2.4.1.47: N-acylsphingosine galactosyltransferase
This is an abbreviated version!
For detailed information about N-acylsphingosine galactosyltransferase, go to the full flat file.
Word Map on EC 2.4.1.47
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2.4.1.47
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myelin
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oligodendrocyte
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sulfatide
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udp-galactose:ceramide
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galactosylceramide
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galactocerebroside
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galcer
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2.4.1.45
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myelin-specific
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3'-phosphohydrolase
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3'-phosphodiesterase
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myelin-related
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sulfoglycolipids
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udp-glucose:ceramide
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galactosphingolipids
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paranodal
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medicine
- 2.4.1.47
- myelin
- oligodendrocyte
- sulfatide
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udp-galactose:ceramide
- galactosylceramide
- galactocerebroside
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galcer
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2.4.1.45
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myelin-specific
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3'-phosphohydrolase
- 3'-phosphodiesterase
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myelin-related
-
sulfoglycolipids
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udp-glucose:ceramide
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galactosphingolipids
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paranodal
- medicine
Reaction
Synonyms
ceramide galactosyltransferase, cerebroside synthase, CGalT, CGT, EC 2.4.1.45, galactosyltransferase, uridine diphosphogalactose-2-hydroxyacylsphingosine, galactosyltransferase, uridine diphosphogalactose-acylsphingosine, GALT, UDP galactose-N-acylsphingosine galactosyltransferase, UDPgalactose-2-hydroxyacylsphingosine galactosyltransferase, UDPgalactose:2-2-hydroxyacylsphingosine galactosyltransferase, UDPgalactose:ceramide galactosyltransferase, UGT8, uridine diphosphogalactose-2-hydroxyacylsphingosine galactosyltransferase, uridine diphosphogalactose-acylsphingosine galactosyltransferase
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Natural Substrates Products
Natural Substrates Products on EC 2.4.1.47 - N-acylsphingosine galactosyltransferase
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REACTION DIAGRAM
UDPgalactose + 2-(2-hydroxyacyl)sphingosine
1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphingosine + UDP
1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphingosine + UDP
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i.e. 2-hydroxy fatty acid ceramide, synthesis of cerebroside
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?
UDPgalactose + 2-(2-hydroxyacyl)sphingosine
1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphingosine + UDP
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enzyme may play an important role in the synthesis of at least one type of myelin
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?
UDPgalactose + 2-(2-hydroxyacyl)sphingosine
1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphingosine + UDP
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key enzymatic step in the biosynthesis of the galactocerebrosides, cell-specific and highly time-regulated expression of the CGT gene in the terminal differentiated oligodendrocytes of CNS and in Schwann cells of PNS
galactocerebroside
?
UDPgalactose + 2-(2-hydroxyacyl)sphingosine
1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphingosine + UDP
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key enzyme in the biosynthesis of galactocerebroside, the most abundant glycosphingolipid in the myelin sheath
galactocerebroside
?
UDPgalactose + 2-(2-hydroxyacyl)sphingosine
1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphingosine + UDP
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i.e. 2-hydroxy fatty acid ceramide, synthesis of cerebroside
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?
additional information
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final step of galactosylceramide synthesis, which plays a role in myelin formation, signal transduction and oligodendrocyte development
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additional information
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key enzyme in the biosynthesis of cerebrosides and sulfatides, cell-specific and highly time-regulated expression of the CGT gene is thought to play an important role in oligodendrocyte and Schwann cell differentiation
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additional information
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oligodendrocyte-specific enzyme is involved in the biosynthesis of the oligodendrocyte- and myelin-specific cerebrosides, time-regulated CGT expression with a peak around postnatal days 15-25
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additional information
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last step in biosynthesis of cerebrosides
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additional information
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enzyme ensures a supply of UDP-galactose in the endoplasmic reticulum lumen by retaining UDP-galactose transporter in a molecular complex
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additional information
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oligodendrocyte-specific enzyme is involved in the biosynthesis of the oligodendrocyte- and myelin-specific cerebrosides, time-regulated CGT expression with a peak around postnatal days 15-25
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?