2.7.7.49: RNA-directed DNA polymerase

This is an abbreviated version!
For detailed information about RNA-directed DNA polymerase, go to the full flat file.

Word Map on EC 2.7.7.49

2.7.7.49

telomeres

htert

antiretroviral

immortalization

nnrti

ribonucleoprotein

viruses

virological

hiv-infected

lymphocyte

nonnucleoside

zidovudine

marrow

lengthen

strand

subtype

carcinogenesis

tumour

efavirenz

retroviral

rnase

nevirapine

tumorigenesis

lamivudine

g-quadruplexes

anti-hiv

drug-resistant

cd4

c-myc

single-stranded

integrase

first-line

alt

tenofovir

karyotype

polymerases

lifespan

retroviruses

ritonavir

proviral

polyproteins

virion

treatment-naive

dntp

indinavir

erosion

duplex

p16ink4a

hiv-positive

papillomavirus

medicine

synthesis

drug development

analysis

Reaction

a 2'-deoxyribonucleoside 5'-triphosphate

Synonyms

Bst DNA polymerase, CS5 pol, DNA nucleotidyltransferase (RNA-directed), DNA polymerase, DNA polymerase I, FeLV RT, FIV RT, FV Pol, FV reverse transcriptase, Gag-Pol, HBV-pol, HIV reverse transcriptase, HIV-1 M RT, HIV-1 O RT, HIV-1 R, HIV-1 reverse transcriptase, HIV-1 RT, HIV-reverse transcriptase, HIV-RT, human hepatitis B virus polymerase, human immunodeficiency virus type 1 reverse transcriptase, iScript enzyme, K4 polymerase, K4PolI, M-MuLV reverse transcriptase, MMLV RT, Moloney Murine leukemia virus reverse transcriptase, Moloney murine leukemia virus RT, MoMLV RT, More, MuLV RT, MX162-RT, MX65-RT, nucleoside reverse transcriptase, nucleotidyltransferase, deoxyribonucleate, RNA-dependent, p66 RT, P72, PFV RT, Pol, polymerase/reverse transcriptase, prototype foamy virus reverse transcriptase, R2-RT, reverse transcriptase, reverse transcriptase/RNA dependent DNA polymerase, reverse-transcriptase, revertase, RNA dependent DNA polymerase, RNA revertase, RNA-dependent DNA polymerase, RNA-instructed DNA polymerase, RT, SFV RT, simian foamy virus reverse transcriptase, SS RT, SuperScript I reverse transcriptase, Superscript II, SUPERSCRIPT II reverse transcriptase, T. Z05 pol, telomerase, telomerase catalytic subunit, telomerase reverse transcriptase, TERT, Tgo-Pol, xenotropic murine leukemia virus-related virus reverse transcriptase, XMRV RT, XNA reverse transcriptase

ECTree

2 Transferases

2.7 Transferring phosphorus-containing groups

2.7.7 Nucleotidyltransferases

2.7.7.49 RNA-directed DNA polymerase

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Results	in table
22	Activating Compound
70257	AA Sequence
28	Application
1	CAS Registry Number
46	Cloned(Commentary)
9	Crystallization (Commentary)
47552	Disease/ Diagnostics
39	General Information
4	General Stability
311	IC50 Value
429	Inhibitors
31	kcat/KM [mM/s]
12	Ki Value [mM]
100	KM Value [mM]
14	Localization
79	Metals/Ions
37	Molecular Weight [Da]
66	Natural Substrates/ Products (Substrates)
4	Organic Solvent Stability
267	Organism
1098	PDB ID
26	pH Optimum
4	pH Range
2	pI Value
4	Posttranslational Modification
166	Protein Variants
48	Purification (Commentary)
1	Reaction
1	Reaction Type
262	Reference
34	Source Tissue
7	Specific Activity [micromol/min/mg]
10	Storage Stability
333	Substrates and Products (Substrate)
43	Subunits
221	Synonyms
1	Systematic Name
17	Temperature Optimum [°C]
2	Temperature Range [°C]
9	Temperature Stability [°C]
69	Turnover Number [1/s]

IC50 Value

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IC50 Value on EC 2.7.7.49 - RNA-directed DNA polymerase

