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Literature summary for 2.7.1.145 extracted from

  • Krawiec, K.; Kierdaszuk, B.; Shugar, D.
    Inorganic tripolyphosphate (PPP(i)) as a phosphate donor for human deoxyribonucleoside kinases (2003), Biochem. Biophys. Res. Commun., 301, 192-197.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
diphosphate competitive versus ATP Drosophila melanogaster
Triphosphate
-
Drosophila melanogaster

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0014
-
ATP
-
Drosophila melanogaster

Localization

Localization Comment Organism GeneOntology No. Textmining

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
Drosophila melanogaster

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 2'-deoxynucleoside Drosophila melanogaster
-
ADP + 2'-deoxynucleoside 5'-phosphate
-
ir

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 2'-deoxyadenosine
-
Drosophila melanogaster ADP + 2'-deoxyadenosine 5'-phosphate
-
?
ATP + 2'-deoxycytidine
-
Drosophila melanogaster ADP + 2'-deoxycytidine 5'-phosphate
-
?
ATP + 2'-deoxynucleoside
-
Drosophila melanogaster ADP + 2'-deoxynucleoside 5'-phosphate
-
ir
additional information no activity with diphosphate, or triphosphate as phosphate donors Drosophila melanogaster ?
-
?

Synonyms

Synonyms Comment Organism
dNK
-
Drosophila melanogaster

Cofactor

Cofactor Comment Organism Structure
ATP cannot be substituted by with diphosphate, triphosphate, or polyphosphate as phosphate donors Drosophila melanogaster

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.08
-
diphosphate versus ATP, with substrate 2'-deoxycytidine Drosophila melanogaster
0.143
-
Triphosphate versus ATP, with substrate 2'-deoxycytidine Drosophila melanogaster