Biochem. Biophys. Res. Commun.
157
949-954
1988
Bos taurus, Rattus norvegicus
Algaier, J.; Uyeda, K.
Molecular cloning, sequence analysis, and expression of a human liver cDNA coding for fructose-6-P,2-kinase:fructose-2,6-bisphosphatase
Biochem. Biophys. Res. Commun.
153
328-333
1988
Homo sapiens
Darville, M.I.; Crepin, K.M.; Vandekerckhove, J.; Van Damme, J.; Octave, J.N.; Rider, MH.; Marchand, M.J.; Hue, L.; Rousseau, G.G.
Complete nucleotide sequence coding for rat liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase derived from a cDNA clone
FEBS Lett.
224
317-321
1987
Rattus norvegicus (P07953)
Francois, J.; Van Schaftingen, E.; Hers, H.G.
Characterization of phosphofructokinase 2 and of enzymes involved in the degradation of fructose 2,6-bisphosphate in yeast
Eur. J. Biochem.
171
599-608
1988
Saccharomyces cerevisiae
Walker, G.H.; Huber, S.C.
ATP-dependent activation of a new form of spinach leaf 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase
Arch. Biochem. Biophys.
258
58-64
1987
Spinacia oleracea
Mertens, E.; Marcellin, P.; Van Schaftingen, E.; Hers, H.G.
Effect of ethylene treatment on the concentration of fructose-2,6-bisphosphate and on the activity of phosphofructokinase 2/fructose-2,6-bisphosphatase in banana
Eur. J. Biochem.
167
579-583
1987
Musa acuminata
Kretschmer, M.; Schellenberger, W.; Otto, A.; Kessler, R.; Hofmann, E.
Fructose-2,6-bisphosphatase and 6-phosphofructo-2-kinase are separable in yeast
Biochem. J.
246
755-759
1987
Saccharomyces cerevisiae
Loiseau, A.M.; Rider, M.H.; Hue, L.
Purification and properties of 6-phosphofructo-2-kinase and fructose-2,6-bisphosphatase from rat hepatoma cells
Biochem. Soc. Trans.
15
384-385
1987
Rattus norvegicus
-
Pilkis, S.J.; Claus, T.H.; Kountz, P.D.; El-Maghrabi, M.R.
Enzymes of the fructose 6-phosphate-fructose 1,6-bisphosphate substrate cycle
The Enzymes, 3rd Ed. (Boyer, P. D. , ed. )
18
3-46
1987
Bos taurus, Rattus norvegicus
-
Kaku, K.; Matsuda, M.; Matsutani, A.; Kaneko, T.
Effect of tolbutamide on fructose-6-phosphate,2-kinase and fructose-2,6-bisphosphatase in rat liver
Biochem. Biophys. Res. Commun.
139
687-692
1986
Rattus norvegicus
El-Maghrabi, M.R.; Correia, J.J.; Heil, P.J.; Pate, T.M.; Cobb, C.E.; Pilkis, S.J.
Tissue distribution, immunoreactivity, and physical properties of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
Proc. Natl. Acad. Sci. USA
83
5005-5009
1986
Rattus norvegicus
Van Schaftingen, E.; Hers, H.G.
Purification and properties of phosphofructokinase 2/fructose 2,6-bisphosphatase from chicken liver and from pigeon muscle
Eur. J. Biochem.
159
359-365
1986
Gallus gallus, Pigeon
Avigad, G.; Bohrer, P.J.
6-Phosphofructo-2-kinase and D-fructose-2,6-bisphosphatase activities in mung bean seedlings
Biochim. Biophys. Acta
798
317-324
1984
Vigna radiata var. radiata
-
Smyth, D.A.; Wu, M.X.; Black, C.C.
Phosphofructokinase and fructose 2,6-bisphosphatase activities in developing corn seedlings (Zea mays L.)
Plant Sci. Lett.
33
61-70
1984
Zea mays
-
Van Schaftingen, E.; Davies, D.R.; Hers, H.G.
Fructose-2,6-bisphosphatase from rat liver
Eur. J. Biochem.