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0.00003 - 0.00006

1,10-di-2',3'-dideoxy-3'-thiacytidine-decanoate

2 entries

0.000004 - 0.000005

1,10-di-3'-azido-2',3'-dideoxythymidine-decanoate

2 entries

0.000001 - 0.000004

1,10-di-3'-fluoro-2',3'-dideoxythymidine-decanoate

2 entries

0.000009 - 0.00002

1,12-di-2',3'-dideoxy-3'-thiacytidine-dodecanoate

2 entries

0.000002 - 0.000004

1,12-di-3'-azido-2',3'-dideoxythymidine-dodecanoate

2 entries

0.00000097 - 0.000004

1,12-di-3'-fluoro-2',3'-dideoxythymidine-dodecanoate

2 entries

0.000003 - 0.00003

1,14-di-2',3'-dideoxy-3'-thiacytidine-tetradecanoate

2 entries

0.000003

1,14-di-3'-azido-2',3'-dideoxythymidine-tetradecanoate

2 entries

0.00000076 - 0.000003

1,14-di-3'-fluoro-2',3'-dideoxythymidine-tetradecanoate

2 entries

0.014

1,2-bis(2-oxopropoxy)anthracene-9,10-dione

Human immunodeficiency virus 1

pH and temperature not specified in the publication

714972

0.1

1,2-bis[(3-oxobutan-2-yl)oxy]anthracene-9,10-dione

Human immunodeficiency virus 1

above, pH and temperature not specified in the publication

714972

0.00013 - 0.00015

1,4-di-2',3'-dideoxy-3'-thiacytidine-succinate

2 entries

0.00036

1-benzyl-4-(2,6-difluorophenyl)-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydro-1H-pyrrolo[2,3-b]quinoline-3-carbonitrile

Human immunodeficiency virus 1

pH and temperature not specified in the publication

760694

0.026

1-benzyl-4-(2,6-dimethylphenyl)-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydro-1H-pyrrolo[2,3-b]quinoline-3-carbonitrile

Human immunodeficiency virus 1

pH and temperature not specified in the publication

760694

0.058

1-benzyl-4-(3-chlorophenyl)-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydro-1H-pyrrolo[2,3-b]quinoline-3-carbonitrile

Human immunodeficiency virus 1

pH and temperature not specified in the publication

760694

0.0029

1-benzyl-4-(4-fluorophenyl)-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydro-1H-pyrrolo[2,3-b]quinoline-3-carbonitrile

Human immunodeficiency virus 1

pH and temperature not specified in the publication

760694

0.0014

1-benzyl-7,7-dimethyl-4-(4-nitrophenyl)-5-oxo-5,6,7,8-tetrahydro-1H-pyrrolo[2,3-b]quinoline-3-carbonitrile

Human immunodeficiency virus 1

pH and temperature not specified in the publication

760694

0.00073

1-benzyl-7,7-dimethyl-5-oxo-4-phenyl-5,6,7,8-tetrahydro-1H-pyrrolo[2,3-b]quinoline-3-carbonitrile

Human immunodeficiency virus 1

pH and temperature not specified in the publication

760694

0.012

1-benzyl-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydro-1H-pyrrolo[2,3-b]quinoline-3-carbonitrile

Human immunodeficiency virus 1

pH and temperature not specified in the publication

760694

0.00058 - 0.0063

1-butyl-4-[2-fluoro-4-(trifluoromethyl)phenyl]-5-oxo-1,5-dihydroindeno[1,2-b]pyrrolo[3,2-e]pyridine-3-carbonitrile

