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2.7.1.145: deoxynucleoside kinase

This is an abbreviated version!
For detailed information about deoxynucleoside kinase, go to the full flat file.

Word Map on EC 2.7.1.145

Reaction

ATP
+
a 2'-deoxyribonucleoside
=
ADP
+
a 2'-deoxyribonucleoside 5'-phosphate

Synonyms

AGCK, AgdNK, BmdNK, D. melanogaster deoxynucleoside kinase, deoxyribonucleoside kinase, deoxyribonucleoside kinase , deoxyribonucleoside phosphotransferase, Dm-dNK, DmdNK, dNK, kinase (phosphorylating), deoxynucleoside, More, ms-dNK, multi-substrate deoxyribonucleoside kinase, multifunctional deoxynucleoside kinase, multispecific deoxynucleoside kinase, multisubstrate deoxyribonucleoside kinase, nucleoside triphosphate: deoxyribonucleoside 5'-phosphotransferase, pyrimidine deoxyribonucleoside kinase, white stripe leaf8, WSL8, Xen-PyK

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.1 Phosphotransferases with an alcohol group as acceptor
                2.7.1.145 deoxynucleoside kinase

Reference

Reference on EC 2.7.1.145 - deoxynucleoside kinase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Munch-Petersen, B.; Piskur, J.; Sondergaard, L.
The single deoxynucleoside kinase in Drosophila melanogaster, Dm-dNK, is multifunctional and differs from the mammalian deoxynucleoside kinases
Adv. Exp. Med. Biol.
431
465-469
1998
Drosophila melanogaster, Drosophila melanogaster S-2
Manually annotated by BRENDA team
Munch-Petersen, B.; Piskur, J.; Sondergaard, L.
Four deoxynucleoside kinase activities from Drosophila melanogaster are contained within a single monomeric enzyme, a new multifunctional deoxynucleoside kinase
J. Biol. Chem.
273
3926-3931
1998
Drosophila melanogaster, Drosophila melanogaster S-2
Manually annotated by BRENDA team
Johansson, M.; van Rompay, A.R.; Degreve, B.; Balzarini, J.; Karlsson, A.
Cloning and characterization of the multisubstrate deoxyribonucleoside kinase of Drosophila melanogaster
J. Biol. Chem.
274
23814-23819
1999
Drosophila melanogaster (Q9XZT6), Drosophila melanogaster
Manually annotated by BRENDA team
Munch-Petersen, B.; Knecht, W.; Lenz, C.; Sondergaard, L.; Piskur, J.
Functional expression of a multisubstrate deoxyribonucleoside kinase from Drosophila melanogaster and its C-terminal deletion mutants
J. Biol. Chem.
275
6673-6679
2000
Drosophila melanogaster (Q9XZT6), Drosophila melanogaster
Manually annotated by BRENDA team
Balzarini, J.; Degreve, B.; Hatse, S.; De Clercq, E.; Breuer, M.; Johansson, M.; Huybrechts, R.; Karlsson, A.
The multifunctional deoxynucleoside kinase of insect cells is a target for the development of new insecticides
Mol. Pharmacol.
57
811-819
2000
Drosophila melanogaster
Manually annotated by BRENDA team
Knecht, W.; Munch-Petersen, B.; Piskur, J.
Identification of residues involved in the specificity and regulation of the highly efficient multisubstrate deoxyribonucleoside kinase from Drosophila melanogaster
J. Mol. Biol.
301
827-837
2000
Drosophila melanogaster
Manually annotated by BRENDA team
Zheng, X.; Johansson, M.; Karlsson, A.
Nucleoside analog cytotoxicity and bystander cell killing of cancer cells expressing Drosophila melanogaster deoxyribonucleoside kinase in the nucleus or cytosol
Biochem. Biophys. Res. Commun.
289
229-233
2001
Drosophila melanogaster
Manually annotated by BRENDA team