124
143-149
1982
Rattus norvegicus
Furuya, E.; Yokoyama, M.; Uyeda, K.
An enzyme that catalyzes hydrolysis of fructose-2,6-bisphosphate
Biochem. Biophys. Res. Commun.
105
264-270
1982
Rattus norvegicus
Pilkis, S.J.; Chrisman, T.; Burgress, B.; McGrane, M.; Colosia, A.; Pilkis, J.; Claus, T.H.; El-Maghrabi, M.R.
Rat hepatic 6-phosphofructo 2-kinase/fructose 2,6-bisphosphatase: a unique bifunctional enzyme
Adv. Enzyme Regul.
21
147-173
1983
Rattus norvegicus
Kitamura, K.; Uyeda, K.; Hartman, F.C.; Kangawa, K.; Matsuo, H.
Catalytic site of rat liver and bovine heart fructose-6-phosphate,2-kinase: fructose-2,6-bisphosphatase
J. Biol. Chem.
264
6344-6348
1989
Bos taurus, Rattus norvegicus
Sakata, J.; Abe, Y.; Uyeda, K.
Molecular cloning of the DNA and expression and characterization of rat testes fructose-6-phosphate,2-kinase: fructose-2,6-bisphosphatase
J. Biol. Chem.
266
15764-15770
1991
Bos taurus
Kurland, I.J.; El-Maghrabi, M.R.; Correia, J.J.; Pilkis S.J.
Rat liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase. Properties of phospho- and dephospho-forms and of two mutants in which Ser32 has been changed by site-directed mutagenesis
J. Biol. Chem.
267
4416-4423
1992
Rattus norvegicus
Kurland, I.J.; Pilkis, S.J.
Covalent control of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase: Insights into autoregulation of a bifunctional enzyme
Protein Sci.
4
1023-1037
1995
Rattus norvegicus
Draborg, H.; Villadsen, D.; Nielsen, T.H.
Cloning, characterization and expression of a bifunctional fructose-6-phosphate, 2-kinase/fructose-2,6-bisphosphatase from potato
Plant Mol. Biol.
39
709-720
1999
Solanum tuberosum (O81398)
Brauer, M.; Stitt, M.
Vanadate inhibits fructose-2,6-bisphosphatase and leads to an inhibition of sucrose synthesis in barley leaves
Physiol. Plant.
78
568-573
1990
Hordeum vulgare
-
Sakurai, T.; Johnson, J.H.; Uyeda, K.
Islet fructose 6-phosphate, 2-kinase: fructose 2,6-bisphosphatase: isozymic form, expression, and characterization
Biochem. Biophys. Res. Commun.
218
159-163
1996
Rattus norvegicus
Sakata, J.; Uyeda, K.
Characterization of two isozymic forms of heart fructose 6-phosphate, 2-kinase:fructose 2,6-bisphosphatase
Biochem. Biophys. Res. Commun.
180
470-474
1991
Bos taurus
Sakakibara, R.; Uemura, M.; Hirata, T.; Okamura, N.; Kato, M.
Human placental fructose-6-phosphate,2-kinase/fructose-2,6-bisphosphatase: its isozymic form, expression and characterization
Biosci. Biotechnol. Biochem.
61
1949-1952
1997
Homo sapiens
Sakakibara, R.; Kato, M.; Okamura, N.; Nakagawa, T.; Komada, Y.; Tominaga, N.; Shimojo, M.; Fukasawa, M.
Characterization of a human placental fructose-6-phosphate,2-kinase fructose-2,6-bisphosphatase
J. Biochem.
122
122-128
1997
Homo sapiens
Pyko, M.; Rider, M.H.; Hue, L.; Wegener, G.
6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase from frog skeletal muscle: purification, kinetics and immunological properties
J. Comp. Physiol. B
163
89-98
1993
Pelophylax lessonae, Rattus norvegicus
Stitt, M.; Mieskes, G.; S"ling, H.D.; Groe, H.; Heldt, H.W.