2 entries

0.014

1-tert-butyl-5-formyl-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile

Human immunodeficiency virus 1

pH and temperature not specified in the publication

760694

0.00077 - 0.00237

2',3'-dehydro-2',3'-deoxythymidine triphosphate

2 entries

0.00009 - 0.0002

2',3'-dideoxy-3'-thiacytidine

2 entries

0.00224

2',3'-dideoxy-CTP

Human immunodeficiency virus 1

674630

0.015

2-acetyl-4-[4-(dimethylamino)phenyl]indeno[1,2-b]pyrrolo[3,2-e]pyridin-5(1H)-one

Human immunodeficiency virus 1

pH and temperature not specified in the publication

760694

0.0234 - 0.05

2-amino-3'-azido-2',3'-dideoxy-N,N-dimethyladenosine 5'-triphosphate

4 entries

0.0441

2-amino-4-(3-benzoylphenyl)thiazole-5-carboxamide

Human immunodeficiency virus 1

P04585

675317

0.118

2-amino-4-(3-bromo-4-chlorophenyl)thiazole-5-carboxamide

Human immunodeficiency virus 1

P04585

675317

0.0544

2-amino-4-(3-chlorophenyl)thiazole-5-carboxamide

Human immunodeficiency virus 1

P04585

675317

0.1254

2-amino-4-(3-iodophenyl)thiazole-5-carboxamide

Human immunodeficiency virus 1

P04585

675317

0.0592

2-amino-4-(3-phenylphenyl)thiazole-5-carboxamide

Human immunodeficiency virus 1

P04585

675317

0.0807

2-amino-4-phenylthiazole-5-carboxamide

Human immunodeficiency virus 1

P04585

675317

0.005

2-[2-(4-bromophenyl)-2-oxoethoxy]-9,10-dioxo-9,10-dihydroanthracen-1-yl acetate

Human immunodeficiency virus 1

pH and temperature not specified in the publication

714972

0.006

2-[2-(biphenyl-4-yl)-2-oxoethoxy]-9,10-dioxo-9,10-dihydroanthracen-1-yl acetate

Human immunodeficiency virus 1

pH and temperature not specified in the publication

714972

0.00034 - 0.0042

3'-azido-2',3'-dideoxy-2,6-diaminopurine-beta-D-ribofuranosyl 5'-triphosphate

5 entries

0.0025 - 0.0308

3'-azido-2',3'-dideoxy-2-amino-6-chloropurine-beta-D-ribofuranosyl 5'-triphosphate

5 entries

0.0244 - 0.1

3'-azido-2',3'-dideoxy-2-amino-6-methoxypurine-beta-D-ribofuranosyl 5'-triphosphate

5 entries

0.0041 - 0.0218

3'-azido-2',3'-dideoxy-2-amino-6-N-allylaminopurine-beta-D-ribofuranosyl 5'-triphosphate

5 entries

0.00016 - 0.0014

3'-azido-2',3'-dideoxyadenosine triphosphate

5 entries

0.00006 - 0.00036

3'-azido-2',3'-dideoxyguanosine triphosphate

5 entries

0.000002 - 0.000008

3'-azido-2',3'-dideoxythymidine

2 entries

0.00002 - 0.00007

3'-azido-2',3'-dideoxythymidine-5'-triphosphate

9 entries

0.042 - 0.06

3'-azido-3'deoxythymidine 5'-triphosphate

2 entries

0.00006 - 0.0001

3'-dideoxythymidine triphosphate

9 entries

0.000002 - 0.00002

3'-fluoro-2',3'-dideoxythymidine

2 entries

0.000129

3,5-dimethyl-4-[[2-([1-[(4-nitrophenyl)methyl]-1,2,3,4-tetrahydropyridin-4-yl]amino)-5,7-dihydrothieno[3,4-d]pyrimidin-4-yl]oxy]benzonitrile

Human immunodeficiency virus 1

inhibition against wild-type enzyme, pH and temperature not specified in the publication

761679

0.000092

3,5-dimethyl-4-[[2-([1-[(4-nitrophenyl)methyl]piperidin-4-yl]amino)-5,7-dihydrofuro[3,4-d]pyrimidin-4-yl]oxy]benzonitrile

Human immunodeficiency virus 1

inhibition against wild-type enzyme, pH and temperature not specified in the publication

761679

0.000241

3,5-dimethyl-4-[[2-([1-[(4-nitrophenyl)methyl]piperidin-4-yl]amino)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]oxy]benzonitrile

Human immunodeficiency virus 1

inhibition against wild-type enzyme, pH and temperature not specified in the publication

761679

0.000175

3,5-dimethyl-4-[[2-([1-[(4-nitrophenyl)methyl]piperidin-4-yl]amino)-6,7-dihydrothieno[3,2-d]pyrimidin-4-yl]oxy]benzonitrile

Human immunodeficiency virus 1

inhibition against wild-type enzyme, pH and temperature not specified in the publication

761679

0.000094

3,5-dimethyl-4-[[2-([1-[(4-nitrophenyl)methyl]piperidin-4-yl]amino)-7,8-dihydro-6H-thiopyrano[3,2-d]pyrimidin-4-yl]oxy]benzonitrile