Krawiec, K.; Kierdaszuk, B.; Shugar, D.
Inorganic tripolyphosphate (PPP(i)) as a phosphate donor for human deoxyribonucleoside kinases
Biochem. Biophys. Res. Commun.
301
192-197
2003
Drosophila melanogaster
Manually annotated by BRENDA team
Mikkelsen, N.E.; Johansson, K.; Karlsson, A.; Knecht, W.; Andersen, G.; Piskur, J.; Munch-Petersen, B.; Eklund, H.
Structural basis for feedback inhibition of the deoxyribonucleoside salvage pathway: studies of the Drosophila deoxyribonucleoside kinase
Biochemistry
42
5706-5712
2003
Drosophila melanogaster (Q9XZT6)
Manually annotated by BRENDA team
Eriksson, S.; Munch-Petersen, B.; Johansson, K.; Eklund, H.
Structure and function of cellular deoxyribonucleoside kinases
Cell. Mol. Life Sci.
59
1327-1346
2002
Bombyx mori, Drosophila melanogaster (Q9XZT6)
Manually annotated by BRENDA team
Knecht, W.; Sandrini, M.P.; Johansson, K.; Eklund, H.; Munch-Petersen, B.; Piskur, J.
A few amino acid substitutions can convert deoxyribonucleoside kinase specificity from pyrimidines to purines
Embo J.
21
1873-1880
2002
Drosophila melanogaster
Manually annotated by BRENDA team
Solaroli, N.; Bjerke, M.; Amiri, M.H.; Johansson, M.; Karlsson, A.
Active site mutants of Drosophila melanogaster multisubstrate deoxyribonucleoside kinase
Eur. J. Biochem.
270
2879-2884
2003
Drosophila melanogaster
Manually annotated by BRENDA team
Welin, M.; Skovgaard, T.; Knecht, W.; Zhu, C.; Berenstein, D.; Munch-Petersen, B.; Piskur, J.; Eklund, H.
Structural basis for the changed substrate specificity of Drosophila melanogaster deoxyribonucleoside kinase mutant N64D
FEBS J.
272
3733-3742
2005
Drosophila melanogaster
Manually annotated by BRENDA team
Piskur, J.; Sandrini, M.P.B.; Knecht, W.; Munch-Petersen, B.
Animal deoxyribonucleoside kinases: 'forward' and 'retrograde' evolution of their substrate specificity
FEBS Lett.
560
3-6
2004
Drosophila melanogaster (Q9XZT6)
Manually annotated by BRENDA team
Knecht, W.; Petersen, G.E.; Munch-Petersen, B.; Piskur, J.
Deoxyribonucleoside kinases belonging to the thymidine kinase 2 (TK2)-like group vary significantly in substrate specificity, kinetics and feed-back regulation
J. Mol. Biol.
315
529-540
2002
Drosophila melanogaster, Xenopus laevis (Q8UVZ9), Xenopus laevis, Bombyx mori (Q9BKL3), Bombyx mori
Manually annotated by BRENDA team
Johansson, K.; Ramaswamy, S.; Ljungcrantz, C.; Knecht, W.; Piskur, J.; Munch-Petersen, B.; Eriksson, S.; Eklund, H.
Structural basis for substrate specificities of cellular deoxyribonucleoside kinases
Nat. Struct. Biol.
8
616-620
2001
Drosophila melanogaster (Q9XZT6)
Manually annotated by BRENDA team
Knecht, W.; Petersen, G.E.; Sandrini, M.P.; Sondergaard, L.; Munch-Petersen, B.; Piskur, J.
Mosquito has a single multisubstrate deoxyribonucleoside kinase characterized by unique substrate specificity
Nucleic Acids Res.
31
1665-1672
2003
Anopheles gambiae (Q86LB8), Anopheles gambiae
Manually annotated by BRENDA team
Krawiec, K.; Kierdaszuk, B.; Kalinichenko, E.N.; Rubinova, E.B.; Mikhailopulo, I.A.; Eriksson, S.; Munch-Petersen, B.; Shugar, D.
Ability of adenosine-2'(3')-deoxy-3'(2')-triphosphates and related analogues to replace ATP as phosphate donor for all human and Drosphila melanogaster deoxyribonucleoside kinases
Nucleosides Nucleotides Nucleic Acids
22
1525-1529
2003
Drosophila melanogaster
Manually annotated by BRENDA team