Diurnal changes of fructose-6-phosphate,2-kinase and fructose-2,6-bis-phosphatase activities in spinach leaves
Z. Naturforsch. C
41
291-296
1986
Spinacia oleracea
-
Rider, M.H.; Bartrons, R.; Hue, L.
Vanadate inhibits liver fructose-2,6-bisphosphatase
Eur. J. Biochem.
190
53-56
1990
Gallus gallus
Asins, G.; Serra, D.; Hegardt, F.G.
Isolation and partial characterization of a protein with HMG-CoA reductase phosphatase activity associated with rat liver microsomal membranes
J. Lipid Res.
32
1391-1401
1991
Rattus norvegicus
Kurland, I.J.; Chapman, B.; El-Maghrabi, M.R.
N- and C-termini modulate the effects of pH and phosphorylation on hepatic 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
Biochem. J.
347
459-467
2000
Rattus norvegicus
Lee, Y.H.; Li, Y.; Uyeda, K.; Hasemann, C.A.
Tissue-specific structure/function differentiation of the liver isoform of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
J. Biol. Chem.
278
523-530
2003
Homo sapiens (P16118), Homo sapiens
Villadsen, D.; Nielsen, T.H.
N-terminal truncation affects the kinetics and structure of fructose-6-phosphate 2-kinase/fructose-2,6-bisphosphatase from Arabidopsis thaliana
Biochem. J.
359
591-597
2001
Arabidopsis thaliana (Q9MB58), Arabidopsis thaliana
Zhu, Z.; Ling, S.; Yang, Q.H.; Li, L.
Involvement of the chicken liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase sequence His444-Arg-Glu-Arg in modulation of the bisphosphatase activity by its kinase domain
Biochem. J.
357
513-520
2001
Gallus gallus
Goldstein, B.N.; Maevsky, A.A.
Critical switch of the metabolic fluxes by phosphofructo-2-kinase:fructose-2,6-bisphosphatase. A kinetic model
FEBS Lett.
532
295-299
2002
Rattus norvegicus
Markham, J.E.; Kruger, N.J.
Kinetic properties of bifunctional 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase from spinach leaves
Eur. J. Biochem.
269
1267-1277
2002
Spinacia oleracea (O64983), Spinacia oleracea
Perez, J.X.; Roig, T.; Manzano, A.; Dalmau, M.; Boada, J.; Ventura, F.; Rosa, J.L.; Bermudez, J.; Bartrons, R.
Overexpression of fructose 2,6-bisphosphatase decreases glycolysis and delays cell cycle progression
Am. J. Physiol.
279
C1359-1365
2000
Rattus norvegicus
Sakurai, M.; Cook, P.F.; Haseman, C.A.; Uyeda, K.
Glutamate 325 is a general acid-base catalyst in the reaction catalyzed by fructose-2,6-bisphosphatase
Biochemistry
39
16238-16243
2000
Rattus norvegicus
Okar, D.A.; Live, D.H.; Devany, M.H.; Lange, A.J.
Mechanism of the bisphosphatase reaction of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase probed by 1H-15N NMR spectroscopy
Biochemistry
39
9754-9762
2000
Rattus norvegicus
Zhu, Z.; Ling, S.; Yang, Q.H.; Li, L.
The difference in the carboxy-terminal sequence is responsible for the difference in the activity of chicken and rat liver fructose-2,6-bisphosphatase
Biol. Chem.
381
1195-1202
2000
Gallus gallus
Kessler, R.; Eschrich, K.
Splice isoforms of ubiquitous 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase in human brain
Brain Res.
87
190-195
2001
Homo sapiens (Q9BQU3), Homo sapiens
El-Maghrabi, M.R.; Noto, F.; Wu, N.; Manes, N.
6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase: suiting structure to need, in a family of tissue-specific enzymes
Curr. Opin. Clin. Nutr. Metab. Care
4
411-418
2001
Mammalia
Massa, L.; Baltrusch, S.; Okar, D.A.; Lange, A.J.; Lenzen, S.; Tiedge, M.
