2.7.7.49: RNA-directed DNA polymerase
This is an abbreviated version!
For detailed information about RNA-directed DNA polymerase, go to the full flat file.
Word Map on EC 2.7.7.49
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2.7.7.49
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telomeres
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htert
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antiretroviral
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immortalization
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nnrti
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ribonucleoprotein
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viruses
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virological
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hiv-infected
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lymphocyte
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nonnucleoside
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zidovudine
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marrow
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lengthen
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strand
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subtype
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carcinogenesis
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tumour
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efavirenz
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retroviral
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rnase
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nevirapine
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tumorigenesis
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lamivudine
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g-quadruplexes
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anti-hiv
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drug-resistant
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cd4
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c-myc
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single-stranded
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integrase
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first-line
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alt
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tenofovir
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karyotype
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polymerases
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lifespan
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retroviruses
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ritonavir
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proviral
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polyproteins
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virion
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treatment-naive
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dntp
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indinavir
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erosion
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duplex
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p16ink4a
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hiv-positive
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papillomavirus
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medicine
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synthesis
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drug development
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analysis
- 2.7.7.49
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telomeres
-
htert
-
antiretroviral
-
immortalization
-
nnrti
- ribonucleoprotein
- viruses
-
virological
-
hiv-infected
- lymphocyte
-
nonnucleoside
- zidovudine
- marrow
-
lengthen
- strand
- subtype
- carcinogenesis
- tumour
- efavirenz
-
retroviral
- rnase
- nevirapine
- tumorigenesis
- lamivudine
-
g-quadruplexes
-
anti-hiv
-
drug-resistant
- cd4
- c-myc
-
single-stranded
-
integrase
-
first-line
-
alt
- tenofovir
-
karyotype
- polymerases
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lifespan
- retroviruses
- ritonavir
-
proviral
- polyproteins
- virion
-
treatment-naive
- dntp
- indinavir
-
erosion
- duplex
- p16ink4a
-
hiv-positive
- papillomavirus
- medicine
- synthesis
- drug development
- analysis
Reaction
Synonyms
Bst DNA polymerase, CS5 pol, DNA nucleotidyltransferase (RNA-directed), DNA polymerase, DNA polymerase I, FeLV RT, FIV RT, FV Pol, FV reverse transcriptase, Gag-Pol, HBV-pol, HIV reverse transcriptase, HIV-1 M RT, HIV-1 O RT, HIV-1 R, HIV-1 reverse transcriptase, HIV-1 RT, HIV-reverse transcriptase, HIV-RT, human hepatitis B virus polymerase, human immunodeficiency virus type 1 reverse transcriptase, iScript enzyme, K4 polymerase, K4PolI, M-MuLV reverse transcriptase, MMLV RT, Moloney Murine leukemia virus reverse transcriptase, Moloney murine leukemia virus RT, MoMLV RT, More, MuLV RT, MX162-RT, MX65-RT, nucleoside reverse transcriptase, nucleotidyltransferase, deoxyribonucleate, RNA-dependent, p66 RT, P72, PFV RT, Pol, polymerase/reverse transcriptase, prototype foamy virus reverse transcriptase, R2-RT, reverse transcriptase, reverse transcriptase/RNA dependent DNA polymerase, reverse-transcriptase, revertase, RNA dependent DNA polymerase, RNA revertase, RNA-dependent DNA polymerase, RNA-instructed DNA polymerase, RT, SFV RT, simian foamy virus reverse transcriptase, SS RT, SuperScript I reverse transcriptase, Superscript II, SUPERSCRIPT II reverse transcriptase, T. Z05 pol, telomerase, telomerase catalytic subunit, telomerase reverse transcriptase, TERT, Tgo-Pol, xenotropic murine leukemia virus-related virus reverse transcriptase, XMRV RT, XNA reverse transcriptase
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2.7.7.49 RNA-directed DNA polymeraseAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 2.7.7.49 - RNA-directed DNA polymerase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2'-deoxyribonucleoside triphosphate + DNAn
diphosphate + DNAn+1
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enzyme mutant N483Q/S486Q/T539N/Y545Q/D547T/P548Q/A570Q/D578Q/A597T/W604R/S612N/V730L/R736Q/S739N/M747R
-
-
?
a 2'-deoxyribonucleoside 5'-triphosphate + DNAn
diphosphate + DNAn+1
-
-
-
?
a 2'-deoxyribonucleoside 5'-triphosphate + DNAn
diphosphate + DNAn+1
-
-
-
-
?
dATP + DNAn
diphosphate + DNAn+1
-
RNA-dependent DNA synthesis
-
-
?
deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
-
-
-
-
?
deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
-
the alpha enzyme form is more active in the single-strand cDNA-directed synthesis of double-stranded cDNA-directed synthesis of double-stranded DNA than the other 2 enzyme forms
-
-
?
deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
-
enzyme plays a central role during the life cycle of a retrovirus. Temperature-sensitive mutants with a lesion in the reverse transcriptase are unable to establish infections
-
-
?
deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
-
the enzyme appears to be required very early after infection to synthesize proviral DNA
-
-
?
deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
-
-
-
-
?
deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
Chicken syncytial virus
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the enzyme appears to be required very early after infection to synthesize proviral DNA
-
-
?
deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
-
the enzyme appears to be required very early after infection to synthesize proviral DNA
-
-
?
deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
-
the enzyme might play a role in normal differentiation
-
-
?
deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
-
enzyme plays a central role during the life cycle of a retrovirus. Temperature-sensitive mutants with a lesion in the reverse transcriptase are unable to establish infections
-
-
?
deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
Hamster leukemia virus
-
enzyme plays a central role during the life cycle of a retrovirus. Temperature-sensitive mutants with a lesion in the reverse transcriptase are unable to establish infections
-
-
?
deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
Hamster leukemia virus HaLV
-
-
-
-
?
deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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DNA polymerase Pol gamma also catalyzes reverse transcription with a slightly higher efficiency than HIV-1 reverse transcriptase. RNA-primed DNA synthesis activity is required for initiation of mtDNA replication. Poly gamma holoenzyme is capable of performing this reaction at a physiologically releavant rate
-
-
?
deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
-
-
-
-
?
deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
-
-
-
?
deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
-
RNA-dependent DNA synthesis
-
-
?
deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
-
-
-
?
deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
-
-
-
?
deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
-
enzyme plays a central role during the life cycle of a retrovirus. Temperature-sensitive mutants with a lesion in the reverse transcriptase are unable to establish infections
-
-
?
deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
-
-
-
-
?
deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
-
the enzyme appears to be required very early after infection to synthesize proviral DNA
-
-
?
deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
-
enzyme plays a central role during the life cycle of a retrovirus. Temperature-sensitive mutants with a lesion in the reverse transcriptase are unable to establish infections
-
-
?
deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
-
the enzyme appears to be required very early after infection to synthesize proviral DNA
-
-
?
deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
-
enzyme plays a central role during the life cycle of a retrovirus. Temperature-sensitive mutants with a lesion in the reverse transcriptase are unable to establish infections
-
-
?
deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
-
the enzyme appears to be required very early after infection to synthesize proviral DNA
-
-
?
deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
-
enzyme plays a central role during the life cycle of a retrovirus. Temperature-sensitive mutants with a lesion in the reverse transcriptase are unable to establish infections
-
-
?
deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
-
the enzyme appears to be required very early after infection to synthesize proviral DNA
-
-
?
deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
-
enzyme plays a central role during the life cycle of a retrovirus. Temperature-sensitive mutants with a lesion in the reverse transcriptase are unable to establish infections
-
-
?
deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
-
the enzyme plays a central role in transposition of retroelements
-
-
?
deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
-
the enzyme appears to be required very early after infection to synthesize proviral DNA
-
-
?
deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
-
enzyme plays a central role during the life cycle of a retrovirus. Temperature-sensitive mutants with a lesion in the reverse transcriptase are unable to establish infections
-
-
?
deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
-
enzyme plays a central role during the life cycle of a retrovirus. Temperature-sensitive mutants with a lesion in the reverse transcriptase are unable to establish infections
-
-
?
deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
-
-
-
?
dGTP + DNAn
diphosphate + DNAn+1
-
RNA-dependent DNA synthesis
-
-
?
additional information
?
-
-
the reverse transcriptase activity of DNA polymerase gamma is not likely to contribute significantly to the biology of mitochondrial DNA replication
-
-
?
additional information
?
-
-
telomerase function comprises lengthening of telomeres, enhancement of DNA repair, promotion of cell growth, modulation of mitochondrial functions under oxidative stress, inhibition of apoptosis, promotion of stem cell proliferation, suppression of DNA damage checkpoints
-
-
?
additional information
?
-
-
reverse transcriptase supports RNA-directed DNA synthesis, DNA-directed DNA synthesis and DNA-directed RNA hydrolysis, the enzyme adopts opposite binding orientations on duplexes containing DNA or RNA primers, directing DNA synthesis or RNA hydrolysis activity respectively, binding orientation determines enzymatic activity of reverse transcriptase
-
-
?
additional information
?
-
-
can use both RNA and DNA as a template for DNA synthesis and can cleave RNA within an RNA/DNA hybrid (RNase H activity)
-
-
?
additional information
?
-
-
uses the cellular tRNALys,3 molecule as primer
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-
?
additional information
?
-
-
ribonucleoside triphosphate are efficiently incorporated into DNA in the macrophage but not in the T cell environment, detailed overview. HIV-1 RT initiates both (-)- and (+)-proviral DNA synthesis using RNA primers (e.g. tRNA3Lys and polypurine tract RNA primer) containing 3'-end ribonucleoside monophosphates during viral replication
-
-
?
additional information
?
-
-
the enzyme performs DNA-dependent DNA synthesis and RNA-dependent DNA synthesis, see also EC 2.7.7.7
-
-
?
additional information
?
-
-
the viral DNA polymerase activity can be both RNA and DNA dependent, see also EC 2.7.7.7
-
-
?
additional information
?
-
-
elongates telomeres to tolerate mutations in the telomeric template
-
-
?
additional information
?
-
-
DNA-dependent DNA polymerase commonly accepts DNA and dNTP and excludes RNA and rNTP, but some enzyme mutants also show RNA-dependent DNA polymerase activity as reverse transcriptases, overview. Reverse transcriptase is the enzyme that catalyzes DNA polymerization using RNA as a template, i.e. RNA-dependent DNA polymerase, see for EC 2.7.7.49
-
-
?
additional information
?
-
-
DNA-dependent DNA polymerase commonly accepts DNA and dNTP and excludes RNA and rNTP, but some enzyme mutants also show RNA-dependent DNA polymerase activity as reverse transcriptases, overview. Reverse transcriptase is the enzyme that catalyzes DNA polymerization using RNA as a template, i.e. RNA-dependent DNA polymerase, see for EC 2.7.7.49
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-
?