Human immunodeficiency virus 1

inhibition against wild-type enzyme, pH and temperature not specified in the publication

761679

0.000072

3,5-dimethyl-4-[[2-([1-[(pyridin-4-yl)methyl]piperidin-4-yl]amino)-5,6,7,8-tetrahydroquinazolin-4-yl]oxy]benzonitrile

Human immunodeficiency virus 1

inhibition against wild-type enzyme, pH and temperature not specified in the publication

761679

0.000056

3,5-dimethyl-4-[[2-([1-[(pyridin-4-yl)methyl]piperidin-4-yl]amino)-5,7-dihydrofuro[3,4-d]pyrimidin-4-yl]oxy]benzonitrile

Human immunodeficiency virus 1

inhibition against wild-type enzyme, pH and temperature not specified in the publication

761679

0.000074

3,5-dimethyl-4-[[2-([1-[(pyridin-4-yl)methyl]piperidin-4-yl]amino)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]oxy]benzonitrile

Human immunodeficiency virus 1

inhibition against wild-type enzyme, pH and temperature not specified in the publication

761679

0.000112

3,5-dimethyl-4-[[2-([1-[(pyridin-4-yl)methyl]piperidin-4-yl]amino)-6,7-dihydrothieno[3,2-d]pyrimidin-4-yl]oxy]benzonitrile

Human immunodeficiency virus 1

inhibition against wild-type enzyme, pH and temperature not specified in the publication

761679

0.0643

3-(2-cyanoacetyl)phenyl diethyl phosphate

Human immunodeficiency virus 1

P04585

675317

0.0041

3-(3-chlorophenyl)-3-oxopropanenitrile

Human immunodeficiency virus 1

P04585

675317

0.0296

3-(3-iodophenyl)-3-oxopropanamide

Human immunodeficiency virus 1

P04585

675317

0.000008 - 0.1

3-([3-bromo-2-oxo-5-[(pyridin-3-yloxy)methyl]-1,2-dihydropyridin-4-yl]oxy)-5-chlorobenzonitrile

4 entries

0.000008 - 0.000014

3-([3-bromo-2-oxo-5-[(pyridin-4-yloxy)methyl]-1,2-dihydropyridin-4-yl]oxy)-5-chlorobenzonitrile

3 entries

0.000001 - 0.000002

3-([3-bromo-5-fluoro-2-oxo-6-[2-(pyridin-4-yl)ethyl]-1,2-dihydropyridin-4-yl]oxy)-5-chlorobenzonitrile

3 entries

0.000008 - 0.000017

3-([3-bromo-6-[2-(3-chlorophenyl)ethyl]-5-fluoro-2-oxo-1,2-dihydropyridin-4-yl]oxy)-5-chlorobenzonitrile

3 entries

0.000004 - 0.000016

3-([6-[2-(1,3-benzoxazol-2-yl)ethyl]-3-chloro-2-oxo-1,2-dihydropyridin-4-yl]oxy)-5-chlorobenzonitrile

3 entries

0.0098

3-benzoyl-3-oxopropanenitrile

Human immunodeficiency virus 1

P04585

675317

0.000021 - 0.000078

3-chloro-5-([3-chloro-2-oxo-6-[2-(pyridin-2-yl)ethyl]-1,2-dihydropyridin-4-yl]oxy)benzonitrile

3 entries

0.000016 - 0.000022

3-chloro-5-([3-chloro-2-oxo-6-[2-(pyridin-3-yl)ethyl]-1,2-dihydropyridin-4-yl]oxy)benzonitrile

3 entries

0.000014 - 0.000021

3-chloro-5-([3-chloro-2-oxo-6-[2-(pyridin-4-yl)ethyl]-1,2-dihydropyridin-4-yl]oxy)benzonitrile

3 entries

0.000002 - 0.000004

3-chloro-5-([3-chloro-6-methyl-2-oxo-5-[2-(pyridin-3-yl)ethyl]-1,2-dihydropyridin-4-yl]oxy)benzonitrile

3 entries

0.00003

3-chloro-5-([3-chloro-6-[2-(3,4-dihydroisoquinolin-2(1H)-yl)-2-oxoethyl]-5-fluoro-2-oxo-1,2-dihydropyridin-4-yl]oxy)benzonitrile