Interaction of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/FBPase-2) with glucokinase activates glucose phosphorylation and glucose metabolism in insulin-producing cells
Diabetes
53
1020-1029
2004
Rattus norvegicus
Boada, J.; Roig, T.; Perez, X.; Gamez, A.; Bartrons, R.; Cascante, M.; Bermudez, J.
Cells overexpressing fructose-2,6-bisphosphatase showed enhanced pentose phosphate pathway flux and resistance to oxidative stress
FEBS Lett.
480
261-264
2000
Rattus norvegicus
Furumoto, T.; Teramoto, M.; Inada, N.; Ito, M.; Nishida, I.; Watanabe, A.
Phosphorylation of a bifunctional enzyme, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphate 2-phosphatase, is regulated physiologically and developmentally in rosette leaves of Arabidopsis thaliana
Plant Cell Physiol.
42
1044-1048
2001
Arabidopsis thaliana (Q9MB58), Arabidopsis thaliana
Chevalier, N.; Bertrand, L.; Rider, M.H.; Opperdoes, F.R.; Rigden, D.J.; Michels, P.A.
6-Phosphofructo-2-kinase and fructose-2,6-bisphosphatase in Trypanosomatidae. Molecular characterization, database searches, modelling studies and evolutionary analysis
FEBS J.
272
3542-3560
2005
Leishmania major, Trypanosoma brucei, Trypanosoma cruzi
Okar, D.A.; Wu, C.; Lange, A.J.
Regulation of the regulatory enzyme, 6-phosphofructo-2-kinase/fructose-2 6-biphosphatase
Adv. Enzyme Regul.
44
123-154
2004
Homo sapiens, Rattus norvegicus
Rider, M.H.; Bertrand, L.; Vertommen, D.; Michels, P.A.; Rousseau, G.G.; Hue, L.
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase: head-to-head with a bifunctional enzyme that controls glycolysis
Biochem. J.
381
561-579
2004
Arabidopsis thaliana (Q9MB58), Bos taurus (P26285), Bos taurus (P49872), Bos taurus (Q28901), Desulfovibrio desulfuricans, Drosophila melanogaster (Q9VWH7), Homo sapiens (O60825), Homo sapiens (P16118), Homo sapiens (Q16875), Homo sapiens (Q16877), Leishmania major, Mus musculus (P70265), Mus musculus (Q9ESY2), Rattus norvegicus (O35552), Rattus norvegicus (P07953), Rattus norvegicus (P25114), Rattus norvegicus (Q9JJH5), Schizosaccharomyces pombe
Minchenko, O.H.; Ochiai, A.; Opentanova, I.L.; Ogura, T.; Minchenko, D.O.; Caro, J.; Komisarenko, S.V.; Esumi, H.
Overexpression of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-4 in the human breast and colon malignant tumors
Biochimie
87
1005-1010
2005
Homo sapiens
Atsumi, T.; Nishio, T.; Niwa, H.; Takeuchi, J.; Bando, H.; Shimizu, C.; Yoshioka, N.; Bucala, R.; Koike, T.
Expression of inducible 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase/PFKFB3 isoforms in adipocytes and their potential role in glycolytic regulation
Diabetes
54
3349-3357
2005
Homo sapiens, Mus musculus
Wu, C.; Okar, D.A.; Stoeckman, A.K.; Peng, L.J.; Herrera, A.H.; Herrera, J.E.; Towle, H.C.; Lange, A.J.
A potential role for fructose-2,6-bisphosphate in the stimulation of hepatic glucokinase gene expression
Endocrinology
145
650-658
2004
Mus musculus
Donthi, R.V.; Ye, G.; Wu, C.; McClain, D.A.; Lange, A.J.; Epstein, P.N.
Cardiac expression of kinase-deficient 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase inhibits glycolysis, promotes hypertrophy, impairs myocyte function, and reduces insulin sensitivity
J. Biol. Chem.
279
48085-48090
2004
Mus musculus
Kim, S.G.; Manes, N.P.; El-Maghrabi, M.R.; Lee, Y.H.