Solaroli, N.; Bjerke, M.; Johansson, M.; Karlsson, A.
Investigation of the substrate recognition of Drosophila melanogaster nucleoside kinase by site directed mutagenesis
Nucleosides Nucleotides Nucleic Acids
23
1527-1529
2004
Drosophila melanogaster
Manually annotated by BRENDA team
Jordheim, L.P.; Galmarini, C.M.; Dumontet, C.
Gemcitabine resistance due to deoxycytidine kinase deficiency can be reverted by fruitfly deoxynucleoside kinase, DmdNK, in human uterine sarcoma cells
Cancer Chemother. Pharmacol.
58
547-554
2006
Drosophila melanogaster
Manually annotated by BRENDA team
Legent, K.; Mas, M.; Dutriaux, A.; Bertrandy, S.; Flagiello, D.; Delanoue, R.; Piskur, J.; Silber, J.
In vivo analysis of Drosophila deoxyribonucleoside kinase function in cell cycle, cell survival and anti-cancer drugs resistance
Cell Cycle
5
740-749
2006
Drosophila melanogaster
Manually annotated by BRENDA team
Egeblad-Welin, L.; Sonntag, Y.; Eklund, H.; Munch-Petersen, B.
Functional studies of active-site mutants from Drosophila melanogaster deoxyribonucleoside kinase. Investigations of the putative catalytic glutamate-arginine pair and of residues responsible for substrate specificity
FEBS J.
274
1542-1551
2007
Drosophila melanogaster
Manually annotated by BRENDA team
Knecht, W.; Rozpedowska, E.; Le Breton, C.; Willer, M.; Gojkovic, Z.; Sandrini, M.P.; Joergensen, T.; Hasholt, L.; Munch-Petersen, B.; Piskur, J.
Drosophila deoxyribonucleoside kinase mutants with enhanced ability to phosphorylate purine analogs
Gene Ther.
14
1278-1286
2007
Drosophila melanogaster
Manually annotated by BRENDA team
Gerth, M.L.; Lutz, S.
Non-homologous recombination of deoxyribonucleoside kinases from human and Drosophila melanogaster yields human-like enzymes with novel activities
J. Mol. Biol.
370
742-751
2007
Drosophila melanogaster
Manually annotated by BRENDA team
Solaroli, N.; Zheng, X.; Johansson, M.; Balzarini, J.; Karlsson, A.
Mitochondrial expression of the Drosophila melanogaster multisubstrate deoxyribonucleoside kinase
Mol. Pharmacol.
72
1593-1598
2007
Drosophila melanogaster
Manually annotated by BRENDA team
Kamiya, H.; Ochiai, H.; Harashima, H.; Ito, M.; Matsuda, A.
Transient expression of Drosophila melanogaster deoxynucleoside kinase gene enhances cytotoxicity of nucleoside analogs
Nucleosides Nucleotides Nucleic Acids
25
553-560
2006
Drosophila melanogaster
Manually annotated by BRENDA team
Mikkelsen, N.E.; Munch-Petersen, B.; Eklund, H.
Structural studies of nucleoside analog and feedback inhibitor binding to Drosophila melanogaster multisubstrate deoxyribonucleoside kinase
FEBS J.
275
2151-2160
2008
Drosophila melanogaster (Q9XZT6), Drosophila melanogaster
Manually annotated by BRENDA team
Clausen, A.R.; Girandon, L.; Knecht, W.; Survery, S.; Andreasson, E.; Munch-Petersen, B.; Piskur, J.
A multisubstrate deoxyribonucleoside kinase from plants
Nucleic Acids Symp. Ser.
52
489-490
2008
Arabidopsis thaliana
Manually annotated by BRENDA team
Knecht, W.; Mikkelsen, N.E.; Clausen, A.R.; Willer, M.; Eklund, H.; Gojkovic, Z.; Piskur, J.
Drosophila melanogaster deoxyribonucleoside kinase activates gemcitabine
Biochem. Biophys. Res. Commun.
382
430-433
2009
Drosophila melanogaster (Q9XZT6), Drosophila melanogaster
Manually annotated by BRENDA team
Betham, B.; Shalhout, S.; Marquez, V.E.; Bhagwat, A.S.