Human immunodeficiency virus 1

wild-type enzyme, pH and temperature not specified in the publication

723089

0.000006 - 0.000012

3-chloro-5-([3-chloro-6-[2-(3-chlorophenyl)ethyl]-2-oxo-1,2-dihydropyridin-4-yl]oxy)benzonitrile

3 entries

0.00022

3-chloro-5-([6-[2-(3,4-dihydroisoquinolin-2(1H)-yl)-2-oxoethyl]-3-(dimethylamino)-5-fluoro-2-oxo-1,2-dihydropyridin-4-yl]oxy)benzonitrile

Human immunodeficiency virus 1

wild-type enzyme, pH and temperature not specified in the publication

723089

0.000008

3-chloro-5-[[3-chloro-2-oxo-6-(2-phenylethyl)-1,2-dihydropyridin-4-yl]oxy]benzonitrile

Human immunodeficiency virus 1

wild-type enzyme, pH and temperature not specified in the publication

723089

0.000007

3-chloro-5-[[3-chloro-5-fluoro-2-oxo-6-(2-phenylethyl)-1,2-dihydropyridin-4-yl]oxy]benzonitrile

Human immunodeficiency virus 1

wild-type enzyme, pH and temperature not specified in the publication

723089

0.000005 - 0.000006

3-chloro-5-[[3-chloro-6-methyl-2-oxo-5-(phenoxymethyl)-1,2-dihydropyridin-4-yl]oxy]benzonitrile

3 entries

0.0334

3-phenyl-3-oxopropanenitrile

Human immunodeficiency virus 1

P04585

675317

0.000101

3-[(4-[[4-(4-cyano-2,6-dimethylphenoxy)-5,6,7,8-tetrahydroquinazolin-2-yl]amino]piperidin-1-yl)methyl]benzamide

Human immunodeficiency virus 1

inhibition against wild-type enzyme, pH and temperature not specified in the publication

761679

0.000091

3-[(4-[[4-(4-cyano-2,6-dimethylphenoxy)-5,7-dihydrofuro[3,4-d]pyrimidin-2-yl]amino]piperidin-1-yl)methyl]benzamide

Human immunodeficiency virus 1

inhibition against wild-type enzyme, pH and temperature not specified in the publication

761679

0.000241

3-[(4-[[4-(4-cyano-2,6-dimethylphenoxy)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-2-yl]amino]piperidin-1-yl)methyl]benzamide

Human immunodeficiency virus 1

inhibition against wild-type enzyme, pH and temperature not specified in the publication

761679

0.000094

3-[(4-[[4-(4-cyano-2,6-dimethylphenoxy)-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl]amino]piperidin-1-yl)methyl]benzamide

Human immunodeficiency virus 1

inhibition against wild-type enzyme, pH and temperature not specified in the publication

761679

0.000034 - 0.000071

3-[(5-benzyl-3-bromo-2-oxo-1,2-dihydropyridin-4-yl)oxy]-5-chlorobenzonitrile

3 entries

0.000007 - 0.00001

3-[(5-benzyl-3-bromo-6-methyl-2-oxo-1,2-dihydropyridin-4-yl)oxy]-5-chlorobenzonitrile

3 entries

0.00094

3-[11-(ethoxycarbonyl)-1,7,9,10,11,12-hexahydro-3,2-(metheno)-10-azaazuleno[1',8',7',6':3,4,5]cyclopenta[6,7]fluoreno[2,1,9,8-fghij]benzo[cd]cyclopenta[mno]acephenanthrylen-9-yl]-1-methylpyridinium

Human Immunodeficiency Virus

pH not specified in the publication, temperature not specified in the publication

737822

0.000012

3-[6-bromo-3-[2-(3,4-dihydroisoquinolin-2(1H)-yl)-2-oxoethyl]-2-fluorophenoxy]-5-chlorobenzonitrile

Human immunodeficiency virus 1

wild-type enzyme, pH and temperature not specified in the publication

723089

0.000011 - 0.000021

3-[[3-bromo-2-oxo-5-(pyridin-4-ylmethoxy)-1,2-dihydropyridin-4-yl]oxy]-5-chlorobenzonitrile