Crystal structure of the hypoxia-inducible form of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB3): a possible new target for cancer therapy
J. Biol. Chem.
281
2939-2944
2006
Homo sapiens (P16118), Homo sapiens
You, E.J.; Khil, L.Y.; Kwak, W.J.; Won, H.S.; Chae, S.H.; Lee, B.H.; Moon, C.K.
Effects of brazilin on the production of fructose-2,6-bisphosphate in rat hepatocytes
J. Ethnopharmacol.
102
53-57
2005
Rattus norvegicus
Minchenko, O.H.; Ogura, T.; Opentanova, I.L.; Minchenko, D.O.; Esumi, H.
Splice isoform of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-4: expression and hypoxic regulation
Mol. Cell. Biochem.
280
227-234
2005
Homo sapiens (Q16877)
Payne, V.A.; Arden, C.; Lange, A.J.; Agius, L.
Contributions of glucokinase and phosphofructokinase-2/fructose bisphosphatase-2 to the elevated glycolysis in hepatocytes from Zucker fa/fa rats
Am. J. Physiol. Regul. Integr. Comp. Physiol.
293
R618-R625
2007
Rattus norvegicus
Chesney, J.
6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase and tumor cell glycolysis
Curr. Opin. Clin. Nutr. Metab. Care
9
535-539
2006
Homo sapiens
Lee, Y.H.; Lee, D.S.; Lim, J.M.; Yoon, J.M.; Bhoo, S.H.; Jeon, J.S.; Hahn, T.R.
Carbon-partitioning in Arabidopsis is regulated by the fructose 6-phosphate, 2-kinase/fructose 2,6-bisphosphatase enzyme
J. Plant Biol.
49
70-79
2006
Arabidopsis thaliana
-
Arden, C.; Hampson, L.J.; Huang, G.C.; Shaw, J.A.; Aldibbiat, A.; Holliman, G.; Manas, D.; Khan, S.; Lange, A.J.; Agius, L.
A role for PFK-2/FBPase-2 as distinct from fructose 2,6-bisphosphate in regulation of insulin secretion in pancreatic beta-cells
Biochem. J.
411
41-51
2007
Homo sapiens, Mus musculus, Mus musculus C57/BL6, Rattus norvegicus, Rattus norvegicus Wistar
Hines, J.K.; Chen, X.; Nix, J.C.; Fromm, H.J.; Honzatko, R.B.
Structures of mammalian and bacterial fructose-1,6-bisphosphatase reveal the basis for synergism in AMP/fructose 2,6-bisphosphate inhibition
J. Biol. Chem.
282
36121-36131
2007
Escherichia coli, Sus scrofa
Kim, S.G.; Cavalier, M.; El-Maghrabi, M.R.; Lee, Y.H.
A direct substrate-substrate interaction found in the kinase domain of the bifunctional enzyme, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
J. Mol. Biol.
370
14-26
2007
Homo sapiens
Shaikh, M.S.; Mittal, A.; Bharatam, P.V.
Design of fructose-2,6-bisphosphatase inhibitors: A novel virtual screening approach
J. Mol. Graph. Model.
26
900-906
2008
Homo sapiens
Kessler, R.; Bleichert, F.; Warnke, J.P.; Eschrich, K.
6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB3) is up-regulated in high-grade astrocytomas
J. Neurooncol.
86
257-264
2008
Homo sapiens
Park, S.; Cho, M.; Bhoo, S.H.; Jeon, J.; Kwon, Y.; Hahn, T.
Altered sucrose synthesis in rice plants with reduced activity of fructose-6-phosphate 2-kinase/fructose-2,6-bisphosphatase
J. Plant Biol.
50
38-43
2007
Oryza sativa
-
Mukhtar, M.H.; Payne, V.A.; Arden, C.; Harbottle, A.; Khan, S.; Lange, A.J.; Agius, L.
Inhibition of glucokinase translocation by AMP-activated protein kinase is associated with phosphorylation of both GKRP and 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
Am. J. Physiol. Regul. Integr. Comp. Physiol.
