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2.7.7.49: RNA-directed DNA polymerase

This is an abbreviated version!
For detailed information about RNA-directed DNA polymerase, go to the full flat file.

Word Map on EC 2.7.7.49

Reaction

a 2'-deoxyribonucleoside 5'-triphosphate
+
DNAn
=
diphosphate
 +
DNAn+1

Synonyms

Bst DNA polymerase, CS5 pol, DNA nucleotidyltransferase (RNA-directed), DNA polymerase, DNA polymerase I, FeLV RT, FIV RT, FV Pol, FV reverse transcriptase, Gag-Pol, HBV-pol, HIV reverse transcriptase, HIV-1 M RT, HIV-1 O RT, HIV-1 R, HIV-1 reverse transcriptase, HIV-1 RT, HIV-reverse transcriptase, HIV-RT, human hepatitis B virus polymerase, human immunodeficiency virus type 1 reverse transcriptase, iScript enzyme, K4 polymerase, K4PolI, M-MuLV reverse transcriptase, MMLV RT, Moloney Murine leukemia virus reverse transcriptase, Moloney murine leukemia virus RT, MoMLV RT, More, MuLV RT, MX162-RT, MX65-RT, nucleoside reverse transcriptase, nucleotidyltransferase, deoxyribonucleate, RNA-dependent, p66 RT, P72, PFV RT, Pol, polymerase/reverse transcriptase, prototype foamy virus reverse transcriptase, R2-RT, reverse transcriptase, reverse transcriptase/RNA dependent DNA polymerase, reverse-transcriptase, revertase, RNA dependent DNA polymerase, RNA revertase, RNA-dependent DNA polymerase, RNA-instructed DNA polymerase, RT, SFV RT, simian foamy virus reverse transcriptase, SS RT, SuperScript I reverse transcriptase, Superscript II, SUPERSCRIPT II reverse transcriptase, T. Z05 pol, telomerase, telomerase catalytic subunit, telomerase reverse transcriptase, TERT, Tgo-Pol, xenotropic murine leukemia virus-related virus reverse transcriptase, XMRV RT, XNA reverse transcriptase

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.7 Nucleotidyltransferases
                2.7.7.49 RNA-directed DNA polymerase

Activating Compound

Activating Compound on EC 2.7.7.49 - RNA-directed DNA polymerase

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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
betapapillomavirus E6 protein 16E6
-
activates telomerase, NFX1-91 protein is important for telomerase activation by betapapillomavirus E6 protein 16E6
-
betapapillomavirus E6 protein 38E6
-
activates telomerase
-
betapapillomavirus E6 protein E6AP
-
important for telomerase activation by betapapillomavirus E6 protein 16E6
-
borano-3TCTP
-
alpha-Boranophosphate nucleoside analogs enhance 3–8fold the binding of Mg2+ ions to the active site of the enzyme-DNA-dNTP complex and alleviate the requirement of critical amino acids involved in phosphodiester bond formation
borano-dTTP
-
100fold decrease in polymerase activity caused by the R72A substitution is restored to wild-type levels using borano-dTTP. alpha-Boranophosphate nucleoside analogs enhance 3–8fold the binding of Mg2+ ions to the active site of the enzyme-DNA-dNTP complex and alleviate the requirement of critical amino acids involved in phosphodiester bond formation
dithiothreitol
DMSO
-
activation at 5-15% v/v
Epidermal growth factor
-
exogenous epidermal growth factor activates TERT gene transcription, epidermal growth factor-induced TERT activity is ERK 1/2-dependent
estrogen
-
administration of estrogen for 3 weeks restores TERT gene expression and telomerase activity in estrogen-deficient mice, telomerase expression is reduced in the absence of estrogen
NFX-91
-
complex formation between betapapillomavirus E6 proteins E6, E6AP, and NFX1-91 is a critical step in mediating telomerase activation
-
Nonionic detergent
-
pontin
-
pontin interacts with TERT and dyskerin and is critical for telomerase activity and for the accumulation of TERC and dyskerin
-
reptin
-
reptin interacts with TERT and dyskerin and is critical for telomerase activity and for the accumulation of TERC and dyskerin
-
Stimulatory protein
-
increases the rate and yield of DNA synthesis in reactions containing viral RNA and purified viral polymerase
-
additional information
-