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2.7.1.145: deoxynucleoside kinase

This is an abbreviated version!
For detailed information about deoxynucleoside kinase, go to the full flat file.

Word Map on EC 2.7.1.145

Reaction

ATP
+
a 2'-deoxyribonucleoside
=
ADP
 +
a 2'-deoxyribonucleoside 5'-phosphate

Synonyms

AGCK, AgdNK, BmdNK, D. melanogaster deoxynucleoside kinase, deoxyribonucleoside kinase, deoxyribonucleoside kinase , deoxyribonucleoside phosphotransferase, Dm-dNK, DmdNK, dNK, kinase (phosphorylating), deoxynucleoside, More, ms-dNK, multi-substrate deoxyribonucleoside kinase, multifunctional deoxynucleoside kinase, multispecific deoxynucleoside kinase, multisubstrate deoxyribonucleoside kinase, nucleoside triphosphate: deoxyribonucleoside 5'-phosphotransferase, pyrimidine deoxyribonucleoside kinase, white stripe leaf8, WSL8, Xen-PyK

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.1 Phosphotransferases with an alcohol group as acceptor
                2.7.1.145 deoxynucleoside kinase

Inhibitors

Inhibitors on EC 2.7.1.145 - deoxynucleoside kinase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(E)-5-(2-bromovinyl)-1-beta-D-arabinofuranosyluracil
IC50: 0.0277 mM for reaction with thymidine and 0.0158 mM for reaction with 2'-deoxycytidine
(E)-5-(2-bromovinyl)-2'-deoxyuridine
(E)-5-(2-bromovinyl)-2'-deoxyuridine 5'-monophosphate
-
IC50: 0.0026 mM, reaction with thymidine, fusion protein with glutathione S-transferase
(E)-5-(2-bromovinyl)-2'-deoxyuridine 5'-triphosphate
-
IC50: 0.0069 mM, reaction with thymidine, fusion protein with glutathione S-transferase. The inhibitor is efficiently metabolized to its 5'-mono-, 5'-di- and 5'-triphosphate derivatives in the insect cell culture and abundently incorporated into the insect cell DNA
1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-5-iodouracil
IC50: 0.0163 mM for reaction with thymidine and 0.0154 mM for reaction with 2'-deoxycytidine
1-beta-D-arabinofuranosylcytosine
IC50: 0.0534 mM for reaction with thymidine and 0.089 mM for reaction with 2'-deoxycytidine
1-beta-D-arabinofuranosylthymidine
IC50: 0.0648 mM for reaction with thymidine and 0.0348 mM for reaction with 2'-deoxycytidine
1-beta-D-arabinofuranosyluracil
IC50: 0.057 mM for reaction with thymidine and 0.058 mM for reaction with 2'-deoxycytidine
2',2'-difluorodeoxycytidine
IC50: 0.145 mM for reaction with thymidine and 0.102 mM for reaction with 2'-deoxycytidine
2',3'-dehydro-3'-deoxythymidine
IC50 for reaction with thymidine is greater than 1000 mM, IC50 for reaction with 2'-deoxycytidine is 0.805 mM
2',3'-dideoxycytidine
IC50: 0.76 mM for reaction with thymidine and 0.838 mM for reaction with 2'-deoxycytidine
2',3'-dideoxythymidine
IC50: 0.075 mM for reaction with thymidine and 0.0703 mM for reaction with 2'-deoxycytidine
2'-deoxy-3'-thiacytidine
IC50: 0.74 mM for reaction with thymidine and 0.868 mM for reaction with 2'-deoxycytidine
2'-deoxyadenosine
-
reaction with thymidine or 2'-deoxyguanosine
2'-deoxycytidine
2'-deoxyguanosine
2'-deoxyuridine
reaction with thymidine and 2'-deoxycytidine
2-chloro-2'-deoxyadenosine
IC50: 0.123 mM for reaction with thymidine and 0.12 mM for reaction with 2'-deoxycytidine
3'-azido-2',3'-dideoxythymidine
IC50: 0.0419 mM for reaction with thymidine and 0.0296 mM for reaction with 2'-deoxycytidine
5-fluoro-2'-deoxyuridine
IC50: 0.0258 mM for reaction with thymidine and 0.02235 mM for reaction with 2'-deoxycytidine
dCTP
competitive versus ATP, feedback inhibition
diphosphate
-
competitive versus ATP
thymidine
Triphosphate
-
-
additional information
-