294
R766-R774
2008
Rattus norvegicus
Wang, Q.; Donthi, R.V.; Wang, J.; Lange, A.J.; Watson, L.J.; Jones, S.P.; Epstein, P.N.
Cardiac phosphatase-deficient 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase increases glycolysis, hypertrophy, and myocyte resistance to hypoxia
Am. J. Physiol. Heart Circ. Physiol.
294
H2889-H2897
2008
Rattus norvegicus
Mykhalchenko, V.G.; Minchenko, D.O.; Tsuchihara, K.; Moenner, M.; Komisarenko, S.V.; Bikfalvi, A.; Esumi, H.; Minchenko, O.H.
Expression of mouse 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 mRNA alternative splice variants in hypoxia
Ukr. Biokhim. Zh.
80
19-25
2008
Mus musculus (Q3U3S6), Mus musculus
Minchenko, D.O.; Mykhalchenko, V.G.; Tsuchihara, K.; Kanehara, S.; Yavorovsky, O.P.; Zaygorodny, I.V.; Paustovsky, Y.O.; Komisarenko, S.V.; Esumi, H.; Minchenko, O.H.
Alternative splice variants of rat 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-4 mRNA
Ukr. Biokhim. Zh.
80
66-73
2008
Rattus norvegicus (B0ZTI0), Rattus norvegicus (P25114)
Myers, R.W.; Baginsky, W.F.; Gattermeir, D.J.; Geissler, W.M.; Harris, G.
Enzymatic preparation of high-specific-activity beta-D-[6,6-3H]fructose-2,6-bisphosphate: application to a sensitive assay for fructose-2,6-bisphosphatase
Anal. Biochem.
406
97-104
2010
Homo sapiens
Crochet, R.B.; Cavalier, M.C.; Seo, M.; Kim, J.D.; Yim, Y.S.; Park, S.J.; Lee, Y.H.
Investigating: a case study for small molecule kinases
Anal. Biochem.
418
143-148
2011
Homo sapiens
Moon, J.S.; Jin, W.J.; Kwak, J.H.; Kim, H.J.; Yun, M.J.; Kim, J.W.; Park, S.W.; Kim, K.S.
Androgen stimulates glycolysis for de novo lipid synthesis by increasing the activities of hexokinase 2 and 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 in prostate cancer cells
Biochem. J.
433
225-233
2011
Homo sapiens
Langer, S.; Kaminski, M.T.; Lenzen, S.; Baltrusch, S.
Endogenous activation of glucokinase by 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase is glucose dependent
Mol. Endocrinol.
24
1988-1997
2010
Rattus norvegicus
Baltrusch, S.; Schmitt, H.; Brix, A.; Langer, S.; Lenzen, S.
Additive activation of glucokinase by the bifunctional enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase and the chemical activator LY2121260
Biochem. Pharmacol.
83
1300-1306
2012
Rattus norvegicus
Langer, S.; Okar, D.A.; Schultz, J.; Lenzen, S.; Baltrusch, S.
Dimer interface rearrangement of the 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase rat liver isoenzyme by cAMP-dependent Ser-32 phosphorylation
FEBS Lett.
586
1419-1425
2012
Rattus norvegicus
Brooke, D.G.; van Dam, E.M.; Watts, C.K.; Khoury, A.; Dziadek, M.A.; Brooks, H.; Graham, L.J.; Flanagan, J.U.; Denny, W.A.
Targeting the Warburg Effect in cancer; relationships for 2-arylpyridazinones as inhibitors of the key glycolytic enzyme 6-phosphofructo-2-kinase/2,6-bisphosphatase 3 (PFKFB3)
Bioorg. Med. Chem.
22
1029-1039
2014
Homo sapiens
Ros, S.; Schulze, A.
Balancing glycolytic flux: the role of 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatases in cancer metabolism
Cancer Metab.
1
8-8
2013
Homo sapiens
Pegoraro, C.; Maczkowiak, F.; Monsoro-Burq, A.H.