3 entries

0.00014 - 0.00018

4'-ethynyl-2-amino-2'-deoxyadenosine triphosphate

2 entries

0.00029 - 0.00043

4'-ethynyl-2-fluoro-2'-deoxyadenosine triphosphate

2 entries

0.0163

4-(3-benzoylphenyl)thiazole-5-carboxamide

Human immunodeficiency virus 1

P04585

675317

0.0099

4-(3-bromo-4-chlorophenyl)-1H-imidazole-5-carboxamide

Human immunodeficiency virus 1

P04585

675317

0.0875

4-(3-bromo-4-chlorophenyl)thiazole-5-carboxamide

Human immunodeficiency virus 1

P04585

675317

0.0798

4-(3-chlorophenyl)-1H-imidazole-5-carboxamide

Human immunodeficiency virus 1

P04585

675317

0.0035

4-(3-iodophenyl)-3-oxobutanenitrile

Human immunodeficiency virus 1

P04585

675317

0.000091

4-([2-[(1-[[4-(methanesulfonyl)phenyl]methyl]-1,2,3,4-tetrahydropyridin-4-yl)amino]-5,7-dihydrothieno[3,4-d]pyrimidin-4-yl]oxy)-3,5-dimethylbenzonitrile

Human immunodeficiency virus 1

inhibition against wild-type enzyme, pH and temperature not specified in the publication

761679

0.0000989

4-([2-[(1-[[4-(methanesulfonyl)phenyl]methyl]piperidin-4-yl)amino]-5,6,7,8-tetrahydroquinazolin-4-yl]oxy)-3,5-dimethylbenzonitrile

Human immunodeficiency virus 1

inhibition against wild-type enzyme, pH and temperature not specified in the publication

761679

0.000077

4-([2-[(1-[[4-(methanesulfonyl)phenyl]methyl]piperidin-4-yl)amino]-5,7-dihydrofuro[3,4-d]pyrimidin-4-yl]oxy)-3,5-dimethylbenzonitrile

Human immunodeficiency virus 1

inhibition against wild-type enzyme, pH and temperature not specified in the publication

761679

0.000157

4-([2-[(1-[[4-(methanesulfonyl)phenyl]methyl]piperidin-4-yl)amino]-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]oxy)-3,5-dimethylbenzonitrile

Human immunodeficiency virus 1

inhibition against wild-type enzyme, pH and temperature not specified in the publication

761679

0.00013

4-([2-[(1-[[4-(methanesulfonyl)phenyl]methyl]piperidin-4-yl)amino]-6,7-dihydrothieno[3,2-d]pyrimidin-4-yl]oxy)-3,5-dimethylbenzonitrile

Human immunodeficiency virus 1

inhibition against wild-type enzyme, pH and temperature not specified in the publication

761679

0.3

4-phenyl-1H-imidazole-5-carboxamide

Human immunodeficiency virus 1

P04585

675317

0.283

4-phenylthiazole-5-carboxamide

Human immunodeficiency virus 1

P04585

675317

0.018

4-[(3,5-dimethylphenyl)sulfanyl]quinolin-2(1H)-one

Human immunodeficiency virus 1

pH and temperature not specified in the publication

723239

0.000051

4-[(4-[[4-(4-cyano-2,6-dimethylphenoxy)-5,6,7,8-tetrahydroquinazolin-2-yl]amino]piperidin-1-yl)methyl]benzamide

Human immunodeficiency virus 1

inhibition against wild-type enzyme, pH and temperature not specified in the publication

761679

0.000084

4-[(4-[[4-(4-cyano-2,6-dimethylphenoxy)-5,6,7,8-tetrahydroquinazolin-2-yl]amino]piperidin-1-yl)methyl]benzene-1-sulfonamide

Human immunodeficiency virus 1

inhibition against wild-type enzyme, pH and temperature not specified in the publication

761679

0.000051

4-[(4-[[4-(4-cyano-2,6-dimethylphenoxy)-5,7-dihydrofuro[3,4-d]pyrimidin-2-yl]amino]piperidin-1-yl)methyl]benzamide

Human immunodeficiency virus 1

inhibition against wild-type enzyme, pH and temperature not specified in the publication

761679

0.000109

4-[(4-[[4-(4-cyano-2,6-dimethylphenoxy)-5,7-dihydrofuro[3,4-d]pyrimidin-2-yl]amino]piperidin-1-yl)methyl]benzene-1-sulfonamide

