2.7.7.49: RNA-directed DNA polymerase

This is an abbreviated version!
For detailed information about RNA-directed DNA polymerase, go to the full flat file.

Reaction

Synonyms

Bst DNA polymerase, CS5 pol, DNA nucleotidyltransferase (RNA-directed), DNA polymerase, DNA polymerase I, FeLV RT, FIV RT, FV Pol, FV reverse transcriptase, Gag-Pol, HBV-pol, HIV reverse transcriptase, HIV-1 M RT, HIV-1 O RT, HIV-1 R, HIV-1 reverse transcriptase, HIV-1 RT, HIV-reverse transcriptase, HIV-RT, human hepatitis B virus polymerase, human immunodeficiency virus type 1 reverse transcriptase, iScript enzyme, K4 polymerase, K4PolI, M-MuLV reverse transcriptase, MMLV RT, Moloney Murine leukemia virus reverse transcriptase, Moloney murine leukemia virus RT, MoMLV RT, More, MuLV RT, MX162-RT, MX65-RT, nucleoside reverse transcriptase, nucleotidyltransferase, deoxyribonucleate, RNA-dependent, p66 RT, P72, PFV RT, Pol, polymerase/reverse transcriptase, prototype foamy virus reverse transcriptase, R2-RT, reverse transcriptase, reverse transcriptase/RNA dependent DNA polymerase, reverse-transcriptase, revertase, RNA dependent DNA polymerase, RNA revertase, RNA-dependent DNA polymerase, RNA-instructed DNA polymerase, RT, SFV RT, simian foamy virus reverse transcriptase, SS RT, SuperScript I reverse transcriptase, Superscript II, SUPERSCRIPT II reverse transcriptase, T. Z05 pol, telomerase, telomerase catalytic subunit, telomerase reverse transcriptase, TERT, Tgo-Pol, xenotropic murine leukemia virus-related virus reverse transcriptase, XMRV RT, XNA reverse transcriptase

ECTree

     2 Transferases

         2.7 Transferring phosphorus-containing groups

             2.7.7 Nucleotidyltransferases

                2.7.7.49 RNA-directed DNA polymerase

Advanced search results

Do not include text mining results

Include results (more...)

Include results (more...)

Results	in table
22	Activating Compound
70257	AA Sequence
28	Application
1	CAS Registry Number
46	Cloned(Commentary)
9	Crystallization (Commentary)
47552	Disease/ Diagnostics
39	General Information
4	General Stability
311	IC50 Value
429	Inhibitors
31	kcat/KM [mM/s]
12	Ki Value [mM]
100	KM Value [mM]
14	Localization
79	Metals/Ions
37	Molecular Weight [Da]
66	Natural Substrates/ Products (Substrates)
4	Organic Solvent Stability
267	Organism
1098	PDB ID
26	pH Optimum
4	pH Range
2	pI Value
4	Posttranslational Modification
166	Protein Variants
48	Purification (Commentary)
1	Reaction
1	Reaction Type
262	Reference
34	Source Tissue
7	Specific Activity [micromol/min/mg]
10	Storage Stability
333	Substrates and Products (Substrate)
43	Subunits
221	Synonyms
1	Systematic Name
17	Temperature Optimum [°C]
2	Temperature Range [°C]
9	Temperature Stability [°C]
69	Turnover Number [1/s]

Application

print visible entries

print all entries

Go back to the abbreviated version
of the Enzyme Summary Page.

Application on EC 2.7.7.49 - RNA-directed DNA polymerase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide show all columns Go to Application Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

APPLICATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

analysis

Pseudomonas aeruginosa

-

the laser capture microdissection microscopycombined with multiplex quantitative real-time reverse transcriptase PCR, LCMM/qRTPCR, technique can be used to resolve and quantify GFP mRNA variability at high spatial resolution, the method is useful for quantification of any gene expressed by bacteria in their native environment, method development, overview

690537

drug development

7 entries

medicine

10 entries

synthesis

10 entries

drug development

Human immunodeficiency virus 1

-

the enzyme is a drug target

714972

drug development

Human immunodeficiency virus 1

AF324493, Q8Q2U5, Q8Q2V9

HIV-1 reverse transcriptase is a major target of antiviral therapy

723753

drug development

Human immunodeficiency virus 1

-

the enzyme is a primary target in the development of antiviral agents against HIV-1

716827

drug development

Human immunodeficiency virus 1

-

characterization, and lead optimization of 7-azaindole non-nucleoside HIV-1 reverse transcriptase inhibitors

760694

drug development

Hepatitis B virus

-

modeling the functional state of the reverse transcriptase of hepatitis B virus and its application to probing drug-protein interaction

760782

drug development

Human immunodeficiency virus 1 M01

-

HIV-1 reverse transcriptase is a major target of antiviral therapy

-

drug development

Human immunodeficiency virus 1 BG05

-

HIV-1 reverse transcriptase is a major target of antiviral therapy

-

medicine

Human immunodeficiency virus 1

-

the recombinant group O enzyme should be useful for studies aimed at discovering and designing drugs directed towards group O isolates of HIV-1

643448

medicine

Human immunodeficiency virus 1

-

the modified vector system harboring the viral DNA polymerase mutant with reduced dNTP binding affinity can be a potential gene delivery system for the specific transduction of cells with high dNTP concentrations, such as tumor cells.The identification and use of unique cellular and virological factors essential for the specificity of viral based vectors can contribute to the development of safe and effective gene delivery tools

674551

medicine

Human immunodeficiency virus 1

-

combination therapy consisting of nucleoside reverse-transcriptase together with non-nucleoside reverse-transcriptase inhibitors or protease inhibitors leads to a suppression of viral replication

