2.7.7.49: RNA-directed DNA polymerase

This is an abbreviated version!
For detailed information about RNA-directed DNA polymerase, go to the full flat file.

Word Map on EC 2.7.7.49

2.7.7.49

telomeres

htert

antiretroviral

immortalization

nnrti

ribonucleoprotein

viruses

virological

hiv-infected

lymphocyte

nonnucleoside

zidovudine

marrow

lengthen

strand

subtype

carcinogenesis

tumour

efavirenz

retroviral

rnase

nevirapine

tumorigenesis

lamivudine

g-quadruplexes

anti-hiv

drug-resistant

cd4

c-myc

single-stranded

integrase

first-line

alt

tenofovir

karyotype

polymerases

lifespan

retroviruses

ritonavir

proviral

polyproteins

virion

treatment-naive

dntp

indinavir

erosion

duplex

p16ink4a

hiv-positive

papillomavirus

medicine

synthesis

drug development

analysis

Reaction

a 2'-deoxyribonucleoside 5'-triphosphate

Synonyms

Bst DNA polymerase, CS5 pol, DNA nucleotidyltransferase (RNA-directed), DNA polymerase, DNA polymerase I, FeLV RT, FIV RT, FV Pol, FV reverse transcriptase, Gag-Pol, HBV-pol, HIV reverse transcriptase, HIV-1 M RT, HIV-1 O RT, HIV-1 R, HIV-1 reverse transcriptase, HIV-1 RT, HIV-reverse transcriptase, HIV-RT, human hepatitis B virus polymerase, human immunodeficiency virus type 1 reverse transcriptase, iScript enzyme, K4 polymerase, K4PolI, M-MuLV reverse transcriptase, MMLV RT, Moloney Murine leukemia virus reverse transcriptase, Moloney murine leukemia virus RT, MoMLV RT, More, MuLV RT, MX162-RT, MX65-RT, nucleoside reverse transcriptase, nucleotidyltransferase, deoxyribonucleate, RNA-dependent, p66 RT, P72, PFV RT, Pol, polymerase/reverse transcriptase, prototype foamy virus reverse transcriptase, R2-RT, reverse transcriptase, reverse transcriptase/RNA dependent DNA polymerase, reverse-transcriptase, revertase, RNA dependent DNA polymerase, RNA revertase, RNA-dependent DNA polymerase, RNA-instructed DNA polymerase, RT, SFV RT, simian foamy virus reverse transcriptase, SS RT, SuperScript I reverse transcriptase, Superscript II, SUPERSCRIPT II reverse transcriptase, T. Z05 pol, telomerase, telomerase catalytic subunit, telomerase reverse transcriptase, TERT, Tgo-Pol, xenotropic murine leukemia virus-related virus reverse transcriptase, XMRV RT, XNA reverse transcriptase

ECTree

2 Transferases

2.7 Transferring phosphorus-containing groups

2.7.7 Nucleotidyltransferases

2.7.7.49 RNA-directed DNA polymerase

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Results	in table
22	Activating Compound
70257	AA Sequence
28	Application
1	CAS Registry Number
46	Cloned(Commentary)
9	Crystallization (Commentary)
47552	Disease/ Diagnostics
39	General Information
4	General Stability
311	IC50 Value
429	Inhibitors
31	kcat/KM [mM/s]
12	Ki Value [mM]
100	KM Value [mM]
14	Localization
79	Metals/Ions
37	Molecular Weight [Da]
66	Natural Substrates/ Products (Substrates)
4	Organic Solvent Stability
267	Organism
1098	PDB ID
26	pH Optimum
4	pH Range
2	pI Value
4	Posttranslational Modification
166	Protein Variants
48	Purification (Commentary)
1	Reaction
1	Reaction Type
262	Reference
34	Source Tissue
7	Specific Activity [micromol/min/mg]
10	Storage Stability
333	Substrates and Products (Substrate)
43	Subunits
221	Synonyms
1	Systematic Name
17	Temperature Optimum [°C]
2	Temperature Range [°C]
9	Temperature Stability [°C]
69	Turnover Number [1/s]

Molecular Weight

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Molecular Weight on EC 2.7.7.49 - RNA-directed DNA polymerase

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100000

mouse mammary tumor virus

643435

103000

Streptococcus agalactiae

gel filtration

691131

120000

Hamster leukemia virus

643414, 643435

120000 - 130000

Simian immunodeficiency virus

glycerol gradient centrifugation

643429

170000

2 entries

40000

Tetrahymena thermophila

O77448

gel filtration

738587

50000

Simian immunodeficiency virus

1 * 50000 + 1 * 64000, both subunits exhibit enzymatic activity, the 64000 Da subunit shows the predominant activity, SDS-PAGE

643429

51000

3 entries

53000

Hamster leukemia virus

1 * 53000 + 1 * 68000, SDS-PAGE

643414, 643435

62865

Thermus aquaticus

x * 62879, mutant DNA polymerase I, sequence calculation, x * 62865, mutant DNA polymerase I, mass spectrometry

723163

62879

Thermus aquaticus

x * 62879, mutant DNA polymerase I, sequence calculation, x * 62865, mutant DNA polymerase I, mass spectrometry

723163

64000

Simian immunodeficiency virus

1 * 50000 + 1 * 64000, both subunits exhibit enzymatic activity, the 64000 Da subunit shows the predominant activity, SDS-PAGE

65000

66000

67227

x * 67227, calculation from nucleotide sequence

643413

68000

2 entries

70000

2 entries

70000 - 84000

Reticuloendotheliosis virus

643435

71000

Moloney murine leukemia virus

glycerol gradient centrifugation

643436

80000 - 100000

2 entries

90000

Rauscher murine leukemia virus

velocity centrifugation in a glycerol gradient containing 0.05 M KCl

643415

95000

Avian sarcoma virus

x * 65000 + x * 95000, SDS-PAGE

643414

95000 - 98000

HTLV-III

gel filtration

643438

additional information

Avian myeloblastosis virus

the enzyme exists in two forms with different sizes: 65000 Da and 105000 Da

643415