Use of Drosophila deoxynucleoside kinase to study mechanism of toxicity and mutagenicity of deoxycytidine analogs in Escherichia coli
DNA Repair
9
153-160
2010
Drosophila melanogaster
Manually annotated by BRENDA team
Ito, M.; Suda, Y.; Harashima, H.; Kamiya, H.
Cytotoxic effect of Drosophila deoxynucleoside kinase gene on replicating plasmid in HeLa cells
Biol. Pharm. Bull.
33
1223-1227
2010
Drosophila melanogaster
Manually annotated by BRENDA team
Serra, I.; Conti, S.; Piškur, J.; Clausen, A.; Munch-Petersen, B.; Terreni, M.; Ubiali, D.
Immobilized Drosophila melanogaster deoxyribonucleoside kinase (DmdNK) as a high performing biocatalyst for the synthesis of purine arabinonucleotides
Adv. Synth. Catal.
356
563-570
2014
Drosophila melanogaster (Q9XZT6)
-
Manually annotated by BRENDA team
Kamiya, H.; Ito, M.; Nishi, K.; Harashima, H.
In vivo selection of active deoxyribonucleoside kinase by a mutagenic nucleoside analog
J. Biotechnol.
228
52-57
2016
Drosophila melanogaster (Q9XZT6), Drosophila melanogaster
Manually annotated by BRENDA team
Slot Christiansen, L.; Munch-Petersen, B.; Knecht, W.
Non-viral deoxyribonucleoside kinases - diversity and practical use
J. Genet. Genomics
42
235-248
2015
Anopheles gambiae (Q86LB8), Bombyx mori (Q9BKL3), Drosophila melanogaster (Q9XZT6)
Manually annotated by BRENDA team
Jiang, H.; Zhao, L.; Dong, X.; He, A.; Zheng, C.; Johansson, M.; Karlsson, A.; Zheng, X.
Tanshinone IIA enhances bystander cell killing of cancer cells expressing Drosophila melanogaster deoxyribonucleoside kinase in nuclei and mitochondria
Oncol. Rep.
34
1487-1493
2015
Drosophila melanogaster (Q9XZT6), Drosophila melanogaster
Manually annotated by BRENDA team
Fatima, M.; Ahmed, M.; Batool, F.; Riaz, A.; Ali, M.; Munch-Petersen, B.; Mutahir, Z.
Recombinant deoxyribonucleoside kinase from Drosophila melanogaster can improve gemcitabine based combined gene/chemotherapy for targeting cancer cells
Bosn. J. Basic Med. Sci.
19
342-349
2019
Drosophila melanogaster (Q9XZT6), Drosophila melanogaster
Manually annotated by BRENDA team
Sun, Y.; Jiang, H.; Gu, M.; Zheng, X.
Efficacy of lentivirus-mediated Drosophila melanogaster deoxyribonucleoside kinase combined with (E)-5-(2-bromovinyl)-2'-deoxyuridine or 1-beta-D-arabinofuranosylthymine therapy in human keloid fibroblasts
Mol. Med. Rep.
18
1660-1665
2018
Drosophila melanogaster (Q9XZT6)
Manually annotated by BRENDA team
Zhao, Y.; Jiang, H.; Gu, M.; Zu, C.; Zheng, X.
Gemcitabine resistance in triple-negative breast cancer cells can be reverted by Drosophila melanogaster deoxyribonucleoside kinase in the nucleus or cytosol
Oncol. Lett.
20
247
2020
Drosophila melanogaster
Manually annotated by BRENDA team
Liu, L.; You, J.; Zhu, Z.; Chen, K.; Hu, M.; Gu, H.; Liu, Z.; Wang, Z.; Wang, Y.; Liu, S.; Chen, L.; Liu, X.; Tian, Y.; Zhou, S.; Jiang, L.; Wan, J.
White stripe leaf8, encoding a deoxyribonucleoside kinase, is involved in chloroplast development in rice
Plant Cell Rep.
39
19-33
2020
Oryza sativa Indica Group
Manually annotated by BRENDA team
Chen, F.; Zhang, Y.; Daugherty, A.B.; Yang, Z.; Shaw, R.; Dong, M.; Lutz, S.; Benner, S.A.
Biological phosphorylation of an unnatural base pair (UBP) using a Drosophila melanogaster deoxynucleoside kinase (DmdNK) mutant
PLoS ONE
12
e0174163
2017
Drosophila melanogaster (Q9XZT6), Drosophila melanogaster
Manually annotated by BRENDA team