Human immunodeficiency virus 1

inhibition against wild-type enzyme, pH and temperature not specified in the publication

761679

0.00041

4-[(4-[[4-(4-cyano-2,6-dimethylphenoxy)-5,7-dihydrothieno[3,4-d]pyrimidin-2-yl]amino]piperidin-1-yl)methyl]benzene-1-sulfonamide

Human immunodeficiency virus 1

inhibition against wild-type enzyme, pH and temperature not specified in the publication

761679

0.000073

4-[(4-[[4-(4-cyano-2,6-dimethylphenoxy)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-2-yl]amino]piperidin-1-yl)methyl]benzamide

Human immunodeficiency virus 1

inhibition against wild-type enzyme, pH and temperature not specified in the publication

761679

0.000091

4-[(4-[[4-(4-cyano-2,6-dimethylphenoxy)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-2-yl]amino]piperidin-1-yl)methyl]benzene-1-sulfonamide

Human immunodeficiency virus 1

inhibition against wild-type enzyme, pH and temperature not specified in the publication

761679

0.000066

4-[(4-[[4-(4-cyano-2,6-dimethylphenoxy)-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl]amino]piperidin-1-yl)methyl]benzamide

Human immunodeficiency virus 1

inhibition against wild-type enzyme, pH and temperature not specified in the publication

761679

0.000074

4-[(4-[[4-(4-cyano-2,6-dimethylphenoxy)-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl]amino]piperidin-1-yl)methyl]benzene-1-sulfonamide

Human immunodeficiency virus 1

inhibition against wild-type enzyme, pH and temperature not specified in the publication

761679

0.0000026

4-[6-(4-methylpiperazin-1-yl)pyridin-3-yl]-1-(3-methoxypropyl)-8-(1-methyl-1H-pyrazol-4-yl)-2,5-dihydro-1H-indeno[1,2-d]pyrimidine

Human immunodeficiency virus 1

pH 7.8, 37°C

737458

0.000115

4-[[2-([1-[(4-aminophenyl)methyl]piperidin-4-yl]amino)-5,7-dihydrothieno[3,4-d]pyrimidin-4-yl]oxy]-3,5-dimethylbenzonitrile

Human immunodeficiency virus 1

inhibition against wild-type enzyme, pH and temperature not specified in the publication

761679

0.0004 - 0.0008

4-[[4-(4-chlorophenyl)piperazin-1-yl]methyl]-7,8-dihydroxy-2H-chromen-2-one

2 entries

0.0011 - 0.0048

6-([4-[(4-cyanophenyl)amino]-1,3,5-triazin-2-yl]amino)-5,7-dimethylnaphthalene-2-carbonitrile