Pfkfb (6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase) isoforms display a tissue-specific and dynamic expression during Xenopus laevis development
Gene Expr. Patterns
13
203-211
2013
Xenopus laevis
Novellasdemunt, L.; Tato, I.; Navarro-Sabate, A.; Ruiz-Meana, M.; Mendez-Lucas, A.; Perales, J.C.; Garcia-Dorado, D.; Ventura, F.; Bartrons, R.; Rosa, J.L.
Akt-dependent activation of the heart 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB2) isoenzyme by amino acids
J. Biol. Chem.
288
10640-10651
2013
Rattus norvegicus, Homo sapiens (O60825), Homo sapiens
Chesney, J.; Clark, J.; Klarer, A.C.; Imbert-Fernandez, Y.; Lane, A.N.; Telang, S.
Fructose-2,6-bisphosphate synthesis by 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4) is required for the glycolytic response to hypoxia and tumor growth
Oncotarget
5
6670-6686
2014
Homo sapiens (Q16877), Homo sapiens
Merrins, M.J.; Bertram, R.; Sherman, A.; Satin, L.S.
Phosphofructo-2-kinase/fructose-2,6-bisphosphatase modulates oscillations of pancreatic islet metabolism
PLoS ONE
7
e34036
2012
Mus musculus
Cavalier, M.C.; Kim, S.G.; Neau, D.; Lee, Y.H.
Molecular basis of the fructose-2,6-bisphosphatase reaction of PFKFB3: transition state and the C-terminal function
Proteins
80
1143-1153
2012
Homo sapiens (Q16875), Homo sapiens
Lea, M.A.; Guzman, Y.; Desbordes, C.
Inhibition of growth by combined treatment with inhibitors of lactate dehydrogenase and either phenformin or inhibitors of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3
Anticancer Res.
36
1479-1488
2016
Homo sapiens (Q16875)
Yalcin, A.; Solakoglu, T.H.; Ozcan, S.C.; Guzel, S.; Peker, S.; Celikler, S.; Balaban, B.D.; Sevinc, E.; Gurpinar, Y.; Chesney, J.A.
6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase-3 is required for transforming growth factor beta1-enhanced invasion of Panc1 cells invitro
Biochem. Biophys. Res. Commun.
484
687-693
2017
Homo sapiens (Q16875)
Tang, Y.; Kwon, H.; Neel, B.A.; Kasher-Meron, M.; Pessin, J.B.; Yamada, E.; Pessin, J.E.
The fructose-2,6-bisphosphatase TIGAR suppresses NF-kappaB signaling by directly inhibiting the linear ubiquitin assembly complex LUBAC
J. Biol. Chem.
293
7578-7591
2018
Mus musculus (Q8BZA9)
Ros, S.; Floeter, J.; Kaymak, I.; Da Costa, C.; Houddane, A.; Dubuis, S.; Griffiths, B.; Mitter, R.; Walz, S.; Blake, S.; Behrens, A.; Brindle, K.M.; Zamboni, N.; Rider, M.H.; Schulze, A.
6-Phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 is essential for p53-null cancer cells
Oncogene
36
3287-3299
2017
Homo sapiens (Q16877)
Du, J.Y.; Wang, L.F.; Wang, Q.; Yu, L.D.
miR-26b inhibits proliferation, migration, invasion and apoptosis induction via the downregulation of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 driven glycolysis in osteosarcoma cells
Oncol. Rep.
33
1890-1898
2015
Homo sapiens (Q16875), Homo sapiens
Yan, S.; Wei, X.; Xu, S.; Sun, H.; Wang, W.; Liu, L.; Jiang, X.; Zhang, Y.; Che, Y.
6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase isoform 3 spatially mediates autophagy through the AMPK signaling pathway
Oncotarget
8
80909-80922
2017
Homo sapiens (Q16875)
Crochet, R.; Kim, J.; Lee, H.; Yim, Y.; Kim, S.; Neau, D.; Lee, Y.
Crystal structure of heart 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB2) and the inhibitory influence of citrate on substrate binding
Proteins
85
117-124
2017
Homo sapiens (O60825), Homo sapiens, Bos taurus (P26285), Bos taurus
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