692252

medicine

Homo sapiens

-

gene inhibition causing reduction of telomerase reverse transcriptase activity may provide a basis for cancer therapeutics

691882

medicine

Homo sapiens

-

target in HIV therapy

692567

medicine

Homo sapiens

-

telomerase activity in exfoliated/disseminated epithelial cells can be used as a reliable marker for gastrointestinal cancers

694207

medicine

Homo sapiens

-

telomerase is a universal tumor antigen

692248

medicine

Human immunodeficiency virus 1

AF324493, Q8Q2U5, Q8Q2V9

HIV-1 reverse transcriptase is a major target of antiviral therapy

723753

medicine

Human immunodeficiency virus 1 M01

-

HIV-1 reverse transcriptase is a major target of antiviral therapy

-

medicine

Human immunodeficiency virus 1 BG05

-

HIV-1 reverse transcriptase is a major target of antiviral therapy

-

synthesis

Avian myeloblastosis virus

-

reverse transcriptase is commonly used to synthesize DNA complementary to a variety of RNA templates, synthesis of cDNA. Reverse transcriptase can utilize single-stranded DNA or RNA-DNA hybrid as template to synthesize double-stranded DNA. The reverse transcriptase, unlike the bacterial DNA polymerase, lacks the 3'-5' and 5'-3' exonuclease and can thus be efficiently used for end labeling or gap filling

643435

synthesis

Rous sarcoma virus

-

reverse transcriptase is commonly used to synthesize DNA complementary to a variety of RNA templates, synthesis of cDNA. Reverse transcriptase can utilize single-stranded DNA or RNA-DNA hybrid as template to synthesize double-stranded DNA. The reverse transcriptase, unlike the bacterial DNA polymerase, lacks the 3'-5' and 5'-3' exonuclease and can thus be efficiently used for end labeling or gap filling

643435

synthesis

murine leukemia virus

-

reverse transcriptase is commonly used to synthesize DNA complementary to a variety of RNA templates, synthesis of cDNA. Reverse transcriptase can utilize single-stranded DNA or RNA-DNA hybrid as template to synthesize double-stranded DNA. The reverse transcriptase, unlike the bacterial DNA polymerase, lacks the 3'-5' and 5'-3' exonuclease and can thus be efficiently used for end labeling or gap filling

643435

synthesis

Mason-Pfizer monkey virus

-

reverse transcriptase is commonly used to synthesize DNA complementary to a variety of RNA templates, synthesis of cDNA. Reverse transcriptase can utilize single-stranded DNA or RNA-DNA hybrid as template to synthesize double-stranded DNA. The reverse transcriptase, unlike the bacterial DNA polymerase, lacks the 3'-5' and 5'-3' exonuclease and can thus be efficiently used for end labeling or gap filling

643435

synthesis

Reticuloendotheliosis virus

-

reverse transcriptase is commonly used to synthesize DNA complementary to a variety of RNA templates, synthesis of cDNA. Reverse transcriptase can utilize single-stranded DNA or RNA-DNA hybrid as template to synthesize double-stranded DNA. The reverse transcriptase, unlike the bacterial DNA polymerase, lacks the 3'-5' and 5'-3' exonuclease and can thus be efficiently used for end labeling or gap filling

643435

synthesis

mouse mammary tumor virus

-

reverse transcriptase is commonly used to synthesize DNA complementary to a variety of RNA templates, synthesis of cDNA. Reverse transcriptase can utilize single-stranded DNA or RNA-DNA hybrid as template to synthesize double-stranded DNA. The reverse transcriptase, unlike the bacterial DNA polymerase, lacks the 3'-5' and 5'-3' exonuclease and can thus be efficiently used for end labeling or gap filling

643435

synthesis

Woolly monkey sarcoma virus

-

reverse transcriptase is commonly used to synthesize DNA complementary to a variety of RNA templates, synthesis of cDNA. Reverse transcriptase can utilize single-stranded DNA or RNA-DNA hybrid as template to synthesize double-stranded DNA. The reverse transcriptase, unlike the bacterial DNA polymerase, lacks the 3'-5' and 5'-3' exonuclease and can thus be efficiently used for end labeling or gap filling

643435

synthesis

Hamster leukemia virus

-

reverse transcriptase is commonly used to synthesize DNA complementary to a variety of RNA templates, synthesis of cDNA. Reverse transcriptase can utilize single-stranded DNA or RNA-DNA hybrid as template to synthesize double-stranded DNA. The reverse transcriptase, unlike the bacterial DNA polymerase, lacks the 3'-5' and 5'-3' exonuclease and can thus be efficiently used for end labeling or gap filling

643435

synthesis

Gibbon ape leukemia virus

-

reverse transcriptase is commonly used to synthesize DNA complementary to a variety of RNA templates, synthesis of cDNA. Reverse transcriptase can utilize single-stranded DNA or RNA-DNA hybrid as template to synthesize double-stranded DNA. The reverse transcriptase, unlike the bacterial DNA polymerase, lacks the 3'-5' and 5'-3' exonuclease and can thus be efficiently used for end labeling or gap filling

643435

synthesis

Squirrel monkey retrovirus

-

reverse transcriptase is commonly used to synthesize DNA complementary to a variety of RNA templates, synthesis of cDNA. Reverse transcriptase can utilize single-stranded DNA or RNA-DNA hybrid as template to synthesize double-stranded DNA. The reverse transcriptase, unlike the bacterial DNA polymerase, lacks the 3'-5' and 5'-3' exonuclease and can thus be efficiently used for end labeling or gap filling

643435