2 entries

0.1

6-chloro-4-(2-fluorophenyl)quinolin-2(1H)-one

Human immunodeficiency virus 1

pH and temperature not specified in the publication

723239

0.00015

6-chloro-4-(3,5-dimethylphenoxy)quinolin-2(1H)-one

Human immunodeficiency virus 1

pH and temperature not specified in the publication

723239

0.0056

6-chloro-4-(phenylsulfanyl)quinolin-2(1H)-one

Human immunodeficiency virus 1

pH and temperature not specified in the publication

723239

0.0089

6-chloro-4-(phenylsulfinyl)quinolin-2(1H)-one

Human immunodeficiency virus 1

pH and temperature not specified in the publication

723239

0.049

6-chloro-4-(phenylsulfonyl)quinolin-2(1H)-one

Human immunodeficiency virus 1

pH and temperature not specified in the publication

723239

0.003

6-chloro-4-phenoxyquinolin-2(1H)-one

Human immunodeficiency virus 1

pH and temperature not specified in the publication

723239

0.1

6-chloro-4-phenylquinolin-2(1H)-one

Human immunodeficiency virus 1

pH and temperature not specified in the publication

723239

0.00021

6-chloro-4-[(3,5-dimethylphenyl)sulfanyl]quinolin-2(1H)-one

Human immunodeficiency virus 1

pH and temperature not specified in the publication

723239

0.0026

6-chloro-4-[(3,5-dimethylphenyl)sulfinyl]quinolin-2(1H)-one

Human immunodeficiency virus 1

pH and temperature not specified in the publication

723239

0.01

6-chloro-4-[(3,5-dimethylphenyl)sulfonyl]quinolin-2(1H)-one

Human immunodeficiency virus 1

pH and temperature not specified in the publication

723239

0.06

9,10-dioxo-2-(2-oxo-2-phenylethoxy)-9,10-dihydroanthracen-1-yl acetate

Human immunodeficiency virus 1

pH and temperature not specified in the publication

714972

0.1

9,10-dioxo-2-(2-oxopropoxy)-9,10-dihydroanthracen-1-yl acetate

Human immunodeficiency virus 1

above, pH and temperature not specified in the publication

714972

0.082

9,10-dioxo-2-(prop-2-en-1-yloxy)-9,10-dihydroanthracen-1-yl acetate

Human immunodeficiency virus 1

pH and temperature not specified in the publication

714972

0.1

9,10-dioxo-2-(prop-2-yn-1-yloxy)-9,10-dihydroanthracen-1-yl acetate

Human immunodeficiency virus 1

above, pH and temperature not specified in the publication

714972

0.1

9,10-dioxo-2-[(2-oxopentan-3-yl)oxy]-9,10-dihydroanthracen-1-yl acetate

Human immunodeficiency virus 1

above, pH and temperature not specified in the publication

714972

0.061

9,10-dioxo-2-[(3-oxobutan-2-yl)oxy]-9,10-dihydroanthracen-1-yl acetate

Human immunodeficiency virus 1

pH and temperature not specified in the publication

714972

0.1

9,10-dioxo-9,10-dihydroanthracene-1,2-diyl diacetate

Human immunodeficiency virus 1

above, pH and temperature not specified in the publication

714972

0.012

9,10-dioxo-9,10-dihydroanthracene-1,2-diyl dibenzoate

Human immunodeficiency virus 1

pH and temperature not specified in the publication

714972

0.00008

9-(pyridin-3-yl)-1,7,9,10,11,12-hexahydro-3,2-(metheno)-10-azaazuleno[1',8',7',6':3,4,5]cyclopenta[6,7]fluoreno[2,1,9,8-fghij]benzo[cd]cyclopenta[mno]acephenanthrylene-11-carboxylic acid

Human Immunodeficiency Virus

pH not specified in the publication, temperature not specified in the publication

737822

0.00092 - 0.00102

adefovir diphosphate

2 entries

0.079

alizarin

Human immunodeficiency virus 1

pH and temperature not specified in the publication

714972

0.00134

azidothymidine triphosphate

Human immunodeficiency virus 1

674630

0.0000054 - 0.000411

capravirine

5 entries

0.00012 - 0.0002

d4T-TP

9 entries

0.00152 - 0.0346

Delavirdine

9 entries

0.000002 - 0.000432

efavirenz

20 entries

0.0000046 - 0.0000679

GW8248

5 entries

0.00464

Hygrophorus russula RNase

Human Immunodeficiency Virus

pH not specified in the publication, temperature not specified in the publication

737469

40 - 50

KCl

mouse mammary tumor virus

IC50: 40-50 mM

643425

0.01 - 0.021

lamivudine triphosphate

2 entries

0.2

loviride

Human immunodeficiency virus 1

IC50: 0.0082-0.16 mM, depending on the substrate used.The enzyme from the group M strain BH10 isolate is sensitive. The enzyme from the Spanish HIV-1 group O isolate shows high-level resistance with IC50 above 0.2 mM

643448

0.00014

N-[4-[(4-[[4-(4-cyano-2,6-dimethylphenoxy)thieno[3,2-d]pyrimidin-2-yl]amino]piperidin-1-yl)methyl]phenyl]methanesulfonamide

Human immunodeficiency virus 1

inhibition against wild-type enzyme, pH and temperature not specified in the publication

761679

40 - 50

NaCl

mouse mammary tumor virus

IC50: 40-50 mM

643425

0.00016 - 0.2

nevirapine

15 entries

0.00126

PHP protein

Human immunodeficiency virus 1

pH and temperature not specified in the publication

721138

0.00151 - 0.0064

tenofovir diphosphate

2 entries

0.0000126 - 0.0000647

TMC-125

5 entries

0.00012 - 0.0027

zidovudine triphosphate

5 entries

additional information

2 entries